Abstract:
:Alignment of class I-hybridizing cosmids from an R21 (AlBlDlEugrc+) genomic DNA library gave two contigs: one [150 kilobases (kb)] encompassed the E/C region, or a large part thereof, and the other (110 kb) contained the grc region which has genes influencing resistance to chemical carcinogens (rcc), fertility (ft), and growth (dw-3). Amplification of gene sequences in the four cosmids in the E/C region using Eu-specific and LW2 (RT1.C)-specific primers showed that each cosmid contained both Eu-like and C-like genes. They are clearly different but closely associated, and they show some variation from the prototypic E (Eu) and C (LW2) genes, respectively. Comparison of DNA from grc+ and grc- strains of rats showed that the deletion in the grc- strains was approximately 50 kb, and that it was located on two of the three cosmids in the grc-region contig. The use of specific class I probes showed that the grc region contained tandemly duplicated RT1.O-RT1.N genes and that the RT.BM1 loci lay outside of the grc region. Neither contig reacted with probes specific for class II, TNFA, Hsp70, or RT1.M genes. The data presented here and the previous data in the literature (summarized in Gill et al. 1995) suggest that the gene order in the major histocompatibility complex (MHC) and MHC-linked region of the rat is: A-E/C-grc-M.
journal_name
Immunogeneticsjournal_title
Immunogeneticsauthors
Yuan XJ,Salgar SK,Hassett AL,McHugh KP,Kunz HW,Gill TJ 3rddoi
10.1007/BF02602652subject
Has Abstractpub_date
1996-01-01 00:00:00pages
9-18issue
1eissn
0093-7711issn
1432-1211journal_volume
44pub_type
杂志文章相关文献
IMMUNOGENETICS文献大全abstract::In this study we have sequenced peptides eluted from a truncated recombinant HLA-A*6602 molecule, and compared their features with data reported for peptides presented in the A*6601 molecule. A striking change in the amino-acid binding preferences was observed at peptide position P1, which interacts with pocket A of t...
journal_title:Immunogenetics
pub_type: 杂志文章
doi:10.1007/s00251-004-0677-y
更新日期:2004-05-01 00:00:00
abstract::The non-major histocompatibility complex (MHC)-encoded CD1 family has recently emerged as a new antigen-presenting system that is distinct from either MHC class I or class II molecules. In the present study, we determined the genomic structure of the rat CD1 locus. It was extremely similar to mouse CD1 genes, especial...
journal_title:Immunogenetics
pub_type: 杂志文章
doi:10.1007/s002510050396
更新日期:1998-06-01 00:00:00
abstract::We have recently mapped the human FCGR2 gene to chromosome 1 bands q23-q24. In situ hybridization of FCGR2 cDNA with a cell line containing a t(1:19)(q23;p13) derived from a patient with pre-B ALL has allowed a more accurate localization of this gene to chromosome 1 band q23. Furthermore, this study indicated a splitt...
journal_title:Immunogenetics
pub_type: 杂志文章
doi:10.1007/BF02115010
更新日期:1990-01-01 00:00:00
abstract::Chickens of the Iowa State S1 line have been selected for ability to regress Rous sarcoma virus-induced (RSV) tumors, humoral immune response to GAT (Ir-GAT), and erythrocyte antigen B. Sublines homozygous at the major histocompatibility complex (MHC), as well as F1 heterozygotes and F2 segregants, were tested for res...
journal_title:Immunogenetics
pub_type: 杂志文章
doi:10.1007/BF00404420
更新日期:1987-01-01 00:00:00
abstract::Human leucocyte antigen (HLA)-DRB1*15 is associated with predisposition to multiple sclerosis (MS), although conjecture surrounds the possible involvement of an alternate risk locus in the class I region of the HLA complex. We have shown previously that an alternate MS risk allele(s) may be encompassed by the telomeri...
journal_title:Immunogenetics
pub_type: 杂志文章
doi:10.1007/s00251-006-0183-5
更新日期:2007-03-01 00:00:00
abstract::Avian influenza is a serious threat to the poultry industry and, as the potential source of a human pandemic virus, to public health. Different Mx alleles have been reported to confer resistance or susceptibility to influenza virus replication, and so knowledge of their frequencies is important when considering the po...
journal_title:Immunogenetics
pub_type: 杂志文章
doi:10.1007/s00251-007-0235-5
更新日期:2007-08-01 00:00:00
abstract::Drosophila larvae react against eggs from the endoparasitoid wasp Leptopilina boulardi by surrounding them in a multilayered cellular capsule. Once a wasp egg is recognized as foreign, circulating macrophage-like cells, known as plasmatocytes, adhere to the invader. After spreading around the wasp egg, plasmatocytes f...
journal_title:Immunogenetics
pub_type: 杂志文章
doi:10.1007/s00251-011-0571-3
更新日期:2012-02-01 00:00:00
abstract::Human natural killer (NK) cells express on their surface several members of the C-type lectin family such as NKR-P1, CD94, and NKG2 that are probably involved in recognition of target cells and delivery of signals modulating NK cell cytotoxicity. To elucidate the mechanisms involved in signaling via these receptors, w...
journal_title:Immunogenetics
pub_type: 杂志文章
doi:10.1007/s002510050267
更新日期:1997-01-01 00:00:00
abstract::Position 45 represents a highly polymorphic residue within HLA class I alleles, which contacts the p2 position of bound peptides in 85% of the peptide-HLA structures analyzed, while the neighboring residues 41 and 46 are not involved in peptide binding. To investigate the influence of residue 45 at the functional leve...
journal_title:Immunogenetics
pub_type: 杂志文章
doi:10.1007/s00251-011-0583-z
更新日期:2012-03-01 00:00:00
abstract::Insect bite hypersensitivity (IBH) is a chronic allergic dermatitis common in horses. Affected horses mainly react against antigens present in the saliva from the biting midges, Culicoides ssp, and occasionally black flies, Simulium ssp. Because of this insect dependency, the disease is clearly seasonal and prevalence...
journal_title:Immunogenetics
pub_type: 杂志文章
doi:10.1007/s00251-011-0573-1
更新日期:2012-03-01 00:00:00
abstract::UV-inactivated GCHV (grass carp hemorrhage virus) is able to induce an antiviral state in cultured CAB cells (crucian carp Carassius auratus blastulae embryonic cells) via the production of interferon (IFN). In the current work, the full-length cDNAs of two Mx genes, termed CaMx1 and CaMx2, have been cloned and sequen...
journal_title:Immunogenetics
pub_type: 杂志文章
doi:10.1007/s00251-004-0658-1
更新日期:2004-04-01 00:00:00
abstract::HLA-B and C are related class I genes which are believed to have arisen by duplication of a common ancestor. Previous study showed the presence of orthologues for both HLA-B and C in African apes but only for HLA-B in Asian apes. These observations suggested that the primate C locus evolved subsequent to the divergenc...
journal_title:Immunogenetics
pub_type: 杂志文章
doi:10.1007/s002510050566
更新日期:1999-09-01 00:00:00
abstract::The cell-surface expression of the class I alloantigen Qa-2 was analyzed on resting and activated spleen and thymus cells using cytotoxic elimination and immunofluorescence and flow cytometry. Spleen cells activated by mitogens or alloantigen were homogeneously positive for cell surface Qa-2, but activated splenic T c...
journal_title:Immunogenetics
pub_type: 杂志文章
doi:10.1007/BF00377958
更新日期:1986-01-01 00:00:00
abstract::Natural killer (NK) cells express receptors for MHC class I that contain immunoreceptor tyrosine-based inhibitory motif (ITIM) sequences in their cytoplasmic domain. Whereas these receptors inhibit NK cell cytotoxicity, certain isoforms of these NK receptors (e.g., KIR2DS, CD94/NKG2C, and Ly49D) do not have ITIMs, but...
journal_title:Immunogenetics
pub_type: 杂志文章
doi:10.1007/s002510050642
更新日期:2000-05-01 00:00:00
abstract::Killer cell immunoglobulin-like receptors (KIRs) represent the most polymorphic genes responsible for natural killer cell function, while human leukocyte antigen (HLA) class I molecules define and restrict cytotoxic T lymphocyte responses. Specific KIR, HLA, or KIR-HLA combinations have been implicated in the outcome ...
journal_title:Immunogenetics
pub_type: 杂志文章
doi:10.1007/s00251-016-0920-3
更新日期:2016-10-01 00:00:00
abstract::Five sets of cytotoxic effector cells were generated, using haplo-identical, first degree relatives in five different families, against the HLA-A3; B7 serological determinants combined with different DR antigens. When tested against a panel of cells bearing combinations of the HLA-A, -B and -DR antigens it was shown t...
journal_title:Immunogenetics
pub_type: 杂志文章
doi:10.1007/BF00364495
更新日期:1981-01-01 00:00:00
abstract::Mouse leukosialin, previously known as the 3E8 antigen, is expressed primarily on cells of the hematopoietic and lymphoid lineages and is shown to be the mouse homologue to the human leukosialin/sialophorin and rat W3/13 molecules. A partial leukosialin cDNA clone was isolated via cross-species hybridization with a po...
journal_title:Immunogenetics
pub_type: 杂志文章
doi:10.1007/BF02115004
更新日期:1990-01-01 00:00:00
abstract::Probes for loci situated near one end of the proximal (Tcp-1) and distal (Qa-2, 3) inversions of the mouse t complex have been hybridized to chromosomes of mice with and without t complexes and with morphologically distinguishable chromosome 17s. Both the probe for Tcp-1 and that for Qa-2, 3 hybridized to clearly diff...
journal_title:Immunogenetics
pub_type: 杂志文章
doi:10.1007/BF00395134
更新日期:1988-01-01 00:00:00
abstract::Direct immunoprecipitation and two-dimensional (2D) gel electrophoresis have been used to identify and characterize genetic variation of the H-2K and H-2D regions. Using inbred strains of mice and alloantisera, haplotype-specific polypeptides were defined for five different H-2 haplotypes. Specific immunoprecipitates ...
journal_title:Immunogenetics
pub_type: 杂志文章
doi:10.1007/BF01561657
更新日期:1981-01-01 00:00:00
abstract::The tripartite motif protein (TRIM)5α/CypA fusion protein TRIMCyp in Old World monkeys is generally considered unable to restrict HIV-1 replication. Monkeys with TRIMCyp can serve as a unique animal model for studies of HIV-1 infection. The present study investigated the distribution and expression status of TRIMCyp i...
journal_title:Immunogenetics
pub_type: 杂志文章
doi:10.1007/s00251-012-0670-9
更新日期:2013-03-01 00:00:00
abstract::Type 1 diabetes is a multigenic autoimmune disease, the genetic basis for which is perhaps best characterized in the nonobese diabetic (NOD) mouse model. We previously located a NOD diabetes susceptibility locus, designated Idd11, on mouse Chromosome (Chr) 4 by analyzing diabetic backcross mice produced after crossing...
journal_title:Immunogenetics
pub_type: 杂志文章
doi:10.1007/s002510050006
更新日期:2000-01-01 00:00:00
abstract::The incidence of arthritis and the antibody response to mouse and to rat type II collagen after immunization with native rat type II collagen was studied in different mouse strains, including wild mouse-derived strains belonging to the H-2p/H-2q family. High serum levels of antibodies to mouse and rat type II collagen...
journal_title:Immunogenetics
pub_type: 杂志文章
doi:10.1007/BF00373114
更新日期:1986-01-01 00:00:00
abstract::Polymorphic insertion frequencies of the retrotransposons known as the "SVA" elements were investigated at four loci in the MHC class I genomic region to determine their allele and haplotype frequencies and associations with the HLA-A, -B or -C genes for 100 Japanese, 100 African Americans, 174 Australian Caucasians a...
journal_title:Immunogenetics
pub_type: 杂志文章
doi:10.1007/s00251-010-0427-2
更新日期:2010-04-01 00:00:00
abstract::Transcription of major histocompatibility complex class I genes is controlled by the class I regulatory complex in the 5' flanking region. To investigate the molecular basis of this region, we studied the polymorphism of the promoter of the HLA-B locus extending from the ATG transcription initiation signal to -284 bas...
journal_title:Immunogenetics
pub_type: 杂志文章
doi:10.1007/BF00163991
更新日期:1995-01-01 00:00:00
abstract::Rheumatoid arthritis (RA) is a chronic autoimmune disease affecting 0.5-1% of the population worldwide. The disease has a heterogeneous character, including clinical subsets of anti-citrullinated protein antibody (ACPA)-positive and APCA-negative disease. Although the pathogenesis of RA is poorly understood, progress ...
journal_title:Immunogenetics
pub_type: 杂志文章,评审
doi:10.1007/s00251-011-0528-6
更新日期:2011-08-01 00:00:00
abstract::We have isolated and characterized cDNAs and genes for pufferfish, Fugu rubripes, (Fugu) orthologues of mammalian interleukin (IL)-12 subunits (IL-12 p35 and IL-12 p40). The deduced amino acid sequences of the Fugu IL-12 subunits showed homology with mammalian IL-12 subunits (p35: 50.4-58.0% similarity; p40: 51.2-55.4...
journal_title:Immunogenetics
pub_type: 杂志文章
doi:10.1007/s00251-003-0582-9
更新日期:2003-08-01 00:00:00
abstract::Virus-specific CD8(+) T cells play an important role in controlling HIV/SIV replication. These T cells recognize intracellular pathogen-derived peptides displayed on the cell surface by individual MHC class I molecules. In the SIV-infected rhesus macaque model, five Mamu class I alleles have been thoroughly characteri...
journal_title:Immunogenetics
pub_type: 杂志文章
doi:10.1007/s00251-011-0541-9
更新日期:2011-12-01 00:00:00
abstract::Immunoglobulin E (IgE) provides important information on the humoral immune status, and the IgE level is routinely detected in clinical practice. There are many diseases associated with IgE, such as atopic disease, autoimmune diseases, and so on. IgE is a genetically complex trait, but comprehensive genetic assessment...
journal_title:Immunogenetics
pub_type: 杂志文章
doi:10.1007/s00251-013-0706-9
更新日期:2013-08-01 00:00:00
abstract::The sheep immunoglobulin heavy chain Igh-J locus has been characterized in order to determine the genomic organization of JH segments and their contribution to heavy chain diversity. The locus contains six segments, of which two are functional and four are apparently pseudogenes. These segments span a 1.8 kilobase (kb...
journal_title:Immunogenetics
pub_type: 杂志文章
doi:10.1007/s002510050274
更新日期:1997-01-01 00:00:00
abstract::With the use of monospecific rabbit anti-G protein and mouse monoclonal anti-H-2Kk, we have analyzed the spatial relationship of the serologically defined H-2Kk antigens and the major surface glycoprotein (G protein) of vesicular stomatitis virus (VSV) to those antigens recognized by B10.A (k, d) anti-VSV cytotoxic T ...
journal_title:Immunogenetics
pub_type: 杂志文章
doi:10.1007/BF01572582
更新日期:1980-01-01 00:00:00