Abstract:
:The serological reactivities of HLA-A3, -B7, and -CW3 heavy chains associated with either mouse, bovine, or human beta-2-microglobulin (beta 2m) and expressed on the surface of transfected mouse fibroblasts were analyzed. All reactivities associated with one cluster (defined by monoclonal antibody W6/32) of antigenic determinants expressed by these HLA class I molecules were lost, or profoundly reduced, after each heavy chain associated with mouse beta 2-m. Expression by the transfected fibroblasts of the HLA-A3, -B7, and -CW3 heavy chains in association with human beta 2m restores these reactivities. Since most of the amino acid differences between mouse and human beta 2m probably correspond to externally oriented hydrophilic residues, these results suggest that critical interactions in the three-dimensional structure of HLA class I molecules occur between the light chain and the first two external domains of the class I heavy chains, to which some of the altered reactivities have been mapped.
journal_name
Immunogeneticsjournal_title
Immunogeneticsauthors
Ferrier P,Fontecilla-Camps JC,Bucchini D,Caillol DH,Jordan BR,Lemonnier FAdoi
10.1007/BF00430798subject
Has Abstractpub_date
1985-01-01 00:00:00pages
321-31issue
4eissn
0093-7711issn
1432-1211journal_volume
21pub_type
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