Abstract:
:Cosmid clones containing T-cell receptor Tcra V2 subfamily gene segments have been isolated from a BALB/c cosmid library and subjected to DNA sequence analysis. The V gene segments in the Tcra V2 subfamily differ from each other by 3%-7% at the nucleotide level and 5%-16% at the amino acid level. T-cell receptor Tcra V2 gene segment polymorphisms have been identified in the B10.PL and PL/J mouse strains with a Tcra V2 subfamily-specific probe. These V gene segment polymorphisms may cause the differential Tcra V gene usage in induced experimental allergic encephalomyelitis between B10.PL and PL/J mice.
journal_name
Immunogeneticsjournal_title
Immunogeneticsauthors
Wang K,Kuo CL,Cheng KC,Lee MK,Paeper B,Koop BF,Yoo TJ,Hood Ldoi
10.1007/BF00188174subject
Has Abstractpub_date
1994-01-01 00:00:00pages
116-22issue
2eissn
0093-7711issn
1432-1211journal_volume
40pub_type
杂志文章相关文献
IMMUNOGENETICS文献大全abstract::We have previously reported that autoimmune pancreatitis (AIP) is a bioclinical entity characterized by high serum immunoglobulin G4 concentrations and association with the HLA-DRB1*0405-DQB1*0401 haplotype. However, the precise identity of gene(s) within this haplotype directly responsible for AIP pathogenesis is yet...
journal_title:Immunogenetics
pub_type: 杂志文章
doi:10.1007/s00251-006-0178-2
更新日期:2007-01-01 00:00:00
abstract::The presentation of identical peptides by different major histocompatibility complex class I (MHC-I) molecules, termed promiscuity, is a controversial feature of T cell-mediated immunity to pathogens. The astounding diversity of MHC-I molecules in human populations, presumably to enable binding of equally diverse pept...
journal_title:Immunogenetics
pub_type: 杂志文章
doi:10.1007/s00251-011-0538-4
更新日期:2011-09-01 00:00:00
abstract::Despite matching donors and recipients for the human leukocyte antigens (HLAs) expressed by the major histocompatibility genomic region of the short arm of chromosome 6, several recipients still develop acute graft-versus-host disease (aGVHD) after bone marrow transplantation (BMT). This is possibly due to non-HLA gen...
journal_title:Immunogenetics
pub_type: 杂志文章
doi:10.1007/s00251-006-0186-2
更新日期:2007-02-01 00:00:00
abstract::The interaction between 9-mer peptides and HLA-B51 molecules was investigated by quantitative peptide binding assay using RMA-S cells expressing human beta2-microglobulin and HLA-B51 molecules. Of 147 chemically synthesized 9-mer peptides possessing two anchor residues corresponding to the motif of HLA-B*5101 binding ...
journal_title:Immunogenetics
pub_type: 杂志文章
doi:10.1007/BF02440994
更新日期:1996-01-01 00:00:00
abstract::Assembly of HLA class I molecules was studied using pulse-chase labeling of B-lymphoblastoid cell lines with 35S-methionine, immunoprecipitation with antibodies detecting free or beta 2-microglobulin-associated heavy chain and isoelectric focusing. Marked differences between the products of different class I alleles w...
journal_title:Immunogenetics
pub_type: 杂志文章
doi:10.1007/BF00216831
更新日期:1993-01-01 00:00:00
abstract::The polymerase chain reaction was used to isolate clones with class I major histocompatibility complex sequences from fish (carp), amphibian (axolotl), and two species of reptile (lizard and snake). The lizard and snake clones were used to isolate class I cDNA clones. All the sequences showed the expected evolutionary...
journal_title:Immunogenetics
pub_type: 杂志文章
doi:10.1007/BF00661093
更新日期:1992-01-01 00:00:00
abstract::The authors regret that an error was present in the Fig. 5 of the above article; some digits in the DRB allele-designations in Fig. 5 have been lost, and are incorrectly presented by only two digits. The correct allele-designations should have been four (or six) digits. The correct Figure is now presented correctly. ...
journal_title:Immunogenetics
pub_type: 杂志文章,已发布勘误
doi:10.1007/s00251-018-1089-8
更新日期:2018-11-01 00:00:00
abstract::The Mep-1 gene on chromosome 17 in mice controls the activity of meprin, a kidney brush border metalloendopeptidase. Most inbred mouse strains of the k haplotype (e.g., CBA, C3H, AKR) are markedly deficient in meprin activity; these mice carry the Mep-1b allele. Mouse strains in which meprin activity levels are normal...
journal_title:Immunogenetics
pub_type: 杂志文章
doi:10.1007/BF00430310
更新日期:1985-01-01 00:00:00
abstract::The major histocompatibility complex (MHC) of the domestic cat has been poorly characterized to date, primarily because of numerous difficulties in the preparation of allotypic sera. We present here a comparative analysis of class I and class II genes in domestic cat populations using molecular probes of the MHC from ...
journal_title:Immunogenetics
pub_type: 杂志文章
doi:10.1007/BF00364427
更新日期:1988-01-01 00:00:00
abstract::Chemokines are small, inducible, structurally related proteins that guide cells expressing the right chemokine receptors to sites of immune response. They have been identified and studied extensively in mammals, but little is known about their presence in other vertebrate groups. Here we describe seven new chemokines ...
journal_title:Immunogenetics
pub_type: 杂志文章
doi:10.1007/s00251-002-0531-z
更新日期:2003-03-01 00:00:00
abstract::An I-J-subregion controlled determinant is expressed on Ly-1 inducer and Ly-1,2 acceptor T cells in the feedback suppression circuit. Ly-1 T cells absorb the I-J antibody reactive with the Ly-1,2 acceptor T cell, suggesting that both inducer and acceptor T cells have the same I-J determinant. Since less than 10 percen...
journal_title:Immunogenetics
pub_type: 杂志文章
doi:10.1007/BF01567824
更新日期:1980-01-01 00:00:00
abstract::Recombinant inbred strains were used to demonstrate the existence of a major locus on chromosome 1, designated Sap, which controls the endogenous concentration of the mouse acute phase reactant, serum amyloid P-component (SAP). Levels of SAP were associated with alleles at the Ly-9 locus in two sets of RI strains: BXD...
journal_title:Immunogenetics
pub_type: 杂志文章
doi:10.1007/BF00430920
更新日期:1985-01-01 00:00:00
abstract::In mammals, there are MHC class II molecules with distinctive sequence features, such as the classical isotypes DR, DQ and DP. These particular isotypes have not been reported in non-mammalian vertebrates. We have isolated the class II (B-L) alpha chain from outbred chickens as the basis for the cloning and sequencing...
journal_title:Immunogenetics
pub_type: 杂志文章
doi:10.1007/s00251-003-0620-7
更新日期:2003-12-01 00:00:00
abstract::The Hawaiian monk seal population has experienced precipitous declines in the last 50 years. In this study, we provide evidence that individuals from remaining endangered population exhibit alarming uniformity in class I major histocompatibility (MHC) genes. The peripheral blood leukocyte-derived mRNA of six captive a...
journal_title:Immunogenetics
pub_type: 杂志文章
doi:10.1007/s00251-005-0069-y
更新日期:2006-04-01 00:00:00
abstract::Determining the genomic organization of the Ovis aries (Ovar) major histocompatibility complex class IIa region is essential for future functional studies related to antigen presentation. In this study, a bacterial artificial chromosome (BAC) library of genomic DNA from peripheral blood leukocytes (PBL) of a Rambouill...
journal_title:Immunogenetics
pub_type: 杂志文章
doi:10.1007/s00251-008-0275-5
更新日期:2008-04-01 00:00:00
abstract::To identify novel mechanisms regulating allogeneic hematopoietic cell engraftment, we used forward genetics and previously described identification, in mice, of a bone marrow (BM) engraftment quantitative trait locus (QTL), termed Bmgr5. This QTL confers dominant and large allele effects for engraftment susceptibility...
journal_title:Immunogenetics
pub_type: 杂志文章
doi:10.1007/s00251-013-0709-6
更新日期:2013-08-01 00:00:00
abstract::A cDNA clone, designated IL-8nL, was obtained by suppression subtractive hybridisation between lipopolysaccharide-stimulated and non-stimulated populations of the rainbow trout macrophage-like cell line, RTS11. IL-8nL was similar but not identical to a recently published sequence of the gene encoding rainbow trout int...
journal_title:Immunogenetics
pub_type: 杂志文章
doi:10.1007/s00251-003-0556-y
更新日期:2003-05-01 00:00:00
abstract::In the present study, we investigate patterns of variation in the KIR cluster in a large and well-characterized sample of worldwide human populations in the Human Genome Diversity Project-Centre d'Etude du Polymorphisme Humain (HGDP-CEPH) panel in order to better understand the patterns of diversity in the region. Com...
journal_title:Immunogenetics
pub_type: 杂志文章
doi:10.1007/s00251-012-0629-x
更新日期:2012-10-01 00:00:00
abstract::The single nucleotide polymorphism (SNP)-derived Epitope Prediction program (SNEP) is now available to the public. It predicts minor histocompatibility antigens (miHAgs), which are T-cell epitopes containing polymorphic spots, from proteins listed in the SWISS-PROT database. SNEP recognizes polymorphisms (termed VARIA...
journal_title:Immunogenetics
pub_type: 杂志文章
doi:10.1007/s00251-005-0054-5
更新日期:2005-12-01 00:00:00
abstract::Control of HIV-1 viremia and progression to AIDS has been associated with specific HLA genes. The tumor necrosis factor ( TNF) and the non-classical major histocompatibility (MHC) class I chain-related A ( MICA) genes are located in the genomic segment between the HLA class I and II genes and variants of both genes ha...
journal_title:Immunogenetics
pub_type: 杂志文章
doi:10.1007/s00251-003-0604-7
更新日期:2003-10-01 00:00:00
abstract::The effect of the H-2dm1 mutation on Qa-m2 expression was examined. The mutant strain B10.D2-H-2dm1 showed a fourfold increase in Qa-m2 expression when compared with the parental strain B10.D2. Qa-m2 molecules immunoprecipitated from B10.D2-H-2dm1, C57BL/10, and B10.D2 spleen cells were identical by two-dimensional (2...
journal_title:Immunogenetics
pub_type: 杂志文章
doi:10.1007/BF00345969
更新日期:1983-01-01 00:00:00
abstract::The heavy and light chain subunits of the DC1 antigen from several cell lines expressing different DR specificities were compared by two-dimensional (2-D) gel electrophoresis. The DC1 light chains from cell lines typed as DR1, DR2, or DRw6 differed in their isoelectric points. No difference in charge was observed for ...
journal_title:Immunogenetics
pub_type: 杂志文章
doi:10.1007/BF00345970
更新日期:1983-01-01 00:00:00
abstract::The genomic organisation of the major histocompatibility complex (MHC) seems to vary considerably between different bird species. In order to understand this variation it is important to gather information from different species. We have, for the first time, investigated MHC class II polymorphism in a wader species, t...
journal_title:Immunogenetics
pub_type: 杂志文章
doi:10.1007/s00251-002-0503-3
更新日期:2003-01-01 00:00:00
abstract::Human leucocyte antigen (HLA)-DRB1*15 is associated with predisposition to multiple sclerosis (MS), although conjecture surrounds the possible involvement of an alternate risk locus in the class I region of the HLA complex. We have shown previously that an alternate MS risk allele(s) may be encompassed by the telomeri...
journal_title:Immunogenetics
pub_type: 杂志文章
doi:10.1007/s00251-006-0183-5
更新日期:2007-03-01 00:00:00
abstract::One mouse with a known recombination (NAK) at the Igk locus on chromosome 6 and two new recombinants [B6.PL (75NS) and B6.PL (85NS)] were examined using a series of probes, each of which is specific for a set of immunoglobulin (Ig) Vk genes. Under high stringency conditions, each probe detects from 1 to 19 Bam HI rest...
journal_title:Immunogenetics
pub_type: 杂志文章
doi:10.1007/BF00373021
更新日期:1986-01-01 00:00:00
abstract::T-bet is a key regulator for the lineage commitment in CD4+ T helper (Th) 1 cells by activating the hallmark production of interferon-γ. Previously, two single nucleotide polymorphisms (SNPs) in the TBX21 promoter, T-1993C and T-1514C, have been shown by statistic studies to associate with systemic lupus erythematosus...
journal_title:Immunogenetics
pub_type: 杂志文章
doi:10.1007/s00251-011-0597-6
更新日期:2012-05-01 00:00:00
abstract::Class I-like molecules have been immunoprecipitated from Xenopus leukocytes and erythrocytes with alloantisera directed against major histocompatibility complex (MHC)-linked antigens. The heavy chains, depending on the allele examined, have molecular weights of 40 000-44 000 of which 3000 daltons are asparagine-linked...
journal_title:Immunogenetics
pub_type: 杂志文章
doi:10.1007/BF00345617
更新日期:1984-01-01 00:00:00
abstract::Antigen-specific CD4+ T cells play a critical role in protective immunity to many infectious pathogens. Although the antigen-specific CD4+ T cells can be measured by functional assays such as proliferation or cytokine enzyme-linked immunospot, such assays are limited to a specific function and cannot quantify anergic ...
journal_title:Immunogenetics
pub_type: 杂志文章
doi:10.1007/s00251-006-0140-3
更新日期:2006-09-01 00:00:00
abstract::Macaques are the most widely used experimental nonhuman primate (NHP) species. Rhesus (Macaca mulatta, Macmul), cynomolgus (Macaca fascicularis, Macfas), and pigtail (Macaca nemestrina, Macnem) macaques continue to be popular models for vaccine and infectious diseases research, especially HIV infection and AIDS, and f...
journal_title:Immunogenetics
pub_type: 杂志文章
doi:10.1007/s00251-014-0775-4
更新日期:2014-06-01 00:00:00
abstract::The present experiments were performed to study whether the genes responsible for the expression of T-idiotypes and allotypes could be mapped in relation to immunoglobulin (Ig) heavy chain V- and C-genes. Use was made of our antiserum 5936, which detects idiotypes in B6 and anti-B10.BR sera and on Lyt-1+, 2.3-B6 anti-...
journal_title:Immunogenetics
pub_type: 杂志文章
doi:10.1007/BF00343312
更新日期:1982-01-01 00:00:00