Abstract:
:The single nucleotide polymorphism (SNP)-derived Epitope Prediction program (SNEP) is now available to the public. It predicts minor histocompatibility antigens (miHAgs), which are T-cell epitopes containing polymorphic spots, from proteins listed in the SWISS-PROT database. SNEP recognizes polymorphisms (termed VARIANT or CONFLICT in SWISS-PROT) and predicts potential T-cell epitopes within a chosen distance around the polymorphic residue. The prediction algorithm is based on the SYFPEITHI T-cell epitope prediction program. SNEP is able to search for proteins according to their accession numbers, sequence stretches or gene names, for example. The predictions are available for several human leucocyte antigen class I and class II allelic products, which allow for a rapid and precise evaluation of potential miHAgs within polymorphic antigens.
journal_name
Immunogeneticsjournal_title
Immunogeneticsauthors
Schuler MM,Dönnes P,Nastke MD,Kohlbacher O,Rammensee HG,Stevanovic Sdoi
10.1007/s00251-005-0054-5subject
Has Abstractpub_date
2005-12-01 00:00:00pages
816-20issue
11eissn
0093-7711issn
1432-1211journal_volume
57pub_type
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