Mouse novel Ly9: a new member of the expanding CD150 (SLAM) family of leukocyte cell-surface receptors.

abstract：:Apoptosis has been suggested as a major mechanism for the CD4(+) T-lymphocyte depletion observed in patients infected with human immunodeficiency virus 1 (HIV-1). To evaluate the impact of genetic variations to apoptosis during progression of acquired immunodeficiency syndrome (AIDS), we have performed an extensive ge...

journal_title：Immunogenetics

authors： Vasilescu A,Heath SC,Diop G,Do H,Hirtzig T,Hendel H,Bertin-Maghit S,Rappaport J,Therwath A,Lathrop GM,Matsuda F,Zagury JF

更新日期：2004-04-01 00:00:00

abstract：:The locus for human immunoglobulin heavy chain constant region genes (IgCH) is characterized by a significant frequency of deleted or duplicated haplotypes, due to unequal crossing-over events. Four types of deletions and one duplication have been reported so far. We describe here a molecular study of four cases of Ig...

journal_title：Immunogenetics

authors： Bottaro A,De Marchi M,De Lange G,Boccazzi C,Caldesi F,Gallina R,Carbonara AO

更新日期：1989-01-01 00:00:00

abstract：:We have previously demonstrated a genetic predisposition among mice regarding their ability to be protected against vaginal candidiasis after peripheral immunization. Both BALB/c and (BALB/cx C57BL/6) F1 mice are protected against vaginal candidiasis after subcutaneous immunization with Candida albicans extract and C5...

journal_title：Immunogenetics

authors： Mulero-Marchese RD,Blank KJ,Sieck TG

更新日期：1999-10-01 00:00:00

abstract：:We cloned the cDNAs and genes of two different types of toll-like receptors from Japanese flounder. The results of homology searches suggested that these genes (designated JF-TLR2 and JF-TLR22) are homologues of human TLR2 and fugu TLR22, respectively. The cDNAs of JF-TLR2 and JF-TLR22 encoded 818 and 961 amino acid r...

journal_title：Immunogenetics

authors： Hirono I,Takami M,Miyata M,Miyazaki T,Han HJ,Takano T,Endo M,Aoki T

更新日期：2004-04-01 00:00:00

abstract：:In the absence of any deliberate immunization, mice, rats, humans and alligators all have detectable titers of antibody against chicken red blood cells (CRBC's). Remarkably, this antibody is directed predominantly against private or public determinants of MHC proteins on the CRBC's, and little or no antibody is direct...

journal_title：Immunogenetics

authors： Longenecker BM,Mosmann TR

更新日期：1980-01-01 00:00:00

abstract：:The organization of the major histocompatibility complex (MHC) class II region in cattle was investigated by Southern blot analysis using human probes corresponding to DO, DP, DQ, and DR genes. Exon-specific probes were also employed to facilitate the assessment of the number of different bovine class II genes. The re...

journal_title：Immunogenetics

authors： Andersson L,Rask L

更新日期：1988-01-01 00:00:00

abstract：:Endemic pemphigus foliaceus (EPF), is an autoimmune disease associated with production of IgG antibodies against epidermal antigens. We have tested 38 patients and 50 control subjects living in endemic areas to investigate whether HLA genes are associated with host factors that determine whether or not exposed individ...

journal_title：Immunogenetics

authors： Moraes JR,Moraes ME,Fernandez-Vina M,Diaz LA,Friedman H,Campbell IT,Alvarez RR,Sampaio SA,Rivitti EA,Stastny P

更新日期：1991-01-01 00:00:00

abstract：:Mice bearing the H-2b haplotype are susceptible to the development of experimental autoimmune myasthenia gravis (EAMG), induced by acetylcholine receptor (AChR) autoimmunity. One of the genes influencing EAMG susceptibility has been mapped to the Ab locus of the major histocompatibility complex, and the A beta chain h...

journal_title：Immunogenetics

authors： Christadoss P,David CS,Shenoy M,Keve S

更新日期：1990-01-01 00:00:00

abstract：:Macrophages (mϕ) from pre-diseased mice of the major murine inbred models of spontaneous autoimmunity (AI), including multiple lupus-prone strains and the type I diabetes-prone NOD (non-obese diabetic) strain, have identical apoptotic target-dependent abnormalities. This characteristic feature of mϕ from AI-prone mice...

journal_title：Immunogenetics

authors： Antoni A,Patel VA,Fan H,Lee DJ,Graham LH,Rosch CL,Spiegel DS,Rauch J,Levine JS

更新日期：2011-05-01 00:00:00

abstract：:The cluster of differentiation 4 (CD4) molecule functions as a co-receptor for MHC class II binding to TCR in T helper cells. A CD4 epitope deficiency was identified in the swine MeLiM (melanoblastoma-bearing Libechov minipig) strain, a model for spontaneous cutaneous melanoma development and regression. Extensive seq...

journal_title：Immunogenetics

authors： Blanc F,Créchet F,Bruneau N,Piton G,Leplat JJ,Andréoletti F,Egidy G,Vincent-Naulleau S,Bourneuf E

更新日期：2018-04-01 00:00:00

abstract：:An H-2-restricted graft-versus-host reaction can be demonstrated when irradiated bone marrow-protected recipients receive injections of cells from radiation chimeras. The cells responsible are Thy-1-positive, thymus-dependent, radiation-sensitive and pass through a nylon wool column, i.e., they are T cells. Treatment ...

journal_title：Immunogenetics

authors： Kindred B

更新日期：1984-01-01 00:00:00

abstract：:A new H-2 mutant involving the H-2d haplotype is described--C.B6-H-2dm4 (dm4). This mutant strain carries a gain and loss mutation which maps to the Kd gene of the H-2 complex. Serological testing comparing the mutant and the parental BALB/cKh strain failed to detect any difference between the two strains and no antib...

journal_title：Immunogenetics

authors： Morgan G,Dellos H,McKenzie IF,Melvold RW

更新日期：1981-03-01 00:00:00

abstract：:The anti-HLA-DQ3 monoclonal antibodies (mAb) KS13, SO1, SO2, SO3, SO4, and SO5 recognize spatially close but distinct antigenic determinants, since they crossinhibit each other in their binding to HLA-DQ3 antigens, but do not share idiotopes recognized in their antigen combining site by syngeneic and anti-id antisera ...

journal_title：Immunogenetics

authors： Iwasaki Y,Takabatake H,Monestier M,Ferrone S

更新日期：1995-01-01 00:00:00

abstract：:Natural killer T (NKT) cells play an important role in controlling cancers, infectious diseases and autoimmune diseases. Although the rhesus macaque is a useful primate model for many human diseases such as infectious and autoimmune diseases, little is known about their NKT cells. We analyzed V alpha 24TCR+ T cells fr...

journal_title：Immunogenetics

authors： Kashiwase K,Kikuchi A,Ando Y,Nicol A,Porcelli SA,Tokunaga K,Omine M,Satake M,Juji T,Nieda M,Koezuka Y

更新日期：2003-02-01 00:00:00

abstract：:One mouse with a known recombination (NAK) at the Igk locus on chromosome 6 and two new recombinants [B6.PL (75NS) and B6.PL (85NS)] were examined using a series of probes, each of which is specific for a set of immunoglobulin (Ig) Vk genes. Under high stringency conditions, each probe detects from 1 to 19 Bam HI rest...

journal_title：Immunogenetics

authors： D'Hoostelaere LA,Gibson DM

更新日期：1986-01-01 00:00:00

abstract：:Rh-related transcripts present in bone marrow samples from several species of nonhuman primates (chimpanzee, gorilla, gibbon, crab-eating macaque) have been amplified by RT-polymerase chain reaction using primers deduced from the sequence of human RH genes. Nucleotide sequence analysis of the nonhuman transcripts reve...

journal_title：Immunogenetics

authors： Salvignol I,Calvas P,Socha WW,Colin Y,Le Van Kim C,Bailly P,Ruffié J,Cartron JP,Blancher A

更新日期：1995-01-01 00:00:00

abstract：:We recently demonstrated that vaccinated rhesus macaques controlled viral replication of a heterologous SIV challenge. Here, we analyzed anamnestic SIV-specific CD4+ T-cell responses expanding immediately after challenge and show that successful vaccinees consistently targeted a short region of the Gag-p27 Capsid (ami...

journal_title：Immunogenetics

authors： Giraldo-Vela JP,Bean AT,Rudersdorf R,Wallace LT,Loffredo JT,Erickson P,Wilson NA,Watkins DI

更新日期：2010-10-01 00:00:00

abstract：:Two new C57BL/6 H-2 mutants, B6.C-H-2bm13 and B6.C-H-2bm14 are described. They arose independently in C57BL/6 as spontaneous mutations of the gain and loss type. Complementation studies map the mutations in both bm13 and bm14 to the H-2Db gene. However, these two mutant strains are not identical, but occurred as indep...

journal_title：Immunogenetics

authors： Morgan GM,Dellos H,McKenzie IF,Melvold RW,Bailey DW

更新日期：1980-01-01 00:00:00

abstract：:To describe the polymorphism of the DRA gene in Macaca fascicularis, we have studied 141 animals either at cDNA level (78 animals from Mauritius, the Philippines, and Vietnam) or genomic level (63 animals from the Philippines, Indonesia, and Vietnam). In total, we characterized 22 cDNA DRA alleles, 13 of which had not...

journal_title：Immunogenetics

authors： Aarnink A,Estrade L,Apoil PA,Kita YF,Saitou N,Shiina T,Blancher A

更新日期：2010-03-01 00:00:00

abstract：:The rhesus macaque ( Macaca mulatta) has become a popular animal model for several human infectious diseases, such as HIV (modeled by SIV infection), hepatitis, and malaria. Investigation of T-cell responses in experimental infectious diseases in rhesus macaques has benefited from an expanding understanding of the div...

journal_title：Immunogenetics

authors： Su J,Luscher MA,MacDonald KS

更新日期：2004-03-01 00:00:00

abstract：:Genetic variation in the major histocompatibility complex (MHC) is directly correlated to differences in disease resistance. Immunity is greatly dependent on highly polymorphic genes in the MHC, such as class I, class II, and class III complement genes. Preliminary studies of wild turkey populations show extreme polym...

journal_title：Immunogenetics

authors： Bauer MM,Reed KM

更新日期：2011-04-01 00:00:00

abstract：:Recurrent pregnancy loss (RPL) is a common problem during early gestation. The aim of our study was to investigate the association of IL-17 F( rs763780), IL-17 A (rs2275913), and leptin (2548 G/A) gene polymorphisms with RPL in obese and lean Egyptian females, and to find out whether these gene polymorphisms affect th...

journal_title：Immunogenetics

authors： Zidan HE,Rezk NA,Alnemr AA,Moniem MI

更新日期：2015-11-01 00:00:00

abstract：:To assess the role interleukins and mitogens play in regulating immunoglobulin (Ig) gene expression via the Ig enhancer and promoter, transgenic mice carrying two different Ig gene regulatory regions were generated. One, EmukCAT, contains the Ig heavy chain enhancer (Emu) and the kappa light chain promoter driving the...

journal_title：Immunogenetics

authors： Miller AE,Ennist DL,Ozato K,Westphal H

更新日期：1992-01-01 00:00:00

abstract：:The chromosomal assignment of the gene encoding the invariant (Ii) chain associated with the mouse immune response antigens (Ia) was determined by Southern blot analysis of DNA from a panel of mouse X Chinese hamster somatic cell hybrids cleaved with Hind III or Eco RI. Using a mouse li cDNA as a hybridization probe, ...

journal_title：Immunogenetics

authors： Yamamoto K,Floyd-Smith G,Francke U,Koch N,Lauer W,Dobberstein B,Schäfer R,Hämmerling GJ

更新日期：1985-01-01 00:00:00

abstract：:Human cDNA probes for 21-hydroxylase (21-OH) and for complement component C4 are used on restriction digests of the members of several families with interesting supratypes. The presence of two Taq I fragments of 3.7 kb and 3.2 kb in size with a 21-OH probe is confirmed in most individuals who show no evidence of C4 de...

journal_title：Immunogenetics

authors： Garlepp MJ,Wilton AN,Dawkins RL,White PC

更新日期：1986-01-01 00:00:00

abstract：:The identification of 19 different HLA-DPB1 sequences implicates the existence of more DP specificities than can be typed for with cellular methods. How many of the DP beta sequences can be specifically recognized by T cells, and which of the polymorphic regions can contribute to the specificity of allorecognition, is...

journal_title：Immunogenetics

authors： de Koster HS,Kenter MJ,D'Amaro J,Luiten RM,Schroeijers WE,Giphart MJ,Termijtelen A

更新日期：1991-01-01 00:00:00

abstract：:Earlier studies suggest that end-stage renal disease (ESRD) is associated with inflammatory state and have become a major cause of morbidity and mortality worldwide. This study speculated the role of interleukins (IL)-2, -4, and -6 cytokines gene polymorphism with risk of susceptibility to ESRD. Polymorphism in IL-2 (...

journal_title：Immunogenetics

authors： Mittal RD,Manchanda PK

更新日期：2007-02-01 00:00:00

abstract：:The protein kinase, interferon-inducible double-stranded (ds)RNA-dependent activator (PRKRA) is a dsRNA-binding protein which activates a protein kinase participating in the antiviral activity of interferon. Our previous studies indicated that the nucleotide sequence encoding PRKRA, which appeared to be an intronless ...

journal_title：Immunogenetics

authors： Chida S,Hohjoh H,Hirai M,Tokunaga K

更新日期：2001-01-01 00:00:00

abstract：:Type II natural killer T cells (NKT) are a subset of the innate-like CD1d-restricted lymphocytes that are reactive to lipid antigens. Unlike the type I NKT cells, which express a semi-invariant TCR, type II NKT cells express a broader TCR repertoire. Additionally, other features, such as their predominance over type I...

journal_title：Immunogenetics

authors： Dasgupta S,Kumar V

更新日期：2016-08-01 00:00:00

abstract：:The immune response to bovine insulin (BI) in the rat is controlled by the major histocompatibility complex (Mhc)-linked immune response gene (Ir-BI) and immune suppression gene (Is-BI). In the present study, we investigated the low responsiveness to BI in the WKAH rat (RT1k) and attempted to explore the functional li...

journal_title：Immunogenetics

authors： Mizuno K,Tsuchimoto S,Matsuno Y,Niiyama T,Fujii H,Natori T,Aizawa M

更新日期：1988-01-01 00:00:00