Abstract:
:We have recently mapped the human FCGR2 gene to chromosome 1 bands q23-q24. In situ hybridization of FCGR2 cDNA with a cell line containing a t(1:19)(q23;p13) derived from a patient with pre-B ALL has allowed a more accurate localization of this gene to chromosome 1 band q23. Furthermore, this study indicated a splitting of the FCGR2 gene or gene cluster by the t(1;19). However, Southern analysis showed no genetic rearrangement when compared with a karyotypically normal Epstein-Barr virus (EBV)-transformed cell line from the same patient. This suggests that the translocation breakpoint does not occur within the coding region of this gene.
journal_name
Immunogeneticsjournal_title
Immunogeneticsauthors
Webber LM,Garson OM,Tate B,McKenzie IF,Hogarth PMdoi
10.1007/BF02115010subject
Has Abstractpub_date
1990-01-01 00:00:00pages
356-60issue
5-6eissn
0093-7711issn
1432-1211journal_volume
31pub_type
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