A high-resolution map of the regulator of the complement activation gene cluster on 1q32 that integrates new genes and markers.

abstract：:Pigtail macaques (Macaca nemestrina) are an increasingly common primate model for the study of human AIDS. Major Histocompatibility complex (MHC) class I-restricted CD8(+) T cell responses are a critical part of the adaptive immune response to HIV-1 in humans and simian immunodeficiency virus (SIV) in macaques; howeve...

journal_title：Immunogenetics

authors： Pratt BF,O'Connor DH,Lafont BA,Mankowski JL,Fernandez CS,Triastuti R,Brooks AG,Kent SJ,Smith MZ

更新日期：2006-12-01 00:00:00

abstract：:Major histocompatibility complex (MHC) molecules are responsible for the antigen presentation to T lymphocytes. High recombination rates in the MHC genes, as observed in humans, are believed to serve the evolutionary goal to achieve a high genetic diversity, allowing for a broad and efficient immune response. In a coh...

journal_title：Immunogenetics

authors： Gimsa U,Ho CS,Hammer SE

更新日期：2017-01-01 00:00:00

abstract：:Immunoprecipitation of NP-40 lysates of 125I-labeled lymph-node cells with different anti-H-2 sera and with anti-Qa-2 serum has shown that the BALB/cByA strain (H-2d, Qa-2-negative) expresses, besides H-2Ld, another molecule that is not detectable in the BALB/c-H-2dm2 strain. Electrophoresis in SDS polyacrylamide gels...

journal_title：Immunogenetics

authors： Démant P,Roos MH

更新日期：1982-01-01 00:00:00

abstract：:Sickle cell anemia (SCA) is characterized by chronic hemolysis, severe vasoocclusive crises (VOCs), and recurrent often severe infections. A cohort of 95 SCA pediatric patients was the background for genotype-to-phenotype association of the patient's infectious disease phenotype and three non-coding polymorphic region...

journal_title：Immunogenetics

authors： David S,Aguiar P,Antunes L,Dias A,Morais A,Sakuntabhai A,Lavinha J

更新日期：2018-01-01 00:00:00

abstract：:We selected 38 consecutive celiac disease (CD) patients (from a group of 316 consecutive CD patients) and 91 healthy blood donors, all of whom were HLA-DQ2 (DQA1*0501/DQB1*0201) negative, and investigated the presence of the classically associated alleles HLA-DQ8 and HLA-DRB4. We also studied the distribution of MICA ...

journal_title：Immunogenetics

authors： Lopez-Vazquez A,Rodrigo L,Fuentes D,Riestra S,Bousoño C,Garcia-Fernandez S,Martinez-Borra J,Gonzalez S,Lopez-Larrea C

更新日期：2002-02-01 00:00:00

abstract：:We analyzed the genetic regulation of spontaneous autoimmune thyroiditis (SAT) by means of crosses between Obese strain (OS) chickens with the disease, and healthy inbred chicken of line CB. Mononuclear cell infiltration of the thyroid was used as a criterion for the disease. We confirmed the existence of one recessiv...

journal_title：Immunogenetics

authors： Vasícek D,Vasícková K,Kaiser P,Drozenová R,Cítek J,Hala K

更新日期：2001-12-01 00:00:00

abstract：:A new H-2 mutant involving the H-2d haplotype is described--C.B6-H-2dm4 (dm4). This mutant strain carries a gain and loss mutation which maps to the Kd gene of the H-2 complex. Serological testing comparing the mutant and the parental BALB/cKh strain failed to detect any difference between the two strains and no antib...

journal_title：Immunogenetics

authors： Morgan G,Dellos H,McKenzie IF,Melvold RW

更新日期：1981-03-01 00:00:00

abstract：:Six IgA allotypes are serologically identifiable in inbred mice. The sequences of the PCR-amplified C alpha 1, C alpha 2 and C alpha 3 exons from the genomic DNA of mice of four previously unsequenced allotypes already have been compared with those of BALB/c and of a wild mouse, Mus pahari, in the literature. Sporadic...

journal_title：Immunogenetics

authors： Phillips-Quagliata JM

更新日期：2002-03-01 00:00:00

abstract：:We have studied the MICA alleles of 196 unrelated subjects from three South American Indian tribes (Toba, Wichi and Terena). They are members of isolated tribes located in the Gran Chaco area in northeastern Argentina and in Mato Grosso do Sul in South Central Brazil. Of 55 previously known alleles, nine were observed...

journal_title：Immunogenetics

authors： Zhang Y,Lazaro AM,Zou Y,Lavingia B,Moraes EM,Moraes RJ,Stastny P

更新日期：2002-02-01 00:00:00

abstract：:Earlier studies suggest that end-stage renal disease (ESRD) is associated with inflammatory state and have become a major cause of morbidity and mortality worldwide. This study speculated the role of interleukins (IL)-2, -4, and -6 cytokines gene polymorphism with risk of susceptibility to ESRD. Polymorphism in IL-2 (...

journal_title：Immunogenetics

authors： Mittal RD,Manchanda PK

更新日期：2007-02-01 00:00:00

abstract：:The rat major histocompatibility complex loci RT1-B and RT1-D are equivalent to the human leucocyte antigens HLA-DQ and HLA-DR respectively. Here we describe the complementary DNA (cDNA) sequence encoding the alpha and beta chains of both the RT1-B and RT1-D locus genes of the rat RT1u haplotype. We have found entire ...

journal_title：Immunogenetics

authors： Easterfield AJ,Bradley JA,Bolton EM

更新日期：2003-08-01 00:00:00

abstract：:Ruminant gammadelta T cells are divided into subpopulations based on the presence or absence of WC1 co-receptors (scavenger-receptor-cysteine-rich family members uniquely expressed on gammadelta T cells). Evidence suggests WC1+ are inflammatory while WC1- are regulatory and that they also differ in their tissue distri...

journal_title：Immunogenetics

authors： Blumerman SL,Herzig CT,Rogers AN,Telfer JC,Baldwin CL

更新日期：2006-08-01 00:00:00

abstract：:We used rabbit antisera to the chicken MHC erythrocyte molecule B-G and to the class I alpha chain (B-F) to screen lambda gt11 cDNA expression libraries made with RNA selected by oligo-dT from bone marrow cells of anemic B19 homozygous chickens. Eight clones were found to encode B-G molecules which hybridize with sequ...

journal_title：Immunogenetics

authors： Kaufman J,Salomonsen J,Skjødt K

更新日期：1989-01-01 00:00:00

abstract：:The major histocompatibility complex (MHC) includes highly polymorphic gene families encoding proteins crucial to the vertebrate acquired immune system. Classical MHC class I (MHCI) genes code for molecules expressed on the surfaces of most nucleated cells and are associated with defense against intracellular pathogen...

journal_title：Immunogenetics

authors： Buehler DM,Verkuil YI,Tavares ES,Baker AJ

更新日期：2013-03-01 00:00:00

abstract：:An analysis of mRNA structures as deduced from the amino acid sequences of immunoglobulin heavy chains reveals possible base-paired regions within the sequences coding for the 20 C-terminal amino acids of the human μ and α chains. The two regions are similar in structure and contain a palindrome which might serve as a...

journal_title：Immunogenetics

authors： Melcher U

更新日期：1978-12-01 00:00:00

abstract：:We have previously demonstrated a genetic predisposition among mice regarding their ability to be protected against vaginal candidiasis after peripheral immunization. Both BALB/c and (BALB/cx C57BL/6) F1 mice are protected against vaginal candidiasis after subcutaneous immunization with Candida albicans extract and C5...

journal_title：Immunogenetics

authors： Mulero-Marchese RD,Blank KJ,Sieck TG

更新日期：1999-10-01 00:00:00

abstract：:The hallmark of the classical major histocompatibility complex (MHC) class I molecules is their astonishing level of polymorphism, a characteristic not shared by the nonclassical MHC class I genes. A distinct family of MHC class I genes has been recently identified within the human MHC class I region. The MICA (MHC cl...

journal_title：Immunogenetics

authors： Fodil N,Laloux L,Wanner V,Pellet P,Hauptmann G,Mizuki N,Inoko H,Spies T,Theodorou I,Bahram S

更新日期：1996-01-01 00:00:00

abstract：:The characterization of genes involved in the generation of the immune repertoire is an active area of research in lower vertebrate taxa. The recombination activating genes (RAG) have been shown to be essential for V (D) J recombination of T-cell antigen receptor (TCR) and immunoglobulin (Ig) genes, leading to the gen...

journal_title：Immunogenetics

authors： Hansen JD,Kaattari SL

更新日期：1995-01-01 00:00:00

abstract：:We report on the analyses of genes encoding immunoglobulin heavy and light chains in the rabbit 6.51× whole genome assembly. This OryCun2.0 assembly confirms previous mapping of the duplicated IGK1 and IGK2 loci to chromosome 2 and the IGL lambda light chain locus to chromosome 21. The most frequently rearranged and e...

journal_title：Immunogenetics

authors： Gertz EM,Schäffer AA,Agarwala R,Bonnet-Garnier A,Rogel-Gaillard C,Hayes H,Mage RG

更新日期：2013-10-01 00:00:00

abstract：:The T- and B-cell surface polypeptides detected by an international workshop panel of 100 mouse monoclonal antibodies (M.Ab) were biochemically defined by radioimmunoprecipitation. Eight T-cell-associated molecules and eight B-cell-associated molecules were identified by multiple antibodies in the panel. Clusters of a...

journal_title：Immunogenetics

authors： Clark EA,Martin PJ,Hansen JA,Ledbetter JA

更新日期：1983-01-01 00:00:00

abstract：:Macaques are the most widely used experimental nonhuman primate (NHP) species. Rhesus (Macaca mulatta, Macmul), cynomolgus (Macaca fascicularis, Macfas), and pigtail (Macaca nemestrina, Macnem) macaques continue to be popular models for vaccine and infectious diseases research, especially HIV infection and AIDS, and f...

journal_title：Immunogenetics

authors： Nguyen DC,Sanghvi R,Scinicariello F,Pulit-Penaloza J,Hill N,Attanasio R

更新日期：2014-06-01 00:00:00

abstract：:Nonaspanins constitute a family of proteins, also called TM9SF, characterized by a large non-cytoplasmic domain and nine putative transmembrane domains. This family is highly conserved through evolution and comprises three members in Saccharomyces cerevisiae, Dictyostelium discoideum, and Drosophila melanogaster, and ...

journal_title：Immunogenetics

authors： Pruvot B,Laurens V,Salvadori F,Solary E,Pichon L,Chluba J

更新日期：2010-10-01 00:00:00

abstract：:Antigen-specific CD4+ T cells play a critical role in protective immunity to many infectious pathogens. Although the antigen-specific CD4+ T cells can be measured by functional assays such as proliferation or cytokine enzyme-linked immunospot, such assays are limited to a specific function and cannot quantify anergic ...

journal_title：Immunogenetics

authors： Norimine J,Han S,Brown WC

更新日期：2006-09-01 00:00:00

abstract：:MICA and MICB genes encode MHC class I chain-related proteins, which are polymorphic, do not appear to present peptides or associate with beta(2)-microglobulin, and are expressed predominantly in epithelial cells, endothelial cells, fibroblasts and several cultured cell lines. Alternatively spliced isoforms are known ...

journal_title：Immunogenetics

authors： Zou Y,Stastny P

更新日期：2002-12-01 00:00:00

abstract：:The genetic factors that determine the size of lymphocyte populations are largely unknown. We studied the genetic control of variations in the size of the CD4 thymic compartment in unmanipulated mouse strains. A time-course experiment showed that the C57BL/6 mouse strain has a consistently reduced proportion of thymic...

journal_title：Immunogenetics

authors： Duarte N,Penha-Gonçalves C

更新日期：2001-10-01 00:00:00

abstract：:The polymerase chain reaction was used to isolate clones with class I major histocompatibility complex sequences from fish (carp), amphibian (axolotl), and two species of reptile (lizard and snake). The lizard and snake clones were used to isolate class I cDNA clones. All the sequences showed the expected evolutionary...

journal_title：Immunogenetics

authors： Grossberger D,Parham P

更新日期：1992-01-01 00:00:00

abstract：:Natural killer (NK) cells constitute the third major population of lymphocytes. They possess the inherent capacity to kill various tumor and virally infected cells and mediate the rejection of bone-marrow grafts in lethally irradiated animals. A large family of NK cell receptors belong to the C-type lectin superfamily...

journal_title：Immunogenetics

authors： Boles KS,Barten R,Kumaresan PR,Trowsdale J,Mathew PA

更新日期：1999-10-01 00:00:00

abstract：:We cloned the cDNAs and genes of two different types of toll-like receptors from Japanese flounder. The results of homology searches suggested that these genes (designated JF-TLR2 and JF-TLR22) are homologues of human TLR2 and fugu TLR22, respectively. The cDNAs of JF-TLR2 and JF-TLR22 encoded 818 and 961 amino acid r...

journal_title：Immunogenetics

authors： Hirono I,Takami M,Miyata M,Miyazaki T,Han HJ,Takano T,Endo M,Aoki T

更新日期：2004-04-01 00:00:00

abstract：:Ia antigens coded by genes of the murine major histocompatibility complex are expressed on the surface of a population of cells critical to the proliferative response of murine spleen cells to the oxidative mitogen neuraminidase/galactose oxidase. By selective depletion with antiserum and complement, Ia antigens coded...

journal_title：Immunogenetics

authors： Phillips ML,Hill SW,Parker JW,O'Brien RL,Frelinger JA

更新日期：1980-01-01 00:00:00

abstract：:The cluster of differentiation 4 (CD4) molecule functions as a co-receptor for MHC class II binding to TCR in T helper cells. A CD4 epitope deficiency was identified in the swine MeLiM (melanoblastoma-bearing Libechov minipig) strain, a model for spontaneous cutaneous melanoma development and regression. Extensive seq...

journal_title：Immunogenetics

authors： Blanc F,Créchet F,Bruneau N,Piton G,Leplat JJ,Andréoletti F,Egidy G,Vincent-Naulleau S,Bourneuf E

更新日期：2018-04-01 00:00:00