当前位置： SCI文献检索 > IMMUNOGENETICS期刊下所有文献 > Structure, diversity and evolutionary patterns of expressed MHC class IIB genes in chub (Squalius cephalus), a cyprinid fish species from Europe.

Structure, diversity and evolutionary patterns of expressed MHC class IIB genes in chub (Squalius cephalus), a cyprinid fish species from Europe.

Abstract：

:The polymorphism of exon 2 of the DAB genes (major histocompatibility complex [MHC] class IIB) was investigated for the first time in the freshwater cyprinid fish species, Squalius cephalus, in the wide range of its distribution in Europe. We identified 111 different MHC class IIB variants in 15 chub populations distributed from Finland to Spain. The sequence analysis showed that many structurally important amino acid sites that were conserved among tetrapods were also conserved in chub. The analysis of recombination indicated that it does not play an important role in producing and maintaining the variation of DAB genes analyzed in the present study. The exon 2 was shown to be subjected to intense positive selection. Phylogenetic analysis and sequence identities suggest the presence of two class IIB loci (DAB1-like and DAB3-like) in chub. Nevertheless, the presence of three DAB3-like sequence variants in several individuals indicates the duplication of the DAB3 gene. A contrasting selection pattern was found in DAB1-like and DAB3-like genes, which suggests the potential functional differences between these genes. Some DAB sequence variants were shared among the populations of different mtDNA lineages. The phylogenetic analyses did not confirm any biogeographical pattern of the genetic structure of MHC IIB in chub, which is in line with balancing selection and trans-species polymorphism in MHC genes. Nevertheless, cluster analysis based on the presence/absence of DAB sequence variants in the populations showed the phylogeophraphical pattern corresponding to the mtDNA lineages, which indicates that neutral selection can partially explain the MHC IIB evolution in chub.

journal_name

Immunogenetics

journal_title

Immunogenetics

authors

Seifertová M,Simková A

doi

10.1007/s00251-010-0495-3

subject

Has Abstract

pub_date

2011-03-01 00:00:00

pages

167-81

issue

3

eissn

0093-7711

issn

1432-1211

journal_volume

63

pub_type

杂志文章

相关文献

IMMUNOGENETICS文献大全
  • Evidence for an HLA-C-like locus in the orangutan Pongo pygmaeus.

    abstract：:HLA-B and C are related class I genes which are believed to have arisen by duplication of a common ancestor. Previous study showed the presence of orthologues for both HLA-B and C in African apes but only for HLA-B in Asian apes. These observations suggested that the primate C locus evolved subsequent to the divergenc...

    journal_title：Immunogenetics

    pub_type： 杂志文章

    doi：10.1007/s002510050566

    authors： Adams EJ,Thomson G,Parham P

    更新日期：1999-09-01 00:00:00

  • Differential TCR gene usage between WC1- and WC1+ ruminant gammadelta T cell subpopulations including those responding to bacterial antigen.

    abstract：:Ruminant gammadelta T cells are divided into subpopulations based on the presence or absence of WC1 co-receptors (scavenger-receptor-cysteine-rich family members uniquely expressed on gammadelta T cells). Evidence suggests WC1+ are inflammatory while WC1- are regulatory and that they also differ in their tissue distri...

    journal_title：Immunogenetics

    pub_type： 杂志文章

    doi：10.1007/s00251-006-0122-5

    authors： Blumerman SL,Herzig CT,Rogers AN,Telfer JC,Baldwin CL

    更新日期：2006-08-01 00:00:00

  • A biochemical characterization of feline MHC products: unusually high expression of class II antigens on peripheral blood lymphocytes.

    abstract：:The polymorphism of feline MHC antigens was examined using biochemical methods. The following observations were made: (1) feline class I and II antigens are polymorphic. Their biochemical features were established using rabbit and mouse reagents directed against human MHC products; they resemble those observed for oth...

    journal_title：Immunogenetics

    pub_type： 杂志文章

    doi：10.1007/BF00398799

    authors： Neefjes JJ,Hensen EJ,de Kroon TI,Ploegh HL

    更新日期：1986-01-01 00:00:00

  • An informative set of SSLP markers and genomic profiles in the rat MHC, the RT1 complex.

    abstract：:Almost 10,000 single nucleotide polymorphisms (SNPs) had been identified in the RT1 complex, the major histocompatibility complex of the rat, but less than approximately 0.5% have been characterized. In the context of the incomplete characterization of most SNPs, simple sequence length polymorphism (SSLP) marker devel...

    journal_title：Immunogenetics

    pub_type： 杂志文章

    doi：10.1007/s00251-008-0352-9

    authors： Takagi Y,Kuramoto T,Voigt B,Tsurumi T,Nakanishi S,Mashimo T,Masui N,Serikawa T

    更新日期：2009-03-01 00:00:00

  • Evidence for non-random distribution of Fcgamma receptor genotype combinations.

    abstract：:Human IgG receptors (FcgammaR) display considerable heterogeneity, and are crucial immune response modulating molecules. FcgammaRIIA, FcgammaRIIIA, and FcgammaRIIIB display functional biallelic polymorphisms. FcgammaR polymorphisms have been found associated with susceptibility to infectious and autoimmune diseases. L...

    journal_title：Immunogenetics

    pub_type： 杂志文章

    doi：10.1007/s00251-003-0574-9

    authors： van der Pol WL,Jansen MD,Sluiter WJ,van de Sluis B,Leppers-van de Straat FG,Kobayashi T,Westendorp RG,Huizinga TW,van de Winkel JG

    更新日期：2003-07-01 00:00:00

  • Protein tyrosine phosphatase domains from the protochordate Styela plicata.

    abstract：:Protein tyrosine phosphorylation is an important regulatory mechanism in cell physiology. While the protein tyrosine kinase (PTKase) family has been extensively studied, only six protein tyrosine phosphatases (PTPases) have been described. By Southern blot analysis, genomic DNA from several different phyla were found ...

    journal_title：Immunogenetics

    pub_type： 杂志文章

    doi：10.1007/BF00211693

    authors： Matthews RJ,Flores E,Thomas ML

    更新日期：1991-01-01 00:00:00

  • Immunogenetic Management Software: a new tool for visualization and analysis of complex immunogenetic datasets.

    abstract：:Here we describe the Immunogenetic Management Software (IMS) system, a novel web-based application that permits multiplexed analysis of complex immunogenetic traits that are necessary for the accurate planning and execution of experiments involving large animal models, including nonhuman primates. IMS is capable of ho...

    journal_title：Immunogenetics

    pub_type： 杂志文章

    doi：10.1007/s00251-011-0587-8

    authors： Johnson ZP,Eady RD,Ahmad SF,Agravat S,Morris T,Else J,Lank SM,Wiseman RW,O'Connor DH,Penedo MC,Larsen CP,Kean LS

    更新日期：2012-04-01 00:00:00

  • Complementary DNA sequences encoding the rat MHC class II RT1-Bu and RT1-Du alpha and beta chains.

    abstract：:The rat major histocompatibility complex loci RT1-B and RT1-D are equivalent to the human leucocyte antigens HLA-DQ and HLA-DR respectively. Here we describe the complementary DNA (cDNA) sequence encoding the alpha and beta chains of both the RT1-B and RT1-D locus genes of the rat RT1u haplotype. We have found entire ...

    journal_title：Immunogenetics

    pub_type： 杂志文章

    doi：10.1007/s00251-003-0584-7

    authors： Easterfield AJ,Bradley JA,Bolton EM

    更新日期：2003-08-01 00:00:00

  • Delayed-type hypersensitivity to allogeneic mouse epidermal cell antigens. I. Lyt-1+2- T cells are important for DTH.

    abstract：:Footpad swelling response was used to measure the alloantigenicity of epidermal cells (ECs) in delayed-type hypersensitivity (DTH). Strong footpad swelling was observed 3 h after the challenge, and it continued for 48 h after the challenge. Genetical incompatibility between the recipients and the ECs was required to i...

    journal_title：Immunogenetics

    pub_type： 杂志文章

    doi：10.1007/BF00372666

    authors： Ishii N,Nakajima H,Aoki I,Ishii T,Takahashi T,Okuda K

    更新日期：1986-01-01 00:00:00

  • MIC-A polymorphism in Japanese and a MIC-A-MIC-B null haplotype.

    abstract：:A polymorphic gene, MIC-A, is one of the MIC family of genes which is composed of a group of homologous genes interspersed in the class III and class I regions of the major histocompatibility complex. MIC-A is located 46 kilobases (kb) centromeric of HLA-B, and is preferentially expressed in the epithelial cells and i...

    journal_title：Immunogenetics

    pub_type： 杂志文章

    doi：10.1007/s002510050658

    authors： Komatsu-Wakui M,Tokunaga K,Ishikawa Y,Kashiwase K,Moriyama S,Tsuchiya N,Ando H,Shiina T,Geraghty DE,Inoko H,Juji T

    更新日期：1999-07-01 00:00:00

  • H-Y antigen in XO mice.

    abstract：:We examined the expression of H-Y antigen in 14 XO female mice using three monoclonal H-Y-specific antibodies. We found that spleen and liver cells from XO mice removed the reactivity of these antibodies at the same efficacy as XY cells. However radiobinding assays on cultured XO cells suggested a qualitative or quant...

    journal_title：Immunogenetics

    pub_type： 杂志文章

    doi：10.1007/BF00401354

    authors： Koo GC,Reidy JA,Nagamine CM

    更新日期：1983-01-01 00:00:00

  • Two novel HLA-DQ2.5-restricted gluten T cell epitopes in the DQ2.5-glia-γ4 epitope family.

    abstract：:Celiac disease is a chronic inflammatory condition of the small intestine caused by aberrant adaptive immune response to gluten protein from wheat and related cereal plants. Over 90% of celiac disease patients carry the HLA-DQ2.5 allotype and HLA-DQ2.5 presents gluten peptides to gluten-reactive CD4+ T cells in celiac...

    journal_title：Immunogenetics

    pub_type： 杂志文章

    doi：10.1007/s00251-019-01138-5

    authors： Qiao SW,Sollid LM

    更新日期：2019-11-01 00:00:00

  • The CD1d natural killer T-cell antigen presentation pathway is highly conserved between humans and rhesus macaques.

    abstract：:Natural killer T (NKT) cells play an important role in controlling cancers, infectious diseases and autoimmune diseases. Although the rhesus macaque is a useful primate model for many human diseases such as infectious and autoimmune diseases, little is known about their NKT cells. We analyzed V alpha 24TCR+ T cells fr...

    journal_title：Immunogenetics

    pub_type： 杂志文章

    doi：10.1007/s00251-002-0527-8

    authors： Kashiwase K,Kikuchi A,Ando Y,Nicol A,Porcelli SA,Tokunaga K,Omine M,Satake M,Juji T,Nieda M,Koezuka Y

    更新日期：2003-02-01 00:00:00

  • Polymorphism and mapping of the class II genes in the rat: RT1.B, RT1.D, and RT1.H, a new DP-like region.

    abstract：:The major histocompatibility complex of the rat (RT1) encodes the class II molecules involved with antigen presentation and cell to cell communication. The organization of these class II genes has been studied by Southern blot hybridization using genomic DNA from inbred and recombinant rat strains digested with variou...

    journal_title：Immunogenetics

    pub_type： 杂志文章

    doi：10.1007/BF00346516

    authors： Watters JW,Locker JD,Kunz HW,Gill TJ 3rd

    更新日期：1987-01-01 00:00:00

  • From transcription to cell surface expression, the induction of MHC class II I-A alpha by interferon-gamma in macrophages is regulated at different levels.

    abstract：:Using mouse bone marrow-derived macrophages we determined the role of interferon (IFN)-gamma at the different steps in expression of the I-A alpha chain of MHC class II molecules, from transcription to the cell surface. Levels of transcription, RNA, and protein were low in cells not stimulated with IFN-gamma. Treatmen...

    journal_title：Immunogenetics

    pub_type： 杂志文章

    doi：10.1007/s002510100312

    authors： Cullell-Young M,Barrachina M,López-López C,Goñalons E,Lloberas J,Soler C,Celada A

    更新日期：2001-03-01 00:00:00

  • Association of human NK cell surface receptors NKR-P1 and CD94 with Src-family protein kinases.

    abstract：:Human natural killer (NK) cells express on their surface several members of the C-type lectin family such as NKR-P1, CD94, and NKG2 that are probably involved in recognition of target cells and delivery of signals modulating NK cell cytotoxicity. To elucidate the mechanisms involved in signaling via these receptors, w...

    journal_title：Immunogenetics

    pub_type： 杂志文章

    doi：10.1007/s002510050267

    authors： Cerný J,Fiserová A,Horváth O,Bezouska K,Pospísil M,Horejsí V

    更新日期：1997-01-01 00:00:00

  • Polymorphism in the regulatory region of HLA-DRB genes correlating with haplotype evolution.

    abstract：:Class II genes of the human major histocompatibility complex (MHC) are polymorphic. Allelic variation of the coding region of these genes is involved in the antigen presentation and is associated with susceptibility to certain autoimmune diseases. The DR region is unique among human class II regions in that multiple D...

    journal_title：Immunogenetics

    pub_type： 杂志文章

    doi：10.1007/BF00216386

    authors： Louis P,Eliaou JF,Kerlan-Candon S,Pinet V,Vincent R,Clot J

    更新日期：1993-01-01 00:00:00

  • Correction to: Limited MHC class II gene polymorphism in the West African chimpanzee is distributed maximally by haplotype diversity.

    abstract：:The authors regret that an error was present in the Fig. 5 of the above article; some digits in the DRB allele-designations in Fig. 5 have been lost, and are incorrectly presented by only two digits. The correct allele-designations should have been four (or six) digits. The correct Figure is now presented correctly. ...

    journal_title：Immunogenetics

    pub_type： 杂志文章,已发布勘误

    doi：10.1007/s00251-018-1089-8

    authors： Otting N,de Groot NG,Bontrop RE

    更新日期：2018-11-01 00:00:00

  • Evolution of immunoglobulin heavy chain variable region genes: a VH family can last for 150-200 million years or longer.

    abstract：:Many immunoglobulin variable region (IgV) genes are present in the vertebrate genome and provide a basis for antibody diversity. IgV genes have been classified into distinct families according to DNA sequence similarity. Comparisons of VH and VL genes from two mammalian species (mouse and human) have led to the conclu...

    journal_title：Immunogenetics

    pub_type： 杂志文章

    doi：10.1007/BF00188428

    authors： Andersson E,Matsunaga T

    更新日期：1995-01-01 00:00:00

  • New types of multiple and single gene deletions in the human IgCH locus.

    abstract：:The locus for human immunoglobulin heavy chain constant region genes (IgCH) is characterized by a significant frequency of deleted or duplicated haplotypes, due to unequal crossing-over events. Four types of deletions and one duplication have been reported so far. We describe here a molecular study of four cases of Ig...

    journal_title：Immunogenetics

    pub_type： 杂志文章

    doi：10.1007/BF02341612

    authors： Bottaro A,De Marchi M,De Lange G,Boccazzi C,Caldesi F,Gallina R,Carbonara AO

    更新日期：1989-01-01 00:00:00

  • Characterization of the MHC class II region in cattle. The number of DQ genes varies between haplotypes.

    abstract：:The organization of the major histocompatibility complex (MHC) class II region in cattle was investigated by Southern blot analysis using human probes corresponding to DO, DP, DQ, and DR genes. Exon-specific probes were also employed to facilitate the assessment of the number of different bovine class II genes. The re...

    journal_title：Immunogenetics

    pub_type： 杂志文章

    doi：10.1007/BF00351084

    authors： Andersson L,Rask L

    更新日期：1988-01-01 00:00:00

  • Extent of the mouse t complex and its inversions shown by in situ hybridization.

    abstract：:Probes for loci situated near one end of the proximal (Tcp-1) and distal (Qa-2, 3) inversions of the mouse t complex have been hybridized to chromosomes of mice with and without t complexes and with morphologically distinguishable chromosome 17s. Both the probe for Tcp-1 and that for Qa-2, 3 hybridized to clearly diff...

    journal_title：Immunogenetics

    pub_type： 杂志文章

    doi：10.1007/BF00395134

    authors： Lyon MF,Zenthon J,Evans EP,Burtenshaw MD,Willison KR

    更新日期：1988-01-01 00:00:00

  • Chinese origin rhesus macaque major histocompatibility complex class I molecules promiscuously present epitopes from SIV associated with molecules of Indian origin; implications for immunodominance and viral escape.

    abstract：:The presentation of identical peptides by different major histocompatibility complex class I (MHC-I) molecules, termed promiscuity, is a controversial feature of T cell-mediated immunity to pathogens. The astounding diversity of MHC-I molecules in human populations, presumably to enable binding of equally diverse pept...

    journal_title：Immunogenetics

    pub_type： 杂志文章

    doi：10.1007/s00251-011-0538-4

    authors： Maness NJ,Walsh AD,Rudersdorf RA,Erickson PA,Piaskowski SM,Wilson NA,Watkins DI

    更新日期：2011-09-01 00:00:00

  • Gm and Km immunoglobulin allotypes in Sicily.

    abstract：:The aim of this study was to evaluate the intra- and inter-population variability of the Gm/Km system in the Madonie Mountains, one of the main geographical barriers in north-central Sicily. We analysed 392 samples: 145 from Alia, 128 from Valledolmo, 25 from Cerda and 94 from Palermo. Serum samples were tested for G1...

    journal_title：Immunogenetics

    pub_type： 历史文章,杂志文章

    doi：10.1007/s00251-003-0628-z

    authors： Cerutti N,Dugoujon JM,Guitard E,Rabino Massa E

    更新日期：2004-01-01 00:00:00

  • Transcription and diversity of immunoglobulin lambda chain variable genes in the rat.

    abstract：:In order to determine the extent of the repertoire of the immunoglobulin light chain V-region locus (Igl-V) in the laboratory rat (Rattus norvegicus), we constructed a specifically primed cDNA library from lipopolysaccharide-stimulated DA strain rat spleens. The library was screened with a rat Igl-C2-specific probe, a...

    journal_title：Immunogenetics

    pub_type： 杂志文章

    doi：10.1007/BF00223543

    authors： Aguilar BA,Gutman GA

    更新日期：1992-01-01 00:00:00

  • B-G cDNA clones have multiple small repeats and hybridize to both chicken MHC regions.

    abstract：:We used rabbit antisera to the chicken MHC erythrocyte molecule B-G and to the class I alpha chain (B-F) to screen lambda gt11 cDNA expression libraries made with RNA selected by oligo-dT from bone marrow cells of anemic B19 homozygous chickens. Eight clones were found to encode B-G molecules which hybridize with sequ...

    journal_title：Immunogenetics

    pub_type： 杂志文章

    doi：10.1007/BF02421176

    authors： Kaufman J,Salomonsen J,Skjødt K

    更新日期：1989-01-01 00:00:00

  • Molecular cloning and characterization of the polymorphic MHC class II DBB from the tammar wallaby (Macropus eugenii).

    abstract：:Genes of the major histocompatibility complex (MHC) have been characterized in all extant lineages of mammals. The tammar wallaby (Macropus eugenii) is well established as a model marsupial species; however, no classical MHC sequences have been described from this species. We have isolated two MHC class II beta-chain ...

    journal_title：Immunogenetics

    pub_type： 杂志文章

    doi：10.1007/s00251-004-0644-7

    authors： Browning TL,Belov K,Miller RD,Eldridge MD

    更新日期：2004-02-01 00:00:00

  • H-2 antigens as genetic markers: a two-dimensional gel electrophoretic study.

    abstract：:Direct immunoprecipitation and two-dimensional (2D) gel electrophoresis have been used to identify and characterize genetic variation of the H-2K and H-2D regions. Using inbred strains of mice and alloantisera, haplotype-specific polypeptides were defined for five different H-2 haplotypes. Specific immunoprecipitates ...

    journal_title：Immunogenetics

    pub_type： 杂志文章

    doi：10.1007/BF01561657

    authors： Sawicki JA,Epstein CJ

    更新日期：1981-01-01 00:00:00

  • Genetic resistance to fowl cholera is linked to the major histocompatibility complex.

    abstract：:Chickens of the Iowa State S1 line have been selected for ability to regress Rous sarcoma virus-induced (RSV) tumors, humoral immune response to GAT (Ir-GAT), and erythrocyte antigen B. Sublines homozygous at the major histocompatibility complex (MHC), as well as F1 heterozygotes and F2 segregants, were tested for res...

    journal_title：Immunogenetics

    pub_type： 杂志文章

    doi：10.1007/BF00404420

    authors： Lamont SJ,Bolin C,Cheville N

    更新日期：1987-01-01 00:00:00

  • Structural and functional characterisation of the Toll like receptor 9 of Aotus nancymaae, a non-human primate model for malaria vaccine development.

    abstract：:In the absence of suitable rodent animal models for Plasmodium falciparum malaria, the efficacy testing of asexual blood-stage vaccine candidates in Aotus nancymaae represents a tool to select between different formulations before conducting expensive human clinical trials. CpG oligonucleotides (ODN) specifically prom...

    journal_title：Immunogenetics

    pub_type： 杂志文章

    doi：10.1007/s00251-005-0789-z

    authors： Spirig R,Peduzzi E,Patarroyo ME,Pluschke G,Daubenberger CA

    更新日期：2005-05-01 00:00:00