Polymorphisms in the human surfactant protein-D (SFTPD) gene: strong evidence that serum levels of surfactant protein-D (SP-D) are genetically influenced.

abstract：:Assembly of HLA class I molecules was studied using pulse-chase labeling of B-lymphoblastoid cell lines with 35S-methionine, immunoprecipitation with antibodies detecting free or beta 2-microglobulin-associated heavy chain and isoelectric focusing. Marked differences between the products of different class I alleles w...

journal_title：Immunogenetics

authors： Hill A,Takiguchi M,McMichael A

更新日期：1993-01-01 00:00:00

abstract：:Early and late primary IgM antibody responses of mice to Thy-1.1 antigens showed different antigenic and cellular requirements. We studied genetic controls of the early primary responses, which could be induced by subcellular thymocyte antigens independently of host T-cell activity. All Thy-1.2 mouse strains of Igha (...

journal_title：Immunogenetics

authors： Isobe K,Nakashima I,Nagase F,Yoshida T,Ando K,Inagi R,Kato N,Ohashi K

更新日期：1984-01-01 00:00:00

abstract：:Over a period of some 20 years, Werner Eugen Mayer played a significant role in establishing a framework for molecular studies of Mhc genes in multiple vertebrates. His work largely concerned gene isolation, sequencing, and related bioinformatic analyses both for the Mhc and for immune system genes of about 200 specie...

journal_title：Immunogenetics

authors： O'hUigin C

更新日期：2012-12-01 00:00:00

abstract：:The polymorphism of exon 2 of the DAB genes (major histocompatibility complex [MHC] class IIB) was investigated for the first time in the freshwater cyprinid fish species, Squalius cephalus, in the wide range of its distribution in Europe. We identified 111 different MHC class IIB variants in 15 chub populations distr...

journal_title：Immunogenetics

authors： Seifertová M,Simková A

更新日期：2011-03-01 00:00:00

abstract：:Rh-related transcripts present in bone marrow samples from several species of nonhuman primates (chimpanzee, gorilla, gibbon, crab-eating macaque) have been amplified by RT-polymerase chain reaction using primers deduced from the sequence of human RH genes. Nucleotide sequence analysis of the nonhuman transcripts reve...

journal_title：Immunogenetics

authors： Salvignol I,Calvas P,Socha WW,Colin Y,Le Van Kim C,Bailly P,Ruffié J,Cartron JP,Blancher A

更新日期：1995-01-01 00:00:00

abstract：:Immunity-related genes are a suitable model for studying effects of selection at the genomic level. Some of them are highly conserved due to functional constraints and purifying selection, while others are variable and change quickly to cope with the variation of pathogens. The SLC11A1 gene encodes a transporter prote...

journal_title：Immunogenetics

authors： Bayerova Z,Janova E,Matiasovic J,Orlando L,Horin P

更新日期：2016-05-01 00:00:00

abstract：:Segregation distortion was found for a haplotype of the equine lymphocyte antigen (ELA) system in an extended family of American Standardbred horses. In one sire family, consisting of a stallion and his 17 sons and grandsons, the gene for ELA-A10 (A10) was transmitted to 57.7% of 638 offspring scored (P = 0.001). Sign...

journal_title：Immunogenetics

authors： Bailey E

更新日期：1986-01-01 00:00:00

abstract：:Type II natural killer T cells (NKT) are a subset of the innate-like CD1d-restricted lymphocytes that are reactive to lipid antigens. Unlike the type I NKT cells, which express a semi-invariant TCR, type II NKT cells express a broader TCR repertoire. Additionally, other features, such as their predominance over type I...

journal_title：Immunogenetics

authors： Dasgupta S,Kumar V

更新日期：2016-08-01 00:00:00

abstract：:The gene for the catalytic subunit of DNA-dependent protein kinase (DNA-PKcs) is responsible for severe combined immune deficiency (SCID) and its products associate with Ku70/Ku86 autoantigens, c-Abl, and other factors to exert its roles. Investigations to date suggest that DNA-PKcs comprises several regions which spe...

journal_title：Immunogenetics

authors： Fujimori A,Araki R,Fukumura R,Ohhata T,Takahashi H,Kawahara A,Tatsumi K,Abe M

更新日期：2000-09-01 00:00:00

abstract：:We examined the expression of H-Y antigen in 14 XO female mice using three monoclonal H-Y-specific antibodies. We found that spleen and liver cells from XO mice removed the reactivity of these antibodies at the same efficacy as XY cells. However radiobinding assays on cultured XO cells suggested a qualitative or quant...

journal_title：Immunogenetics

authors： Koo GC,Reidy JA,Nagamine CM

更新日期：1983-01-01 00:00:00

abstract：:In order to further our understanding of major histocompatibility complex (MHC) class I gene organization, we began a comparative analysis of the large scale organization of the class I region in diverse haplotypes. For these studies, the MHC in healthy Japanese donors who have the predominant MHC haplotypes and/or HL...

journal_title：Immunogenetics

authors： Watanabe Y,Tokunaga K,Geraghty DE,Tadokoro K,Juji T

更新日期：1997-01-01 00:00:00

abstract：:The presentation of identical peptides by different major histocompatibility complex class I (MHC-I) molecules, termed promiscuity, is a controversial feature of T cell-mediated immunity to pathogens. The astounding diversity of MHC-I molecules in human populations, presumably to enable binding of equally diverse pept...

journal_title：Immunogenetics

authors： Maness NJ,Walsh AD,Rudersdorf RA,Erickson PA,Piaskowski SM,Wilson NA,Watkins DI

更新日期：2011-09-01 00:00:00

abstract：:In mammals many natural killer (NK) cell receptors, encoded by the leukocyte receptor complex (LRC), regulate the cytotoxic activity of NK cells and provide protection against virus-infected and tumor cells. To investigate the origin of the Ig-like domains encoded by the LRC genes, a subset of C2-type Ig-like domain s...

journal_title：Immunogenetics

authors： Nikolaidis N,Klein J,Nei M

更新日期：2005-04-01 00:00:00

abstract：:Human IgG receptors (FcgammaR) display considerable heterogeneity, and are crucial immune response modulating molecules. FcgammaRIIA, FcgammaRIIIA, and FcgammaRIIIB display functional biallelic polymorphisms. FcgammaR polymorphisms have been found associated with susceptibility to infectious and autoimmune diseases. L...

journal_title：Immunogenetics

authors： van der Pol WL,Jansen MD,Sluiter WJ,van de Sluis B,Leppers-van de Straat FG,Kobayashi T,Westendorp RG,Huizinga TW,van de Winkel JG

更新日期：2003-07-01 00:00:00

abstract：:Immunoglobulin (IG) gene rearrangement and expression are central to disease resistance and health maintenance in animals. The IG kappa (IGK) locus in swine (Sus scrofa domestica) contributes to approximately half of all antibody molecules, in contrast to many other Cetartiodactyla, whose members provide the majority ...

journal_title：Immunogenetics

authors： Schwartz JC,Lefranc MP,Murtaugh MP

更新日期：2012-04-01 00:00:00

abstract：:Position 45 represents a highly polymorphic residue within HLA class I alleles, which contacts the p2 position of bound peptides in 85% of the peptide-HLA structures analyzed, while the neighboring residues 41 and 46 are not involved in peptide binding. To investigate the influence of residue 45 at the functional leve...

journal_title：Immunogenetics

authors： Badrinath S,Huyton T,Schumacher H,Blasczyk R,Bade-Doeding C

更新日期：2012-03-01 00:00:00

abstract：:We investigated the genetic control of heterotopic heart allograft rejection using a family of standard inbred, major histocompatibility complex (MHC)-congenic, and intra-MHC recombinant rat strains. Gene products of the various regions within the rat MHC differed markedly in their capacity to induce rejection. Isolat...

journal_title：Immunogenetics

authors： Klempnauer J,Steiniger B,Lück R,Günther E

更新日期：1989-01-01 00:00:00

abstract：:An optimized alignment of related protein sequences helps to see their important shared features and to deduce their phylogenetic relationships. At low levels of sequence similarity, there are no suitable computer programs for making the best possible alignment. This review summarizes some guidelines for how in such i...

journal_title：Immunogenetics

authors： Dijkstra JM

更新日期：2021-01-29 00:00:00

abstract：:Complement is one of primary defense mechanisms against intravascular microorganisms and could play a role in the immune response to malignancy and hence its clinical behavior. We evaluated if the sole coding polymorphism of C1qA associates with outcome in patients with breast carcinoma. Genotyping for C1qA[276A/G] wa...

journal_title：Immunogenetics

authors： Racila E,Racila DM,Ritchie JM,Taylor C,Dahle C,Weiner GJ

更新日期：2006-02-01 00:00:00

abstract：:Although major histocompatibility complex (MHC) class I molecules are, as a rule, highly polymorphic in mammalian species, those of the New World primate Saguinus oedipus (cotton-top tamarin) exhibit limited polymorphism. We have cloned and sequenced twelve MHC class I cDNAs from this species. Since cloned cotton-top ...

journal_title：Immunogenetics

authors： Watkins DI,Garber TL,Chen ZW,Toukatly G,Hughes AL,Letvin NL

更新日期：1991-01-01 00:00:00

abstract：:The human complement C4 genes in the HLA exhibit an unusual, dichotomous size polymorphism and a four-gene, modular variation involving novel gene RP, complement C4, steroid 21-hydroxylase (CYP21), and tenascin-like Gene X (RCCX). The C4 gene size dichotomy is mediated by an endogenous retrovirus, HERV-K(C4). Nearly i...

journal_title：Immunogenetics

authors： Dangel AW,Mendoza AR,Baker BJ,Daniel CM,Carroll MC,Wu LC,Yu CY

更新日期：1994-01-01 00:00:00

abstract：:To assess the role interleukins and mitogens play in regulating immunoglobulin (Ig) gene expression via the Ig enhancer and promoter, transgenic mice carrying two different Ig gene regulatory regions were generated. One, EmukCAT, contains the Ig heavy chain enhancer (Emu) and the kappa light chain promoter driving the...

journal_title：Immunogenetics

authors： Miller AE,Ennist DL,Ozato K,Westphal H

更新日期：1992-01-01 00:00:00

abstract：:The major histocompatibility complex (MHC) class I-related molecule, MR1, presents vitamin B metabolites from bacteria and yeast to mucosal-associated invariant T (MAIT) cells. Despite the evolutionary conservation of MR1, we do not know whether different allele variants of MR1 exist within the nonhuman primate (NHP) ...

journal_title：Immunogenetics

authors： Ellis-Connell AL,Kannal NM,Balgeman AJ,O'Connor SL

更新日期：2019-02-01 00:00:00

abstract：:Development of an accurate and efficient molecular-based equine MHC class I typing method would facilitate the study of T lymphocyte immune responses in horses. Here, a DNA microarray was designed to detect expressed classical MHC class I genes comprising serologically defined equine leukocyte antigen (ELA)-A haplotyp...

journal_title：Immunogenetics

authors： Ramsay JD,Leib SR,Orfe L,Call DR,Tallmadge RL,Fraser DG,Mealey RH

更新日期：2010-09-01 00:00:00

abstract：:Many immunoglobulin variable region (IgV) genes are present in the vertebrate genome and provide a basis for antibody diversity. IgV genes have been classified into distinct families according to DNA sequence similarity. Comparisons of VH and VL genes from two mammalian species (mouse and human) have led to the conclu...

journal_title：Immunogenetics

authors： Andersson E,Matsunaga T

更新日期：1995-01-01 00:00:00

abstract：:In three families with an apparent non-expressed factor B (BF) allele (BF*Q0), advanced methods of isoelectric focusing for the determination of BF F subtypes revealed different hypomorphic BF products (BF QL) with functional hemolytic activity expressed by the assumed BF*Q0 allele. A Taq I and a Msp I restriction fra...

journal_title：Immunogenetics

authors： Siemens I,Brenden M,Mauff G,Abbal M,Du Toit E,Bertrams J,Geserick G

更新日期：1992-01-01 00:00:00

abstract：:Recent genome-wide association studies (GWAs) have identified several new genetic risk factors for asthma; however, their influence on disease behavior and treatment response is still unclear. The aim of our study was the association analysis of the most significant single nucleotide polymorphisms (SNPs) recently repo...

journal_title：Immunogenetics

authors： Perin P,Potočnik U

更新日期：2014-03-01 00:00:00

abstract：:The evolution of the mouse immunoglobulin heavy chain variable region (Igh-V) locus was investigated by the comprehensive analysis of variable region (Vh) gene family content and restriction fragment polymorphism in the genus Mus. The examination of natural Mus domesticus populations suggests an important role for rec...

journal_title：Immunogenetics

authors： Tutter A,Riblet R

更新日期：1989-01-01 00:00:00

abstract：:A large number of diseases occur in association with specific HLA-B or -C alleles. Recently a new gene, termed major histocompatibility complex class I chain-related gene A (MICA), has been identified in close proximity to HLA-B. The function of this gene is still unknown, but, it is structurally related to HLA class ...

journal_title：Immunogenetics

authors： Mendoza-Rincon J,Argüello JR,Pérez-Rodríguez M,McWhinnie A,Marsh SG,Fischer G,Madrigal JA

更新日期：1999-06-01 00:00:00

abstract：:Transgenic mice were produced in which human HLA-Cw4 is stably integrated, behaves as a single Mendelian trait, and, being under the transcriptional control of human CD2, is selectively and efficiently expressed in T lymphocytes. These mice were used as a model system to determine whether HLA-type C molecules can be e...

journal_title：Immunogenetics

authors： Aiuti A,Forte P,Simeoni L,Lino M,Pozzi L,Fattorossi A,Giacomini P,Ginelli E,Beretta A,Siccardi A

更新日期：1995-01-01 00:00:00