Abstract:
:The recombination activating genes RAG-1 and RAG-2 are adjacent genes that act synergistically to activate variable-diversity-joining (V(D)J) recombination. Southern analysis of hybrid cell lines derived from patients with the Wilms tumor-aniridia-genitourinary defects-mental retardation (WAGR) syndrome and from mutagenized cell hybrids selected for deletions in chromosome 11 has allowed us to map the chromosomal location of the human RAG locus. The RAG locus defines a new interval of human chromosome 11p, but is not associated with any genetically mapped human disease. Guided by the chromosomal localization of the human recombination activating genes, we have also mapped the location of the mouse Rag locus.
journal_name
Immunogeneticsjournal_title
Immunogeneticsauthors
Oettinger MA,Stanger B,Schatz DG,Glaser T,Call K,Housman D,Baltimore Ddoi
10.1007/BF00189518subject
Has Abstractpub_date
1992-01-01 00:00:00pages
97-101issue
2eissn
0093-7711issn
1432-1211journal_volume
35pub_type
杂志文章相关文献
IMMUNOGENETICS文献大全abstract::Zaïre ebolavirus (ZEBOV) infection rapidly outruns the host's immunity and leads to death within a week. Fatal cases have been associated with an aberrant innate, proinflammatory immune response followed by a suppressed adaptive response leading to the rapid depletion of peripheral NK cells and lymphocytes. A critical...
journal_title:Immunogenetics
pub_type: 杂志文章
doi:10.1007/s00251-010-0480-x
更新日期:2010-12-01 00:00:00
abstract::Class I-like molecules have been immunoprecipitated from Xenopus leukocytes and erythrocytes with alloantisera directed against major histocompatibility complex (MHC)-linked antigens. The heavy chains, depending on the allele examined, have molecular weights of 40 000-44 000 of which 3000 daltons are asparagine-linked...
journal_title:Immunogenetics
pub_type: 杂志文章
doi:10.1007/BF00345617
更新日期:1984-01-01 00:00:00
abstract::Human and mouse major histocompatibility complex class II beta chain alleles associated with predisposition to type I diabetes often encode a non-charged residue at position 57 rather than the negatively charged aspartate residue characteristic of non-susceptible haplotypes. The mechanism(s) whereby this polymorphism ...
journal_title:Immunogenetics
pub_type: 杂志文章
doi:10.1007/s002510050351
更新日期:1998-01-01 00:00:00
abstract::The gene for the catalytic subunit of DNA-dependent protein kinase (DNA-PKcs) is responsible for severe combined immune deficiency (SCID) and its products associate with Ku70/Ku86 autoantigens, c-Abl, and other factors to exert its roles. Investigations to date suggest that DNA-PKcs comprises several regions which spe...
journal_title:Immunogenetics
pub_type: 杂志文章
doi:10.1007/s002510000227
更新日期:2000-09-01 00:00:00
abstract::Recurrent pregnancy loss (RPL) is a common problem during early gestation. The aim of our study was to investigate the association of IL-17 F( rs763780), IL-17 A (rs2275913), and leptin (2548 G/A) gene polymorphisms with RPL in obese and lean Egyptian females, and to find out whether these gene polymorphisms affect th...
journal_title:Immunogenetics
pub_type: 杂志文章
doi:10.1007/s00251-015-0876-8
更新日期:2015-11-01 00:00:00
abstract::Cichlid fishes of the East African Rift Valley lakes constitute an important model of adaptive radiation. Explosive speciation in the Great Lakes, in some cases as recently as 12 400 years ago, generated large species flocks that have been the focus of evolutionary studies for some time. The studies have, however, bee...
journal_title:Immunogenetics
pub_type: 杂志文章
doi:10.1007/s002510050243
更新日期:1997-01-01 00:00:00
abstract::Transgenic mice were produced in which human HLA-Cw4 is stably integrated, behaves as a single Mendelian trait, and, being under the transcriptional control of human CD2, is selectively and efficiently expressed in T lymphocytes. These mice were used as a model system to determine whether HLA-type C molecules can be e...
journal_title:Immunogenetics
pub_type: 杂志文章
doi:10.1007/BF00179398
更新日期:1995-01-01 00:00:00
abstract::The serological reactivities of HLA-A3, -B7, and -CW3 heavy chains associated with either mouse, bovine, or human beta-2-microglobulin (beta 2m) and expressed on the surface of transfected mouse fibroblasts were analyzed. All reactivities associated with one cluster (defined by monoclonal antibody W6/32) of antigenic ...
journal_title:Immunogenetics
pub_type: 杂志文章
doi:10.1007/BF00430798
更新日期:1985-01-01 00:00:00
abstract::The heavy and light chain subunits of the DC1 antigen from several cell lines expressing different DR specificities were compared by two-dimensional (2-D) gel electrophoresis. The DC1 light chains from cell lines typed as DR1, DR2, or DRw6 differed in their isoelectric points. No difference in charge was observed for ...
journal_title:Immunogenetics
pub_type: 杂志文章
doi:10.1007/BF00345970
更新日期:1983-01-01 00:00:00
abstract::In this study we analyzed fibroblasts derived from an MHC class II deficiency patient (type III bare lymphocyte syndrome). Northern blot analysis showed that upon induction with IFN-gamma these fibroblasts did not express HLA class II genes and displayed a strongly reduced level of HLA class I gene expression when com...
journal_title:Immunogenetics
pub_type: 杂志文章
doi:10.1007/BF00172153
更新日期:1995-01-01 00:00:00
abstract::Human Ia(-like) specificities controlled by gene loci other than HLA-DR were searched for at the molecular level in cells of human B-cell-type cell lines which carry two established DR specificities. Chevalier cells of DRw3 and 7 and U698M cells of DRw2 and 4 were used. Their Ia molecules were partially purified, radi...
journal_title:Immunogenetics
pub_type: 杂志文章
doi:10.1007/BF01561564
更新日期:1980-01-01 00:00:00
abstract::Segregation distortion was found for a haplotype of the equine lymphocyte antigen (ELA) system in an extended family of American Standardbred horses. In one sire family, consisting of a stallion and his 17 sons and grandsons, the gene for ELA-A10 (A10) was transmitted to 57.7% of 638 offspring scored (P = 0.001). Sign...
journal_title:Immunogenetics
pub_type: 杂志文章
doi:10.1007/BF00364526
更新日期:1986-01-01 00:00:00
abstract::An analysis of mRNA structures as deduced from the amino acid sequences of immunoglobulin heavy chains reveals possible base-paired regions within the sequences coding for the 20 C-terminal amino acids of the human μ and α chains. The two regions are similar in structure and contain a palindrome which might serve as a...
journal_title:Immunogenetics
pub_type: 杂志文章
doi:10.1007/BF01843981
更新日期:1978-12-01 00:00:00
abstract::Toll-interleukin-1R resistance (TIR) domains are ubiquitously present in all forms of cellular life. They are most commonly found in signaling proteins, as units responsible for signal-dependent formation of protein complexes that enable amplification and spatial propagation of the signal. A less common function of TI...
journal_title:Immunogenetics
pub_type: 杂志文章
doi:10.1007/s00251-020-01157-7
更新日期:2020-04-01 00:00:00
abstract::A new H-2 mutant involving the H-2d haplotype is described--C.B6-H-2dm4 (dm4). This mutant strain carries a gain and loss mutation which maps to the Kd gene of the H-2 complex. Serological testing comparing the mutant and the parental BALB/cKh strain failed to detect any difference between the two strains and no antib...
journal_title:Immunogenetics
pub_type: 杂志文章
doi:10.1007/BF01561695
更新日期:1981-03-01 00:00:00
abstract::Monoclonal antibodies reacting with TL-like class I antigens expressed on the surface of human thymocytes and some T leukemia lines were found to define three independent epitopic clusters, two of which could be shown to reside on serologically distinct molecular subsets by a solid-phase radioimmunoassay as well as by...
journal_title:Immunogenetics
pub_type: 杂志文章
doi:10.1007/BF00364207
更新日期:1984-01-01 00:00:00
abstract::Coeliac disease is strongly associated with HLA-DQ2, but it is possible that additional major histocompatibility complex genes also confer disease susceptibility. Encoded close to HLA-DQ are two genes, TAP1 and TAP2, whose products are believed to transport antigenic peptides from the cytoplasm into the endoplasmic re...
journal_title:Immunogenetics
pub_type: 杂志文章
doi:10.1007/BF00210476
更新日期:1993-01-01 00:00:00
abstract::The membrane immunoglobulin M (mIgM) of a B lymphocyte serves as a receptor for its cognate antigen. Our aim is to elucidate the structure and function of this membrane-bound receptor. The first step is to determine the requirements for proper membrane placement of IgM. We have used mIgM-positive B lymphocyte tumors f...
journal_title:Immunogenetics
pub_type: 杂志文章
doi:10.1007/BF00364758
更新日期:1983-01-01 00:00:00
abstract::The major histocompatibility complex (MHC) is critical to host-pathogen interactions. Class II MHC is a heterodimer, with α and β subunits encoded by different genes. The peptide-binding groove is formed by the first domain of both subunits (α1 and β1), but studies of class II variation or natural selection focus prim...
journal_title:Immunogenetics
pub_type: 杂志文章
doi:10.1007/s00251-019-01130-z
更新日期:2019-09-01 00:00:00
abstract::Immunoglobulin (IG) gene rearrangement and expression are central to disease resistance and health maintenance in animals. The IG kappa (IGK) locus in swine (Sus scrofa domestica) contributes to approximately half of all antibody molecules, in contrast to many other Cetartiodactyla, whose members provide the majority ...
journal_title:Immunogenetics
pub_type: 杂志文章
doi:10.1007/s00251-011-0589-6
更新日期:2012-04-01 00:00:00
abstract::The Hawaiian monk seal population has experienced precipitous declines in the last 50 years. In this study, we provide evidence that individuals from remaining endangered population exhibit alarming uniformity in class I major histocompatibility (MHC) genes. The peripheral blood leukocyte-derived mRNA of six captive a...
journal_title:Immunogenetics
pub_type: 杂志文章
doi:10.1007/s00251-005-0069-y
更新日期:2006-04-01 00:00:00
abstract::Avian influenza is a serious threat to the poultry industry and, as the potential source of a human pandemic virus, to public health. Different Mx alleles have been reported to confer resistance or susceptibility to influenza virus replication, and so knowledge of their frequencies is important when considering the po...
journal_title:Immunogenetics
pub_type: 杂志文章
doi:10.1007/s00251-007-0235-5
更新日期:2007-08-01 00:00:00
abstract::We investigated the genetic control of heterotopic heart allograft rejection using a family of standard inbred, major histocompatibility complex (MHC)-congenic, and intra-MHC recombinant rat strains. Gene products of the various regions within the rat MHC differed markedly in their capacity to induce rejection. Isolat...
journal_title:Immunogenetics
pub_type: 杂志文章
doi:10.1007/BF02421535
更新日期:1989-01-01 00:00:00
abstract::In the mouse three lymphocyte gene families have been positioned on the proximal region of chromosome 6. Originally the immunoglobulin kappa light chain (Igk) and the thymocyte surface antigens Lyt-2 and Lyt-3 were assigned to chromosome 6, and recently the beta chain of the T-cell receptor for antigen was positioned ...
journal_title:Immunogenetics
pub_type: 杂志文章
doi:10.1007/BF00404487
更新日期:1985-01-01 00:00:00
abstract::Kinetics and family transmission of antigen-specific in vitro cell-mediated responses were investigated in 68, and serum-antibody responses to tetanus toxoid (TT) in 73 individuals from a total of 12 families. Proliferative responses to highly purified TT monomer were studied in 6- to 7-day lymphocyte cultures. The ef...
journal_title:Immunogenetics
pub_type: 杂志文章
doi:10.1007/BF00372467
更新日期:1983-01-01 00:00:00
abstract::In the absence of suitable rodent animal models for Plasmodium falciparum malaria, the efficacy testing of asexual blood-stage vaccine candidates in Aotus nancymaae represents a tool to select between different formulations before conducting expensive human clinical trials. CpG oligonucleotides (ODN) specifically prom...
journal_title:Immunogenetics
pub_type: 杂志文章
doi:10.1007/s00251-005-0789-z
更新日期:2005-05-01 00:00:00
abstract::The human Lutheran (Lu) blood group antigens are carried by two glycoproteins (gps) that belong to the immunoglobulin (Ig) superfamily. These gps represent adhesion molecules that function as the unique erythroid receptors for laminin. We report here the cloning and functional expression of the orthologous mouse Lu mR...
journal_title:Immunogenetics
pub_type: 杂志文章
doi:10.1007/s002510050602
更新日期:1999-12-01 00:00:00
abstract::The size of B-cell subsets appears to be under genetic control, but the mechanism of this regulation is unknown. By analyzing five congenic strains of mice that differ only in their H2 haplotype, we addressed the issue of whether the MHC genes are involved in the relative proportions of B-1a, B-1b and B-2 cells. Not o...
journal_title:Immunogenetics
pub_type: 杂志文章
doi:10.1007/s00251-002-0457-5
更新日期:2002-06-01 00:00:00
abstract::Human cDNA probes for 21-hydroxylase (21-OH) and for complement component C4 are used on restriction digests of the members of several families with interesting supratypes. The presence of two Taq I fragments of 3.7 kb and 3.2 kb in size with a 21-OH probe is confirmed in most individuals who show no evidence of C4 de...
journal_title:Immunogenetics
pub_type: 杂志文章
doi:10.1007/BF00377968
更新日期:1986-01-01 00:00:00
abstract::Macaques are the most widely used experimental nonhuman primate (NHP) species. Rhesus (Macaca mulatta, Macmul), cynomolgus (Macaca fascicularis, Macfas), and pigtail (Macaca nemestrina, Macnem) macaques continue to be popular models for vaccine and infectious diseases research, especially HIV infection and AIDS, and f...
journal_title:Immunogenetics
pub_type: 杂志文章
doi:10.1007/s00251-014-0775-4
更新日期:2014-06-01 00:00:00