Genetic influences on spontaneous autoimmune thyroiditis in (CS X OS)F2 chickens.

abstract：:The potential value of in vitro cytotoxic T lymphocyte (CTL) assays for predicting the occurrence of graft vs host disease (GVHD) following allogeneic bone marrow transplantation was evaluated in 12 mouse donor-host combinations associated with various degrees of GVHD. These donor-host combinations were selected after...

journal_title：Immunogenetics

authors： Fontaine P,Langlais J,Perreault C

更新日期：1991-01-01 00:00:00

abstract：:A contribution of allelic variation of T-cell receptor (Tcr) genes to the immune response has not been studied. Here we report that the presence of insertion-deletion-related polymorphisms (IDRP) of the Tcr beta chain (Tcrb) can be utilized to distinguish the parental origin of the gene complex that undergoes rearrang...

journal_title：Immunogenetics

authors： Seboun E,Joshi N,Hauser SL

更新日期：1992-01-01 00:00:00

abstract：:Described here is a new, more efficient method for defining major histocompatibility complex-Y (MHC-Y) genotypes in chickens. The MHC-Y region is genetically independent from the classical MHC (MHC-B) region. MHC-Y is highly polymorphic and potentially important in the genetics of disease resistance. MHC-Y haplotypes ...

journal_title：Immunogenetics

authors： Zhang J,Goto RM,Miller MM

更新日期：2020-07-01 00:00:00

abstract：:We have performed an extensive analysis of Th1/Th2 cytokine receptors IL2Ralpha, IL4Ralpha, IL10Ralpha, and IFNgammaR1 gene polymorphisms to evaluate their impact on AIDS progression. The coding regions and promoters of these genes were sequenced in the genetics of resistance to immunodeficiency virus cohort, composed...

journal_title：Immunogenetics

authors： Do H,Vasilescu A,Diop G,Hirtzig T,Coulonges C,Labib T,Heath SC,Spadoni JL,Therwath A,Lathrop M,Matsuda F,Zagury JF

更新日期：2006-04-01 00:00:00

abstract：:The interaction between 9-mer peptides and HLA-B51 molecules was investigated by quantitative peptide binding assay using RMA-S cells expressing human beta2-microglobulin and HLA-B51 molecules. Of 147 chemically synthesized 9-mer peptides possessing two anchor residues corresponding to the motif of HLA-B*5101 binding ...

journal_title：Immunogenetics

authors： Kikuchi A,Sakaguchi T,Miwa K,Takamiya Y,Rammensee HG,Kaneko Y,Takiguchi M

更新日期：1996-01-01 00:00:00

abstract：:The anti-HLA-DQ3 monoclonal antibodies (mAb) KS13, SO1, SO2, SO3, SO4, and SO5 recognize spatially close but distinct antigenic determinants, since they crossinhibit each other in their binding to HLA-DQ3 antigens, but do not share idiotopes recognized in their antigen combining site by syngeneic and anti-id antisera ...

journal_title：Immunogenetics

authors： Iwasaki Y,Takabatake H,Monestier M,Ferrone S

更新日期：1995-01-01 00:00:00

abstract：:The vertebrate complement system is composed of about 30 serum and cell surface proteins that make up three activation pathways, a lytic pathway, and a set of proteins that regulate complement. Regulatory proteins are required for host protection against autologous complement attack and to control the amplification fe...

journal_title：Immunogenetics

authors： Multerer KA,Smith LC

更新日期：2004-05-01 00:00:00

abstract：:Genes of the major histocompatibility complex (MHC) have been characterized in all extant lineages of mammals. The tammar wallaby (Macropus eugenii) is well established as a model marsupial species; however, no classical MHC sequences have been described from this species. We have isolated two MHC class II beta-chain ...

journal_title：Immunogenetics

authors： Browning TL,Belov K,Miller RD,Eldridge MD

更新日期：2004-02-01 00:00:00

abstract：:Ranatuerins are antimicrobial peptides of the innate immune system found in ranid frogs. We previously presented evidence that a positive selective sweep had fixed a single allele at the Ranatuerin2 locus in the northern leopard frog (Rana pipiens). In this paper, we further investigate the evolutionary history of ran...

journal_title：Immunogenetics

authors： Tennessen JA,Blouin MS

更新日期：2010-05-01 00:00:00

abstract：:Human and mouse major histocompatibility complex class II beta chain alleles associated with predisposition to type I diabetes often encode a non-charged residue at position 57 rather than the negatively charged aspartate residue characteristic of non-susceptible haplotypes. The mechanism(s) whereby this polymorphism ...

journal_title：Immunogenetics

authors： Antoniou AN,Elliott J,Rosmarakis E,Dyson PJ

更新日期：1998-01-01 00:00:00

abstract：:We have evaluated the ability of certain inbred strains of mice to develop a delayed-type hypersensitivity response to the male H-Y antigen. It was found that C57BL/10, B10.GD and B10.A(5R) female mice responded to syngeneic male cells. B10.A(4R) females also responded to B10.A(4R) male cells although the reactivity w...

journal_title：Immunogenetics

authors： Greene MI,Benacerraf B,Dorf ME

更新日期：1980-01-01 00:00:00

abstract：:The polymorphism of major histocompatibility complex (MHC) class II DQ and DR genes in five common equine leukocyte antigen (ELA) haplotypes was determined through sequencing of mRNA transcripts isolated from lymphocytes of eight ELA homozygous horses. Ten expressed MHC class II genes were detected in horses of the EL...

journal_title：Immunogenetics

authors： Miller D,Tallmadge RL,Binns M,Zhu B,Mohamoud YA,Ahmed A,Brooks SA,Antczak DF

更新日期：2017-03-01 00:00:00

abstract：:The Ly49 family of natural killer (NK) cell receptors is encoded by a polygenic genetic locus. Allelic forms have been described and their expression appears to be regulated. The best-characterized Ly49 molecule, the C57BL/6 form of Ly49A, is an NK cell inhibitory receptor that binds H2Dd. To determine whether differe...

journal_title：Immunogenetics

authors： Mehta IK,Wang J,Roland J,Margulies DH,Yokoyama WM

更新日期：2001-09-01 00:00:00

abstract：:Human leukocyte antigen (HLA)-E molecules are potent inhibitors of NK cell-mediated killing. Low in polymorphisms, two alleles are widely expressed among diverse populations: HLA-E*01:01 and HLA-E*01:03. Both alleles are distinguished by one SNP resulting in the substitution Arg107Gly. Both alleles present a limited s...

journal_title：Immunogenetics

authors： Celik AA,Kraemer T,Huyton T,Blasczyk R,Bade-Döding C

更新日期：2016-01-01 00:00:00

abstract：:In this report we present data demonstrating the endogenous expression of I-region associated (Ia) antigens on a cloned line of mouse T cells, CTLL, as well as transcription of the invariant chain gene in these cells. We demonstrate further that this Ia-bearing T-cell clone, CTLL, can utilize the expressed Ia molecule...

journal_title：Immunogenetics

authors： Ben-Nun A,Strauss W,Leeman SA,Cohn LE,Murre C,Duby A,Seidman JG,Glimcher LH

更新日期：1985-01-01 00:00:00

abstract：:Alpha-2-macroglobulin (A2M) binds proteases, thereby acting as defense barriers against pathogens in the plasma and tissues of vertebrates and invertebrates. Quantitative real-time polymerase chain reaction (PCR) and the isobaric tags for relative and absolute quantitation method were used to determine the expression ...

journal_title：Immunogenetics

authors： Wang X,Huang J,Zhao L,Wang C,Ju Z,Li Q,Qi C,Zhang Y,Zhang Z,Zhang W,Hou M,Yuan J,Zhong J

更新日期：2012-11-01 00:00:00

abstract：:The protein kinase, interferon-inducible double-stranded (ds)RNA-dependent activator (PRKRA) is a dsRNA-binding protein which activates a protein kinase participating in the antiviral activity of interferon. Our previous studies indicated that the nucleotide sequence encoding PRKRA, which appeared to be an intronless ...

journal_title：Immunogenetics

authors： Chida S,Hohjoh H,Hirai M,Tokunaga K

更新日期：2001-01-01 00:00:00

abstract：:Human CS1, also known as novel Ly9, 19A24, or CRACC, is a member of the immunoglobulin gene superfamily (IgSF) expressed on natural killer cells and other leukocytes. Here we describe the cloning of the mouse homologue of this gene. The mouse novel Ly9 gene is shown to encode a transmembrane protein composed of two ex...

journal_title：Immunogenetics

authors： Tovar V,del Valle J,Zapater N,Martin M,Romero X,Pizcueta P,Bosch J,Terhorst C,Engel P

更新日期：2002-09-01 00:00:00

abstract：:Herein, we review the epitope approach to vaccine development, and discuss how knowledge of HLA supertypes might be used as a tool in the development of such vaccines. After reviewing the main structural features of the A2-, A3-, B7-, and B44- supertype alleles, and biological data demonstrating their immunological re...

journal_title：Immunogenetics

authors： Sette A,Sidney J

更新日期：1999-11-01 00:00:00

abstract：:UV-inactivated GCHV (grass carp hemorrhage virus) is able to induce an antiviral state in cultured CAB cells (crucian carp Carassius auratus blastulae embryonic cells) via the production of interferon (IFN). In the current work, the full-length cDNAs of two Mx genes, termed CaMx1 and CaMx2, have been cloned and sequen...

journal_title：Immunogenetics

authors： Zhang YB,Li Q,Gui JF

更新日期：2004-04-01 00:00:00

abstract：:The KIR gene cluster exhibits a high degree of polymorphism in terms of gene content as well as allelic polymorphism, and data suggest that it is evolving rapidly. The KIR3DL1 locus is one of the most polymorphic loci within this cluster and is unique in that it encodes an activating receptor KIR3DS1, as well as multi...

journal_title：Immunogenetics

authors： Martin MP,Pascal V,Yeager M,Phair J,Kirk GD,Hoots K,O'Brien SJ,Anderson SK,Carrington M

更新日期：2007-10-01 00:00:00

abstract：:Binding of peptides to major histocompatibility complex (MHC) molecules is the single most selective step in the recognition of pathogens by the cellular immune system. The human MHC genomic region (called HLA) is extremely polymorphic comprising several thousand alleles, each encoding a distinct MHC molecule. The pot...

journal_title：Immunogenetics

authors： Hoof I,Peters B,Sidney J,Pedersen LE,Sette A,Lund O,Buus S,Nielsen M

更新日期：2009-01-01 00:00:00

abstract：:Using mouse bone marrow-derived macrophages we determined the role of interferon (IFN)-gamma at the different steps in expression of the I-A alpha chain of MHC class II molecules, from transcription to the cell surface. Levels of transcription, RNA, and protein were low in cells not stimulated with IFN-gamma. Treatmen...

journal_title：Immunogenetics

authors： Cullell-Young M,Barrachina M,López-López C,Goñalons E,Lloberas J,Soler C,Celada A

更新日期：2001-03-01 00:00:00

abstract：:Mechanisms to account for the unusual properties of a DR1 alpha beta complex (designated DRgp50) that is resistant to dissociation under normal conditions utilized were investigated. Expression of this DRgp50 complex is highly correlated with the failure of cells from certain DR1 individuals (DR1x) to stimulate specif...

journal_title：Immunogenetics

authors： Davis JE,Cook RG,Van M,Rich RR

更新日期：1988-01-01 00:00:00

abstract：:The level of HLA-B27 transgene expression on the cell surface is dependent on the host H-2 haplotype. Mice homozygous for the H-2b, H-2f, H-2s, H-2p, H-2r, and H-2k haplotypes express B27 at high levels. An intermediate level of B27 expression is observed in H-2v mice whereas low levels of B27 are expressed in H-2q an...

journal_title：Immunogenetics

authors： Nickerson-Nutter CL,Hogen KL,David CS

更新日期：1992-01-01 00:00:00

abstract：:We examined the expression of H-Y antigen in 14 XO female mice using three monoclonal H-Y-specific antibodies. We found that spleen and liver cells from XO mice removed the reactivity of these antibodies at the same efficacy as XY cells. However radiobinding assays on cultured XO cells suggested a qualitative or quant...

journal_title：Immunogenetics

authors： Koo GC,Reidy JA,Nagamine CM

更新日期：1983-01-01 00:00:00

abstract：:Major histocompatibility complex (MHC) molecules are only found in jawed vertebrates and not in more primitive species. MHC class II type structures likely represent the ancestral structure of MHC molecules. Efficient MHC class II transport to endosomal compartments depends on association with a specialized chaperone,...

journal_title：Immunogenetics

authors： Dijkstra JM,Yamaguchi T

更新日期：2019-03-01 00:00:00

abstract：:MICA and MICB genes encode MHC class I chain-related proteins, which are polymorphic, do not appear to present peptides or associate with beta(2)-microglobulin, and are expressed predominantly in epithelial cells, endothelial cells, fibroblasts and several cultured cell lines. Alternatively spliced isoforms are known ...

journal_title：Immunogenetics

authors： Zou Y,Stastny P

更新日期：2002-12-01 00:00:00

abstract：:A large number of diseases occur in association with specific HLA-B or -C alleles. Recently a new gene, termed major histocompatibility complex class I chain-related gene A (MICA), has been identified in close proximity to HLA-B. The function of this gene is still unknown, but, it is structurally related to HLA class ...

journal_title：Immunogenetics

authors： Mendoza-Rincon J,Argüello JR,Pérez-Rodríguez M,McWhinnie A,Marsh SG,Fischer G,Madrigal JA

更新日期：1999-06-01 00:00:00

abstract：:Observations have frequently been interpreted as showing that the helper T cells which collaborate with alloantigen-specific cytotoxic T-cell precursors can only recognize antigens encoded in the I region of the H-2 gene complex. An experimental system is described here that allows analysis of the recognition repertoi...

journal_title：Immunogenetics

authors： Pilarski LM,Wegmann TG

更新日期：1984-01-01 00:00:00