Organization of the genes encoding the human proteasome activators PA28alpha and beta.

abstract：:Sixteen microsatellite markers, including two described here, were used to construct a high-resolution map of the 1q32 region encompassing the regulator of the complement activation (RCA) gene cluster. The RCA genes are a group of related genes coding for plasma and membrane associated proteins that collectively contr...

journal_title：Immunogenetics

authors： Heine-Suñer D,Díaz-Guillén MA,de Villena FP,Robledo M,Benítez J,Rodríguez de Córdoba S

更新日期：1997-01-01 00:00:00

abstract：:Among the genes with the highest allelic polymorphism and sequence diversity are those encoding the classical class I and class II molecules of the major histocompatibility complex (MHC). Although many thousands of MHC sequences have been deposited in general sequence databases like GenBank, the availability of curate...

journal_title：Immunogenetics

authors： Afrache H,Tregaskes CA,Kaufman J

更新日期：2020-02-01 00:00:00

abstract：:Transgenic mice were produced in which human HLA-Cw4 is stably integrated, behaves as a single Mendelian trait, and, being under the transcriptional control of human CD2, is selectively and efficiently expressed in T lymphocytes. These mice were used as a model system to determine whether HLA-type C molecules can be e...

journal_title：Immunogenetics

authors： Aiuti A,Forte P,Simeoni L,Lino M,Pozzi L,Fattorossi A,Giacomini P,Ginelli E,Beretta A,Siccardi A

更新日期：1995-01-01 00:00:00

abstract：:The single nucleotide polymorphism (SNP)-derived Epitope Prediction program (SNEP) is now available to the public. It predicts minor histocompatibility antigens (miHAgs), which are T-cell epitopes containing polymorphic spots, from proteins listed in the SWISS-PROT database. SNEP recognizes polymorphisms (termed VARIA...

journal_title：Immunogenetics

authors： Schuler MM,Dönnes P,Nastke MD,Kohlbacher O,Rammensee HG,Stevanovic S

更新日期：2005-12-01 00:00:00

abstract：:Genes of the major histocompatibility complex (MHC) in the mouse (H-2 complex) have been shown to be an important factor in determining the immune responsiveness of various strains of mice to isolated antigens (e.g., lysozyme). The role of MHC genes in controlling the responsiveness of mice to multiple alloantigens is...

journal_title：Immunogenetics

authors： Peugh WN,Superina RA,Wood KJ,Morris PJ

更新日期：1986-01-01 00:00:00

abstract：:There have been several attempts over the years to identify positions in the peptide-binding region (PBR) of human leukocyte antigens (HLA) that influence the specificity of bound amino acids (AAs) at each position in the peptide. Originally, six pockets (A-F) were defined by calculating the surface area of the PBR on...

journal_title：Immunogenetics

authors： Bade-Doeding C,DeLuca DS,Seltsam A,Blasczyk R,Eiz-Vesper B

更新日期：2007-04-01 00:00:00

abstract：:Multiple sclerosis (MS) is a common disease of the central nervous system characterized by myelin loss and progressive neurological dysfunction. An underlying genetic susceptibility plays a clear role in the etiology of MS, likely acting in concert with an undefined environmental exposure. Full-genome screenings in mu...

journal_title：Immunogenetics

authors： Barcellos LF,Schito AM,Rimmler JB,Vittinghoff E,Shih A,Lincoln R,Callier S,Elkins MK,Goodkin DE,Haines JL,Pericak-Vance MA,Hauser SL,Oksenberg JR

更新日期：2000-04-01 00:00:00

abstract：:The serological reactivities of HLA-A3, -B7, and -CW3 heavy chains associated with either mouse, bovine, or human beta-2-microglobulin (beta 2m) and expressed on the surface of transfected mouse fibroblasts were analyzed. All reactivities associated with one cluster (defined by monoclonal antibody W6/32) of antigenic ...

journal_title：Immunogenetics

authors： Ferrier P,Fontecilla-Camps JC,Bucchini D,Caillol DH,Jordan BR,Lemonnier FA

更新日期：1985-01-01 00:00:00

abstract：:Individual mice were tested for their proliferation T-cell response to H-Y- and H-3-incompatible stimulator cells in secondary mixed lymphocyte culture. Responders expressing the H-2b haplotype were restricted in their response to stimulators presenting H-Y and H-3 in the context of H-2b. Lymphocytes from individual B...

journal_title：Immunogenetics

authors： Wettstein PJ

更新日期：1981-01-01 00:00:00

abstract：:IgM and IgD genes of the Japanese flounder were cloned and characterized from a genomic bacterial artificial chromosome (BAC) library. The micro gene contained four constant region exons (Cmi1-Cmi4), and two transmembrane exons (miTM1 and miTM2), which conforms to the organizational pattern of all other vertebrate mic...

journal_title：Immunogenetics

authors： Srisapoome P,Ohira T,Hirono I,Aoki T

更新日期：2004-07-01 00:00:00

abstract：:Class I-like molecules have been immunoprecipitated from Xenopus leukocytes and erythrocytes with alloantisera directed against major histocompatibility complex (MHC)-linked antigens. The heavy chains, depending on the allele examined, have molecular weights of 40 000-44 000 of which 3000 daltons are asparagine-linked...

journal_title：Immunogenetics

authors： Flajnik MF,Kaufman JF,Riegert P,Du Pasquier L

更新日期：1984-01-01 00:00:00

abstract：:Eleven new C4d genomic primate sequences of the fourth complement factor (C4) have been obtained. Seven of them belong to five species not yet explored for this gene: Pan paniscus (pygmy chimpanzee), Cercopithecus aethiops (green monkey), Macaca mulatta (rhesus monkey), Macaca fascicularis (cynomolgus), and Saguinus o...

journal_title：Immunogenetics

authors： Paz-Artal E,Corell A,Alvarez M,Varela P,Allende L,Madroño A,Rosal M,Arnaiz-Villena A

更新日期：1994-01-01 00:00:00

abstract：:The genomic organisation of the major histocompatibility complex (MHC) seems to vary considerably between different bird species. In order to understand this variation it is important to gather information from different species. We have, for the first time, investigated MHC class II polymorphism in a wader species, t...

journal_title：Immunogenetics

authors： Ekblom R,Grahn M,Höglund J

更新日期：2003-01-01 00:00:00

abstract：:Chemokines are small, inducible, structurally related proteins that guide cells expressing the right chemokine receptors to sites of immune response. They have been identified and studied extensively in mammals, but little is known about their presence in other vertebrate groups. Here we describe seven new chemokines ...

journal_title：Immunogenetics

authors： Kuroda N,Uinuk-ool TS,Sato A,Samonte IE,Figueroa F,Mayer WE,Klein J

更新日期：2003-03-01 00:00:00

abstract：:Drosophila larvae react against eggs from the endoparasitoid wasp Leptopilina boulardi by surrounding them in a multilayered cellular capsule. Once a wasp egg is recognized as foreign, circulating macrophage-like cells, known as plasmatocytes, adhere to the invader. After spreading around the wasp egg, plasmatocytes f...

journal_title：Immunogenetics

authors： Howell L,Sampson CJ,Xavier MJ,Bolukbasi E,Heck MM,Williams MJ

更新日期：2012-02-01 00:00:00

abstract：:Recurrent pregnancy loss (RPL) is a common problem during early gestation. The aim of our study was to investigate the association of IL-17 F( rs763780), IL-17 A (rs2275913), and leptin (2548 G/A) gene polymorphisms with RPL in obese and lean Egyptian females, and to find out whether these gene polymorphisms affect th...

journal_title：Immunogenetics

authors： Zidan HE,Rezk NA,Alnemr AA,Moniem MI

更新日期：2015-11-01 00:00:00

abstract：:Rheumatoid arthritis (RA) is a chronic autoimmune disease affecting 0.5-1% of the population worldwide. The disease has a heterogeneous character, including clinical subsets of anti-citrullinated protein antibody (ACPA)-positive and APCA-negative disease. Although the pathogenesis of RA is poorly understood, progress ...

journal_title：Immunogenetics

authors： Bax M,van Heemst J,Huizinga TW,Toes RE

更新日期：2011-08-01 00:00:00

abstract：:In the present study, we investigate patterns of variation in the KIR cluster in a large and well-characterized sample of worldwide human populations in the Human Genome Diversity Project-Centre d'Etude du Polymorphisme Humain (HGDP-CEPH) panel in order to better understand the patterns of diversity in the region. Com...

journal_title：Immunogenetics

authors： Hollenbach JA,Nocedal I,Ladner MB,Single RM,Trachtenberg EA

更新日期：2012-10-01 00:00:00

abstract：:The recombination activating genes RAG-1 and RAG-2 are adjacent genes that act synergistically to activate variable-diversity-joining (V(D)J) recombination. Southern analysis of hybrid cell lines derived from patients with the Wilms tumor-aniridia-genitourinary defects-mental retardation (WAGR) syndrome and from mutag...

journal_title：Immunogenetics

authors： Oettinger MA,Stanger B,Schatz DG,Glaser T,Call K,Housman D,Baltimore D

更新日期：1992-01-01 00:00:00

abstract：:The A15, L6, and S5.7(TAPA1) proteins are members of the transmembrane 4 superfamily (TM4SF). The A15 is expressed in immature human T cells and in the human brain. The MXS1(CCG-B7) gene which codes for A15 contains triplet nucleotide repeats which have been associated with neuropsychiatric diseases such as Huntington...

journal_title：Immunogenetics

authors： Virtaneva KI,Emi N,Marken JS,Aruffo A,Jones C,Spurr NK,Schröder JP

更新日期：1994-01-01 00:00:00

abstract：:The rat major histocompatibility complex loci RT1-B and RT1-D are equivalent to the human leucocyte antigens HLA-DQ and HLA-DR respectively. Here we describe the complementary DNA (cDNA) sequence encoding the alpha and beta chains of both the RT1-B and RT1-D locus genes of the rat RT1u haplotype. We have found entire ...

journal_title：Immunogenetics

authors： Easterfield AJ,Bradley JA,Bolton EM

更新日期：2003-08-01 00:00:00

abstract：:Genes of the major histocompatibility complex (MHC) have been characterized in all extant lineages of mammals. The tammar wallaby (Macropus eugenii) is well established as a model marsupial species; however, no classical MHC sequences have been described from this species. We have isolated two MHC class II beta-chain ...

journal_title：Immunogenetics

authors： Browning TL,Belov K,Miller RD,Eldridge MD

更新日期：2004-02-01 00:00:00

abstract：:Natural-killer group 2 member D (NKG2D) is an activating receptor that plays an important role in the immune response mediated by NK cells, γδ(+) T cells, and CD8(+) T cells. In humans, MHC class I chain-related genes and UL-16 binding protein (ULBP)/retinoic acid early transcript 1 (REAT1) gene family encode ligands ...

journal_title：Immunogenetics

authors： Naruse TK,Okuda Y,Mori K,Akari H,Matano T,Kimura A

更新日期：2011-08-01 00:00:00

abstract：:The anti-HLA-DQ3 monoclonal antibodies (mAb) KS13, SO1, SO2, SO3, SO4, and SO5 recognize spatially close but distinct antigenic determinants, since they crossinhibit each other in their binding to HLA-DQ3 antigens, but do not share idiotopes recognized in their antigen combining site by syngeneic and anti-id antisera ...

journal_title：Immunogenetics

authors： Iwasaki Y,Takabatake H,Monestier M,Ferrone S

更新日期：1995-01-01 00:00:00

abstract：:Antibody diversity, as measured by isoelectric focusing of dinitrophenol-specific antibodies, was compared in different polyploid species of the clawed toad Xenopus. Antibody heterogeneity increased with chromosome number and DNA content from Xenopus tropicalis (2n = 20 chromosome) to Xenopus ruwenzoriensis (2n = 108 ...

journal_title：Immunogenetics

authors： Du Pasquier L,Blomberg B

更新日期：1982-03-01 00:00:00

abstract：:Presentation of peptide antigens by MHC-II proteins is prerequisite to effective CD4 T cell tolerance to self and to recognition of foreign antigens. Antigen uptake and processing pathways as well as expression of the peptide exchange factors HLA-DM and HLA-DO differ among the various professional and non-professional...

journal_title：Immunogenetics

authors： Jurewicz MM,Stern LJ

更新日期：2019-03-01 00:00:00

abstract：:The genealogy of 14 H-2Kb mutations arising spontaneously in the C57BL/6Kh colony is presented together with data from skin-graft monitoring and husbandry procedures. Eight of the 14 mutations have phenotypic and structural similarities, but the pedigree analysis and evaluation of the histocompatibility genetics of th...

journal_title：Immunogenetics

authors： Melvold RW,Kohn HI,Dunn GR

更新日期：1982-01-01 00:00:00

abstract：:The killer cell immunoglobulin-like receptor (KIR) gene cluster exhibits extensive allelic and haplotypic diversity. Variation at the locus is associated with an increasing number of human diseases, reminiscent of the HLA loci. Characterization of diversity at the KIR locus has progressed over the past several years, ...

journal_title：Immunogenetics

authors： Martin MP,Single RM,Wilson MJ,Trowsdale J,Carrington M

更新日期：2008-12-01 00:00:00

abstract：:Individual variation in immune responses is always encountered after vaccination. This phenomenon is also seen after acellular pertussis vaccination. The aim of this present study was to investigate whether single nucleotide polymorphisms (SNPs) in the IL-10 gene promoter region (rs1800890, rs1800896, rs1800871), IL-1...

journal_title：Immunogenetics

authors： Gröndahl-Yli-Hannuksela K,Vahlberg T,Ilonen J,Mertsola J,He Q

更新日期：2016-10-01 00:00:00

abstract：:A retrovirus element (TLev1) is located within the Thymus leukemia antigen (Tla) locus of the C57BL/10 mouse major histocompatibility complex. Low-copy probes have been isolated from sequences flanking the TLev1 integration site to examine the distribution of TLev1 among inbred mouse strains having genotypically deter...

journal_title：Immunogenetics

authors： Pampeno C,Meruelo D

更新日期：1988-01-01 00:00:00