Patterns of polymorphism in the MHC class II of a non-passerine bird, the great snipe (Gallinago media).

abstract：:Mouse lymphocyte alloantigens Ly-19 and Ly-32 are controlled by the genes tightly linked to the Lyb-2 locus on chromosome 4. Despite the similarity in mouse strain distribution patterns, Ly-19 and Ly-32 antigens which have been detected on both B- and T-cell lineages are distinct from Lyb-2 antigen whose expression is...

journal_title：Immunogenetics

authors： Nakamura S,Ikegami S,Dairiki K,Kochiya M,Fujimori T,Tamaoki N,Tada N

更新日期：1988-01-01 00:00:00

abstract：:The N-terminal domain of the chemokine CCL5/regulated upon activation normal T cell expressed and secreted (RANTES) has been shown to be critical for its biological activity on leukocytes. Several N-terminus-modified CCL5/RANTES derivatives, such as N-Terminal truncated CCL5/RANTES, Met-RANTES, and amino-oxypentane (A...

journal_title：Immunogenetics

authors： Capoulade-Métay C,Ayouba A,Kfutwah A,Lole K,Pêtres S,Dudoit Y,Deterre P,Menu E,Barré-Sinoussi F,Debré P,Theodorou I

更新日期：2006-07-01 00:00:00

abstract：:In mammals many natural killer (NK) cell receptors, encoded by the leukocyte receptor complex (LRC), regulate the cytotoxic activity of NK cells and provide protection against virus-infected and tumor cells. To investigate the origin of the Ig-like domains encoded by the LRC genes, a subset of C2-type Ig-like domain s...

journal_title：Immunogenetics

authors： Nikolaidis N,Klein J,Nei M

更新日期：2005-04-01 00:00:00

abstract：:We studied the relationship between human leukocyte antigen (HLA) class I alleles and cervical cancer among Indian women. Seventy-five cervical cancer cases were compared with 175 noncancer controls. Cervical biopsy tissue specimen from cancer cases and cervical swab specimen from controls were collected for HPV detec...

journal_title：Immunogenetics

authors： Gokhale P,Mania-Pramanik J,Sonawani A,Idicula-Thomas S,Kerkar S,Tongaonkar H,Chaudhari H,Warke H,Salvi V

更新日期：2014-12-01 00:00:00

abstract：:The genealogy of 14 H-2Kb mutations arising spontaneously in the C57BL/6Kh colony is presented together with data from skin-graft monitoring and husbandry procedures. Eight of the 14 mutations have phenotypic and structural similarities, but the pedigree analysis and evaluation of the histocompatibility genetics of th...

journal_title：Immunogenetics

authors： Melvold RW,Kohn HI,Dunn GR

更新日期：1982-01-01 00:00:00

abstract：:The region inclusive of the thioester and the isotype-determining sites of the sheep C4 genes from a single animal was amplified by polymerase chain reaction (PCR). Two bands, at 880 base pairs (bp) and 1000 bp, were resolved by agarose gel electrophoresis. Four different clones were obtained for the 880 bp (type 1) p...

journal_title：Immunogenetics

authors： Ren XD,Dodds AW,Law SK

更新日期：1993-01-01 00:00:00

abstract：:A duplicated locus encoding the major heat shock-induced protein HSP70 is located in the major histocompatibility complex (MHC) class III region 92 kilobases (kb) telomeric to the C2 gene. Nucleotide sequence analysis of the two intronless genes, HSP70-1 and HSP70-2, has shown that they encode an identical protein pro...

journal_title：Immunogenetics

authors： Milner CM,Campbell RD

更新日期：1990-01-01 00:00:00

abstract：:Phenotypic variability is often observed in cynomolgus monkeys on preclinical studies and may, in part, be driven by genetic variability. However, the role of monkey genetic variation remains largely unexplored in the context of drug response. This study evaluated genetic variation in cynomolgus monkey FcγR3A and TAP1...

journal_title：Immunogenetics

authors： Sanford JC,Wu H,Abdiche Y,Harney JA,Chaparro-Riggers J,Adkins K

更新日期：2017-04-01 00:00:00

abstract：:The serological reactivities of HLA-A3, -B7, and -CW3 heavy chains associated with either mouse, bovine, or human beta-2-microglobulin (beta 2m) and expressed on the surface of transfected mouse fibroblasts were analyzed. All reactivities associated with one cluster (defined by monoclonal antibody W6/32) of antigenic ...

journal_title：Immunogenetics

authors： Ferrier P,Fontecilla-Camps JC,Bucchini D,Caillol DH,Jordan BR,Lemonnier FA

更新日期：1985-01-01 00:00:00

abstract：:The immune capacity of young and adult axolotls (Ambystoma mexicanum) was evaluated by examining the combinatorial and junctional diversity of the VH chain. A large number of VDJ rearrangements isolated from 2.5-, 3.5-, 10-, and 24-month-old animals were sequenced. Six JH segments were identified with the canonical st...

journal_title：Immunogenetics

authors： Golub R,Fellah JS,Charlemagne J

更新日期：1997-01-01 00:00:00

abstract：:Probes for loci situated near one end of the proximal (Tcp-1) and distal (Qa-2, 3) inversions of the mouse t complex have been hybridized to chromosomes of mice with and without t complexes and with morphologically distinguishable chromosome 17s. Both the probe for Tcp-1 and that for Qa-2, 3 hybridized to clearly diff...

journal_title：Immunogenetics

authors： Lyon MF,Zenthon J,Evans EP,Burtenshaw MD,Willison KR

更新日期：1988-01-01 00:00:00

abstract：:The susceptibility to cell-mediated cytolysis of cells of the recently developed C57BL/Ka(H-2 ( b )) lymphoma cell line, BL/VL(3), was investigated in allogeneic assays with thymus-dependent lymphocytes (T cells). Compared to EL4, the widely used C57BL/6(H-2 ( b )) lymphoma cell line, BL/VL(3) cells were found to be i...

journal_title：Immunogenetics

authors： Finn OJ,Lieberman M,Kaplan HS

更新日期：1978-12-01 00:00:00

abstract：:Human and mouse major histocompatibility complex class II beta chain alleles associated with predisposition to type I diabetes often encode a non-charged residue at position 57 rather than the negatively charged aspartate residue characteristic of non-susceptible haplotypes. The mechanism(s) whereby this polymorphism ...

journal_title：Immunogenetics

authors： Antoniou AN,Elliott J,Rosmarakis E,Dyson PJ

更新日期：1998-01-01 00:00:00

abstract：:Immunogenicity for T cell-independent B-cell response assessed by splenic plaque-forming cell (PFC) response and cell-surface expression measured by laser flow cytometry of various class I H-2 antigens on mouse red blood cells (RBC) were compared. It was found that the order of magnitude of both immunogenicity and cel...

journal_title：Immunogenetics

authors： Nakashima I,Yoshida T,Yokochi T,Ohashi K,Nagase F,Isobe K,Hasegawa Y,Ando K,Inagi R

更新日期：1986-01-01 00:00:00

abstract：:Genetic and functional analyses of the inflammasome suggest a role for this multiprotein complex in the biological mechanisms leading to the onset and progression of multiple sclerosis (MS). Nucleotide-binding, leucine-rich repeat (NLR) receptors trigger the activation and assembly of specific inflammasomes in respons...

journal_title：Immunogenetics

authors： Popplewell LF,Encarnacion M,Bernales CQ,Sadovnick AD,Traboulsee AL,Quandt JA,Vilariño-Güell C

更新日期：2020-09-01 00:00:00

abstract：:To determine the nucleotide polymorphism of activating killer-cell immunoglobulin-like receptors (aKIR) 3DS1 and 2DS3, we developed a novel direct-sequencing method and analyzed DNA samples of 175 KIR3DS1(+) individuals and 72 KIR2DS3(+) individuals from the white population. The putative ligand-binding extracellular ...

journal_title：Immunogenetics

authors： Luo L,Du Z,Sharma SK,Cullen R,Spellman S,Reed EF,Rajalingam R

更新日期：2007-10-01 00:00:00

abstract：:Here we describe the Immunogenetic Management Software (IMS) system, a novel web-based application that permits multiplexed analysis of complex immunogenetic traits that are necessary for the accurate planning and execution of experiments involving large animal models, including nonhuman primates. IMS is capable of ho...

journal_title：Immunogenetics

authors： Johnson ZP,Eady RD,Ahmad SF,Agravat S,Morris T,Else J,Lank SM,Wiseman RW,O'Connor DH,Penedo MC,Larsen CP,Kean LS

更新日期：2012-04-01 00:00:00

abstract：:We have studied the MICA alleles of 196 unrelated subjects from three South American Indian tribes (Toba, Wichi and Terena). They are members of isolated tribes located in the Gran Chaco area in northeastern Argentina and in Mato Grosso do Sul in South Central Brazil. Of 55 previously known alleles, nine were observed...

journal_title：Immunogenetics

authors： Zhang Y,Lazaro AM,Zou Y,Lavingia B,Moraes EM,Moraes RJ,Stastny P

更新日期：2002-02-01 00:00:00

abstract：:A strong correlation between the TT(-889) genotype over CC(-889) of the interleukin-1 alpha (IL-1 alpha) transcription regulatory region and age of Alzheimer's disease onset has recently been reported. To determine the functional effects of the genetic variants on plasma protein levels, we cloned the promoter region a...

journal_title：Immunogenetics

authors： Dominici R,Cattaneo M,Malferrari G,Archi D,Mariani C,Grimaldi LM,Biunno I

更新日期：2002-05-01 00:00:00

abstract：:Transgenic mice were produced in which human HLA-Cw4 is stably integrated, behaves as a single Mendelian trait, and, being under the transcriptional control of human CD2, is selectively and efficiently expressed in T lymphocytes. These mice were used as a model system to determine whether HLA-type C molecules can be e...

journal_title：Immunogenetics

authors： Aiuti A,Forte P,Simeoni L,Lino M,Pozzi L,Fattorossi A,Giacomini P,Ginelli E,Beretta A,Siccardi A

更新日期：1995-01-01 00:00:00

abstract：:By determining the nucleotide sequences of more than 700 cDNA clones isolated from 16 cynomolgus monkeys, we identified 26 Mafa-B alleles. In addition, nine sequences with similarity to Mamu-I alleles were identified. Since multiple Mafa-B alleles were found in each individual, it was strongly suggested that the cynom...

journal_title：Immunogenetics

authors： Uda A,Tanabayashi K,Fujita O,Hotta A,Terao K,Yamada A

更新日期：2005-05-01 00:00:00

abstract：:We have performed an extensive analysis of Th1/Th2 cytokine receptors IL2Ralpha, IL4Ralpha, IL10Ralpha, and IFNgammaR1 gene polymorphisms to evaluate their impact on AIDS progression. The coding regions and promoters of these genes were sequenced in the genetics of resistance to immunodeficiency virus cohort, composed...

journal_title：Immunogenetics

authors： Do H,Vasilescu A,Diop G,Hirtzig T,Coulonges C,Labib T,Heath SC,Spadoni JL,Therwath A,Lathrop M,Matsuda F,Zagury JF

更新日期：2006-04-01 00:00:00

abstract：:We recently demonstrated that vaccinated rhesus macaques controlled viral replication of a heterologous SIV challenge. Here, we analyzed anamnestic SIV-specific CD4+ T-cell responses expanding immediately after challenge and show that successful vaccinees consistently targeted a short region of the Gag-p27 Capsid (ami...

journal_title：Immunogenetics

authors： Giraldo-Vela JP,Bean AT,Rudersdorf R,Wallace LT,Loffredo JT,Erickson P,Wilson NA,Watkins DI

更新日期：2010-10-01 00:00:00

abstract：:To search for host genes for resistance/susceptibility to cancer metastasis, mutation analysis was employed. Ten putative mutants of resistance to lymphoma EL4 and four putative mutants of resistance to sarcoma MCA/77-23 of C57BL/6J (B6) mice were produced. These mutants were designated S (for "survivor") mutants; the...

journal_title：Immunogenetics

authors： Egorov OS,Liu Y,Sargent EE,Drizlikh GI,Egorov IK

更新日期：1992-01-01 00:00:00

abstract：:Determining the genomic organization of the Ovis aries (Ovar) major histocompatibility complex class IIa region is essential for future functional studies related to antigen presentation. In this study, a bacterial artificial chromosome (BAC) library of genomic DNA from peripheral blood leukocytes (PBL) of a Rambouill...

journal_title：Immunogenetics

authors： Herrmann-Hoesing LM,White SN,Kappmeyer LS,Herndon DR,Knowles DP

更新日期：2008-04-01 00:00:00

abstract：:Almost 10,000 single nucleotide polymorphisms (SNPs) had been identified in the RT1 complex, the major histocompatibility complex of the rat, but less than approximately 0.5% have been characterized. In the context of the incomplete characterization of most SNPs, simple sequence length polymorphism (SSLP) marker devel...

journal_title：Immunogenetics

authors： Takagi Y,Kuramoto T,Voigt B,Tsurumi T,Nakanishi S,Mashimo T,Masui N,Serikawa T

更新日期：2009-03-01 00:00:00

abstract：:Multiple sclerosis (MS) is a common disease of the central nervous system characterized by myelin loss and progressive neurological dysfunction. An underlying genetic susceptibility plays a clear role in the etiology of MS, likely acting in concert with an undefined environmental exposure. Full-genome screenings in mu...

journal_title：Immunogenetics

authors： Barcellos LF,Schito AM,Rimmler JB,Vittinghoff E,Shih A,Lincoln R,Callier S,Elkins MK,Goodkin DE,Haines JL,Pericak-Vance MA,Hauser SL,Oksenberg JR

更新日期：2000-04-01 00:00:00

abstract：:The genes of the major histocompatibility complex (MHC) are amongst the most variable in vertebrates and represent some of the best candidates to study processes of adaptive evolution. However, despite the number of studies available, most of the information on the structure and function of these genes come from studi...

journal_title：Immunogenetics

authors： Gómez D,Conejeros P,Marshall SH,Consuegra S

更新日期：2010-08-01 00:00:00

abstract：:The major histocompatibility complex (MHC) of the domestic cat has been poorly characterized to date, primarily because of numerous difficulties in the preparation of allotypic sera. We present here a comparative analysis of class I and class II genes in domestic cat populations using molecular probes of the MHC from ...

journal_title：Immunogenetics

authors： Yuhki N,O'Brien SJ

更新日期：1988-01-01 00:00:00

abstract：:In order to determine the extent of the repertoire of the immunoglobulin light chain V-region locus (Igl-V) in the laboratory rat (Rattus norvegicus), we constructed a specifically primed cDNA library from lipopolysaccharide-stimulated DA strain rat spleens. The library was screened with a rat Igl-C2-specific probe, a...

journal_title：Immunogenetics

authors： Aguilar BA,Gutman GA

更新日期：1992-01-01 00:00:00