Preliminary characterization of the cells causing an H-2-restricted GVH reaction.

Abstract:

:An H-2-restricted graft-versus-host reaction can be demonstrated when irradiated bone marrow-protected recipients receive injections of cells from radiation chimeras. The cells responsible are Thy-1-positive, thymus-dependent, radiation-sensitive and pass through a nylon wool column, i.e., they are T cells. Treatment of the cells with anti-Lyt-1 or anti-Lyt-2 serum and complement reduces but does not eliminate the activity which can be eliminated by treatment with both antisera. Combining anti-Lyt-1-treated and anti-Lyt-2-treated cells does not restore the original activity.

journal_name

Immunogenetics

journal_title

Immunogenetics

authors

Kindred B

doi

10.1007/BF00364767

subject

Has Abstract

pub_date

1984-01-01 00:00:00

pages

243-8

issue

3

eissn

0093-7711

issn

1432-1211

journal_volume

19

pub_type

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