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Mhc haplotype H6 is associated with sustained control of SIVmac251 infection in Mauritian cynomolgus macaques.

Abstract：

:The restricted diversity of the major histocompatibility complex (MHC) of Mauritian cynomolgus macaques provides powerful opportunities for insight into host-viral interactions and cellular immune responses that restrict lentiviral infections. However, little is known about the effects of Mhc haplotypes on control of SIV in this species. Using microsatellite-based genotyping and allele-specific PCR, Mhc haplotypes were deduced for 35 macaques infected with the same stock of SIVmac251. Class I haplotype H6 was associated with a reduction in chronic phase viraemia (p = 0.0145) while a similar association was observed for H6 class II (p = 0.0063). An increase in chronic phase viraemia, albeit an insignificant trend, was observed in haplotype H5-positive animals. These results further emphasise the value of genetically defined populations of non-human primates in AIDS research and provide a foundation for detailed characterisation of MHC restricted cellular immune responses and the effects of host genetics on SIV replication in cynomolgus macaques.

journal_name

Immunogenetics

journal_title

Immunogenetics

authors

Mee ET,Berry N,Ham C,Sauermann U,Maggiorella MT,Martinon F,Verschoor EJ,Heeney JL,Le Grand R,Titti F,Almond N,Rose NJ

doi

10.1007/s00251-009-0369-8

subject

Has Abstract

pub_date

2009-05-01 00:00:00

pages

327-39

issue

5

eissn

0093-7711

issn

1432-1211

journal_volume

61

pub_type

杂志文章

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