Abstract:
:A polymorphic gene, MIC-A, is one of the MIC family of genes which is composed of a group of homologous genes interspersed in the class III and class I regions of the major histocompatibility complex. MIC-A is located 46 kilobases (kb) centromeric of HLA-B, and is preferentially expressed in the epithelial cells and intestinal mucosa. Recently, MIC-A and the closely related MIC-B were reported as the molecules that conferred specificity in the recognition by the Vdelta1gammadeltaT cells. In the present study, polymorphic exons 2, 3, and 4 of the MIC-A gene were analyzed using the polymerase chain reaction-single-strand conformation polymorphism method. The number of patterns found in exons 2, 3, and 4 were 5, 6, and 4, respectively, in 114 healthy Japanese subjects. Eight MIC-A alleles were observed in Japanese individuals, among which one, tentatively named MIC-AMW, has not previously been reported. There was a strong linkage disequilibrium between MIC-A and HLA-B loci: each MIC-A allele showed strong association with a particular HLA-B group. In contrast, B*3901 showed association with multiple MIC-A alleles. Furthermore, the existence of a MIC-A-MIC-B null haplotype, which is associated with HLA-B*4801, was identified. In this haplotype, a large-scale deletion (of approximately 100 kb) including the entire MIC-A gene was indicated and the MIC-B gene possessed a stop codon.
journal_name
Immunogeneticsjournal_title
Immunogeneticsauthors
Komatsu-Wakui M,Tokunaga K,Ishikawa Y,Kashiwase K,Moriyama S,Tsuchiya N,Ando H,Shiina T,Geraghty DE,Inoko H,Juji Tdoi
10.1007/s002510050658subject
Has Abstractpub_date
1999-07-01 00:00:00pages
620-8issue
7-8eissn
0093-7711issn
1432-1211pii
90490620.251journal_volume
49pub_type
杂志文章相关文献
IMMUNOGENETICS文献大全abstract::The recent identification of a large and diverse family of leukocyte immune-type receptors (IpLITRs) in channel catfish (Ictalurus punctatus) indicates that immunoglobulin superfamily (IgSF) members related to both mammalian Fc receptors (FcRs) and leukocyte receptor complex (LRC)-encoded proteins exist in fish. In th...
journal_title:Immunogenetics
pub_type: 杂志文章
doi:10.1007/s00251-006-0169-3
更新日期:2007-01-01 00:00:00
abstract::Two proteasome activators PA28alpha and beta, which have been implicated in antigen processing for loading class I MHC molecules, are synthesized in response to Ifn-gamma. The human genes encoding these activators (PSME1 and PSME2, respectively) were analyzed by sequencing. Each gene comprised 11 exons, consistent wit...
journal_title:Immunogenetics
pub_type: 杂志文章
doi:10.1007/s002510050517
更新日期:1999-05-01 00:00:00
abstract::The effect of the H-2dm1 mutation on Qa-m2 expression was examined. The mutant strain B10.D2-H-2dm1 showed a fourfold increase in Qa-m2 expression when compared with the parental strain B10.D2. Qa-m2 molecules immunoprecipitated from B10.D2-H-2dm1, C57BL/10, and B10.D2 spleen cells were identical by two-dimensional (2...
journal_title:Immunogenetics
pub_type: 杂志文章
doi:10.1007/BF00345969
更新日期:1983-01-01 00:00:00
abstract::TL antigens are class I glycoproteins which are expressed on thymocytes and which are coded by the Tla region of the major histocompatibility complex of the mouse. Biochemical analysis of TL molecules from different strains of mice revealed structural variation determined by the Tla region which is detectable by pepti...
journal_title:Immunogenetics
pub_type: 杂志文章
doi:10.1007/BF00373117
更新日期:1986-01-01 00:00:00
abstract::Antibody diversity, as measured by isoelectric focusing of dinitrophenol-specific antibodies, was compared in different polyploid species of the clawed toad Xenopus. Antibody heterogeneity increased with chromosome number and DNA content from Xenopus tropicalis (2n = 20 chromosome) to Xenopus ruwenzoriensis (2n = 108 ...
journal_title:Immunogenetics
pub_type: 杂志文章
doi:10.1007/BF00364333
更新日期:1982-03-01 00:00:00
abstract::Leukocyte immunoglobulin-like receptor (LILR)B3 and LILRA6 represent a pair of inhibitory/activating receptors with identical extracellular domains and unknown ligands. LILRB3 can mediate inhibitory signaling via immunoreceptor tyrosine-based inhibition motifs in its cytoplasmic tail whereas LILRA6 can signal through ...
journal_title:Immunogenetics
pub_type: 杂志文章
doi:10.1007/s00251-013-0730-9
更新日期:2014-01-01 00:00:00
abstract::With the use of monospecific rabbit anti-G protein and mouse monoclonal anti-H-2Kk, we have analyzed the spatial relationship of the serologically defined H-2Kk antigens and the major surface glycoprotein (G protein) of vesicular stomatitis virus (VSV) to those antigens recognized by B10.A (k, d) anti-VSV cytotoxic T ...
journal_title:Immunogenetics
pub_type: 杂志文章
doi:10.1007/BF01572582
更新日期:1980-01-01 00:00:00
abstract::Sixteen microsatellite markers, including two described here, were used to construct a high-resolution map of the 1q32 region encompassing the regulator of the complement activation (RCA) gene cluster. The RCA genes are a group of related genes coding for plasma and membrane associated proteins that collectively contr...
journal_title:Immunogenetics
pub_type: 杂志文章
doi:10.1007/s002510050224
更新日期:1997-01-01 00:00:00
abstract::A cDNA library prepared from lymphocytes of a cow (E98), homozygous at major histocompatibility complex (MHC) loci (BoLA phenotype w10, KN104), was screened with a bovine MHC class I probe. Of the cDNA clones isolated, two, (2.1 and 5.1) were selected and showed divergence at both 5' and 3' termini. E98 DNA was digest...
journal_title:Immunogenetics
pub_type: 杂志文章
doi:10.1007/BF00230502
更新日期:1991-01-01 00:00:00
abstract::We have studied the MICA alleles of 196 unrelated subjects from three South American Indian tribes (Toba, Wichi and Terena). They are members of isolated tribes located in the Gran Chaco area in northeastern Argentina and in Mato Grosso do Sul in South Central Brazil. Of 55 previously known alleles, nine were observed...
journal_title:Immunogenetics
pub_type: 杂志文章
doi:10.1007/s00251-001-0426-4
更新日期:2002-02-01 00:00:00
abstract::Phenotypic variability is often observed in cynomolgus monkeys on preclinical studies and may, in part, be driven by genetic variability. However, the role of monkey genetic variation remains largely unexplored in the context of drug response. This study evaluated genetic variation in cynomolgus monkey FcγR3A and TAP1...
journal_title:Immunogenetics
pub_type: 杂志文章
doi:10.1007/s00251-017-0970-1
更新日期:2017-04-01 00:00:00
abstract::Avian influenza is a serious threat to the poultry industry and, as the potential source of a human pandemic virus, to public health. Different Mx alleles have been reported to confer resistance or susceptibility to influenza virus replication, and so knowledge of their frequencies is important when considering the po...
journal_title:Immunogenetics
pub_type: 杂志文章
doi:10.1007/s00251-007-0235-5
更新日期:2007-08-01 00:00:00
abstract::Observations have frequently been interpreted as showing that the helper T cells which collaborate with alloantigen-specific cytotoxic T-cell precursors can only recognize antigens encoded in the I region of the H-2 gene complex. An experimental system is described here that allows analysis of the recognition repertoi...
journal_title:Immunogenetics
pub_type: 杂志文章
doi:10.1007/BF00345403
更新日期:1984-01-01 00:00:00
abstract::Multiple sclerosis (MS) is a common disease of the central nervous system characterized by myelin loss and progressive neurological dysfunction. An underlying genetic susceptibility plays a clear role in the etiology of MS, likely acting in concert with an undefined environmental exposure. Full-genome screenings in mu...
journal_title:Immunogenetics
pub_type: 杂志文章
doi:10.1007/s002510050621
更新日期:2000-04-01 00:00:00
abstract::Footpad swelling response was used to measure the alloantigenicity of epidermal cells (ECs) in delayed-type hypersensitivity (DTH). Strong footpad swelling was observed 3 h after the challenge, and it continued for 48 h after the challenge. Genetical incompatibility between the recipients and the ECs was required to i...
journal_title:Immunogenetics
pub_type: 杂志文章
doi:10.1007/BF00372666
更新日期:1986-01-01 00:00:00
abstract::Ruminant gammadelta T cells are divided into subpopulations based on the presence or absence of WC1 co-receptors (scavenger-receptor-cysteine-rich family members uniquely expressed on gammadelta T cells). Evidence suggests WC1+ are inflammatory while WC1- are regulatory and that they also differ in their tissue distri...
journal_title:Immunogenetics
pub_type: 杂志文章
doi:10.1007/s00251-006-0122-5
更新日期:2006-08-01 00:00:00
abstract::In three families with an apparent non-expressed factor B (BF) allele (BF*Q0), advanced methods of isoelectric focusing for the determination of BF F subtypes revealed different hypomorphic BF products (BF QL) with functional hemolytic activity expressed by the assumed BF*Q0 allele. A Taq I and a Msp I restriction fra...
journal_title:Immunogenetics
pub_type: 杂志文章
doi:10.1007/BF00223541
更新日期:1992-01-01 00:00:00
abstract::Mouse lymphocyte alloantigens Ly-19 and Ly-32 are controlled by the genes tightly linked to the Lyb-2 locus on chromosome 4. Despite the similarity in mouse strain distribution patterns, Ly-19 and Ly-32 antigens which have been detected on both B- and T-cell lineages are distinct from Lyb-2 antigen whose expression is...
journal_title:Immunogenetics
pub_type: 杂志文章
doi:10.1007/BF00364229
更新日期:1988-01-01 00:00:00
abstract::Eleven new C4d genomic primate sequences of the fourth complement factor (C4) have been obtained. Seven of them belong to five species not yet explored for this gene: Pan paniscus (pygmy chimpanzee), Cercopithecus aethiops (green monkey), Macaca mulatta (rhesus monkey), Macaca fascicularis (cynomolgus), and Saguinus o...
journal_title:Immunogenetics
pub_type: 杂志文章
doi:10.1007/BF00177822
更新日期:1994-01-01 00:00:00
abstract::The susceptibility to cell-mediated cytolysis of cells of the recently developed C57BL/Ka(H-2 ( b )) lymphoma cell line, BL/VL(3), was investigated in allogeneic assays with thymus-dependent lymphocytes (T cells). Compared to EL4, the widely used C57BL/6(H-2 ( b )) lymphoma cell line, BL/VL(3) cells were found to be i...
journal_title:Immunogenetics
pub_type: 杂志文章
doi:10.1007/BF01843991
更新日期:1978-12-01 00:00:00
abstract::Genetic effects on spontaneous autoimmune thyroiditis in chickens were assessed by measuring phenotypic symptoms, the titer of circulating antibody to thyroglobulin, and the pathological change in the thyroids of young chicks. One or more loci within the B complex (the major histocompatibility complex of the chicken) ...
journal_title:Immunogenetics
pub_type: 杂志文章
doi:10.1007/BF01561675
更新日期:1981-01-01 00:00:00
abstract::We recently demonstrated that vaccinated rhesus macaques controlled viral replication of a heterologous SIV challenge. Here, we analyzed anamnestic SIV-specific CD4+ T-cell responses expanding immediately after challenge and show that successful vaccinees consistently targeted a short region of the Gag-p27 Capsid (ami...
journal_title:Immunogenetics
pub_type: 杂志文章
doi:10.1007/s00251-010-0473-9
更新日期:2010-10-01 00:00:00
abstract::Rheumatoid arthritis (RA) is a chronic autoimmune disease affecting 0.5-1% of the population worldwide. The disease has a heterogeneous character, including clinical subsets of anti-citrullinated protein antibody (ACPA)-positive and APCA-negative disease. Although the pathogenesis of RA is poorly understood, progress ...
journal_title:Immunogenetics
pub_type: 杂志文章,评审
doi:10.1007/s00251-011-0528-6
更新日期:2011-08-01 00:00:00
abstract::An I-J-subregion controlled determinant is expressed on Ly-1 inducer and Ly-1,2 acceptor T cells in the feedback suppression circuit. Ly-1 T cells absorb the I-J antibody reactive with the Ly-1,2 acceptor T cell, suggesting that both inducer and acceptor T cells have the same I-J determinant. Since less than 10 percen...
journal_title:Immunogenetics
pub_type: 杂志文章
doi:10.1007/BF01567824
更新日期:1980-01-01 00:00:00
abstract::The size of B-cell subsets appears to be under genetic control, but the mechanism of this regulation is unknown. By analyzing five congenic strains of mice that differ only in their H2 haplotype, we addressed the issue of whether the MHC genes are involved in the relative proportions of B-1a, B-1b and B-2 cells. Not o...
journal_title:Immunogenetics
pub_type: 杂志文章
doi:10.1007/s00251-002-0457-5
更新日期:2002-06-01 00:00:00
abstract::On a B10 (Lshs) genetic background the development of acquired T-cell-mediated immunity to Leishmania donovani infection in mice is under H-2-linked genetic control. Three phenotypic patterns of recovery were previously observed: "early cure" (H-2s, H-2r), "cure" (H-2b) and "noncure" (H-2d, H-2q, H-2f), with cure beha...
journal_title:Immunogenetics
pub_type: 杂志文章
doi:10.1007/BF00368537
更新日期:1983-01-01 00:00:00
abstract::The nucleotide sequences of 11 variable gene segments coding for rabbit T-cell receptor beta (Tcrb-V) chains were determined by directly sequencing fragments amplified by the cassette-ligation mediated polymerase chain reaction (CLM-PCR) and by modified anchor PCR without the cloning procedure. The nucleotide sequence...
journal_title:Immunogenetics
pub_type: 杂志文章
doi:10.1007/BF00188786
更新日期:1994-01-01 00:00:00
abstract::Comparison of the rate of synonymous and nonsynonymous nucleotide substitutions suggests that certain regions of the functional H-2 genes, which are part of the mouse major histocompatibility complex (Mhc), are under strong positive selection pressure. Thus far, however, little evidence has been provided for the exist...
journal_title:Immunogenetics
pub_type: 杂志文章
doi:10.1007/BF00205819
更新日期:1991-01-01 00:00:00
abstract::Ia antigens coded by genes of the murine major histocompatibility complex are expressed on the surface of a population of cells critical to the proliferative response of murine spleen cells to the oxidative mitogen neuraminidase/galactose oxidase. By selective depletion with antiserum and complement, Ia antigens coded...
journal_title:Immunogenetics
pub_type: 杂志文章
doi:10.1007/BF01561562
更新日期:1980-01-01 00:00:00
abstract::Chemokines are small, inducible, structurally related proteins that guide cells expressing the right chemokine receptors to sites of immune response. They have been identified and studied extensively in mammals, but little is known about their presence in other vertebrate groups. Here we describe seven new chemokines ...
journal_title:Immunogenetics
pub_type: 杂志文章
doi:10.1007/s00251-002-0531-z
更新日期:2003-03-01 00:00:00