Fc receptor gene translocation in a t(1;19) pre-B ALL cell line.

Abstract:

:We have recently mapped the human FCGR2 gene to chromosome 1 bands q23-q24. In situ hybridization of FCGR2 cDNA with a cell line containing a t(1:19)(q23;p13) derived from a patient with pre-B ALL has allowed a more accurate localization of this gene to chromosome 1 band q23. Furthermore, this study indicated a splitting of the FCGR2 gene or gene cluster by the t(1;19). However, Southern analysis showed no genetic rearrangement when compared with a karyotypically normal Epstein-Barr virus (EBV)-transformed cell line from the same patient. This suggests that the translocation breakpoint does not occur within the coding region of this gene.

journal_name

Immunogenetics

journal_title

Immunogenetics

authors

Webber LM,Garson OM,Tate B,McKenzie IF,Hogarth PM

doi

10.1007/BF02115010

subject

Has Abstract

pub_date

1990-01-01 00:00:00

pages

356-60

issue

5-6

eissn

0093-7711

issn

1432-1211

journal_volume

31

pub_type

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