Abstract：
:Coeliac disease is strongly associated with HLA-DQ2, but it is possible that additional major histocompatibility complex genes also confer disease susceptibility. Encoded close to HLA-DQ are two genes, TAP1 and TAP2, whose products are believed to transport antigenic peptides from the cytoplasm into the endoplasmic reticulum. Comparison of 81 coeliac disease patients with caucasoid controls revealed an increased frequency of the alleles TAP1A and TAP2A in the patient population. However, no significant difference was found when patients were compared with HLA-DR and -DQ matched controls, indicating linkage disequilibrium between TAP1A, TAP2A, and HLA-DQ2. The TAP gene products do not have a major influence on susceptibility or resistance to coeliac disease in a Northern European Caucasoid population.
journal_name
Immunogeneticsjournal_title
Immunogeneticsauthors
Powis SH,Rosenberg WM,Hall M,Mockridge I,Tonks S,Ivinson A,Ciclitira PJ,Jewell DP,Lanchbury JS,Bell JIdoi
10.1007/BF00210476subject
Has Abstract,Author List Incompletepub_date
1993-01-01 00:00:00pages
345-50issue
5eissn
0093-7711issn
1432-1211journal_volume
38pub_type
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