Histocompatibility gene mutation rates in the mouse: a 25-year review.

abstract：:The present experiments were performed to study whether the genes responsible for the expression of T-idiotypes and allotypes could be mapped in relation to immunoglobulin (Ig) heavy chain V- and C-genes. Use was made of our antiserum 5936, which detects idiotypes in B6 and anti-B10.BR sera and on Lyt-1+, 2.3-B6 anti-...

journal_title：Immunogenetics

authors： Suzan M,Valsted F,Boned A,Rubin B

更新日期：1982-01-01 00:00:00

abstract：:The hallmark of the classical major histocompatibility complex (MHC) class I molecules is their astonishing level of polymorphism, a characteristic not shared by the nonclassical MHC class I genes. A distinct family of MHC class I genes has been recently identified within the human MHC class I region. The MICA (MHC cl...

journal_title：Immunogenetics

authors： Fodil N,Laloux L,Wanner V,Pellet P,Hauptmann G,Mizuki N,Inoko H,Spies T,Theodorou I,Bahram S

更新日期：1996-01-01 00:00:00

abstract：:Nonaspanins constitute a family of proteins, also called TM9SF, characterized by a large non-cytoplasmic domain and nine putative transmembrane domains. This family is highly conserved through evolution and comprises three members in Saccharomyces cerevisiae, Dictyostelium discoideum, and Drosophila melanogaster, and ...

journal_title：Immunogenetics

authors： Pruvot B,Laurens V,Salvadori F,Solary E,Pichon L,Chluba J

更新日期：2010-10-01 00:00:00

abstract：:In this study we analyzed fibroblasts derived from an MHC class II deficiency patient (type III bare lymphocyte syndrome). Northern blot analysis showed that upon induction with IFN-gamma these fibroblasts did not express HLA class II genes and displayed a strongly reduced level of HLA class I gene expression when com...

journal_title：Immunogenetics

authors： Peijnenburg A,Godthelp B,van Boxel-Dezaire A,van den Elsen PJ

更新日期：1995-01-01 00:00:00

abstract：:The major histocompatibility complex (MHC) is critical to host-pathogen interactions. Class II MHC is a heterodimer, with α and β subunits encoded by different genes. The peptide-binding groove is formed by the first domain of both subunits (α1 and β1), but studies of class II variation or natural selection focus prim...

journal_title：Immunogenetics

authors： Rand LM,Woodward C,May R,Ackerman RA,Tweedie B,Zicarelli TB,Dearborn DC

更新日期：2019-09-01 00:00:00

abstract：:We have previously demonstrated a genetic predisposition among mice regarding their ability to be protected against vaginal candidiasis after peripheral immunization. Both BALB/c and (BALB/cx C57BL/6) F1 mice are protected against vaginal candidiasis after subcutaneous immunization with Candida albicans extract and C5...

journal_title：Immunogenetics

authors： Mulero-Marchese RD,Blank KJ,Sieck TG

更新日期：1999-10-01 00:00:00

abstract：:Among the genes with the highest allelic polymorphism and sequence diversity are those encoding the classical class I and class II molecules of the major histocompatibility complex (MHC). Although many thousands of MHC sequences have been deposited in general sequence databases like GenBank, the availability of curate...

journal_title：Immunogenetics

authors： Afrache H,Tregaskes CA,Kaufman J

更新日期：2020-02-01 00:00:00

abstract：:We have isolated and characterized cDNAs and genes for pufferfish, Fugu rubripes, (Fugu) orthologues of mammalian interleukin (IL)-12 subunits (IL-12 p35 and IL-12 p40). The deduced amino acid sequences of the Fugu IL-12 subunits showed homology with mammalian IL-12 subunits (p35: 50.4-58.0% similarity; p40: 51.2-55.4...

journal_title：Immunogenetics

authors： Yoshiura Y,Kiryu I,Fujiwara A,Suetake H,Suzuki Y,Nakanishi T,Ototake M

更新日期：2003-08-01 00:00:00

abstract：:Position 45 represents a highly polymorphic residue within HLA class I alleles, which contacts the p2 position of bound peptides in 85% of the peptide-HLA structures analyzed, while the neighboring residues 41 and 46 are not involved in peptide binding. To investigate the influence of residue 45 at the functional leve...

journal_title：Immunogenetics

authors： Badrinath S,Huyton T,Schumacher H,Blasczyk R,Bade-Doeding C

更新日期：2012-03-01 00:00:00

abstract：:Class I major histocompatibility complex (Mhc) cDNA clones were isolated from axolotl mRNA by polymerase chain reaction (PCR) and by screening a cDNA phage library. The nucleotide and predicted amino acid sequences show definite similarities to the Mhc class Ialpha molecules of higher vertebrates. Most of the amino ac...

journal_title：Immunogenetics

authors： Sammut B,Laurens V,Tournefier A

更新日期：1997-01-01 00:00:00

abstract：:Recurrent pregnancy loss (RPL) is a common problem during early gestation. The aim of our study was to investigate the association of IL-17 F( rs763780), IL-17 A (rs2275913), and leptin (2548 G/A) gene polymorphisms with RPL in obese and lean Egyptian females, and to find out whether these gene polymorphisms affect th...

journal_title：Immunogenetics

authors： Zidan HE,Rezk NA,Alnemr AA,Moniem MI

更新日期：2015-11-01 00:00:00

abstract：:Lentinan, a beta-1,6;1,3-glucan, is tumor-specific for transplantable mouse solid-type tumors and it also stimulates the production of acute phase proteins (APPs). The APP response to lentinan is of the delayed type (DT-APR) and differs from that to lipopolysaccharide, which is acute. We found that the responses were ...

journal_title：Immunogenetics

authors： Maeda YY,Takahama S,Kohara Y,Yonekawa H

更新日期：1996-01-01 00:00:00

abstract：:The rabbit has long been a model for studies of the immune system. Work using rabbits contributed both to the battle against infectious diseases such as rabies and syphilis, and to our knowledge, of antibodies' structure, function, and regulated expression. With the description of rabbit Ig allotypes, the discovery of...

journal_title：Immunogenetics

authors： Pinheiro A,Lanning D,Alves PC,Mage RG,Knight KL,van der Loo W,Esteves PJ

更新日期：2011-07-01 00:00:00

abstract：:In three families with an apparent non-expressed factor B (BF) allele (BF*Q0), advanced methods of isoelectric focusing for the determination of BF F subtypes revealed different hypomorphic BF products (BF QL) with functional hemolytic activity expressed by the assumed BF*Q0 allele. A Taq I and a Msp I restriction fra...

journal_title：Immunogenetics

authors： Siemens I,Brenden M,Mauff G,Abbal M,Du Toit E,Bertrams J,Geserick G

更新日期：1992-01-01 00:00:00

abstract：:Asthma is a chronic inflammatory disorder of the airways, and a number of genetic loci are associated with the disease. Candidate gene association studies have been regarded as effective tools to study complex traits. Knowledge of the sequence variation and structure of the candidate genes is required for association ...

journal_title：Immunogenetics

authors： Kim JJ,Kim HH,Park JH,Ryu HJ,Kim J,Moon S,Gu H,Kim HT,Lee JY,Han BG,Park C,Kimm K,Park CS,Lee JK,Oh B

更新日期：2005-10-01 00:00:00

abstract：:Phenotypic variability is often observed in cynomolgus monkeys on preclinical studies and may, in part, be driven by genetic variability. However, the role of monkey genetic variation remains largely unexplored in the context of drug response. This study evaluated genetic variation in cynomolgus monkey FcγR3A and TAP1...

journal_title：Immunogenetics

authors： Sanford JC,Wu H,Abdiche Y,Harney JA,Chaparro-Riggers J,Adkins K

更新日期：2017-04-01 00:00:00

abstract：:The J chain is a component of polymeric immunoglobulin (Ig) molecules and may play an important role in their polymerization and the transport of polymeric Ig across epithelial cells. In this study, the primary structure of the chicken J chain was determined by sequencing cDNA clones. The cDNA had an open reading fram...

journal_title：Immunogenetics

authors： Takahashi T,Iwase T,Tachibana T,Komiyama K,Kobayashi K,Chen CL,Mestecky J,Moro I

更新日期：2000-02-01 00:00:00

abstract：:Rh-related transcripts present in bone marrow samples from several species of nonhuman primates (chimpanzee, gorilla, gibbon, crab-eating macaque) have been amplified by RT-polymerase chain reaction using primers deduced from the sequence of human RH genes. Nucleotide sequence analysis of the nonhuman transcripts reve...

journal_title：Immunogenetics

authors： Salvignol I,Calvas P,Socha WW,Colin Y,Le Van Kim C,Bailly P,Ruffié J,Cartron JP,Blancher A

更新日期：1995-01-01 00:00:00

abstract：:In order to determine the extent of the repertoire of the immunoglobulin light chain V-region locus (Igl-V) in the laboratory rat (Rattus norvegicus), we constructed a specifically primed cDNA library from lipopolysaccharide-stimulated DA strain rat spleens. The library was screened with a rat Igl-C2-specific probe, a...

journal_title：Immunogenetics

authors： Aguilar BA,Gutman GA

更新日期：1992-01-01 00:00:00

abstract：:Human Ia(-like) specificities controlled by gene loci other than HLA-DR were searched for at the molecular level in cells of human B-cell-type cell lines which carry two established DR specificities. Chevalier cells of DRw3 and 7 and U698M cells of DRw2 and 4 were used. Their Ia molecules were partially purified, radi...

journal_title：Immunogenetics

authors： Tanigaki N,Tosi R,Pressman D,Ferrara GB

更新日期：1980-01-01 00:00:00

abstract：:Human IgG receptors (FcgammaR) display considerable heterogeneity, and are crucial immune response modulating molecules. FcgammaRIIA, FcgammaRIIIA, and FcgammaRIIIB display functional biallelic polymorphisms. FcgammaR polymorphisms have been found associated with susceptibility to infectious and autoimmune diseases. L...

journal_title：Immunogenetics

authors： van der Pol WL,Jansen MD,Sluiter WJ,van de Sluis B,Leppers-van de Straat FG,Kobayashi T,Westendorp RG,Huizinga TW,van de Winkel JG

更新日期：2003-07-01 00:00:00

abstract：:The cattle major histocompatibility complex (MHC) region contains a variable number of classical class I genes encoding polymorphic molecules involved in antigen presentation. Six classical class I genes have been described, but assigning sequences to these genes has proved problematic. We propose a refinement of the ...

journal_title：Immunogenetics

authors： Hammond JA,Marsh SG,Robinson J,Davies CJ,Stear MJ,Ellis SA

更新日期：2012-06-01 00:00:00

abstract：:Mammalian interleukin-4 (IL-4) and IL-13 are T helper type 2 (Th2) cytokines with pleiotropic functions in immunity. They signal through receptors containing IL-4Rα and IL-2Rγ or IL-13Rα1. In addition, a decoy receptor, IL-13Rα2, is known to exist and modulates the function of IL-13. The existence of fish orthologues ...

journal_title：Immunogenetics

authors： Wang T,Huang W,Costa MM,Martin SA,Secombes CJ

更新日期：2011-04-01 00:00:00

abstract：:The effect of the H-2dm1 mutation on Qa-m2 expression was examined. The mutant strain B10.D2-H-2dm1 showed a fourfold increase in Qa-m2 expression when compared with the parental strain B10.D2. Qa-m2 molecules immunoprecipitated from B10.D2-H-2dm1, C57BL/10, and B10.D2 spleen cells were identical by two-dimensional (2...

journal_title：Immunogenetics

authors： Hogarth PM,Walker ID,Rigby AJ,McKenzie IF

更新日期：1983-01-01 00:00:00

abstract：:To identify novel mechanisms regulating allogeneic hematopoietic cell engraftment, we used forward genetics and previously described identification, in mice, of a bone marrow (BM) engraftment quantitative trait locus (QTL), termed Bmgr5. This QTL confers dominant and large allele effects for engraftment susceptibility...

journal_title：Immunogenetics

authors： Wang Y,Chen X,Tsai S,Thomas A,Shizuru JA,Cao TM

更新日期：2013-08-01 00:00:00

abstract：:Apoptosis has been suggested as a major mechanism for the CD4(+) T-lymphocyte depletion observed in patients infected with human immunodeficiency virus 1 (HIV-1). To evaluate the impact of genetic variations to apoptosis during progression of acquired immunodeficiency syndrome (AIDS), we have performed an extensive ge...

journal_title：Immunogenetics

authors： Vasilescu A,Heath SC,Diop G,Do H,Hirtzig T,Hendel H,Bertin-Maghit S,Rappaport J,Therwath A,Lathrop GM,Matsuda F,Zagury JF

更新日期：2004-04-01 00:00:00

abstract：:The A15, L6, and S5.7(TAPA1) proteins are members of the transmembrane 4 superfamily (TM4SF). The A15 is expressed in immature human T cells and in the human brain. The MXS1(CCG-B7) gene which codes for A15 contains triplet nucleotide repeats which have been associated with neuropsychiatric diseases such as Huntington...

journal_title：Immunogenetics

authors： Virtaneva KI,Emi N,Marken JS,Aruffo A,Jones C,Spurr NK,Schröder JP

更新日期：1994-01-01 00:00:00

abstract：:Many fishes express high levels of intraspecific variability, often linked to resource partitioning. Several studies show that a species' evolutionary trajectory of adaptive divergence can undergo reversals caused by changes in its environment. Such a reversal in neutral genetic and morphological variation among lake ...

journal_title：Immunogenetics

authors： Baillie SM,Hemstock RR,Muir AM,Krueger CC,Bentzen P

更新日期：2018-01-01 00:00:00

abstract：:The rhesus macaque ( Macaca mulatta) has become a popular animal model for several human infectious diseases, such as HIV (modeled by SIV infection), hepatitis, and malaria. Investigation of T-cell responses in experimental infectious diseases in rhesus macaques has benefited from an expanding understanding of the div...

journal_title：Immunogenetics

authors： Su J,Luscher MA,MacDonald KS

更新日期：2004-03-01 00:00:00

abstract：:We report on the analyses of genes encoding immunoglobulin heavy and light chains in the rabbit 6.51× whole genome assembly. This OryCun2.0 assembly confirms previous mapping of the duplicated IGK1 and IGK2 loci to chromosome 2 and the IGL lambda light chain locus to chromosome 21. The most frequently rearranged and e...

journal_title：Immunogenetics

authors： Gertz EM,Schäffer AA,Agarwala R,Bonnet-Garnier A,Rogel-Gaillard C,Hayes H,Mage RG

更新日期：2013-10-01 00:00:00