Abstract：
:The recent identification of a large and diverse family of leukocyte immune-type receptors (IpLITRs) in channel catfish (Ictalurus punctatus) indicates that immunoglobulin superfamily (IgSF) members related to both mammalian Fc receptors (FcRs) and leukocyte receptor complex (LRC)-encoded proteins exist in fish. In the present study, it was found that IpLITR messages were preferentially up regulated in catfish peripheral blood leukocytes (PBL) and clonal cytotoxic T cells (CTL) after alloantigen stimulation. Detailed sequence analyses of the expressed IpLITR cDNAs from two clonal CTL lines indicated an unexpectedly large array of putative activatory and inhibitory IpLITR-types containing variable numbers of extracellular immunoglobulin (Ig)-like domains. Importantly, all expressed IpLITRs shared similar membrane distal Ig domains (i.e., D1 and D2), suggesting that they may bind a common type of ligand. Sequence alignments and comparative homology modeling revealed that IpLITR domains, D1 and D2, have similar predicted 3-D structural properties with the corresponding domains of the human LRC-encoded leukocyte Ig-like receptor (LILR) family. Furthermore, conservation of key major histocompatibility class I (MHC I)-binding residues were located at similar positions within the membrane distal tip of D1 between representative IpLITRs and group 1 LILRs. Taken together, these results suggest that fish LITRs have an orthologous relationship to LRC-encoded receptors such as the human LILRs and could potentially function as a diverse family of MHC class I-binding receptors.
journal_name
Immunogeneticsjournal_title
Immunogeneticsauthors
Stafford JL,Bengtén E,Du Pasquier L,Miller NW,Wilson Mdoi
10.1007/s00251-006-0169-3subject
Has Abstractpub_date
2007-01-01 00:00:00pages
77-91issue
1eissn
0093-7711issn
1432-1211journal_volume
59pub_type
杂志文章相关文献
IMMUNOGENETICS文献大全abstract：:T cell receptor genes are assembled in developing T lymphocytes from discrete V, D, and J genes by a site-specific somatic rearrangement mechanism. A flanking recombination signal, composed of a conserved heptamer and a semiconserved nonamer separated by 12 or 23 variable nucleotides, targets the activity of the rearr...
journal_title：Immunogenetics
pub_type： 杂志文章
doi：10.1007/s00251-006-0150-1
更新日期：2006-11-01 00:00:00
abstract：:The Mep-1 gene on chromosome 17 in mice controls the activity of meprin, a kidney brush border metalloendopeptidase. Most inbred mouse strains of the k haplotype (e.g., CBA, C3H, AKR) are markedly deficient in meprin activity; these mice carry the Mep-1b allele. Mouse strains in which meprin activity levels are normal...
journal_title：Immunogenetics
pub_type： 杂志文章
doi：10.1007/BF00430310
更新日期：1985-01-01 00:00:00
abstract：:A graft-vs-host reaction (GVHR) develops after major histocompatibility complex (MHC)-compatible bone marrow-transplantation. In the genetic combination studied, B10.D2 donor cells differed from those of (DBA/2 x B10.D2)F1 mice for multiple DBA/2 minor histocompatibility antigens (mHAg) and minor lymphocyte stimulatin...
journal_title：Immunogenetics
pub_type： 杂志文章
doi：10.1007/BF00241258
更新日期：1994-01-01 00:00:00
abstract：:The factors which influence expression of autoimmune disease in the central nervous system are still poorly understood. We determined the characteristics of experimental autoimmune encephalomyelitis (EAE) in twelve different inbred strains of mice using either mouse spinal cord homogenate or synthetic peptides as the ...
journal_title：Immunogenetics
pub_type： 杂志文章
doi：10.1007/BF02602559
更新日期：1996-01-01 00:00:00
abstract：:Analysis of a Japanese population by oligonucleotide genotyping revealed that one Japanese HLA-DRw14 allele had a DRB1 genotype different from that of the known HLA-DRw14-related alleles, DRB1*1401 (DRw14-Dw9) and DRB1*1402 (DRw14-Dw16). The second exon of the DRB1 gene of the novel DRw14 allele (designated DRB1-14c) ...
journal_title：Immunogenetics
pub_type： 杂志文章
doi：10.1007/BF00211645
更新日期：1990-01-01 00:00:00
abstract：:The complexity and polymorphism of sequences related to the class I and class II genes of mammalian major histocompatibility complexes (MHCs) were investigated in the tassel-eared squirrel subspecies Sciurus aberti kaibabensis or Kaibab squirrel. Kaibab squirrels are geographically isolated on the Kaibab plateau north...
journal_title：Immunogenetics
pub_type： 杂志文章
doi：10.1007/BF00364527
更新日期：1986-01-01 00:00:00
abstract：:The immune response of the rat to group A streptococcal carbohydrate (SACHO) and an associated idiotype, Id-1, was used to examine the effect of paternal immunity on Id-1 and SACHO-specific antibody expression by the offspring. First litters, conceived before immunization of the father, had significantly higher Id-1 l...
journal_title：Immunogenetics
pub_type： 杂志文章
doi：10.1007/BF00372236
更新日期：1985-01-01 00:00:00
abstract：:A contribution of allelic variation of T-cell receptor (Tcr) genes to the immune response has not been studied. Here we report that the presence of insertion-deletion-related polymorphisms (IDRP) of the Tcr beta chain (Tcrb) can be utilized to distinguish the parental origin of the gene complex that undergoes rearrang...
journal_title：Immunogenetics
pub_type： 杂志文章
doi：10.1007/BF00218043
更新日期：1992-01-01 00:00:00
abstract：:We reported previously that human gene MAGE-1 directs the expression of a tumor antigen recognized on a melanoma by autologous cytolytic T lymphocytes. Probing cosmid libraries with a MAGE-1 sequence, we identified 11 closely related genes. The analysis of hamster-human somatic cell hybrids indicated that the 12 MAGE ...
journal_title：Immunogenetics
pub_type： 杂志文章
doi：10.1007/BF01246677
更新日期：1994-01-01 00:00:00
abstract：:The membrane immunoglobulin M (mIgM) of a B lymphocyte serves as a receptor for its cognate antigen. Our aim is to elucidate the structure and function of this membrane-bound receptor. The first step is to determine the requirements for proper membrane placement of IgM. We have used mIgM-positive B lymphocyte tumors f...
journal_title：Immunogenetics
pub_type： 杂志文章
doi：10.1007/BF00364758
更新日期：1983-01-01 00:00:00
abstract：:Mutants of the EB virus-transformed cell line T5-1 (HLA-A1, 2; B8, 27), bearing well-characterized alterations in HLA-A2 antigen expression and unable to bind the HLA-A2-specific monoclonal antibody BB7.2, have been tested for their susceptibility to EB virus-specific cytolysis using effector T-cell preparations funct...
journal_title：Immunogenetics
pub_type： 杂志文章
doi：10.1007/BF00403438
更新日期：1984-01-01 00:00:00
abstract：:The evolution of the mouse immunoglobulin heavy chain variable region (Igh-V) locus was investigated by the comprehensive analysis of variable region (Vh) gene family content and restriction fragment polymorphism in the genus Mus. The examination of natural Mus domesticus populations suggests an important role for rec...
journal_title：Immunogenetics
pub_type： 杂志文章
doi：10.1007/BF02425271
更新日期：1989-01-01 00:00:00
abstract：:Human IgG receptors (FcgammaR) display considerable heterogeneity, and are crucial immune response modulating molecules. FcgammaRIIA, FcgammaRIIIA, and FcgammaRIIIB display functional biallelic polymorphisms. FcgammaR polymorphisms have been found associated with susceptibility to infectious and autoimmune diseases. L...
journal_title：Immunogenetics
pub_type： 杂志文章
doi：10.1007/s00251-003-0574-9
更新日期：2003-07-01 00:00:00
abstract：:Sickle cell anemia (SCA) is characterized by chronic hemolysis, severe vasoocclusive crises (VOCs), and recurrent often severe infections. A cohort of 95 SCA pediatric patients was the background for genotype-to-phenotype association of the patient's infectious disease phenotype and three non-coding polymorphic region...
journal_title：Immunogenetics
pub_type： 杂志文章
doi：10.1007/s00251-017-1013-7
更新日期：2018-01-01 00:00:00
abstract：:Mammalian interleukin-4 (IL-4) and IL-13 are T helper type 2 (Th2) cytokines with pleiotropic functions in immunity. They signal through receptors containing IL-4Rα and IL-2Rγ or IL-13Rα1. In addition, a decoy receptor, IL-13Rα2, is known to exist and modulates the function of IL-13. The existence of fish orthologues ...
journal_title：Immunogenetics
pub_type： 杂志文章
doi：10.1007/s00251-010-0508-2
更新日期：2011-04-01 00:00:00
abstract：:The genealogy of 14 H-2Kb mutations arising spontaneously in the C57BL/6Kh colony is presented together with data from skin-graft monitoring and husbandry procedures. Eight of the 14 mutations have phenotypic and structural similarities, but the pedigree analysis and evaluation of the histocompatibility genetics of th...
journal_title：Immunogenetics
pub_type： 杂志文章
doi：10.1007/BF00621950
更新日期：1982-01-01 00:00:00
abstract：:The single nucleotide polymorphism (SNP)-derived Epitope Prediction program (SNEP) is now available to the public. It predicts minor histocompatibility antigens (miHAgs), which are T-cell epitopes containing polymorphic spots, from proteins listed in the SWISS-PROT database. SNEP recognizes polymorphisms (termed VARIA...
journal_title：Immunogenetics
pub_type： 杂志文章
doi：10.1007/s00251-005-0054-5
更新日期：2005-12-01 00:00:00
abstract：:The aim of this study was to evaluate the intra- and inter-population variability of the Gm/Km system in the Madonie Mountains, one of the main geographical barriers in north-central Sicily. We analysed 392 samples: 145 from Alia, 128 from Valledolmo, 25 from Cerda and 94 from Palermo. Serum samples were tested for G1...
journal_title：Immunogenetics
pub_type： 历史文章,杂志文章
doi：10.1007/s00251-003-0628-z
更新日期：2004-01-01 00:00:00
abstract：:The collectin surfactant protein-D (SP-D) plays a significant role in innate immunity. Epidemiological studies described associations between single nucleotide polymorphisms (SNPs) of the human gene coding surfactant protein-D (SFTPD) and infectious pulmonary diseases. Studies on twins indicated very strong genetic de...
journal_title：Immunogenetics
pub_type： 杂志文章
doi：10.1007/s00251-005-0775-5
更新日期：2005-04-01 00:00:00
abstract：:In this study we have sequenced peptides eluted from a truncated recombinant HLA-A*6602 molecule, and compared their features with data reported for peptides presented in the A*6601 molecule. A striking change in the amino-acid binding preferences was observed at peptide position P1, which interacts with pocket A of t...
journal_title：Immunogenetics
pub_type： 杂志文章
doi：10.1007/s00251-004-0677-y
更新日期：2004-05-01 00:00:00
abstract：:Using the fluorescence-activated cell sorter (FACS II), we have analyzed the expression of H-2K- and H-2D-gene products on the membrane of various cellular components of the murine immune system. Using this serological technique we show a basic difference between T and B lymphocytes. Whereas all cellular components an...
journal_title：Immunogenetics
pub_type： 杂志文章
doi：10.1007/BF01567827
更新日期：1980-01-01 00:00:00
abstract：:The protein kinase, interferon-inducible double-stranded (ds)RNA-dependent activator (PRKRA) is a dsRNA-binding protein which activates a protein kinase participating in the antiviral activity of interferon. Our previous studies indicated that the nucleotide sequence encoding PRKRA, which appeared to be an intronless ...
journal_title：Immunogenetics
pub_type： 杂志文章
doi：10.1007/s002510000270
更新日期：2001-01-01 00:00:00
abstract：:Human CS1, also known as novel Ly9, 19A24, or CRACC, is a member of the immunoglobulin gene superfamily (IgSF) expressed on natural killer cells and other leukocytes. Here we describe the cloning of the mouse homologue of this gene. The mouse novel Ly9 gene is shown to encode a transmembrane protein composed of two ex...
journal_title：Immunogenetics
pub_type： 杂志文章
doi：10.1007/s00251-002-0483-3
更新日期：2002-09-01 00:00:00
abstract：:The chromosomal assignment of the gene encoding the invariant (Ii) chain associated with the mouse immune response antigens (Ia) was determined by Southern blot analysis of DNA from a panel of mouse X Chinese hamster somatic cell hybrids cleaved with Hind III or Eco RI. Using a mouse li cDNA as a hybridization probe, ...
journal_title：Immunogenetics
pub_type： 杂志文章
doi：10.1007/BF00372244
更新日期：1985-01-01 00:00:00
abstract：:Six IgA allotypes are serologically identifiable in inbred mice. The sequences of the PCR-amplified C alpha 1, C alpha 2 and C alpha 3 exons from the genomic DNA of mice of four previously unsequenced allotypes already have been compared with those of BALB/c and of a wild mouse, Mus pahari, in the literature. Sporadic...
journal_title：Immunogenetics
pub_type： 杂志文章
doi：10.1007/s00251-002-0434-z
更新日期：2002-03-01 00:00:00
abstract：:The T- and B-cell surface polypeptides detected by an international workshop panel of 100 mouse monoclonal antibodies (M.Ab) were biochemically defined by radioimmunoprecipitation. Eight T-cell-associated molecules and eight B-cell-associated molecules were identified by multiple antibodies in the panel. Clusters of a...
journal_title：Immunogenetics
pub_type： 杂志文章
doi：10.1007/BF00345968
更新日期：1983-01-01 00:00:00
abstract：:A 280 kilobase (kb) contig was isolated from mouse genomic P1 and cosmid libraries, using as probes human cDNA and genomic DNA fragments that map in the interval between the second component of complement and tumor necrosis factor genes of the HLA complex. The clone contig demonstrates synteny of eleven mouse genes th...
journal_title：Immunogenetics
pub_type： 杂志文章
doi：10.1007/BF00171796
更新日期：1994-01-01 00:00:00
abstract：:Described here is a new, more efficient method for defining major histocompatibility complex-Y (MHC-Y) genotypes in chickens. The MHC-Y region is genetically independent from the classical MHC (MHC-B) region. MHC-Y is highly polymorphic and potentially important in the genetics of disease resistance. MHC-Y haplotypes ...
journal_title：Immunogenetics
pub_type： 杂志文章
doi：10.1007/s00251-020-01166-6
更新日期：2020-07-01 00:00:00
abstract：:On a B10 (Lshs) genetic background the development of acquired T-cell-mediated immunity to Leishmania donovani infection in mice is under H-2-linked genetic control. Three phenotypic patterns of recovery were previously observed: "early cure" (H-2s, H-2r), "cure" (H-2b) and "noncure" (H-2d, H-2q, H-2f), with cure beha...
journal_title：Immunogenetics
pub_type： 杂志文章
doi：10.1007/BF00368537
更新日期：1983-01-01 00:00:00
abstract：:The incidence of arthritis and the antibody response to mouse and to rat type II collagen after immunization with native rat type II collagen was studied in different mouse strains, including wild mouse-derived strains belonging to the H-2p/H-2q family. High serum levels of antibodies to mouse and rat type II collagen...
journal_title：Immunogenetics
pub_type： 杂志文章
doi：10.1007/BF00373114
更新日期：1986-01-01 00:00:00
