Abstract:
:Dendritic cells (DC) are specialist antigen presenting cells which capture antigens in the periphery, migrate centrally, and present the processed antigens in the context of major histocompatibility complex and appropriate co-stimulatory molecules to T lymphocytes for the initiation of an immune response. DEC-205 has been identified as a putative antigen-uptake receptor, which is expressed abundantly on mouse DC. The recently cloned mouse DEC-205 cDNA predicts a molecular structure which has a marked similarity to the macrophage mannose receptor. Using reverse transcriptase-polymerase chain reaction (RT-PCR) and cDNA library screening, we obtained the full coding region of human DEC-205 cDNA from the Hodgkin's disease-derived L428 cell line. The predicted protein structure is a type I transmembrane protein of 1722 amino acids consisting of a signal peptide, cysteine-rich domain, fibronectin type II domain, ten carbohydrate recognition-like domains, transmembrane domain, and a cytoplasmic tail. Human DEC-205 is 77% identical to the mouse protein with completely conserved cysteines. The DEC-205 gene (LY75) was mapped to chromosome band 2q24 by somatic cell hybrid panel analysis and fluorescent in situ hybridization. Northern blot analysis detected 7.8 and 9.5 kilobase DEC-205 transcripts in myeloid, B lymphoid, and Hodgkin's disease-derived cell lines. RT-PCR analysis indicated that immature blood DC contain a barely detectable amount of DEC-205 transcripts but these were markedly increased upon differentiation/activation.
journal_name
Immunogeneticsjournal_title
Immunogeneticsauthors
Kato M,Neil TK,Clark GJ,Morris CM,Sorg RV,Hart DNdoi
10.1007/s002510050381subject
Has Abstractpub_date
1998-05-01 00:00:00pages
442-50issue
6eissn
0093-7711issn
1432-1211journal_volume
47pub_type
杂志文章相关文献
IMMUNOGENETICS文献大全abstract::Experimental infection of Mauritian cynomolgus macaques by simian immunodeficiency virus is a representative model of HIV infection, currently in favour for evaluating the efficacy of new preventive or curative treatments. Extensive studies of major histocompatibility complex (MHC) polymorphism by microsatellites reve...
journal_title:Immunogenetics
pub_type: 杂志文章
doi:10.1007/s00251-010-0504-6
更新日期:2011-05-01 00:00:00
abstract::Genes encoded by the major histocompatibility complex (MHC) play key roles in the vertebrate immune system. However, our understanding of the evolutionary processes and underlying genetic mechanisms shaping these genes is limited in many taxa, including amphibians, a group currently impacted by emerging infectious dis...
journal_title:Immunogenetics
pub_type: 杂志文章
doi:10.1007/s00251-010-0476-6
更新日期:2010-12-01 00:00:00
abstract::Asthma is a chronic inflammatory disorder of the airways, and a number of genetic loci are associated with the disease. Candidate gene association studies have been regarded as effective tools to study complex traits. Knowledge of the sequence variation and structure of the candidate genes is required for association ...
journal_title:Immunogenetics
pub_type: 杂志文章
doi:10.1007/s00251-005-0024-y
更新日期:2005-10-01 00:00:00
abstract::Herein, we review the epitope approach to vaccine development, and discuss how knowledge of HLA supertypes might be used as a tool in the development of such vaccines. After reviewing the main structural features of the A2-, A3-, B7-, and B44- supertype alleles, and biological data demonstrating their immunological re...
journal_title:Immunogenetics
pub_type: 杂志文章,评审
doi:10.1007/s002510050594
更新日期:1999-11-01 00:00:00
abstract::The killer cell immunoglobulin-like receptor (KIR) gene cluster exhibits extensive allelic and haplotypic diversity. Variation at the locus is associated with an increasing number of human diseases, reminiscent of the HLA loci. Characterization of diversity at the KIR locus has progressed over the past several years, ...
journal_title:Immunogenetics
pub_type: 杂志文章
doi:10.1007/s00251-008-0334-y
更新日期:2008-12-01 00:00:00
abstract::We recently demonstrated that vaccinated rhesus macaques controlled viral replication of a heterologous SIV challenge. Here, we analyzed anamnestic SIV-specific CD4+ T-cell responses expanding immediately after challenge and show that successful vaccinees consistently targeted a short region of the Gag-p27 Capsid (ami...
journal_title:Immunogenetics
pub_type: 杂志文章
doi:10.1007/s00251-010-0473-9
更新日期:2010-10-01 00:00:00
abstract::Segregation distortion was found for a haplotype of the equine lymphocyte antigen (ELA) system in an extended family of American Standardbred horses. In one sire family, consisting of a stallion and his 17 sons and grandsons, the gene for ELA-A10 (A10) was transmitted to 57.7% of 638 offspring scored (P = 0.001). Sign...
journal_title:Immunogenetics
pub_type: 杂志文章
doi:10.1007/BF00364526
更新日期:1986-01-01 00:00:00
abstract::The potential association between integration or deletion of mouse mammary tumor virus (MMTV) retroviral sequences and the appearance of non-H-2 histocompatibility (H) antigen mutations was investigated. Genomic blots from inbred strains carrying 22 loss, gain-loss, and gain mutations on the BALB/c and C57BL/6 backgro...
journal_title:Immunogenetics
pub_type: 杂志文章
doi:10.1007/BF00345461
更新日期:1987-01-01 00:00:00
abstract::Pigtail macaques (Macaca nemestrina) are an increasingly common primate model for the study of human AIDS. Major Histocompatibility complex (MHC) class I-restricted CD8(+) T cell responses are a critical part of the adaptive immune response to HIV-1 in humans and simian immunodeficiency virus (SIV) in macaques; howeve...
journal_title:Immunogenetics
pub_type: 杂志文章
doi:10.1007/s00251-006-0164-8
更新日期:2006-12-01 00:00:00
abstract::Loss of major histocompatibility complex class II (MHCII) antigen expression on diffuse large B cell lymphoma (DLBCL) corresponds closely with significant decreases in patient survival. However, the mechanisms accounting for MHCII loss in DLBCL have not been thoroughly characterized to date. In this report, we demonst...
journal_title:Immunogenetics
pub_type: 杂志文章
doi:10.1007/s00251-009-0418-3
更新日期:2010-02-01 00:00:00
abstract::A large number of HLA-Cw4 (Cw *0402) peptides were purified, sequenced, and identified from breast and ovarian carcinoma cell lines. HLA-Cw4 molecules were expressed in these cells as soluble, secreted HLA (sHLA) and recovered from the growth medium. The peptides were separated by capillary reversed-phase HPLC and ana...
journal_title:Immunogenetics
pub_type: 杂志文章
doi:10.1007/s00251-003-0570-0
更新日期:2003-06-01 00:00:00
abstract::Cattle in Africa are a genetically diverse population that has resulted from successive introduction of Asian Bos indicus and European B. taurus cattle. However, analysis of mitochondrial genetic diversity in African cattle identified three lineages, one associated with Asian B. indicus, one with European B. taurus, a...
journal_title:Immunogenetics
pub_type: 杂志文章
doi:10.1007/s002510000276
更新日期:2001-01-01 00:00:00
abstract::The nucleotide sequences of 11 variable gene segments coding for rabbit T-cell receptor beta (Tcrb-V) chains were determined by directly sequencing fragments amplified by the cassette-ligation mediated polymerase chain reaction (CLM-PCR) and by modified anchor PCR without the cloning procedure. The nucleotide sequence...
journal_title:Immunogenetics
pub_type: 杂志文章
doi:10.1007/BF00188786
更新日期:1994-01-01 00:00:00
abstract::The chromosomal assignment of the gene encoding the invariant (Ii) chain associated with the mouse immune response antigens (Ia) was determined by Southern blot analysis of DNA from a panel of mouse X Chinese hamster somatic cell hybrids cleaved with Hind III or Eco RI. Using a mouse li cDNA as a hybridization probe, ...
journal_title:Immunogenetics
pub_type: 杂志文章
doi:10.1007/BF00372244
更新日期:1985-01-01 00:00:00
abstract::Mice bearing the H-2w7 haplotype have five C4-related genes, one C4, one Slp, and three C4/Slp hybrid genes. The expression of these five genes in the liver of H-2w7 mice was estimated at the steady state level of their respective mRNA. We have amplified by the polymerase chain reaction (PCR) three regions of the C4/S...
journal_title:Immunogenetics
pub_type: 杂志文章
doi:10.1007/BF00216695
更新日期:1991-01-01 00:00:00
abstract::Chemokines are small, inducible, structurally related proteins that guide cells expressing the right chemokine receptors to sites of immune response. They have been identified and studied extensively in mammals, but little is known about their presence in other vertebrate groups. Here we describe seven new chemokines ...
journal_title:Immunogenetics
pub_type: 杂志文章
doi:10.1007/s00251-002-0531-z
更新日期:2003-03-01 00:00:00
abstract::Insect bite hypersensitivity (IBH) is a chronic allergic dermatitis common in horses. Affected horses mainly react against antigens present in the saliva from the biting midges, Culicoides ssp, and occasionally black flies, Simulium ssp. Because of this insect dependency, the disease is clearly seasonal and prevalence...
journal_title:Immunogenetics
pub_type: 杂志文章
doi:10.1007/s00251-011-0573-1
更新日期:2012-03-01 00:00:00
abstract::The interaction of bacterial pathogens with their hosts' innate immune systems can be extremely complex and is often difficult to disentangle experimentally. Using mouse models of bacterial infections, several laboratories have successfully applied genetic approaches to identify novel host genes required for innate im...
journal_title:Immunogenetics
pub_type: 杂志文章,评审
doi:10.1007/s00251-007-0248-0
更新日期:2007-10-01 00:00:00
abstract::Genes encoding the horse (Equus caballus) T-cell receptor beta chain (TCRB) were cloned and characterized. Of 33 cDNA clones isolated from the mesenteric lymph node, 30 had functionally rearranged gene segments, and three contained germline sequences. Sixteen unique variable segments (TCRBV), 14 joining genes (TCRBJ),...
journal_title:Immunogenetics
pub_type: 杂志文章
doi:10.1007/BF00188177
更新日期:1994-01-01 00:00:00
abstract::A graft-vs-host reaction (GVHR) develops after major histocompatibility complex (MHC)-compatible bone marrow-transplantation. In the genetic combination studied, B10.D2 donor cells differed from those of (DBA/2 x B10.D2)F1 mice for multiple DBA/2 minor histocompatibility antigens (mHAg) and minor lymphocyte stimulatin...
journal_title:Immunogenetics
pub_type: 杂志文章
doi:10.1007/BF00241258
更新日期:1994-01-01 00:00:00
abstract::Eight families (121 individuals) with two or more members affected with systemic lupus erythematosus (SLE) were analyzed for histocompatibility antigens (HLA-A, B, C, DR, MT, and MB) and complement antigens (C4A, C4B, and BF). These data were correlated with serological markers (antinuclear antibodies, single- and dou...
journal_title:Immunogenetics
pub_type: 杂志文章
doi:10.1007/BF00430796
更新日期:1985-01-01 00:00:00
abstract::We report here the structure of cDNA clones encoding axolotl light chains of the lambda type. A single IGLC gene and eight different potential IGLV genes belonging to four different families were detected. The axolotl Cgamma domain has several residues or stretches of residues that are typically conserved in mammalian...
journal_title:Immunogenetics
pub_type: 杂志文章
doi:10.1007/s002510000264
更新日期:2000-11-01 00:00:00
abstract::The present experiments were performed to study whether the genes responsible for the expression of T-idiotypes and allotypes could be mapped in relation to immunoglobulin (Ig) heavy chain V- and C-genes. Use was made of our antiserum 5936, which detects idiotypes in B6 and anti-B10.BR sera and on Lyt-1+, 2.3-B6 anti-...
journal_title:Immunogenetics
pub_type: 杂志文章
doi:10.1007/BF00343312
更新日期:1982-01-01 00:00:00
abstract::Nova Scotia duck tolling retrievers are predisposed to a SLE-related disease complex including immune-mediated rheumatic disease (IMRD) and steroid-responsive meningitis-arteritis (SRMA). IMRD involves symptoms that resemble those seen in systemic autoimmune rheumatic diseases, such as systemic lupus erythematosus, SL...
journal_title:Immunogenetics
pub_type: 杂志文章
doi:10.1007/s00251-009-0387-6
更新日期:2009-08-01 00:00:00
abstract::Avian influenza is a serious threat to the poultry industry and, as the potential source of a human pandemic virus, to public health. Different Mx alleles have been reported to confer resistance or susceptibility to influenza virus replication, and so knowledge of their frequencies is important when considering the po...
journal_title:Immunogenetics
pub_type: 杂志文章
doi:10.1007/s00251-007-0235-5
更新日期:2007-08-01 00:00:00
abstract::A mouse monoclonal antibody, Mo. Ab. 108.45, detecting cell-surface determinants associated with the T-cell receptor for alloantigen was produced by immunizing mice with an alloreactive human T-cell clone and fusing the splenocytes with the NS1 plasmocytoma. This Mo. Ab. reacts with the immunizing T-cell clone but not...
journal_title:Immunogenetics
pub_type: 杂志文章
doi:10.1007/BF00345614
更新日期:1984-01-01 00:00:00
abstract::Rh and its homologous Rh50 gene products are considered to form heterotetramers on erythrocyte membranes. Rh protein has Rh blood group antigen sites, while Rh50 protein does not, and is more conserved than Rh protein. We previously determined both Rh and Rh50 gene cDNA coding regions from mouse and rat, and carried o...
journal_title:Immunogenetics
pub_type: 杂志文章
doi:10.1007/s002510000202
更新日期:2000-08-01 00:00:00
abstract::We describe a bioinformatic analysis of germline and rearranged immunoglobulin kappa chain (IGK) gene sequences, performed in order to assess the completeness and reliability of the reported IGK repertoire. In contrast to the reported heavy-chain gene repertoire, which includes many dubious sequences, only five IGK va...
journal_title:Immunogenetics
pub_type: 杂志文章
doi:10.1007/s00251-008-0325-z
更新日期:2008-11-01 00:00:00
abstract::MHC class II deficiency provokes a severe immunodeficiency characterized by a lack of antigen-specific immune response. In the absence of bone marrow transplantation (the only curative treatment), patients affected by this genetic recessive disease die in early childhood. However, others and we have recently described...
journal_title:Immunogenetics
pub_type: 杂志文章
doi:10.1007/s00251-003-0609-2
更新日期:2003-11-01 00:00:00
abstract::The ability of local ultraviolet B (UVB) irradiation to impair the induction of dinitrofluorobenzene (DNFB)-specific contact hypersensitivity (CH) in mice has been shown to be genetically determined. We have explored the possibility that the mouse Tnfa and Lps loci are involved. We demonstrate that C3H/HeN (Lpsn) stra...
journal_title:Immunogenetics
pub_type: 杂志文章
doi:10.1007/BF00241633
更新日期:1990-01-01 00:00:00