Identification of seven new human MHC class I region genes around the HLA-F locus.

abstract：:Genes encoding the immunoglobulin heavy-chain variable region (Ig VH) in rainbow trout (Oncorhynchus mykiss) have been grouped into 11 families. While obtaining a baseline assessment of the various gene families utilized by trout in the production of secreted antibody, we discovered two new families. These proposed Ig...

journal_title：Immunogenetics

authors： Brown GD,Kaattari IM,Kaattari SL

更新日期：2006-11-01 00:00:00

abstract：:In this study we have sequenced peptides eluted from a truncated recombinant HLA-A*6602 molecule, and compared their features with data reported for peptides presented in the A*6601 molecule. A striking change in the amino-acid binding preferences was observed at peptide position P1, which interacts with pocket A of t...

journal_title：Immunogenetics

authors： Bade-Doeding C,Elsner HA,Eiz-Vesper B,Seltsam A,Holtkamp U,Blasczyk R

更新日期：2004-05-01 00:00:00

abstract：:Development of an accurate and efficient molecular-based equine MHC class I typing method would facilitate the study of T lymphocyte immune responses in horses. Here, a DNA microarray was designed to detect expressed classical MHC class I genes comprising serologically defined equine leukocyte antigen (ELA)-A haplotyp...

journal_title：Immunogenetics

authors： Ramsay JD,Leib SR,Orfe L,Call DR,Tallmadge RL,Fraser DG,Mealey RH

更新日期：2010-09-01 00:00:00

abstract：:Immunity-related genes are a suitable model for studying effects of selection at the genomic level. Some of them are highly conserved due to functional constraints and purifying selection, while others are variable and change quickly to cope with the variation of pathogens. The SLC11A1 gene encodes a transporter prote...

journal_title：Immunogenetics

authors： Bayerova Z,Janova E,Matiasovic J,Orlando L,Horin P

更新日期：2016-05-01 00:00:00

abstract：:Early and late primary IgM antibody responses of mice to Thy-1.1 antigens showed different antigenic and cellular requirements. We studied genetic controls of the early primary responses, which could be induced by subcellular thymocyte antigens independently of host T-cell activity. All Thy-1.2 mouse strains of Igha (...

journal_title：Immunogenetics

authors： Isobe K,Nakashima I,Nagase F,Yoshida T,Ando K,Inagi R,Kato N,Ohashi K

更新日期：1984-01-01 00:00:00

abstract：:The immune response to bovine insulin (BI) in the rat is controlled by the major histocompatibility complex (Mhc)-linked immune response gene (Ir-BI) and immune suppression gene (Is-BI). In the present study, we investigated the low responsiveness to BI in the WKAH rat (RT1k) and attempted to explore the functional li...

journal_title：Immunogenetics

authors： Mizuno K,Tsuchimoto S,Matsuno Y,Niiyama T,Fujii H,Natori T,Aizawa M

更新日期：1988-01-01 00:00:00

abstract：:The gene for the catalytic subunit of DNA-dependent protein kinase (DNA-PKcs) is responsible for severe combined immune deficiency (SCID) and its products associate with Ku70/Ku86 autoantigens, c-Abl, and other factors to exert its roles. Investigations to date suggest that DNA-PKcs comprises several regions which spe...

journal_title：Immunogenetics

authors： Fujimori A,Araki R,Fukumura R,Ohhata T,Takahashi H,Kawahara A,Tatsumi K,Abe M

更新日期：2000-09-01 00:00:00

abstract：:Observations have frequently been interpreted as showing that the helper T cells which collaborate with alloantigen-specific cytotoxic T-cell precursors can only recognize antigens encoded in the I region of the H-2 gene complex. An experimental system is described here that allows analysis of the recognition repertoi...

journal_title：Immunogenetics

authors： Pilarski LM,Wegmann TG

更新日期：1984-01-01 00:00:00

abstract：:Mice bearing the H-2w7 haplotype have five C4-related genes, one C4, one Slp, and three C4/Slp hybrid genes. The expression of these five genes in the liver of H-2w7 mice was estimated at the steady state level of their respective mRNA. We have amplified by the polymerase chain reaction (PCR) three regions of the C4/S...

journal_title：Immunogenetics

authors： Huang ZM,Takahashi M,Nonaka M

更新日期：1991-01-01 00:00:00

abstract：:In the present study, we investigate patterns of variation in the KIR cluster in a large and well-characterized sample of worldwide human populations in the Human Genome Diversity Project-Centre d'Etude du Polymorphisme Humain (HGDP-CEPH) panel in order to better understand the patterns of diversity in the region. Com...

journal_title：Immunogenetics

authors： Hollenbach JA,Nocedal I,Ladner MB,Single RM,Trachtenberg EA

更新日期：2012-10-01 00:00:00

abstract：:The protein kinase, interferon-inducible double-stranded (ds)RNA-dependent activator (PRKRA) is a dsRNA-binding protein which activates a protein kinase participating in the antiviral activity of interferon. Our previous studies indicated that the nucleotide sequence encoding PRKRA, which appeared to be an intronless ...

journal_title：Immunogenetics

authors： Chida S,Hohjoh H,Hirai M,Tokunaga K

更新日期：2001-01-01 00:00:00

abstract：:To identify novel mechanisms regulating allogeneic hematopoietic cell engraftment, we used forward genetics and previously described identification, in mice, of a bone marrow (BM) engraftment quantitative trait locus (QTL), termed Bmgr5. This QTL confers dominant and large allele effects for engraftment susceptibility...

journal_title：Immunogenetics

authors： Wang Y,Chen X,Tsai S,Thomas A,Shizuru JA,Cao TM

更新日期：2013-08-01 00:00:00

abstract：:Alpha-2-macroglobulin (A2M) binds proteases, thereby acting as defense barriers against pathogens in the plasma and tissues of vertebrates and invertebrates. Quantitative real-time polymerase chain reaction (PCR) and the isobaric tags for relative and absolute quantitation method were used to determine the expression ...

journal_title：Immunogenetics

authors： Wang X,Huang J,Zhao L,Wang C,Ju Z,Li Q,Qi C,Zhang Y,Zhang Z,Zhang W,Hou M,Yuan J,Zhong J

更新日期：2012-11-01 00:00:00

abstract：:Genetic and functional analyses of the inflammasome suggest a role for this multiprotein complex in the biological mechanisms leading to the onset and progression of multiple sclerosis (MS). Nucleotide-binding, leucine-rich repeat (NLR) receptors trigger the activation and assembly of specific inflammasomes in respons...

journal_title：Immunogenetics

authors： Popplewell LF,Encarnacion M,Bernales CQ,Sadovnick AD,Traboulsee AL,Quandt JA,Vilariño-Güell C

更新日期：2020-09-01 00:00:00

abstract：:Ruminant gammadelta T cells are divided into subpopulations based on the presence or absence of WC1 co-receptors (scavenger-receptor-cysteine-rich family members uniquely expressed on gammadelta T cells). Evidence suggests WC1+ are inflammatory while WC1- are regulatory and that they also differ in their tissue distri...

journal_title：Immunogenetics

authors： Blumerman SL,Herzig CT,Rogers AN,Telfer JC,Baldwin CL

更新日期：2006-08-01 00:00:00

abstract：:Over a period of some 20 years, Werner Eugen Mayer played a significant role in establishing a framework for molecular studies of Mhc genes in multiple vertebrates. His work largely concerned gene isolation, sequencing, and related bioinformatic analyses both for the Mhc and for immune system genes of about 200 specie...

journal_title：Immunogenetics

authors： O'hUigin C

更新日期：2012-12-01 00:00:00

abstract：:The restricted diversity of the major histocompatibility complex (MHC) of Mauritian cynomolgus macaques provides powerful opportunities for insight into host-viral interactions and cellular immune responses that restrict lentiviral infections. However, little is known about the effects of Mhc haplotypes on control of ...

journal_title：Immunogenetics

authors： Mee ET,Berry N,Ham C,Sauermann U,Maggiorella MT,Martinon F,Verschoor EJ,Heeney JL,Le Grand R,Titti F,Almond N,Rose NJ

更新日期：2009-05-01 00:00:00

abstract：:The N-terminal domain of the chemokine CCL5/regulated upon activation normal T cell expressed and secreted (RANTES) has been shown to be critical for its biological activity on leukocytes. Several N-terminus-modified CCL5/RANTES derivatives, such as N-Terminal truncated CCL5/RANTES, Met-RANTES, and amino-oxypentane (A...

journal_title：Immunogenetics

authors： Capoulade-Métay C,Ayouba A,Kfutwah A,Lole K,Pêtres S,Dudoit Y,Deterre P,Menu E,Barré-Sinoussi F,Debré P,Theodorou I

更新日期：2006-07-01 00:00:00

abstract：:The region inclusive of the thioester and the isotype-determining sites of the sheep C4 genes from a single animal was amplified by polymerase chain reaction (PCR). Two bands, at 880 base pairs (bp) and 1000 bp, were resolved by agarose gel electrophoresis. Four different clones were obtained for the 880 bp (type 1) p...

journal_title：Immunogenetics

authors： Ren XD,Dodds AW,Law SK

更新日期：1993-01-01 00:00:00

abstract：:We report the sequence of a cDNA encoding a rabbit immunoglobulin gamma heavy chain of d12 and e14 allotypes with high homology to partial cDNA sequences from rabbits of d11 and e15 allotypes. The encoded rabbit protein shows homologies with human (68-70%) and mouse (60-63%) gamma chains. The nucleotide sequence homol...

journal_title：Immunogenetics

authors： Bernstein KE,Alexander CB,Mage RG

更新日期：1983-01-01 00:00:00

abstract：:CD99, the product of the MIC2 gene, exhibits an erythroid-specific quantitative polymorphism co-regulated with the Xga blood group polymorphism. The co-expression of X-linked MIC2 and XG genes is presumably controlled at the transcriptional level by a single XGR locus in the pseudoautosomal region of sexual chromosome...

journal_title：Immunogenetics

authors： Fouchet C,Gane P,Cartron JP,Lopez C

更新日期：2000-07-01 00:00:00

abstract：:Immunofluorescent and immunoelectron-microscopic staining methods were utilized to investigate the localization of Ia antigens in murine keratinizing epithelia. Approximately 3-5% of epidermal cells were shown to be Ia positive. Only dendritic Langerhans cells in the interfollicular epidermis and outer root sheaths we...

journal_title：Immunogenetics

authors： Rowden G,Phillips TM,Delovitch TL

更新日期：1978-12-01 00:00:00

abstract：:We have performed an extensive analysis of Th1/Th2 cytokine receptors IL2Ralpha, IL4Ralpha, IL10Ralpha, and IFNgammaR1 gene polymorphisms to evaluate their impact on AIDS progression. The coding regions and promoters of these genes were sequenced in the genetics of resistance to immunodeficiency virus cohort, composed...

journal_title：Immunogenetics

authors： Do H,Vasilescu A,Diop G,Hirtzig T,Coulonges C,Labib T,Heath SC,Spadoni JL,Therwath A,Lathrop M,Matsuda F,Zagury JF

更新日期：2006-04-01 00:00:00

abstract：:Dendritic cells (DC) are specialist antigen presenting cells which capture antigens in the periphery, migrate centrally, and present the processed antigens in the context of major histocompatibility complex and appropriate co-stimulatory molecules to T lymphocytes for the initiation of an immune response. DEC-205 has ...

journal_title：Immunogenetics

authors： Kato M,Neil TK,Clark GJ,Morris CM,Sorg RV,Hart DN

更新日期：1998-05-01 00:00:00

abstract：:Parasites exert a selection pressure on their hosts and are accountable for driving diversity within gene families and immune gene polymorphisms in a host population. The overwhelming response of regulatory T cells during infectious challenges directs the host immune system to lose the ability to mount parasite specif...

journal_title：Immunogenetics

authors： Hanel SA,Velavan TP,Kremsner PG,Kun JF

更新日期：2011-07-01 00:00:00

abstract：:The tripartite motif protein (TRIM)5α/CypA fusion protein TRIMCyp in Old World monkeys is generally considered unable to restrict HIV-1 replication. Monkeys with TRIMCyp can serve as a unique animal model for studies of HIV-1 infection. The present study investigated the distribution and expression status of TRIMCyp i...

journal_title：Immunogenetics

authors： Yu CQ,Na L,Lv XL,Liu JD,Liu XM,Ji F,Zheng YH,Du HL,Kong XG,Zhou JH

更新日期：2013-03-01 00:00:00

abstract：:Phenotypic variability is often observed in cynomolgus monkeys on preclinical studies and may, in part, be driven by genetic variability. However, the role of monkey genetic variation remains largely unexplored in the context of drug response. This study evaluated genetic variation in cynomolgus monkey FcγR3A and TAP1...

journal_title：Immunogenetics

authors： Sanford JC,Wu H,Abdiche Y,Harney JA,Chaparro-Riggers J,Adkins K

更新日期：2017-04-01 00:00:00

abstract：:Transcription of major histocompatibility complex class I genes is controlled by the class I regulatory complex in the 5' flanking region. To investigate the molecular basis of this region, we studied the polymorphism of the promoter of the HLA-B locus extending from the ATG transcription initiation signal to -284 bas...

journal_title：Immunogenetics

authors： Yao Z,Volgger A,Scholz S,Albert ED

更新日期：1995-01-01 00:00:00

abstract：:Rh and its homologous Rh50 gene products are considered to form heterotetramers on erythrocyte membranes. Rh protein has Rh blood group antigen sites, while Rh50 protein does not, and is more conserved than Rh protein. We previously determined both Rh and Rh50 gene cDNA coding regions from mouse and rat, and carried o...

journal_title：Immunogenetics

authors： Kitano T,Saitou N

更新日期：2000-08-01 00:00:00

abstract：:A cDNA library prepared from lymphocytes of a cow (E98), homozygous at major histocompatibility complex (MHC) loci (BoLA phenotype w10, KN104), was screened with a bovine MHC class I probe. Of the cDNA clones isolated, two, (2.1 and 5.1) were selected and showed divergence at both 5' and 3' termini. E98 DNA was digest...

journal_title：Immunogenetics

authors： Bensaid A,Kaushal A,Baldwin CL,Clevers H,Young JR,Kemp SJ,MacHugh ND,Toye PG,Teale AJ

更新日期：1991-01-01 00:00:00