Abstract:
:We recently demonstrated that vaccinated rhesus macaques controlled viral replication of a heterologous SIV challenge. Here, we analyzed anamnestic SIV-specific CD4+ T-cell responses expanding immediately after challenge and show that successful vaccinees consistently targeted a short region of the Gag-p27 Capsid (amino acids 249-291). We have also defined the major histocompatibility complex class II (MHC-II) restricting alleles for several of these responses and show that DQ-restricted CD4+ T-cells depend on unique combinations of both the DQA and DQB alleles. Analysis of SIV-specific CD4+ T-cell responses elicited by a successful vaccine may have important implications in the understanding of vaccine design.
journal_name
Immunogeneticsjournal_title
Immunogeneticsauthors
Giraldo-Vela JP,Bean AT,Rudersdorf R,Wallace LT,Loffredo JT,Erickson P,Wilson NA,Watkins DIdoi
10.1007/s00251-010-0473-9subject
Has Abstractpub_date
2010-10-01 00:00:00pages
701-7issue
10eissn
0093-7711issn
1432-1211journal_volume
62pub_type
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