Abstract:
:The nucleotide sequences of 11 variable gene segments coding for rabbit T-cell receptor beta (Tcrb-V) chains were determined by directly sequencing fragments amplified by the cassette-ligation mediated polymerase chain reaction (CLM-PCR) and by modified anchor PCR without the cloning procedure. The nucleotide sequences in two of these 11 rabbit Tcrb-V gene segments coincided with those in two of the four rabbit Tcrb-V gene segments previously reported; the others have not been described. The percentage similarity of each nucleotide sequence of the 11 rabbit Tcrb-V gene segments was analyzed and the segments were divided into nine families, which were homologous to nine human families (Vb 2, 3, 4, 5, 7, 8, 10, 18, and 22), respectively.
journal_name
Immunogeneticsjournal_title
Immunogeneticsauthors
Isono T,Isegawa Y,Seto Adoi
10.1007/BF00188786subject
Has Abstractpub_date
1994-01-01 00:00:00pages
243-8issue
4eissn
0093-7711issn
1432-1211journal_volume
39pub_type
杂志文章相关文献
IMMUNOGENETICS文献大全abstract::TAP1 and TAP2 are two major histocompatibility complex (MHC) genes, located between HLA-DP and -DQ, whose products form a transporter molecule involved in endogenous antigen processing. Polymorphic residues have been described in both genes and, in this study, we have identified another polymorphic site within the ade...
journal_title:Immunogenetics
pub_type: 杂志文章
doi:10.1007/BF00216802
更新日期:1993-01-01 00:00:00
abstract::We report the sequence of a cDNA encoding a rabbit immunoglobulin gamma heavy chain of d12 and e14 allotypes with high homology to partial cDNA sequences from rabbits of d11 and e15 allotypes. The encoded rabbit protein shows homologies with human (68-70%) and mouse (60-63%) gamma chains. The nucleotide sequence homol...
journal_title:Immunogenetics
pub_type: 杂志文章
doi:10.1007/BF00372471
更新日期:1983-01-01 00:00:00
abstract::The variability of immune responses modulated by human leukocyte antigen (HLA) genes and secreted cytokines is a significant factor in the development of a protective effect of measles vaccine. We studied the association between type 1 helper T cells (Th1)- and Th2-like cytokine immune responses and HLA class I allele...
journal_title:Immunogenetics
pub_type: 杂志文章
doi:10.1007/s00251-005-0061-6
更新日期:2005-12-01 00:00:00
abstract::The guppy, Poecilia reticulata, a teleostean fish of the order Cyprinodontiformes, has been used extensively in studies of host-parasite interactions, courtship behavior, and mating preference, as well as in ecological and evolutionary genetics. A related species was among the first poikilotherm vertebrates to be used...
journal_title:Immunogenetics
pub_type: 杂志文章
doi:10.1007/BF00186602
更新日期:1996-01-01 00:00:00
abstract::Binding of peptides to major histocompatibility complex (MHC) molecules is the single most selective step in the recognition of pathogens by the cellular immune system. The human MHC genomic region (called HLA) is extremely polymorphic comprising several thousand alleles, each encoding a distinct MHC molecule. The pot...
journal_title:Immunogenetics
pub_type: 杂志文章
doi:10.1007/s00251-008-0341-z
更新日期:2009-01-01 00:00:00
abstract::Natural killer (NK) cells constitute the third major population of lymphocytes. They possess the inherent capacity to kill various tumor and virally infected cells and mediate the rejection of bone-marrow grafts in lethally irradiated animals. A large family of NK cell receptors belong to the C-type lectin superfamily...
journal_title:Immunogenetics
pub_type: 杂志文章
doi:10.1007/s002510050679
更新日期:1999-10-01 00:00:00
abstract::The serological reactivities of HLA-A3, -B7, and -CW3 heavy chains associated with either mouse, bovine, or human beta-2-microglobulin (beta 2m) and expressed on the surface of transfected mouse fibroblasts were analyzed. All reactivities associated with one cluster (defined by monoclonal antibody W6/32) of antigenic ...
journal_title:Immunogenetics
pub_type: 杂志文章
doi:10.1007/BF00430798
更新日期:1985-01-01 00:00:00
abstract::A polymorphic gene, MIC-A, is one of the MIC family of genes which is composed of a group of homologous genes interspersed in the class III and class I regions of the major histocompatibility complex. MIC-A is located 46 kilobases (kb) centromeric of HLA-B, and is preferentially expressed in the epithelial cells and i...
journal_title:Immunogenetics
pub_type: 杂志文章
doi:10.1007/s002510050658
更新日期:1999-07-01 00:00:00
abstract::The gray short-tailed opossum Monodelphis domestica is one of the few marsupial species for which a high quality whole genome sequence is available and the major histocompatibility complex (MHC) region has been annotated. Previous analyses revealed only a single locus within the opossum MHC region, designated Modo-UA1...
journal_title:Immunogenetics
pub_type: 杂志文章
doi:10.1007/s00251-015-0826-5
更新日期:2015-04-01 00:00:00
abstract::Human Ia(-like) specificities controlled by gene loci other than HLA-DR were searched for at the molecular level in cells of human B-cell-type cell lines which carry two established DR specificities. Chevalier cells of DRw3 and 7 and U698M cells of DRw2 and 4 were used. Their Ia molecules were partially purified, radi...
journal_title:Immunogenetics
pub_type: 杂志文章
doi:10.1007/BF01561564
更新日期:1980-01-01 00:00:00
abstract::Mice bearing the H-2w7 haplotype have five C4-related genes, one C4, one Slp, and three C4/Slp hybrid genes. The expression of these five genes in the liver of H-2w7 mice was estimated at the steady state level of their respective mRNA. We have amplified by the polymerase chain reaction (PCR) three regions of the C4/S...
journal_title:Immunogenetics
pub_type: 杂志文章
doi:10.1007/BF00216695
更新日期:1991-01-01 00:00:00
abstract::The membrane immunoglobulin M (mIgM) of a B lymphocyte serves as a receptor for its cognate antigen. Our aim is to elucidate the structure and function of this membrane-bound receptor. The first step is to determine the requirements for proper membrane placement of IgM. We have used mIgM-positive B lymphocyte tumors f...
journal_title:Immunogenetics
pub_type: 杂志文章
doi:10.1007/BF00364758
更新日期:1983-01-01 00:00:00
abstract::We used rabbit antisera to the chicken MHC erythrocyte molecule B-G and to the class I alpha chain (B-F) to screen lambda gt11 cDNA expression libraries made with RNA selected by oligo-dT from bone marrow cells of anemic B19 homozygous chickens. Eight clones were found to encode B-G molecules which hybridize with sequ...
journal_title:Immunogenetics
pub_type: 杂志文章
doi:10.1007/BF02421176
更新日期:1989-01-01 00:00:00
abstract::The protein kinase, interferon-inducible double-stranded (ds)RNA-dependent activator (PRKRA) is a dsRNA-binding protein which activates a protein kinase participating in the antiviral activity of interferon. Our previous studies indicated that the nucleotide sequence encoding PRKRA, which appeared to be an intronless ...
journal_title:Immunogenetics
pub_type: 杂志文章
doi:10.1007/s002510000270
更新日期:2001-01-01 00:00:00
abstract::We analyzed the genetic regulation of spontaneous autoimmune thyroiditis (SAT) by means of crosses between Obese strain (OS) chickens with the disease, and healthy inbred chicken of line CB. Mononuclear cell infiltration of the thyroid was used as a criterion for the disease. We confirmed the existence of one recessiv...
journal_title:Immunogenetics
pub_type: 杂志文章
doi:10.1007/s00251-001-0388-6
更新日期:2001-12-01 00:00:00
abstract::The tripartite motif protein (TRIM)5α/CypA fusion protein TRIMCyp in Old World monkeys is generally considered unable to restrict HIV-1 replication. Monkeys with TRIMCyp can serve as a unique animal model for studies of HIV-1 infection. The present study investigated the distribution and expression status of TRIMCyp i...
journal_title:Immunogenetics
pub_type: 杂志文章
doi:10.1007/s00251-012-0670-9
更新日期:2013-03-01 00:00:00
abstract::The rat major histocompatibility complex loci RT1-B and RT1-D are equivalent to the human leucocyte antigens HLA-DQ and HLA-DR respectively. Here we describe the complementary DNA (cDNA) sequence encoding the alpha and beta chains of both the RT1-B and RT1-D locus genes of the rat RT1u haplotype. We have found entire ...
journal_title:Immunogenetics
pub_type: 杂志文章
doi:10.1007/s00251-003-0584-7
更新日期:2003-08-01 00:00:00
abstract::Described here is a new, more efficient method for defining major histocompatibility complex-Y (MHC-Y) genotypes in chickens. The MHC-Y region is genetically independent from the classical MHC (MHC-B) region. MHC-Y is highly polymorphic and potentially important in the genetics of disease resistance. MHC-Y haplotypes ...
journal_title:Immunogenetics
pub_type: 杂志文章
doi:10.1007/s00251-020-01166-6
更新日期:2020-07-01 00:00:00
abstract::Rh-related transcripts present in bone marrow samples from several species of nonhuman primates (chimpanzee, gorilla, gibbon, crab-eating macaque) have been amplified by RT-polymerase chain reaction using primers deduced from the sequence of human RH genes. Nucleotide sequence analysis of the nonhuman transcripts reve...
journal_title:Immunogenetics
pub_type: 杂志文章
doi:10.1007/BF00172151
更新日期:1995-01-01 00:00:00
abstract::A healthy adult having no serologically detectable HLA class I A locus antigens was identified. The parents of the individual are consanguineous. Results of a family study indicated that the individual is homozygous for the B46-Cw1-DR8.1 haplotype, which was shown to be positively associated with A*0207 in our previou...
journal_title:Immunogenetics
pub_type: 杂志文章
doi:10.1007/BF00186597
更新日期:1996-01-01 00:00:00
abstract::We examined the expression of H-Y antigen in 14 XO female mice using three monoclonal H-Y-specific antibodies. We found that spleen and liver cells from XO mice removed the reactivity of these antibodies at the same efficacy as XY cells. However radiobinding assays on cultured XO cells suggested a qualitative or quant...
journal_title:Immunogenetics
pub_type: 杂志文章
doi:10.1007/BF00401354
更新日期:1983-01-01 00:00:00
abstract::Direct immunoprecipitation and two-dimensional (2D) gel electrophoresis have been used to identify and characterize genetic variation of the H-2K and H-2D regions. Using inbred strains of mice and alloantisera, haplotype-specific polypeptides were defined for five different H-2 haplotypes. Specific immunoprecipitates ...
journal_title:Immunogenetics
pub_type: 杂志文章
doi:10.1007/BF01561657
更新日期:1981-01-01 00:00:00
abstract::Coeliac disease is strongly associated with HLA-DQ2, but it is possible that additional major histocompatibility complex genes also confer disease susceptibility. Encoded close to HLA-DQ are two genes, TAP1 and TAP2, whose products are believed to transport antigenic peptides from the cytoplasm into the endoplasmic re...
journal_title:Immunogenetics
pub_type: 杂志文章
doi:10.1007/BF00210476
更新日期:1993-01-01 00:00:00
abstract::Cathepsins are key mammalian proteases that play an important role in the immune response. Several studies have revealed the versatile and critical functions of cathepsins. Here, we obtained ten kinds of cathepsin homologs and identified seven homologs with complete coding sequences. Phylogenetic analysis verified the...
journal_title:Immunogenetics
pub_type: 杂志文章
doi:10.1007/s00251-019-01117-w
更新日期:2019-05-01 00:00:00
abstract::Mutation rates of H2 and non-H2 histocompatibility genes in the mouse are examined over a 25-year period. Detected by skin graft rejections, the mutations were screened in inbred and hybrid mice from a continuously maintained and monitored colony and from a regularly supplied set of mice provided from the National Can...
journal_title:Immunogenetics
pub_type: 杂志文章
doi:10.1007/s002510050325
更新日期:1997-01-01 00:00:00
abstract::CD99, the product of the MIC2 gene, exhibits an erythroid-specific quantitative polymorphism co-regulated with the Xga blood group polymorphism. The co-expression of X-linked MIC2 and XG genes is presumably controlled at the transcriptional level by a single XGR locus in the pseudoautosomal region of sexual chromosome...
journal_title:Immunogenetics
pub_type: 杂志文章
doi:10.1007/s002510000193
更新日期:2000-07-01 00:00:00
abstract::Drosophila larvae react against eggs from the endoparasitoid wasp Leptopilina boulardi by surrounding them in a multilayered cellular capsule. Once a wasp egg is recognized as foreign, circulating macrophage-like cells, known as plasmatocytes, adhere to the invader. After spreading around the wasp egg, plasmatocytes f...
journal_title:Immunogenetics
pub_type: 杂志文章
doi:10.1007/s00251-011-0571-3
更新日期:2012-02-01 00:00:00
abstract::Resistance to two cultured lines of murine embryonal carcinoma was studied in F1 hybrids constructed between the tumor-syngeneic mouse strain 129/J and several allogeneic strains. Three of four such hybrid strains were significantly more resistant to the multipotent embryonal carcinoma line PCC3 than the tumor-syngene...
journal_title:Immunogenetics
pub_type: 杂志文章
doi:10.1007/BF01561588
更新日期:1980-01-01 00:00:00
abstract::The human T-cell receptor gamma (TCRG) locus comprises 14 variable genes (TRGV), five joining segments (TRGJ), and two constant region genes (TRGC). The constant gamma 1 gene, TRGC1, consists of three exons, whereas the TRGC2 gene contains four or five exons due to the duplication or triplication of exon 2 and spans 9...
journal_title:Immunogenetics
pub_type: 杂志文章
doi:10.1007/BF00373641
更新日期:1989-01-01 00:00:00
abstract::A mouse monoclonal antibody, Mo. Ab. 108.45, detecting cell-surface determinants associated with the T-cell receptor for alloantigen was produced by immunizing mice with an alloreactive human T-cell clone and fusing the splenocytes with the NS1 plasmocytoma. This Mo. Ab. reacts with the immunizing T-cell clone but not...
journal_title:Immunogenetics
pub_type: 杂志文章
doi:10.1007/BF00345614
更新日期:1984-01-01 00:00:00