The expression of antibody diversity in natural and laboratory-made polyploid individuals of the clawed toad Xenopus.

abstract：:The CCL4 chemokine is secreted by a variety of cells following stimulation. CCL4 affects several different types of cells that are important for acute inflammatory responses and are critical for the development of specific immune responses to foreign antigens. The human genome contains two genes for the CCL4 chemokine...

journal_title：Immunogenetics

authors： Lu J,Honczarenko M,Sloan SR

更新日期：2004-01-01 00:00:00

abstract：:Determining the genomic organization of the Ovis aries (Ovar) major histocompatibility complex class IIa region is essential for future functional studies related to antigen presentation. In this study, a bacterial artificial chromosome (BAC) library of genomic DNA from peripheral blood leukocytes (PBL) of a Rambouill...

journal_title：Immunogenetics

authors： Herrmann-Hoesing LM,White SN,Kappmeyer LS,Herndon DR,Knowles DP

更新日期：2008-04-01 00:00:00

abstract：:Natural killer (NK) cells express receptors for MHC class I that contain immunoreceptor tyrosine-based inhibitory motif (ITIM) sequences in their cytoplasmic domain. Whereas these receptors inhibit NK cell cytotoxicity, certain isoforms of these NK receptors (e.g., KIR2DS, CD94/NKG2C, and Ly49D) do not have ITIMs, but...

journal_title：Immunogenetics

authors： Yim D,Jie HB,Lanier LL,Kim YB

更新日期：2000-05-01 00:00:00

abstract：:TL antigens are class I glycoproteins which are expressed on thymocytes and which are coded by the Tla region of the major histocompatibility complex of the mouse. Biochemical analysis of TL molecules from different strains of mice revealed structural variation determined by the Tla region which is detectable by pepti...

journal_title：Immunogenetics

authors： Michaelson J,Boyse EA,Ciccia L,Flaherty L,Fleissner E,Garnick E,Hämmerling U,Lawrence M,Mauch P,Shen FW

更新日期：1986-01-01 00:00:00

abstract：:Coeliac disease is strongly associated with HLA-DQ2, but it is possible that additional major histocompatibility complex genes also confer disease susceptibility. Encoded close to HLA-DQ are two genes, TAP1 and TAP2, whose products are believed to transport antigenic peptides from the cytoplasm into the endoplasmic re...

journal_title：Immunogenetics

authors： Powis SH,Rosenberg WM,Hall M,Mockridge I,Tonks S,Ivinson A,Ciclitira PJ,Jewell DP,Lanchbury JS,Bell JI

更新日期：1993-01-01 00:00:00

abstract：:The susceptibility to cell-mediated cytolysis of cells of the recently developed C57BL/Ka(H-2 ( b )) lymphoma cell line, BL/VL(3), was investigated in allogeneic assays with thymus-dependent lymphocytes (T cells). Compared to EL4, the widely used C57BL/6(H-2 ( b )) lymphoma cell line, BL/VL(3) cells were found to be i...

journal_title：Immunogenetics

authors： Finn OJ,Lieberman M,Kaplan HS

更新日期：1978-12-01 00:00:00

abstract：:In the absence of any deliberate immunization, mice, rats, humans and alligators all have detectable titers of antibody against chicken red blood cells (CRBC's). Remarkably, this antibody is directed predominantly against private or public determinants of MHC proteins on the CRBC's, and little or no antibody is direct...

journal_title：Immunogenetics

authors： Longenecker BM,Mosmann TR

更新日期：1980-01-01 00:00:00

abstract：:The human complement C4 genes in the HLA exhibit an unusual, dichotomous size polymorphism and a four-gene, modular variation involving novel gene RP, complement C4, steroid 21-hydroxylase (CYP21), and tenascin-like Gene X (RCCX). The C4 gene size dichotomy is mediated by an endogenous retrovirus, HERV-K(C4). Nearly i...

journal_title：Immunogenetics

authors： Dangel AW,Mendoza AR,Baker BJ,Daniel CM,Carroll MC,Wu LC,Yu CY

更新日期：1994-01-01 00:00:00

abstract：:A large number of diseases occur in association with specific HLA-B or -C alleles. Recently a new gene, termed major histocompatibility complex class I chain-related gene A (MICA), has been identified in close proximity to HLA-B. The function of this gene is still unknown, but, it is structurally related to HLA class ...

journal_title：Immunogenetics

authors： Mendoza-Rincon J,Argüello JR,Pérez-Rodríguez M,McWhinnie A,Marsh SG,Fischer G,Madrigal JA

更新日期：1999-06-01 00:00:00

abstract：:We report on the analyses of genes encoding immunoglobulin heavy and light chains in the rabbit 6.51× whole genome assembly. This OryCun2.0 assembly confirms previous mapping of the duplicated IGK1 and IGK2 loci to chromosome 2 and the IGL lambda light chain locus to chromosome 21. The most frequently rearranged and e...

journal_title：Immunogenetics

authors： Gertz EM,Schäffer AA,Agarwala R,Bonnet-Garnier A,Rogel-Gaillard C,Hayes H,Mage RG

更新日期：2013-10-01 00:00:00

abstract：:On a B10 (Lshs) genetic background the development of acquired T-cell-mediated immunity to Leishmania donovani infection in mice is under H-2-linked genetic control. Three phenotypic patterns of recovery were previously observed: "early cure" (H-2s, H-2r), "cure" (H-2b) and "noncure" (H-2d, H-2q, H-2f), with cure beha...

journal_title：Immunogenetics

authors： Blackwell JM

更新日期：1983-01-01 00:00:00

abstract：:Mutants of the EB virus-transformed cell line T5-1 (HLA-A1, 2; B8, 27), bearing well-characterized alterations in HLA-A2 antigen expression and unable to bind the HLA-A2-specific monoclonal antibody BB7.2, have been tested for their susceptibility to EB virus-specific cytolysis using effector T-cell preparations funct...

journal_title：Immunogenetics

authors： Gaston JS,Wallace LE,Rickinson AB,Epstein MA,Pious D

更新日期：1984-01-01 00:00:00

abstract：:The size of B-cell subsets appears to be under genetic control, but the mechanism of this regulation is unknown. By analyzing five congenic strains of mice that differ only in their H2 haplotype, we addressed the issue of whether the MHC genes are involved in the relative proportions of B-1a, B-1b and B-2 cells. Not o...

journal_title：Immunogenetics

authors： Pers JO,Jamin C,Lydyard PM,Charreire J,Youinou P

更新日期：2002-06-01 00:00:00

abstract：:Severe combined immune deficiency (scid) mice are assumed to have two types of abnormalities: one is high radiosensitivity and the other is abnormal recombination in immunoglobulin and T-cell receptor genes. The human chromosome 8 q1.1 region has an ability to complement the scid aberrations. Moreover, the localizatio...

journal_title：Immunogenetics

authors： Hamatani K,Matsuda Y,Araki R,Itoh M,Abe M

更新日期：1996-01-01 00:00:00

abstract：:The present experiments were performed to study whether the genes responsible for the expression of T-idiotypes and allotypes could be mapped in relation to immunoglobulin (Ig) heavy chain V- and C-genes. Use was made of our antiserum 5936, which detects idiotypes in B6 and anti-B10.BR sera and on Lyt-1+, 2.3-B6 anti-...

journal_title：Immunogenetics

authors： Suzan M,Valsted F,Boned A,Rubin B

更新日期：1982-01-01 00:00:00

abstract：:The organization of the major histocompatibility complex (MHC) class II region in cattle was investigated by Southern blot analysis using human probes corresponding to DO, DP, DQ, and DR genes. Exon-specific probes were also employed to facilitate the assessment of the number of different bovine class II genes. The re...

journal_title：Immunogenetics

authors： Andersson L,Rask L

更新日期：1988-01-01 00:00:00

abstract：:The interaction between 9-mer peptides and HLA-B51 molecules was investigated by quantitative peptide binding assay using RMA-S cells expressing human beta2-microglobulin and HLA-B51 molecules. Of 147 chemically synthesized 9-mer peptides possessing two anchor residues corresponding to the motif of HLA-B*5101 binding ...

journal_title：Immunogenetics

authors： Kikuchi A,Sakaguchi T,Miwa K,Takamiya Y,Rammensee HG,Kaneko Y,Takiguchi M

更新日期：1996-01-01 00:00:00

abstract：:The peptide repertoire presented on human leukocyte antigen (HLA) class I molecules is largely determined by the structure of the peptide binding groove. It is expected that the molecules having similar grooves (i.e., belonging to the same supertype) might present similar/overlapping peptides. However, the extent of p...

journal_title：Immunogenetics

authors： Rao X,Hoof I,Costa AI,van Baarle D,Keşmir C

更新日期：2011-11-01 00:00:00

abstract：:Macrophages (mϕ) from pre-diseased mice of the major murine inbred models of spontaneous autoimmunity (AI), including multiple lupus-prone strains and the type I diabetes-prone NOD (non-obese diabetic) strain, have identical apoptotic target-dependent abnormalities. This characteristic feature of mϕ from AI-prone mice...

journal_title：Immunogenetics

authors： Antoni A,Patel VA,Fan H,Lee DJ,Graham LH,Rosch CL,Spiegel DS,Rauch J,Levine JS

更新日期：2011-05-01 00:00:00

abstract：:To identify novel mechanisms regulating allogeneic hematopoietic cell engraftment, we used forward genetics and previously described identification, in mice, of a bone marrow (BM) engraftment quantitative trait locus (QTL), termed Bmgr5. This QTL confers dominant and large allele effects for engraftment susceptibility...

journal_title：Immunogenetics

authors： Wang Y,Chen X,Tsai S,Thomas A,Shizuru JA,Cao TM

更新日期：2013-08-01 00:00:00

abstract：:The nucleotide sequences of 11 variable gene segments coding for rabbit T-cell receptor beta (Tcrb-V) chains were determined by directly sequencing fragments amplified by the cassette-ligation mediated polymerase chain reaction (CLM-PCR) and by modified anchor PCR without the cloning procedure. The nucleotide sequence...

journal_title：Immunogenetics

authors： Isono T,Isegawa Y,Seto A

更新日期：1994-01-01 00:00:00

abstract：:Mutation rates of H2 and non-H2 histocompatibility genes in the mouse are examined over a 25-year period. Detected by skin graft rejections, the mutations were screened in inbred and hybrid mice from a continuously maintained and monitored colony and from a regularly supplied set of mice provided from the National Can...

journal_title：Immunogenetics

authors： Melvold RW,Wang K,Kohn HI

更新日期：1997-01-01 00:00:00

abstract：:The polymorphism of feline MHC antigens was examined using biochemical methods. The following observations were made: (1) feline class I and II antigens are polymorphic. Their biochemical features were established using rabbit and mouse reagents directed against human MHC products; they resemble those observed for oth...

journal_title：Immunogenetics

authors： Neefjes JJ,Hensen EJ,de Kroon TI,Ploegh HL

更新日期：1986-01-01 00:00:00

abstract：:Using the fluorescence-activated cell sorter (FACS II), we have analyzed the expression of H-2K- and H-2D-gene products on the membrane of various cellular components of the murine immune system. Using this serological technique we show a basic difference between T and B lymphocytes. Whereas all cellular components an...

journal_title：Immunogenetics

authors： Tartakovsky B,De Baetselier P,Segal S

更新日期：1980-01-01 00:00:00

abstract：:In this study we analyzed fibroblasts derived from an MHC class II deficiency patient (type III bare lymphocyte syndrome). Northern blot analysis showed that upon induction with IFN-gamma these fibroblasts did not express HLA class II genes and displayed a strongly reduced level of HLA class I gene expression when com...

journal_title：Immunogenetics

authors： Peijnenburg A,Godthelp B,van Boxel-Dezaire A,van den Elsen PJ

更新日期：1995-01-01 00:00:00

abstract：:The potential association between integration or deletion of mouse mammary tumor virus (MMTV) retroviral sequences and the appearance of non-H-2 histocompatibility (H) antigen mutations was investigated. Genomic blots from inbred strains carrying 22 loss, gain-loss, and gain mutations on the BALB/c and C57BL/6 backgro...

journal_title：Immunogenetics

authors： Colombo MP,Melvold RW,Wettstein PJ

更新日期：1987-01-01 00:00:00

abstract：:Immunoglobulin (IG) gene rearrangement and expression are central to disease resistance and health maintenance in animals. The IG kappa (IGK) locus in swine (Sus scrofa domestica) contributes to approximately half of all antibody molecules, in contrast to many other Cetartiodactyla, whose members provide the majority ...

journal_title：Immunogenetics

authors： Schwartz JC,Lefranc MP,Murtaugh MP

更新日期：2012-04-01 00:00:00

abstract：:Human Ia(-like) specificities controlled by gene loci other than HLA-DR were searched for at the molecular level in cells of human B-cell-type cell lines which carry two established DR specificities. Chevalier cells of DRw3 and 7 and U698M cells of DRw2 and 4 were used. Their Ia molecules were partially purified, radi...

journal_title：Immunogenetics

authors： Tanigaki N,Tosi R,Pressman D,Ferrara GB

更新日期：1980-01-01 00:00:00

abstract：:Pigtail macaques (Macaca nemestrina) are an increasingly common primate model for the study of human AIDS. Major Histocompatibility complex (MHC) class I-restricted CD8(+) T cell responses are a critical part of the adaptive immune response to HIV-1 in humans and simian immunodeficiency virus (SIV) in macaques; howeve...

journal_title：Immunogenetics

authors： Pratt BF,O'Connor DH,Lafont BA,Mankowski JL,Fernandez CS,Triastuti R,Brooks AG,Kent SJ,Smith MZ

更新日期：2006-12-01 00:00:00

abstract：:As part of an investigation of the immune system in the developing zebrafish, Danio rerio, we cloned and characterized a genomic V(H) segment and a number of cDNAs encoding IgM heavy chains. The genomic V(H) has the characteristic features of V(H) in other vertebrates, including a leader segment interrupted by a short...

journal_title：Immunogenetics

authors： Danilova N,Hohman VS,Kim EH,Steiner LA

更新日期：2000-11-01 00:00:00