Localization of CT beta and C kappa on mouse chromosome 6.

abstract：:The presentation of identical peptides by different major histocompatibility complex class I (MHC-I) molecules, termed promiscuity, is a controversial feature of T cell-mediated immunity to pathogens. The astounding diversity of MHC-I molecules in human populations, presumably to enable binding of equally diverse pept...

journal_title：Immunogenetics

authors： Maness NJ,Walsh AD,Rudersdorf RA,Erickson PA,Piaskowski SM,Wilson NA,Watkins DI

更新日期：2011-09-01 00:00:00

abstract：:The polymorphism of major histocompatibility complex class I chain-related gene B (MICB) and variations in MICB alleles in a variety of populations have been characterized using several genotyping approaches. In the present study, a novel polymerase chain reaction sequence-based typing (PCR-SBT) method was established...

journal_title：Immunogenetics

authors： Ying Y,He Y,Tao S,Han Z,Wang W,Chen N,He J,Zhang W,He J,Zhu F,Lv H

更新日期：2013-07-01 00:00:00

abstract：:The immune response of the rat to group A streptococcal carbohydrate (SACHO) and an associated idiotype, Id-1, was used to examine the effect of paternal immunity on Id-1 and SACHO-specific antibody expression by the offspring. First litters, conceived before immunization of the father, had significantly higher Id-1 l...

journal_title：Immunogenetics

authors： Cooper-Willis CA,Olson JC,Brewer ME,Leslie GA

更新日期：1985-01-01 00:00:00

abstract：:We have used seven HLA-D homozygous typing cells (HTC) in a comparative study of the DRw8 antigen complex in three racial groups. Three distinct HLA-D specificities were recognized, each associated with HLA-DRw8. Four of the HTC defined a DRw8-associated HLA-D specificity designated 8.1, one defined a specificity desi...

journal_title：Immunogenetics

authors： Mickelson EM,Nisperos B,Layrisse Z,Kim SJ,Thomas ED,Hansen JA

更新日期：1983-01-01 00:00:00

abstract：:Binding of peptides to major histocompatibility complex (MHC) molecules is the single most selective step in the recognition of pathogens by the cellular immune system. The human MHC genomic region (called HLA) is extremely polymorphic comprising several thousand alleles, each encoding a distinct MHC molecule. The pot...

journal_title：Immunogenetics

authors： Hoof I,Peters B,Sidney J,Pedersen LE,Sette A,Lund O,Buus S,Nielsen M

更新日期：2009-01-01 00:00:00

abstract：:MICA and MICB genes encode MHC class I chain-related proteins, which are polymorphic, do not appear to present peptides or associate with beta(2)-microglobulin, and are expressed predominantly in epithelial cells, endothelial cells, fibroblasts and several cultured cell lines. Alternatively spliced isoforms are known ...

journal_title：Immunogenetics

authors： Zou Y,Stastny P

更新日期：2002-12-01 00:00:00

abstract：:With the use of monospecific rabbit anti-G protein and mouse monoclonal anti-H-2Kk, we have analyzed the spatial relationship of the serologically defined H-2Kk antigens and the major surface glycoprotein (G protein) of vesicular stomatitis virus (VSV) to those antigens recognized by B10.A (k, d) anti-VSV cytotoxic T ...

journal_title：Immunogenetics

authors： Hale AH

更新日期：1980-01-01 00:00:00

abstract：:Chickens of the Iowa State S1 line have been selected for ability to regress Rous sarcoma virus-induced (RSV) tumors, humoral immune response to GAT (Ir-GAT), and erythrocyte antigen B. Sublines homozygous at the major histocompatibility complex (MHC), as well as F1 heterozygotes and F2 segregants, were tested for res...

journal_title：Immunogenetics

authors： Lamont SJ,Bolin C,Cheville N

更新日期：1987-01-01 00:00:00

abstract：:A 280 kilobase (kb) contig was isolated from mouse genomic P1 and cosmid libraries, using as probes human cDNA and genomic DNA fragments that map in the interval between the second component of complement and tumor necrosis factor genes of the HLA complex. The clone contig demonstrates synteny of eleven mouse genes th...

journal_title：Immunogenetics

authors： Gasser DL,Sternberg NL,Pierce JC,Goldner-Sauve A,Feng H,Haq AK,Spies T,Hunt C,Buetow KH,Chaplin DD

更新日期：1994-01-01 00:00:00

abstract：:The Ly49 family of natural killer (NK) cell receptors is encoded by a polygenic genetic locus. Allelic forms have been described and their expression appears to be regulated. The best-characterized Ly49 molecule, the C57BL/6 form of Ly49A, is an NK cell inhibitory receptor that binds H2Dd. To determine whether differe...

journal_title：Immunogenetics

authors： Mehta IK,Wang J,Roland J,Margulies DH,Yokoyama WM

更新日期：2001-09-01 00:00:00

abstract：:The human major histocompatibility complex (MHC) is located within a 4 megabase segment on chromosome 6p21.3. Recently, a highly divergent MHC class I chain-related gene family, MIC was identified within the class I region. The MICA and MICB genes in this family have unique patterns of tissue expression. The MICA gene...

journal_title：Immunogenetics

authors： Ando H,Mizuki N,Ota M,Yamazaki M,Ohno S,Goto K,Miyata Y,Wakisaka K,Bahram S,Inoko H

更新日期：1997-01-01 00:00:00

abstract：:Coeliac disease is strongly associated with HLA-DQ2, but it is possible that additional major histocompatibility complex genes also confer disease susceptibility. Encoded close to HLA-DQ are two genes, TAP1 and TAP2, whose products are believed to transport antigenic peptides from the cytoplasm into the endoplasmic re...

journal_title：Immunogenetics

authors： Powis SH,Rosenberg WM,Hall M,Mockridge I,Tonks S,Ivinson A,Ciclitira PJ,Jewell DP,Lanchbury JS,Bell JI

更新日期：1993-01-01 00:00:00

abstract：:Ruminant gammadelta T cells are divided into subpopulations based on the presence or absence of WC1 co-receptors (scavenger-receptor-cysteine-rich family members uniquely expressed on gammadelta T cells). Evidence suggests WC1+ are inflammatory while WC1- are regulatory and that they also differ in their tissue distri...

journal_title：Immunogenetics

authors： Blumerman SL,Herzig CT,Rogers AN,Telfer JC,Baldwin CL

更新日期：2006-08-01 00:00:00

abstract：:In the African clawed frog (Xenopus laevis), two deeply divergent allelic lineages of multiple genes of the class I MHC region have been discovered. For the MHC class I UAA locus, functional differences and the molecular basis for lineages maintenance are unknown. Alleles of linked class I region genes also exhibit st...

journal_title：Immunogenetics

authors： Bos DH,Waldman B

更新日期：2006-06-01 00:00:00

abstract：:T-bet is a key regulator for the lineage commitment in CD4+ T helper (Th) 1 cells by activating the hallmark production of interferon-γ. Previously, two single nucleotide polymorphisms (SNPs) in the TBX21 promoter, T-1993C and T-1514C, have been shown by statistic studies to associate with systemic lupus erythematosus...

journal_title：Immunogenetics

authors： Li J,Li J,You Y,Chen S

更新日期：2012-05-01 00:00:00

abstract：:The generation and maintenance of allelic polymorphism in genes of the major histocompatibility complex (MHC) is a central issue in evolutionary genetics. Recently, the focus has changed from ex situ to in situ populations to understand the mechanisms that determine adaptive MHC polymorphism under natural selection. B...

journal_title：Immunogenetics

authors： Axtner J,Sommer S

更新日期：2007-05-01 00:00:00

abstract：:The role of H-2- and T-region products in determining allogeneic cell rejection was evaluated in H-2 congenic and recombinant mice by transplanting A1ATH and A6ATL leukemia cell lines induced in A.TH and A.TL strains, respectively, by Moloney murine leukemia virus.--In K- or D-region incompatible hosts transplant fail...

journal_title：Immunogenetics

authors： Biasi G,Collavo D,Zanovello P,Chieco-Bianchi L

更新日期：1981-03-01 00:00:00

abstract：:The evolution of the mouse immunoglobulin heavy chain variable region (Igh-V) locus was investigated by the comprehensive analysis of variable region (Vh) gene family content and restriction fragment polymorphism in the genus Mus. The examination of natural Mus domesticus populations suggests an important role for rec...

journal_title：Immunogenetics

authors： Tutter A,Riblet R

更新日期：1989-01-01 00:00:00

abstract：:The collectin surfactant protein-D (SP-D) plays a significant role in innate immunity. Epidemiological studies described associations between single nucleotide polymorphisms (SNPs) of the human gene coding surfactant protein-D (SFTPD) and infectious pulmonary diseases. Studies on twins indicated very strong genetic de...

journal_title：Immunogenetics

authors： Heidinger K,König IR,Bohnert A,Kleinsteiber A,Hilgendorff A,Gortner L,Ziegler A,Chakraborty T,Bein G

更新日期：2005-04-01 00:00:00

abstract：:The gray short-tailed opossum Monodelphis domestica is one of the few marsupial species for which a high quality whole genome sequence is available and the major histocompatibility complex (MHC) region has been annotated. Previous analyses revealed only a single locus within the opossum MHC region, designated Modo-UA1...

journal_title：Immunogenetics

authors： Krasnec KV,Sharp AR,Williams TL,Miller RD

更新日期：2015-04-01 00:00:00

abstract：:The human complement C4 genes in the HLA exhibit an unusual, dichotomous size polymorphism and a four-gene, modular variation involving novel gene RP, complement C4, steroid 21-hydroxylase (CYP21), and tenascin-like Gene X (RCCX). The C4 gene size dichotomy is mediated by an endogenous retrovirus, HERV-K(C4). Nearly i...

journal_title：Immunogenetics

authors： Dangel AW,Mendoza AR,Baker BJ,Daniel CM,Carroll MC,Wu LC,Yu CY

更新日期：1994-01-01 00:00:00

abstract：:We have isolated and characterized cDNAs and genes for pufferfish, Fugu rubripes, (Fugu) orthologues of mammalian interleukin (IL)-12 subunits (IL-12 p35 and IL-12 p40). The deduced amino acid sequences of the Fugu IL-12 subunits showed homology with mammalian IL-12 subunits (p35: 50.4-58.0% similarity; p40: 51.2-55.4...

journal_title：Immunogenetics

authors： Yoshiura Y,Kiryu I,Fujiwara A,Suetake H,Suzuki Y,Nakanishi T,Ototake M

更新日期：2003-08-01 00:00:00

abstract：:CD99, the product of the MIC2 gene, exhibits an erythroid-specific quantitative polymorphism co-regulated with the Xga blood group polymorphism. The co-expression of X-linked MIC2 and XG genes is presumably controlled at the transcriptional level by a single XGR locus in the pseudoautosomal region of sexual chromosome...

journal_title：Immunogenetics

authors： Fouchet C,Gane P,Cartron JP,Lopez C

更新日期：2000-07-01 00:00:00

abstract：:We have reported that susceptibility to glucocorticoid- and phenytoin-induced cleft palate and glucocorticoid receptor levels in mice are influenced by the H-2 histocompatibility complex on chromosome 17. Phenytoin competes with glucocorticoids for the glucocorticoid receptor and inhibits production of prostaglandins ...

journal_title：Immunogenetics

authors： Gupta C,Katsumata M,Goldman AS

更新日期：1984-01-01 00:00:00

abstract：:The present experiments were performed to study whether the genes responsible for the expression of T-idiotypes and allotypes could be mapped in relation to immunoglobulin (Ig) heavy chain V- and C-genes. Use was made of our antiserum 5936, which detects idiotypes in B6 and anti-B10.BR sera and on Lyt-1+, 2.3-B6 anti-...

journal_title：Immunogenetics

authors： Suzan M,Valsted F,Boned A,Rubin B

更新日期：1982-01-01 00:00:00

abstract：:The genomic organisation of the major histocompatibility complex (MHC) seems to vary considerably between different bird species. In order to understand this variation it is important to gather information from different species. We have, for the first time, investigated MHC class II polymorphism in a wader species, t...

journal_title：Immunogenetics

authors： Ekblom R,Grahn M,Höglund J

更新日期：2003-01-01 00:00:00

abstract：:Class I major histocompatibility complex (Mhc) cDNA clones were isolated from axolotl mRNA by polymerase chain reaction (PCR) and by screening a cDNA phage library. The nucleotide and predicted amino acid sequences show definite similarities to the Mhc class Ialpha molecules of higher vertebrates. Most of the amino ac...

journal_title：Immunogenetics

authors： Sammut B,Laurens V,Tournefier A

更新日期：1997-01-01 00:00:00

abstract：:The emergence in Camelidae species of functional antibodies devoid of light chains (referred to as heavy-chain antibodies or HCAbs) is an intriguing evolutionary event. Homodimeric HCAbs have also been documented in spotted ratfish ( Cos5-Abs) and nurse shark (NAR). To reveal the evolutionary history of HCAbs, we eval...

journal_title：Immunogenetics

authors： Nguyen VK,Su C,Muyldermans S,van der Loo W

更新日期：2002-04-01 00:00:00

abstract：:A large number of HLA-Cw4 (Cw *0402) peptides were purified, sequenced, and identified from breast and ovarian carcinoma cell lines. HLA-Cw4 molecules were expressed in these cells as soluble, secreted HLA (sHLA) and recovered from the growth medium. The peptides were separated by capillary reversed-phase HPLC and ana...

journal_title：Immunogenetics

authors： Buchsbaum S,Barnea E,Dassau L,Beer I,Milner E,Admon A

更新日期：2003-06-01 00:00:00

abstract：:Described here is a new, more efficient method for defining major histocompatibility complex-Y (MHC-Y) genotypes in chickens. The MHC-Y region is genetically independent from the classical MHC (MHC-B) region. MHC-Y is highly polymorphic and potentially important in the genetics of disease resistance. MHC-Y haplotypes ...

journal_title：Immunogenetics

authors： Zhang J,Goto RM,Miller MM

更新日期：2020-07-01 00:00:00