Abstract：
:IgM and IgD genes of the Japanese flounder were cloned and characterized from a genomic bacterial artificial chromosome (BAC) library. The micro gene contained four constant region exons (Cmi1-Cmi4), and two transmembrane exons (miTM1 and miTM2), which conforms to the organizational pattern of all other vertebrate micro-chain genes examined so far. In the same BAC clone, the delta gene, which is homologous to the IgD gene in mammals and teleost fish, was found immediately (0.9 kb) downstream of the IgM gene. This gene encoded seven exons (Cdelta1-Cdelta7) and two deltaTM exons (deltaTM1 and deltaTM2) and had no duplication of Cdelta1-Cdelta2, as found in Atlantic cod, or Cdelta2-Cdelta3-Cdelta4, as found in Atlantic salmon and channel catfish. Phylogenetic and sequence analyses strongly suggest that teleost delta is more closely related to non-IgM isotypes than IgM isotypes. The heavy chain (IgH) locus of Japanese flounder, which encodes microm, micros and deltam, was found to be fully functional.
journal_name
Immunogeneticsjournal_title
Immunogeneticsauthors
Srisapoome P,Ohira T,Hirono I,Aoki Tdoi
10.1007/s00251-004-0689-7subject
Has Abstractpub_date
2004-07-01 00:00:00pages
292-300issue
4eissn
0093-7711issn
1432-1211journal_volume
56pub_type
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