A genetic analysis of natural resistance to nonsyngeneic cells: the role of H-2.

abstract：:The organization of the major histocompatibility complex (MHC) class II region in cattle was investigated by Southern blot analysis using human probes corresponding to DO, DP, DQ, and DR genes. Exon-specific probes were also employed to facilitate the assessment of the number of different bovine class II genes. The re...

journal_title：Immunogenetics

authors： Andersson L,Rask L

更新日期：1988-01-01 00:00:00

abstract：:Mutants of the EB virus-transformed cell line T5-1 (HLA-A1, 2; B8, 27), bearing well-characterized alterations in HLA-A2 antigen expression and unable to bind the HLA-A2-specific monoclonal antibody BB7.2, have been tested for their susceptibility to EB virus-specific cytolysis using effector T-cell preparations funct...

journal_title：Immunogenetics

authors： Gaston JS,Wallace LE,Rickinson AB,Epstein MA,Pious D

更新日期：1984-01-01 00:00:00

abstract：:Here we describe the Immunogenetic Management Software (IMS) system, a novel web-based application that permits multiplexed analysis of complex immunogenetic traits that are necessary for the accurate planning and execution of experiments involving large animal models, including nonhuman primates. IMS is capable of ho...

journal_title：Immunogenetics

authors： Johnson ZP,Eady RD,Ahmad SF,Agravat S,Morris T,Else J,Lank SM,Wiseman RW,O'Connor DH,Penedo MC,Larsen CP,Kean LS

更新日期：2012-04-01 00:00:00

abstract：:The major histocompatibility complex (MHC) includes highly polymorphic gene families encoding proteins crucial to the vertebrate acquired immune system. Classical MHC class I (MHCI) genes code for molecules expressed on the surfaces of most nucleated cells and are associated with defense against intracellular pathogen...

journal_title：Immunogenetics

authors： Buehler DM,Verkuil YI,Tavares ES,Baker AJ

更新日期：2013-03-01 00:00:00

abstract：:In order to determine the extent of the repertoire of the immunoglobulin light chain V-region locus (Igl-V) in the laboratory rat (Rattus norvegicus), we constructed a specifically primed cDNA library from lipopolysaccharide-stimulated DA strain rat spleens. The library was screened with a rat Igl-C2-specific probe, a...

journal_title：Immunogenetics

authors： Aguilar BA,Gutman GA

更新日期：1992-01-01 00:00:00

abstract：:Genomic copy number variants (CNVs) are a common, heritable source of inter-individual differences in genomic sequence. Their influence on phenotypic variability and their involvement in the pathogenesis of several common diseases is well established and the object of many current studies. In the course of examining C...

journal_title：Immunogenetics

authors： Schwienbacher C,De Grandi A,Fuchsberger C,Facheris MF,Svaldi M,Wjst M,Pramstaller PP,Hicks AA

更新日期：2010-08-01 00:00:00

abstract：:A cDNA library screening using the conserved exon 4 of Atlantic salmon Mhc class I as probe provided the basis for a study on Mhc class I polymorphism in a breeding population. Twelve different alleles were identified in the 82 dams and sires studied. No individual expressed more than two alleles, which corresponded t...

journal_title：Immunogenetics

authors： Grimholt U,Drabløs F,Jørgensen SM,Høyheim B,Stet RJ

更新日期：2002-11-01 00:00:00

abstract：:Human and mouse major histocompatibility complex class II beta chain alleles associated with predisposition to type I diabetes often encode a non-charged residue at position 57 rather than the negatively charged aspartate residue characteristic of non-susceptible haplotypes. The mechanism(s) whereby this polymorphism ...

journal_title：Immunogenetics

authors： Antoniou AN,Elliott J,Rosmarakis E,Dyson PJ

更新日期：1998-01-01 00:00:00

abstract：:Cytotoxic CD8+ T-cell immunosurveillance for intracellular pathogens, such as viruses, is controlled by classical major histocompatibility complex (MHC) class Ia molecules, and ideally, these antiviral T-cell populations are defined by the specific peptide and restricting MHC allele. Surprisingly, despite the utility ...

journal_title：Immunogenetics

authors： Holmes JC,Holmer SG,Ross P,Buntzman AS,Frelinger JA,Hess PR

更新日期：2013-09-01 00:00:00

abstract：:Lentinan, a beta-1,6;1,3-glucan, is tumor-specific for transplantable mouse solid-type tumors and it also stimulates the production of acute phase proteins (APPs). The APP response to lentinan is of the delayed type (DT-APR) and differs from that to lipopolysaccharide, which is acute. We found that the responses were ...

journal_title：Immunogenetics

authors： Maeda YY,Takahama S,Kohara Y,Yonekawa H

更新日期：1996-01-01 00:00:00

abstract：:Insect bite hypersensitivity (IBH) is a chronic allergic dermatitis common in horses. Affected horses mainly react against antigens present in the saliva from the biting midges, Culicoides ssp, and occasionally black flies, Simulium ssp. Because of this insect dependency, the disease is clearly seasonal and prevalence...

journal_title：Immunogenetics

authors： Andersson LS,Swinburne JE,Meadows JR,Broström H,Eriksson S,Fikse WF,Frey R,Sundquist M,Tseng CT,Mikko S,Lindgren G

更新日期：2012-03-01 00:00:00

abstract：:Individual mice were tested for their proliferation T-cell response to H-Y- and H-3-incompatible stimulator cells in secondary mixed lymphocyte culture. Responders expressing the H-2b haplotype were restricted in their response to stimulators presenting H-Y and H-3 in the context of H-2b. Lymphocytes from individual B...

journal_title：Immunogenetics

authors： Wettstein PJ

更新日期：1981-01-01 00:00:00

abstract：:Pigtail macaques (Macaca nemestrina) are an increasingly common primate model for the study of human AIDS. Major Histocompatibility complex (MHC) class I-restricted CD8(+) T cell responses are a critical part of the adaptive immune response to HIV-1 in humans and simian immunodeficiency virus (SIV) in macaques; howeve...

journal_title：Immunogenetics

authors： Pratt BF,O'Connor DH,Lafont BA,Mankowski JL,Fernandez CS,Triastuti R,Brooks AG,Kent SJ,Smith MZ

更新日期：2006-12-01 00:00:00

abstract：:A retrovirus element (TLev1) is located within the Thymus leukemia antigen (Tla) locus of the C57BL/10 mouse major histocompatibility complex. Low-copy probes have been isolated from sequences flanking the TLev1 integration site to examine the distribution of TLev1 among inbred mouse strains having genotypically deter...

journal_title：Immunogenetics

authors： Pampeno C,Meruelo D

更新日期：1988-01-01 00:00:00

abstract：:Type II natural killer T cells (NKT) are a subset of the innate-like CD1d-restricted lymphocytes that are reactive to lipid antigens. Unlike the type I NKT cells, which express a semi-invariant TCR, type II NKT cells express a broader TCR repertoire. Additionally, other features, such as their predominance over type I...

journal_title：Immunogenetics

authors： Dasgupta S,Kumar V

更新日期：2016-08-01 00:00:00

abstract：:The cell-surface expression of the class I alloantigen Qa-2 was analyzed on resting and activated spleen and thymus cells using cytotoxic elimination and immunofluorescence and flow cytometry. Spleen cells activated by mitogens or alloantigen were homogeneously positive for cell surface Qa-2, but activated splenic T c...

journal_title：Immunogenetics

authors： Rabinowitz R,Sharrow SO,Chatterjee-Das S,Rogers MJ,Sachs DH

更新日期：1986-01-01 00:00:00

abstract：:T-bet is a key regulator for the lineage commitment in CD4+ T helper (Th) 1 cells by activating the hallmark production of interferon-γ. Previously, two single nucleotide polymorphisms (SNPs) in the TBX21 promoter, T-1993C and T-1514C, have been shown by statistic studies to associate with systemic lupus erythematosus...

journal_title：Immunogenetics

authors： Li J,Li J,You Y,Chen S

更新日期：2012-05-01 00:00:00

abstract：:A duplicated locus encoding the major heat shock-induced protein HSP70 is located in the major histocompatibility complex (MHC) class III region 92 kilobases (kb) telomeric to the C2 gene. Nucleotide sequence analysis of the two intronless genes, HSP70-1 and HSP70-2, has shown that they encode an identical protein pro...

journal_title：Immunogenetics

authors： Milner CM,Campbell RD

更新日期：1990-01-01 00:00:00

abstract：:Macaques are the most widely used experimental nonhuman primate (NHP) species. Rhesus (Macaca mulatta, Macmul), cynomolgus (Macaca fascicularis, Macfas), and pigtail (Macaca nemestrina, Macnem) macaques continue to be popular models for vaccine and infectious diseases research, especially HIV infection and AIDS, and f...

journal_title：Immunogenetics

authors： Nguyen DC,Sanghvi R,Scinicariello F,Pulit-Penaloza J,Hill N,Attanasio R

更新日期：2014-06-01 00:00:00

abstract：:Immunoprecipitation of NP-40 lysates of 125I-labeled lymph-node cells with different anti-H-2 sera and with anti-Qa-2 serum has shown that the BALB/cByA strain (H-2d, Qa-2-negative) expresses, besides H-2Ld, another molecule that is not detectable in the BALB/c-H-2dm2 strain. Electrophoresis in SDS polyacrylamide gels...

journal_title：Immunogenetics

authors： Démant P,Roos MH

更新日期：1982-01-01 00:00:00

abstract：:Mice bearing the H-2w7 haplotype have five C4-related genes, one C4, one Slp, and three C4/Slp hybrid genes. The expression of these five genes in the liver of H-2w7 mice was estimated at the steady state level of their respective mRNA. We have amplified by the polymerase chain reaction (PCR) three regions of the C4/S...

journal_title：Immunogenetics

authors： Huang ZM,Takahashi M,Nonaka M

更新日期：1991-01-01 00:00:00

abstract：:MHC genes are key components in disease resistance and an excellent system for studying selection acting on genetic variation in natural populations. Current patterns of variation in MHC genes are likely to be influenced by past and ongoing selection as well as demographic fluctuations in population size such as those...

journal_title：Immunogenetics

authors： Cortázar-Chinarro M,Meyer-Lucht Y,Laurila A,Höglund J

更新日期：2018-07-01 00:00:00

abstract：:T cell receptor genes are assembled in developing T lymphocytes from discrete V, D, and J genes by a site-specific somatic rearrangement mechanism. A flanking recombination signal, composed of a conserved heptamer and a semiconserved nonamer separated by 12 or 23 variable nucleotides, targets the activity of the rearr...

journal_title：Immunogenetics

authors： Touvrey C,Cowell LG,Lieberman AE,Marche PN,Jouvin-Marche E,Candéias SM

更新日期：2006-11-01 00:00:00

abstract：:A polymorphic gene, MIC-A, is one of the MIC family of genes which is composed of a group of homologous genes interspersed in the class III and class I regions of the major histocompatibility complex. MIC-A is located 46 kilobases (kb) centromeric of HLA-B, and is preferentially expressed in the epithelial cells and i...

journal_title：Immunogenetics

authors： Komatsu-Wakui M,Tokunaga K,Ishikawa Y,Kashiwase K,Moriyama S,Tsuchiya N,Ando H,Shiina T,Geraghty DE,Inoko H,Juji T

更新日期：1999-07-01 00:00:00

abstract：:Mutation rates of H2 and non-H2 histocompatibility genes in the mouse are examined over a 25-year period. Detected by skin graft rejections, the mutations were screened in inbred and hybrid mice from a continuously maintained and monitored colony and from a regularly supplied set of mice provided from the National Can...

journal_title：Immunogenetics

authors： Melvold RW,Wang K,Kohn HI

更新日期：1997-01-01 00:00:00

abstract：:Mouse lymphocyte alloantigens Ly-19 and Ly-32 are controlled by the genes tightly linked to the Lyb-2 locus on chromosome 4. Despite the similarity in mouse strain distribution patterns, Ly-19 and Ly-32 antigens which have been detected on both B- and T-cell lineages are distinct from Lyb-2 antigen whose expression is...

journal_title：Immunogenetics

authors： Nakamura S,Ikegami S,Dairiki K,Kochiya M,Fujimori T,Tamaoki N,Tada N

更新日期：1988-01-01 00:00:00

abstract：:C3, C4, and C5 are thiolester-containing proteins (TEPs) of vertebrate complement. The identification of the molecular origin of the TEP family, and more specifically the ancestor protein of complement components C3, C4, and C5, remains a fundamental question. The prevailing paradigm suggests that duplication and dive...

journal_title：Immunogenetics

authors： Dishaw LJ,Smith SL,Bigger CH

更新日期：2005-08-01 00:00:00

abstract：:Comparison of the rate of synonymous and nonsynonymous nucleotide substitutions suggests that certain regions of the functional H-2 genes, which are part of the mouse major histocompatibility complex (Mhc), are under strong positive selection pressure. Thus far, however, little evidence has been provided for the exist...

journal_title：Immunogenetics

authors： Ritte U,Neufeld E,O'hUigin C,Figueroa F,Klein J

更新日期：1991-01-01 00:00:00

abstract：:The human complement C4 genes in the HLA exhibit an unusual, dichotomous size polymorphism and a four-gene, modular variation involving novel gene RP, complement C4, steroid 21-hydroxylase (CYP21), and tenascin-like Gene X (RCCX). The C4 gene size dichotomy is mediated by an endogenous retrovirus, HERV-K(C4). Nearly i...

journal_title：Immunogenetics

authors： Dangel AW,Mendoza AR,Baker BJ,Daniel CM,Carroll MC,Wu LC,Yu CY

更新日期：1994-01-01 00:00:00

abstract：:Immunoglobulin-A deficiency (IgA-D) is the most common human Ig class deficiency with an estimated frequency of approximately 1 in 500 in the Swedish population. We investigated the immunoglobulin heavy chain constant region gene segments (IGHC) in 103 individuals with IgA-D and the immunoglobulin heavy chain variable...

journal_title：Immunogenetics

authors： Olsson PG,Hammarström L,Cox DW,Smith CI

更新日期：1992-01-01 00:00:00