Abstract:
:In the absence of any deliberate immunization, mice, rats, humans and alligators all have detectable titers of antibody against chicken red blood cells (CRBC's). Remarkably, this antibody is directed predominantly against private or public determinants of MHC proteins on the CRBC's, and little or no antibody is directed against species-specific determinants on MHC or other proteins, including other polymorphic blood group antigens. In chickens, "natural" antibody can be detected against CRBC's from all chickens differing at the MHC locus, but "natural" antibodies against other polymorphic antigens are not detected. Using a rosette-forming cell (RFC) assay, we have also shown that a large percentage of mouse spleen cells will rosette with chicken erythrocytes, and that the majority of these RFC's also recognize polymorphic antigens.
journal_name
Immunogeneticsjournal_title
Immunogeneticsauthors
Longenecker BM,Mosmann TRdoi
10.1007/BF01567795subject
Has Abstractpub_date
1980-01-01 00:00:00pages
293-302issue
3eissn
0093-7711issn
1432-1211journal_volume
11pub_type
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