Analysis of the sheep MHC using HLA class I, II, and C4 cDNA probes.

Abstract:

:Four cDNA probes for the human major histocompatibility complex (MHC) were used to investigate the sheep MHC, in conjunction with serological typing for ovine lymphocyte antigen (OLA). Lymphocytes from a family (two parents and five offspring) of Romanov sheep were subjected to genomic DNA digestion by the restriction endonuclease Eco RI, followed by gel electrophoresis. A single Southern blot representing all seven individuals was then consecutively hybridized with the class I, alpha-DC, beta-DR, and C4 probes, which were originally designed to identify HLA class I, class II (DC and DR), and C4 products, respectively. Using each of the three class I/class II probes, several bands showing DNA polymorphism were detected. The segregation of these bands in the five offspring exactly paralleled the OLA haplotype segregation established by serological typing. A further eight individuals carrying haplotypes which were phenotypically identical to those in the above-mentioned family showed bands in the corresponding positions when tested with the same three probes. Using the C4 probe, no polymorphism was detected in these fifteen individuals.

journal_name

Immunogenetics

journal_title

Immunogenetics

authors

Chardon P,Kirszenbaum M,Cullen PR,Geffrotin C,Auffray C,Strominger JL,Cohen D,Vaiman M

doi

10.1007/BF00430918

subject

Has Abstract

pub_date

1985-01-01 00:00:00

pages

349-58

issue

4

eissn

0093-7711

issn

1432-1211

journal_volume

22

pub_type

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