Nine major HLA class I supertypes account for the vast preponderance of HLA-A and -B polymorphism.

Abstract:

:Herein, we review the epitope approach to vaccine development, and discuss how knowledge of HLA supertypes might be used as a tool in the development of such vaccines. After reviewing the main structural features of the A2-, A3-, B7-, and B44- supertype alleles, and biological data demonstrating their immunological relevance, we analyze the frequency at which these supertype alleles are expressed in various ethnicities and discuss the relevance of those observations to vaccine development. Next, the existence of five new supertypes (A1, A24, B27, B58, and B62) is reported. As a result, it is possible to account for the predominance of all known HLA class I with only nine main functional binding specificities. The practical implications of this finding, as well as its relevance to understanding the functional implication of MHC polymorphism in humans, are discussed.

journal_name

Immunogenetics

journal_title

Immunogenetics

authors

Sette A,Sidney J

doi

10.1007/s002510050594

subject

Has Abstract

pub_date

1999-11-01 00:00:00

pages

201-12

issue

3-4

eissn

0093-7711

issn

1432-1211

pii

90500201.251

journal_volume

50

pub_type

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