Ek alpha transgene in B10 mice suppresses the development of myasthenia gravis.


:Mice bearing the H-2b haplotype are susceptible to the development of experimental autoimmune myasthenia gravis (EAMG), induced by acetylcholine receptor (AChR) autoimmunity. One of the genes influencing EAMG susceptibility has been mapped to the Ab locus of the major histocompatibility complex, and the A beta chain has been implicated in the pathogenesis. Mice of the H-2b haplotype, including C57BL/10 (B10), have a genomic deletion of the E alpha gene and therefore fail to express the E molecule on their cell surface. To test the hypothesis that failure to express the cell surface E molecule in B10 mice contributes to EAMG pathogenesis, Ek alpha transgenic B10 mice expressing the E molecule were examined. Expression of the E molecule in Ek alpha transgenic B10 mice partially prevented the development of EAMG.






Christadoss P,David CS,Shenoy M,Keve S




Has Abstract


1990-01-01 00:00:00












  • Patterns of MHC-DRB1 polymorphism in a post-glacial island canid, the Newfoundland red fox (Vulpes vulpes deletrix), suggest balancing selection at species and population timescales.

    abstract::As the only native insular Newfoundland canid between the extinction of the wolf in the 1930s and the recent arrival of coyotes, the red fox (Vulpes vulpes deletrix Bangs 1898) poses interesting questions about genetic distinctiveness and the post-glacial colonization history of the island's depauperate mammalian faun...


    pub_type: 杂志文章


    authors: Marshall HD,Langille BL,Hann CA,Whitney HG

    更新日期:2016-05-01 00:00:00

  • B-G cDNA clones have multiple small repeats and hybridize to both chicken MHC regions.

    abstract::We used rabbit antisera to the chicken MHC erythrocyte molecule B-G and to the class I alpha chain (B-F) to screen lambda gt11 cDNA expression libraries made with RNA selected by oligo-dT from bone marrow cells of anemic B19 homozygous chickens. Eight clones were found to encode B-G molecules which hybridize with sequ...


    pub_type: 杂志文章


    authors: Kaufman J,Salomonsen J,Skjødt K

    更新日期:1989-01-01 00:00:00

  • Two distinct TL-like molecular subsets defined by monoclonal antibodies on the surface of human thymocytes with different expression on leukemia lines.

    abstract::Monoclonal antibodies reacting with TL-like class I antigens expressed on the surface of human thymocytes and some T leukemia lines were found to define three independent epitopic clusters, two of which could be shown to reside on serologically distinct molecular subsets by a solid-phase radioimmunoassay as well as by...


    pub_type: 杂志文章


    authors: Olive D,Dubreuil P,Mawas C

    更新日期:1984-01-01 00:00:00

  • The functional link between the immune suppression gene and Mhc class II molecules.

    abstract::The immune response to bovine insulin (BI) in the rat is controlled by the major histocompatibility complex (Mhc)-linked immune response gene (Ir-BI) and immune suppression gene (Is-BI). In the present study, we investigated the low responsiveness to BI in the WKAH rat (RT1k) and attempted to explore the functional li...


    pub_type: 杂志文章


    authors: Mizuno K,Tsuchimoto S,Matsuno Y,Niiyama T,Fujii H,Natori T,Aizawa M

    更新日期:1988-01-01 00:00:00

  • Structure and diversity of the heavy chain VDJ junctions in the developing Mexican axolotl.

    abstract::The immune capacity of young and adult axolotls (Ambystoma mexicanum) was evaluated by examining the combinatorial and junctional diversity of the VH chain. A large number of VDJ rearrangements isolated from 2.5-, 3.5-, 10-, and 24-month-old animals were sequenced. Six JH segments were identified with the canonical st...


    pub_type: 杂志文章


    authors: Golub R,Fellah JS,Charlemagne J

    更新日期:1997-01-01 00:00:00

  • Chimpanzee susceptibility to hepatitis C virus infection correlates with presence of Pt-KIR3DS2 and Pt-KIR2DL9: paired activating and inhibitory natural killer cell receptors.

    abstract::Infection of humans and chimpanzees with Hepatitis C virus (HCV) results in either the resolution of the acute infection or its progression to a persistent infection associated with chronic liver disease. In cohorts of human patients, resolution of HCV infection has been associated with homozygosity for both C1(+)HLA-...


    pub_type: 杂志文章


    authors: Abi-Rached L,Guethlein LA,Norman PJ,Parham P

    更新日期:2015-10-01 00:00:00

  • Killer cell immunoglobulin-like receptor (KIR) gene content variation in the HGDP-CEPH populations.

    abstract::In the present study, we investigate patterns of variation in the KIR cluster in a large and well-characterized sample of worldwide human populations in the Human Genome Diversity Project-Centre d'Etude du Polymorphisme Humain (HGDP-CEPH) panel in order to better understand the patterns of diversity in the region. Com...


    pub_type: 杂志文章


    authors: Hollenbach JA,Nocedal I,Ladner MB,Single RM,Trachtenberg EA

    更新日期:2012-10-01 00:00:00

  • Ancient features of the MHC class II presentation pathway, and a model for the possible origin of MHC molecules.

    abstract::Major histocompatibility complex (MHC) molecules are only found in jawed vertebrates and not in more primitive species. MHC class II type structures likely represent the ancestral structure of MHC molecules. Efficient MHC class II transport to endosomal compartments depends on association with a specialized chaperone,...


    pub_type: 杂志文章,评审


    authors: Dijkstra JM,Yamaguchi T

    更新日期:2019-03-01 00:00:00

  • cDNA cloning and localization of the mouse leukosialin gene (Ly48) to chromosome 7.

    abstract::Mouse leukosialin, previously known as the 3E8 antigen, is expressed primarily on cells of the hematopoietic and lymphoid lineages and is shown to be the mouse homologue to the human leukosialin/sialophorin and rat W3/13 molecules. A partial leukosialin cDNA clone was isolated via cross-species hybridization with a po...


    pub_type: 杂志文章


    authors: Baecher CM,Dorfman KS,Mattei MG,Frelinger JG

    更新日期:1990-01-01 00:00:00

  • Two novel HLA-DQ2.5-restricted gluten T cell epitopes in the DQ2.5-glia-γ4 epitope family.

    abstract::Celiac disease is a chronic inflammatory condition of the small intestine caused by aberrant adaptive immune response to gluten protein from wheat and related cereal plants. Over 90% of celiac disease patients carry the HLA-DQ2.5 allotype and HLA-DQ2.5 presents gluten peptides to gluten-reactive CD4+ T cells in celiac...


    pub_type: 杂志文章


    authors: Qiao SW,Sollid LM

    更新日期:2019-11-01 00:00:00

  • Nine major HLA class I supertypes account for the vast preponderance of HLA-A and -B polymorphism.

    abstract::Herein, we review the epitope approach to vaccine development, and discuss how knowledge of HLA supertypes might be used as a tool in the development of such vaccines. After reviewing the main structural features of the A2-, A3-, B7-, and B44- supertype alleles, and biological data demonstrating their immunological re...


    pub_type: 杂志文章,评审


    authors: Sette A,Sidney J

    更新日期:1999-11-01 00:00:00

  • Two new Ig VH gene families in Oncorhynchus mykiss.

    abstract::Genes encoding the immunoglobulin heavy-chain variable region (Ig VH) in rainbow trout (Oncorhynchus mykiss) have been grouped into 11 families. While obtaining a baseline assessment of the various gene families utilized by trout in the production of secreted antibody, we discovered two new families. These proposed Ig...


    pub_type: 杂志文章


    authors: Brown GD,Kaattari IM,Kaattari SL

    更新日期:2006-11-01 00:00:00

  • Evolution of the porcine (Sus scrofa domestica) immunoglobulin kappa locus through germline gene conversion.

    abstract::Immunoglobulin (IG) gene rearrangement and expression are central to disease resistance and health maintenance in animals. The IG kappa (IGK) locus in swine (Sus scrofa domestica) contributes to approximately half of all antibody molecules, in contrast to many other Cetartiodactyla, whose members provide the majority ...


    pub_type: 杂志文章


    authors: Schwartz JC,Lefranc MP,Murtaugh MP

    更新日期:2012-04-01 00:00:00

  • Leishmania donovani infection in heterozygous and recombinant H-2 haplotype mice.

    abstract::On a B10 (Lshs) genetic background the development of acquired T-cell-mediated immunity to Leishmania donovani infection in mice is under H-2-linked genetic control. Three phenotypic patterns of recovery were previously observed: "early cure" (H-2s, H-2r), "cure" (H-2b) and "noncure" (H-2d, H-2q, H-2f), with cure beha...


    pub_type: 杂志文章


    authors: Blackwell JM

    更新日期:1983-01-01 00:00:00

  • NetCTLpan: pan-specific MHC class I pathway epitope predictions.

    abstract::Reliable predictions of immunogenic peptides are essential in rational vaccine design and can minimize the experimental effort needed to identify epitopes. In this work, we describe a pan-specific major histocompatibility complex (MHC) class I epitope predictor, NetCTLpan. The method integrates predictions of proteaso...


    pub_type: 杂志文章


    authors: Stranzl T,Larsen MV,Lundegaard C,Nielsen M

    更新日期:2010-06-01 00:00:00

  • Characterization of the MHC class II region in cattle. The number of DQ genes varies between haplotypes.

    abstract::The organization of the major histocompatibility complex (MHC) class II region in cattle was investigated by Southern blot analysis using human probes corresponding to DO, DP, DQ, and DR genes. Exon-specific probes were also employed to facilitate the assessment of the number of different bovine class II genes. The re...


    pub_type: 杂志文章


    authors: Andersson L,Rask L

    更新日期:1988-01-01 00:00:00

  • Cloning and expression of the chicken immunoglobulin joining (J)-chain cDNA.

    abstract::The J chain is a component of polymeric immunoglobulin (Ig) molecules and may play an important role in their polymerization and the transport of polymeric Ig across epithelial cells. In this study, the primary structure of the chicken J chain was determined by sequencing cDNA clones. The cDNA had an open reading fram...


    pub_type: 杂志文章


    authors: Takahashi T,Iwase T,Tachibana T,Komiyama K,Kobayashi K,Chen CL,Mestecky J,Moro I

    更新日期:2000-02-01 00:00:00

  • Association of human NK cell surface receptors NKR-P1 and CD94 with Src-family protein kinases.

    abstract::Human natural killer (NK) cells express on their surface several members of the C-type lectin family such as NKR-P1, CD94, and NKG2 that are probably involved in recognition of target cells and delivery of signals modulating NK cell cytotoxicity. To elucidate the mechanisms involved in signaling via these receptors, w...


    pub_type: 杂志文章


    authors: Cerný J,Fiserová A,Horváth O,Bezouska K,Pospísil M,Horejsí V

    更新日期:1997-01-01 00:00:00

  • The chicken CD4 gene has remained conserved in evolution.

    abstract::CD4 has a central role in thymocyte differentiation and cell-mediated immunity. We isolated and analyzed chicken CD4. The gene spans 11.5 kb and is composed of ten exons. The promoter is TATA-less and similar to the mouse and human CD4 promoters, with two transcription start sites as determined by 5'RACE analysis. In ...


    pub_type: 杂志文章


    authors: Koskinen R,Salomonsen J,Tregaskes CA,Young JR,Goodchild M,Bumstead N,Vainio O

    更新日期:2002-10-01 00:00:00

  • The major histocompatibility class I locus in Atlantic salmon (Salmo salar L.): polymorphism, linkage analysis and protein modelling.

    abstract::A cDNA library screening using the conserved exon 4 of Atlantic salmon Mhc class I as probe provided the basis for a study on Mhc class I polymorphism in a breeding population. Twelve different alleles were identified in the 82 dams and sires studied. No individual expressed more than two alleles, which corresponded t...


    pub_type: 杂志文章


    authors: Grimholt U,Drabløs F,Jørgensen SM,Høyheim B,Stet RJ

    更新日期:2002-11-01 00:00:00

  • Cloning and functional analysis of the allelic polymorphism in the transcription regulatory region of interleukin-1 alpha.

    abstract::A strong correlation between the TT(-889) genotype over CC(-889) of the interleukin-1 alpha (IL-1 alpha) transcription regulatory region and age of Alzheimer's disease onset has recently been reported. To determine the functional effects of the genetic variants on plasma protein levels, we cloned the promoter region a...


    pub_type: 杂志文章


    authors: Dominici R,Cattaneo M,Malferrari G,Archi D,Mariani C,Grimaldi LM,Biunno I

    更新日期:2002-05-01 00:00:00

  • Lyb-8.2: A new B cell antigen defined and characterized with a monoclonal antibody.

    abstract::A DBA/1 B10.D2-specific monoclonal antibody (CY34) is described which defines a new murine B lymphocyte differentiation antigen designated Lyb-8.2. The ontogeny, strain distribution, and cell-surface density of the antigen were studied by radioimmunoassay and by fluorescence-activated cell sorter (FACS) analysis. Lyb-...


    pub_type: 杂志文章


    authors: Symington FW,Subbarao B,Mosier DE,Sprent J

    更新日期:1982-01-01 00:00:00

  • Preliminary characterization of the cells causing an H-2-restricted GVH reaction.

    abstract::An H-2-restricted graft-versus-host reaction can be demonstrated when irradiated bone marrow-protected recipients receive injections of cells from radiation chimeras. The cells responsible are Thy-1-positive, thymus-dependent, radiation-sensitive and pass through a nylon wool column, i.e., they are T cells. Treatment ...


    pub_type: 杂志文章


    authors: Kindred B

    更新日期:1984-01-01 00:00:00

  • Localization of CT beta and C kappa on mouse chromosome 6.

    abstract::In the mouse three lymphocyte gene families have been positioned on the proximal region of chromosome 6. Originally the immunoglobulin kappa light chain (Igk) and the thymocyte surface antigens Lyt-2 and Lyt-3 were assigned to chromosome 6, and recently the beta chain of the T-cell receptor for antigen was positioned ...


    pub_type: 杂志文章


    authors: D'Hoostelaere LA,Jouvin-Marche E,Huppi K

    更新日期:1985-01-01 00:00:00

  • A genetic analysis of natural resistance to nonsyngeneic cells: the role of H-2.

    abstract::The genetic control of natural resistance in vivo to four natural killer (NK) cell-resistant H-2 homozygous lymphoid tumor cell lines was investigated by following the survival and organ distribution of cells prelabeled with radioactive iododeoxyuridine. Backcross mice derived from DBA/2J and CBA/J parents were inject...


    pub_type: 杂志文章


    authors: Carlson GA,Taylor BA,Marshall ST,Greenberg AH

    更新日期:1984-01-01 00:00:00

  • The recombination activation gene 1 (RAG1) of rainbow trout (Oncorhynchus mykiss): cloning, expression, and phylogenetic analysis.

    abstract::The characterization of genes involved in the generation of the immune repertoire is an active area of research in lower vertebrate taxa. The recombination activating genes (RAG) have been shown to be essential for V (D) J recombination of T-cell antigen receptor (TCR) and immunoglobulin (Ig) genes, leading to the gen...


    pub_type: 杂志文章


    authors: Hansen JD,Kaattari SL

    更新日期:1995-01-01 00:00:00

  • The research of W.E. Mayer (1953-2012): a spectrum of immune systems.

    abstract::Over a period of some 20 years, Werner Eugen Mayer played a significant role in establishing a framework for molecular studies of Mhc genes in multiple vertebrates. His work largely concerned gene isolation, sequencing, and related bioinformatic analyses both for the Mhc and for immune system genes of about 200 specie...


    pub_type: 传,历史文章,杂志文章,评审


    authors: O'hUigin C

    更新日期:2012-12-01 00:00:00

  • Mouse novel Ly9: a new member of the expanding CD150 (SLAM) family of leukocyte cell-surface receptors.

    abstract::Human CS1, also known as novel Ly9, 19A24, or CRACC, is a member of the immunoglobulin gene superfamily (IgSF) expressed on natural killer cells and other leukocytes. Here we describe the cloning of the mouse homologue of this gene. The mouse novel Ly9 gene is shown to encode a transmembrane protein composed of two ex...


    pub_type: 杂志文章


    authors: Tovar V,del Valle J,Zapater N,Martin M,Romero X,Pizcueta P,Bosch J,Terhorst C,Engel P

    更新日期:2002-09-01 00:00:00

  • Killer cell immunoglobulin-like receptor and human leukocyte antigen gene profiles in a cohort of HIV-infected Mexican Mestizos.

    abstract::Killer cell immunoglobulin-like receptors (KIRs) represent the most polymorphic genes responsible for natural killer cell function, while human leukocyte antigen (HLA) class I molecules define and restrict cytotoxic T lymphocyte responses. Specific KIR, HLA, or KIR-HLA combinations have been implicated in the outcome ...


    pub_type: 杂志文章


    authors: Garrido-Rodríguez D,Ávila-Ríos S,García-Morales C,Valenzuela-Ponce H,Ormsby C,Reyes-Gopar H,Fernandez-Lopez JC,Reyes-Terán G

    更新日期:2016-10-01 00:00:00

  • Binding of nonamer peptides to three HLA-B51 molecules which differ by a single amino acid substitution in the A-pocket.

    abstract::The interaction between 9-mer peptides and HLA-B51 molecules was investigated by quantitative peptide binding assay using RMA-S cells expressing human beta2-microglobulin and HLA-B51 molecules. Of 147 chemically synthesized 9-mer peptides possessing two anchor residues corresponding to the motif of HLA-B*5101 binding ...


    pub_type: 杂志文章


    authors: Kikuchi A,Sakaguchi T,Miwa K,Takamiya Y,Rammensee HG,Kaneko Y,Takiguchi M

    更新日期:1996-01-01 00:00:00