Altered structure of HLA class I heavy chains associated with mouse beta-2 microglobulin.

Abstract:

:The serological reactivities of HLA-A3, -B7, and -CW3 heavy chains associated with either mouse, bovine, or human beta-2-microglobulin (beta 2m) and expressed on the surface of transfected mouse fibroblasts were analyzed. All reactivities associated with one cluster (defined by monoclonal antibody W6/32) of antigenic determinants expressed by these HLA class I molecules were lost, or profoundly reduced, after each heavy chain associated with mouse beta 2-m. Expression by the transfected fibroblasts of the HLA-A3, -B7, and -CW3 heavy chains in association with human beta 2m restores these reactivities. Since most of the amino acid differences between mouse and human beta 2m probably correspond to externally oriented hydrophilic residues, these results suggest that critical interactions in the three-dimensional structure of HLA class I molecules occur between the light chain and the first two external domains of the class I heavy chains, to which some of the altered reactivities have been mapped.

journal_name

Immunogenetics

journal_title

Immunogenetics

authors

Ferrier P,Fontecilla-Camps JC,Bucchini D,Caillol DH,Jordan BR,Lemonnier FA

doi

10.1007/BF00430798

subject

Has Abstract

pub_date

1985-01-01 00:00:00

pages

321-31

issue

4

eissn

0093-7711

issn

1432-1211

journal_volume

21

pub_type

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