Molecular identification of human Ia antigens coded for by a gene locus closely linked to HLA-DR locus.

abstract：:Human cDNA probes for 21-hydroxylase (21-OH) and for complement component C4 are used on restriction digests of the members of several families with interesting supratypes. The presence of two Taq I fragments of 3.7 kb and 3.2 kb in size with a 21-OH probe is confirmed in most individuals who show no evidence of C4 de...

journal_title：Immunogenetics

authors： Garlepp MJ,Wilton AN,Dawkins RL,White PC

更新日期：1986-01-01 00:00:00

abstract：:The anti-HLA-DQ3 monoclonal antibodies (mAb) KS13, SO1, SO2, SO3, SO4, and SO5 recognize spatially close but distinct antigenic determinants, since they crossinhibit each other in their binding to HLA-DQ3 antigens, but do not share idiotopes recognized in their antigen combining site by syngeneic and anti-id antisera ...

journal_title：Immunogenetics

authors： Iwasaki Y,Takabatake H,Monestier M,Ferrone S

更新日期：1995-01-01 00:00:00

abstract：:Mice bearing the H-2b haplotype are susceptible to the development of experimental autoimmune myasthenia gravis (EAMG), induced by acetylcholine receptor (AChR) autoimmunity. One of the genes influencing EAMG susceptibility has been mapped to the Ab locus of the major histocompatibility complex, and the A beta chain h...

journal_title：Immunogenetics

authors： Christadoss P,David CS,Shenoy M,Keve S

更新日期：1990-01-01 00:00:00

abstract：:Eight families (121 individuals) with two or more members affected with systemic lupus erythematosus (SLE) were analyzed for histocompatibility antigens (HLA-A, B, C, DR, MT, and MB) and complement antigens (C4A, C4B, and BF). These data were correlated with serological markers (antinuclear antibodies, single- and dou...

journal_title：Immunogenetics

authors： Reveille JD,Arnett FC,Wilson RW,Bias WB,McLean RH

更新日期：1985-01-01 00:00:00

abstract：:Protein tyrosine phosphorylation is an important regulatory mechanism in cell physiology. While the protein tyrosine kinase (PTKase) family has been extensively studied, only six protein tyrosine phosphatases (PTPases) have been described. By Southern blot analysis, genomic DNA from several different phyla were found ...

journal_title：Immunogenetics

authors： Matthews RJ,Flores E,Thomas ML

更新日期：1991-01-01 00:00:00

abstract：:The H-2K glycoprotein from the MHC mutant bm10 was analyzed biochemically to determine where primary structural differences distinguished it from the parental standard molecule, Kb. Comparative peptide maps showed differences in two peptides known to be part of the parental CNBr fragment spanning amino acids 139 to 22...

journal_title：Immunogenetics

authors： Pease LR,Ewenstein BM,McGovern D,Melvold RW,Nisizawa T,Nathenson SG

更新日期：1983-01-01 00:00:00

abstract：:Chickens of the Iowa State S1 line have been selected for ability to regress Rous sarcoma virus-induced (RSV) tumors, humoral immune response to GAT (Ir-GAT), and erythrocyte antigen B. Sublines homozygous at the major histocompatibility complex (MHC), as well as F1 heterozygotes and F2 segregants, were tested for res...

journal_title：Immunogenetics

authors： Lamont SJ,Bolin C,Cheville N

更新日期：1987-01-01 00:00:00

abstract：:We have isolated and characterized cDNAs and genes for pufferfish, Fugu rubripes, (Fugu) orthologues of mammalian interleukin (IL)-12 subunits (IL-12 p35 and IL-12 p40). The deduced amino acid sequences of the Fugu IL-12 subunits showed homology with mammalian IL-12 subunits (p35: 50.4-58.0% similarity; p40: 51.2-55.4...

journal_title：Immunogenetics

authors： Yoshiura Y,Kiryu I,Fujiwara A,Suetake H,Suzuki Y,Nakanishi T,Ototake M

更新日期：2003-08-01 00:00:00

abstract：:Footpad swelling response was used to measure the alloantigenicity of epidermal cells (ECs) in delayed-type hypersensitivity (DTH). Strong footpad swelling was observed 3 h after the challenge, and it continued for 48 h after the challenge. Genetical incompatibility between the recipients and the ECs was required to i...

journal_title：Immunogenetics

authors： Ishii N,Nakajima H,Aoki I,Ishii T,Takahashi T,Okuda K

更新日期：1986-01-01 00:00:00

abstract：:Mouse Ly6A and Ly6C cDNA probes were hybridized to total RNA of rat tissues and, as in mouse, the highest level of Ly6-related transcripts was detected in kidney. Therefore, Ly6-related cDNA clones were isolated from a commercial rat kidney cDNA library in lambda gt11. Four of these (RK3, RK6, RK10, and RK11) have bee...

journal_title：Immunogenetics

authors： Friedman S,Palfree RG,Sirlin S,Hämmerling U

更新日期：1990-01-01 00:00:00

abstract：:Ia antigens coded by genes of the murine major histocompatibility complex are expressed on the surface of a population of cells critical to the proliferative response of murine spleen cells to the oxidative mitogen neuraminidase/galactose oxidase. By selective depletion with antiserum and complement, Ia antigens coded...

journal_title：Immunogenetics

authors： Phillips ML,Hill SW,Parker JW,O'Brien RL,Frelinger JA

更新日期：1980-01-01 00:00:00

abstract：:Control of HIV-1 viremia and progression to AIDS has been associated with specific HLA genes. The tumor necrosis factor ( TNF) and the non-classical major histocompatibility (MHC) class I chain-related A ( MICA) genes are located in the genomic segment between the HLA class I and II genes and variants of both genes ha...

journal_title：Immunogenetics

authors： Delgado JC,Leung JY,Baena A,Clavijo OP,Vittinghoff E,Buchbinder S,Wolinsky S,Addo M,Walker BD,Yunis EJ,Goldfeld AE

更新日期：2003-10-01 00:00:00

abstract：:Four cDNA probes for the human major histocompatibility complex (MHC) were used to investigate the sheep MHC, in conjunction with serological typing for ovine lymphocyte antigen (OLA). Lymphocytes from a family (two parents and five offspring) of Romanov sheep were subjected to genomic DNA digestion by the restriction...

journal_title：Immunogenetics

authors： Chardon P,Kirszenbaum M,Cullen PR,Geffrotin C,Auffray C,Strominger JL,Cohen D,Vaiman M

更新日期：1985-01-01 00:00:00

abstract：:Zaïre ebolavirus (ZEBOV) infection rapidly outruns the host's immunity and leads to death within a week. Fatal cases have been associated with an aberrant innate, proinflammatory immune response followed by a suppressed adaptive response leading to the rapid depletion of peripheral NK cells and lymphocytes. A critical...

journal_title：Immunogenetics

authors： Wauquier N,Padilla C,Becquart P,Leroy E,Vieillard V

更新日期：2010-12-01 00:00:00

abstract：:Immunoglobulin E (IgE) provides important information on the humoral immune status, and the IgE level is routinely detected in clinical practice. There are many diseases associated with IgE, such as atopic disease, autoimmune diseases, and so on. IgE is a genetically complex trait, but comprehensive genetic assessment...

journal_title：Immunogenetics

authors： Liao M,Shi D,Wang Y,Zhang K,Chen X,Gao Y,Tan A,Xuan Q,Yang X,Hu Y,Qin X,Zhang H,Mo Z

更新日期：2013-08-01 00:00:00

abstract：:Here we describe the Immunogenetic Management Software (IMS) system, a novel web-based application that permits multiplexed analysis of complex immunogenetic traits that are necessary for the accurate planning and execution of experiments involving large animal models, including nonhuman primates. IMS is capable of ho...

journal_title：Immunogenetics

authors： Johnson ZP,Eady RD,Ahmad SF,Agravat S,Morris T,Else J,Lank SM,Wiseman RW,O'Connor DH,Penedo MC,Larsen CP,Kean LS

更新日期：2012-04-01 00:00:00

abstract：:The mechanisms underlying Ir gene control of CMI were addressed by examining the DTH and Tprlf responses specific for the synthetic polymers GT, GAT, and GA. We show that BALB/c mice (GAT/GA responders, GT nonresponders) primed with GT fail to develop DTH and Tprlf responses specific for GT, GAT, or GA. GAT immunizati...

journal_title：Immunogenetics

authors： Kennedy MK,Jenkins MK,Miller SD

更新日期：1986-01-01 00:00:00

abstract：:T-bet is a key regulator for the lineage commitment in CD4+ T helper (Th) 1 cells by activating the hallmark production of interferon-γ. Previously, two single nucleotide polymorphisms (SNPs) in the TBX21 promoter, T-1993C and T-1514C, have been shown by statistic studies to associate with systemic lupus erythematosus...

journal_title：Immunogenetics

authors： Li J,Li J,You Y,Chen S

更新日期：2012-05-01 00:00:00

abstract：:KIR2DL5 alleles were physically linked to alleles at adjacent KIR loci to define this region of KIR haplotypes in 55 gene-positive random African Americans. The majority carried KIR2DL5B. Three KIR2DL5A and six KIR2DL5B alleles that have been previously described and 11 novel KIR2DL5 alleles were identified by DNA seq...

journal_title：Immunogenetics

authors： Hou L,Chen M,Jiang B,Wu D,Ng J,Hurley CK

更新日期：2010-08-01 00:00:00

abstract：:In three families with an apparent non-expressed factor B (BF) allele (BF*Q0), advanced methods of isoelectric focusing for the determination of BF F subtypes revealed different hypomorphic BF products (BF QL) with functional hemolytic activity expressed by the assumed BF*Q0 allele. A Taq I and a Msp I restriction fra...

journal_title：Immunogenetics

authors： Siemens I,Brenden M,Mauff G,Abbal M,Du Toit E,Bertrams J,Geserick G

更新日期：1992-01-01 00:00:00

abstract：:The major histocompatibility complex (MHC) of the domestic cat has been poorly characterized to date, primarily because of numerous difficulties in the preparation of allotypic sera. We present here a comparative analysis of class I and class II genes in domestic cat populations using molecular probes of the MHC from ...

journal_title：Immunogenetics

authors： Yuhki N,O'Brien SJ

更新日期：1988-01-01 00:00:00

abstract：:On a B10 (Lshs) genetic background the development of acquired T-cell-mediated immunity to Leishmania donovani infection in mice is under H-2-linked genetic control. Three phenotypic patterns of recovery were previously observed: "early cure" (H-2s, H-2r), "cure" (H-2b) and "noncure" (H-2d, H-2q, H-2f), with cure beha...

journal_title：Immunogenetics

authors： Blackwell JM

更新日期：1983-01-01 00:00:00

abstract：:The N-terminal domain of the chemokine CCL5/regulated upon activation normal T cell expressed and secreted (RANTES) has been shown to be critical for its biological activity on leukocytes. Several N-terminus-modified CCL5/RANTES derivatives, such as N-Terminal truncated CCL5/RANTES, Met-RANTES, and amino-oxypentane (A...

journal_title：Immunogenetics

authors： Capoulade-Métay C,Ayouba A,Kfutwah A,Lole K,Pêtres S,Dudoit Y,Deterre P,Menu E,Barré-Sinoussi F,Debré P,Theodorou I

更新日期：2006-07-01 00:00:00

abstract：:In this study we analyzed fibroblasts derived from an MHC class II deficiency patient (type III bare lymphocyte syndrome). Northern blot analysis showed that upon induction with IFN-gamma these fibroblasts did not express HLA class II genes and displayed a strongly reduced level of HLA class I gene expression when com...

journal_title：Immunogenetics

authors： Peijnenburg A,Godthelp B,van Boxel-Dezaire A,van den Elsen PJ

更新日期：1995-01-01 00:00:00

abstract：:An H-2-restricted graft-versus-host reaction can be demonstrated when irradiated bone marrow-protected recipients receive injections of cells from radiation chimeras. The cells responsible are Thy-1-positive, thymus-dependent, radiation-sensitive and pass through a nylon wool column, i.e., they are T cells. Treatment ...

journal_title：Immunogenetics

authors： Kindred B

更新日期：1984-01-01 00:00:00

abstract：:Despite matching donors and recipients for the human leukocyte antigens (HLAs) expressed by the major histocompatibility genomic region of the short arm of chromosome 6, several recipients still develop acute graft-versus-host disease (aGVHD) after bone marrow transplantation (BMT). This is possibly due to non-HLA gen...

journal_title：Immunogenetics

authors： Kikuchi T,Naruse TK,Onizuka M,Li S,Kimura T,Oka A,Morishima Y,Kulski JK,Ichimiya S,Sato N,Inoko H

更新日期：2007-02-01 00:00:00

abstract：:Ruminant gammadelta T cells are divided into subpopulations based on the presence or absence of WC1 co-receptors (scavenger-receptor-cysteine-rich family members uniquely expressed on gammadelta T cells). Evidence suggests WC1+ are inflammatory while WC1- are regulatory and that they also differ in their tissue distri...

journal_title：Immunogenetics

authors： Blumerman SL,Herzig CT,Rogers AN,Telfer JC,Baldwin CL

更新日期：2006-08-01 00:00:00

abstract：:In mammals many natural killer (NK) cell receptors, encoded by the leukocyte receptor complex (LRC), regulate the cytotoxic activity of NK cells and provide protection against virus-infected and tumor cells. To investigate the origin of the Ig-like domains encoded by the LRC genes, a subset of C2-type Ig-like domain s...

journal_title：Immunogenetics

authors： Nikolaidis N,Klein J,Nei M

更新日期：2005-04-01 00:00:00

abstract：:In the African clawed frog (Xenopus laevis), two deeply divergent allelic lineages of multiple genes of the class I MHC region have been discovered. For the MHC class I UAA locus, functional differences and the molecular basis for lineages maintenance are unknown. Alleles of linked class I region genes also exhibit st...

journal_title：Immunogenetics

authors： Bos DH,Waldman B

更新日期：2006-06-01 00:00:00

abstract：:Avian influenza is a serious threat to the poultry industry and, as the potential source of a human pandemic virus, to public health. Different Mx alleles have been reported to confer resistance or susceptibility to influenza virus replication, and so knowledge of their frequencies is important when considering the po...

journal_title：Immunogenetics

authors： Balkissoon D,Staines K,McCauley J,Wood J,Young J,Kaufman J,Butter C

更新日期：2007-08-01 00:00:00