What to do with HLA-DO?

abstract：:The anti-HLA-DQ3 monoclonal antibodies (mAb) KS13, SO1, SO2, SO3, SO4, and SO5 recognize spatially close but distinct antigenic determinants, since they crossinhibit each other in their binding to HLA-DQ3 antigens, but do not share idiotopes recognized in their antigen combining site by syngeneic and anti-id antisera ...

journal_title：Immunogenetics

authors： Iwasaki Y,Takabatake H,Monestier M,Ferrone S

更新日期：1995-01-01 00:00:00

abstract：:Resistance to two cultured lines of murine embryonal carcinoma was studied in F1 hybrids constructed between the tumor-syngeneic mouse strain 129/J and several allogeneic strains. Three of four such hybrid strains were significantly more resistant to the multipotent embryonal carcinoma line PCC3 than the tumor-syngene...

journal_title：Immunogenetics

authors： Bishop GA,Dove WF

更新日期：1980-01-01 00:00:00

abstract：:We have previously reported that autoimmune pancreatitis (AIP) is a bioclinical entity characterized by high serum immunoglobulin G4 concentrations and association with the HLA-DRB1*0405-DQB1*0401 haplotype. However, the precise identity of gene(s) within this haplotype directly responsible for AIP pathogenesis is yet...

journal_title：Immunogenetics

authors： Ota M,Katsuyama Y,Hamano H,Umemura T,Kimura A,Yoshizawa K,Kiyosawa K,Fukushima H,Bahram S,Inoko H,Kawa S

更新日期：2007-01-01 00:00:00

abstract：:Sixteen microsatellite markers, including two described here, were used to construct a high-resolution map of the 1q32 region encompassing the regulator of the complement activation (RCA) gene cluster. The RCA genes are a group of related genes coding for plasma and membrane associated proteins that collectively contr...

journal_title：Immunogenetics

authors： Heine-Suñer D,Díaz-Guillén MA,de Villena FP,Robledo M,Benítez J,Rodríguez de Córdoba S

更新日期：1997-01-01 00:00:00

abstract：:Genes encoding the immunoglobulin heavy-chain variable region (Ig VH) in rainbow trout (Oncorhynchus mykiss) have been grouped into 11 families. While obtaining a baseline assessment of the various gene families utilized by trout in the production of secreted antibody, we discovered two new families. These proposed Ig...

journal_title：Immunogenetics

authors： Brown GD,Kaattari IM,Kaattari SL

更新日期：2006-11-01 00:00:00

abstract：:We have used seven HLA-D homozygous typing cells (HTC) in a comparative study of the DRw8 antigen complex in three racial groups. Three distinct HLA-D specificities were recognized, each associated with HLA-DRw8. Four of the HTC defined a DRw8-associated HLA-D specificity designated 8.1, one defined a specificity desi...

journal_title：Immunogenetics

authors： Mickelson EM,Nisperos B,Layrisse Z,Kim SJ,Thomas ED,Hansen JA

更新日期：1983-01-01 00:00:00

abstract：:Eight families (121 individuals) with two or more members affected with systemic lupus erythematosus (SLE) were analyzed for histocompatibility antigens (HLA-A, B, C, DR, MT, and MB) and complement antigens (C4A, C4B, and BF). These data were correlated with serological markers (antinuclear antibodies, single- and dou...

journal_title：Immunogenetics

authors： Reveille JD,Arnett FC,Wilson RW,Bias WB,McLean RH

更新日期：1985-01-01 00:00:00

abstract：:By determining the nucleotide sequences of more than 700 cDNA clones isolated from 16 cynomolgus monkeys, we identified 26 Mafa-B alleles. In addition, nine sequences with similarity to Mamu-I alleles were identified. Since multiple Mafa-B alleles were found in each individual, it was strongly suggested that the cynom...

journal_title：Immunogenetics

authors： Uda A,Tanabayashi K,Fujita O,Hotta A,Terao K,Yamada A

更新日期：2005-05-01 00:00:00

abstract：:Virus-specific CD8(+) T cells play an important role in controlling HIV/SIV replication. These T cells recognize intracellular pathogen-derived peptides displayed on the cell surface by individual MHC class I molecules. In the SIV-infected rhesus macaque model, five Mamu class I alleles have been thoroughly characteri...

journal_title：Immunogenetics

authors： Reed JS,Sidney J,Piaskowski SM,Glidden CE,León EJ,Burwitz BJ,Kolar HL,Eernisse CM,Furlott JR,Maness NJ,Walsh AD,Rudersdorf RA,Bardet W,McMurtrey CP,O'Connor DH,Hildebrand WH,Sette A,Watkins DI,Wilson NA

更新日期：2011-12-01 00:00:00

abstract：:Class II genes of the human major histocompatibility complex (MHC) are polymorphic. Allelic variation of the coding region of these genes is involved in the antigen presentation and is associated with susceptibility to certain autoimmune diseases. The DR region is unique among human class II regions in that multiple D...

journal_title：Immunogenetics

authors： Louis P,Eliaou JF,Kerlan-Candon S,Pinet V,Vincent R,Clot J

更新日期：1993-01-01 00:00:00

abstract：:To determine the nucleotide polymorphism of activating killer-cell immunoglobulin-like receptors (aKIR) 3DS1 and 2DS3, we developed a novel direct-sequencing method and analyzed DNA samples of 175 KIR3DS1(+) individuals and 72 KIR2DS3(+) individuals from the white population. The putative ligand-binding extracellular ...

journal_title：Immunogenetics

authors： Luo L,Du Z,Sharma SK,Cullen R,Spellman S,Reed EF,Rajalingam R

更新日期：2007-10-01 00:00:00

abstract：:An optimized alignment of related protein sequences helps to see their important shared features and to deduce their phylogenetic relationships. At low levels of sequence similarity, there are no suitable computer programs for making the best possible alignment. This review summarizes some guidelines for how in such i...

journal_title：Immunogenetics

authors： Dijkstra JM

更新日期：2021-01-29 00:00:00

abstract：:Observations have frequently been interpreted as showing that the helper T cells which collaborate with alloantigen-specific cytotoxic T-cell precursors can only recognize antigens encoded in the I region of the H-2 gene complex. An experimental system is described here that allows analysis of the recognition repertoi...

journal_title：Immunogenetics

authors： Pilarski LM,Wegmann TG

更新日期：1984-01-01 00:00:00

abstract：:We have reported that susceptibility to glucocorticoid- and phenytoin-induced cleft palate and glucocorticoid receptor levels in mice are influenced by the H-2 histocompatibility complex on chromosome 17. Phenytoin competes with glucocorticoids for the glucocorticoid receptor and inhibits production of prostaglandins ...

journal_title：Immunogenetics

authors： Gupta C,Katsumata M,Goldman AS

更新日期：1984-01-01 00:00:00

abstract：:The genetic control of natural resistance in vivo to four natural killer (NK) cell-resistant H-2 homozygous lymphoid tumor cell lines was investigated by following the survival and organ distribution of cells prelabeled with radioactive iododeoxyuridine. Backcross mice derived from DBA/2J and CBA/J parents were inject...

journal_title：Immunogenetics

authors： Carlson GA,Taylor BA,Marshall ST,Greenberg AH

更新日期：1984-01-01 00:00:00

abstract：:HLA-B and C are related class I genes which are believed to have arisen by duplication of a common ancestor. Previous study showed the presence of orthologues for both HLA-B and C in African apes but only for HLA-B in Asian apes. These observations suggested that the primate C locus evolved subsequent to the divergenc...

journal_title：Immunogenetics

authors： Adams EJ,Thomson G,Parham P

更新日期：1999-09-01 00:00:00

abstract：:The A15, L6, and S5.7(TAPA1) proteins are members of the transmembrane 4 superfamily (TM4SF). The A15 is expressed in immature human T cells and in the human brain. The MXS1(CCG-B7) gene which codes for A15 contains triplet nucleotide repeats which have been associated with neuropsychiatric diseases such as Huntington...

journal_title：Immunogenetics

authors： Virtaneva KI,Emi N,Marken JS,Aruffo A,Jones C,Spurr NK,Schröder JP

更新日期：1994-01-01 00:00:00

abstract：:The locus for human immunoglobulin heavy chain constant region genes (IgCH) is characterized by a significant frequency of deleted or duplicated haplotypes, due to unequal crossing-over events. Four types of deletions and one duplication have been reported so far. We describe here a molecular study of four cases of Ig...

journal_title：Immunogenetics

authors： Bottaro A,De Marchi M,De Lange G,Boccazzi C,Caldesi F,Gallina R,Carbonara AO

更新日期：1989-01-01 00:00:00

abstract：:Four cDNA probes for the human major histocompatibility complex (MHC) were used to investigate the sheep MHC, in conjunction with serological typing for ovine lymphocyte antigen (OLA). Lymphocytes from a family (two parents and five offspring) of Romanov sheep were subjected to genomic DNA digestion by the restriction...

journal_title：Immunogenetics

authors： Chardon P,Kirszenbaum M,Cullen PR,Geffrotin C,Auffray C,Strominger JL,Cohen D,Vaiman M

更新日期：1985-01-01 00:00:00

abstract：:The region inclusive of the thioester and the isotype-determining sites of the sheep C4 genes from a single animal was amplified by polymerase chain reaction (PCR). Two bands, at 880 base pairs (bp) and 1000 bp, were resolved by agarose gel electrophoresis. Four different clones were obtained for the 880 bp (type 1) p...

journal_title：Immunogenetics

authors： Ren XD,Dodds AW,Law SK

更新日期：1993-01-01 00:00:00

abstract：:Two new C57BL/6 H-2 mutants, B6.C-H-2bm13 and B6.C-H-2bm14 are described. They arose independently in C57BL/6 as spontaneous mutations of the gain and loss type. Complementation studies map the mutations in both bm13 and bm14 to the H-2Db gene. However, these two mutant strains are not identical, but occurred as indep...

journal_title：Immunogenetics

authors： Morgan GM,Dellos H,McKenzie IF,Melvold RW,Bailey DW

更新日期：1980-01-01 00:00:00

abstract：:Genomic copy number variants (CNVs) are a common, heritable source of inter-individual differences in genomic sequence. Their influence on phenotypic variability and their involvement in the pathogenesis of several common diseases is well established and the object of many current studies. In the course of examining C...

journal_title：Immunogenetics

authors： Schwienbacher C,De Grandi A,Fuchsberger C,Facheris MF,Svaldi M,Wjst M,Pramstaller PP,Hicks AA

更新日期：2010-08-01 00:00:00

abstract：:Immunogenicity for T cell-independent B-cell response assessed by splenic plaque-forming cell (PFC) response and cell-surface expression measured by laser flow cytometry of various class I H-2 antigens on mouse red blood cells (RBC) were compared. It was found that the order of magnitude of both immunogenicity and cel...

journal_title：Immunogenetics

authors： Nakashima I,Yoshida T,Yokochi T,Ohashi K,Nagase F,Isobe K,Hasegawa Y,Ando K,Inagi R

更新日期：1986-01-01 00:00:00

abstract：:The size of B-cell subsets appears to be under genetic control, but the mechanism of this regulation is unknown. By analyzing five congenic strains of mice that differ only in their H2 haplotype, we addressed the issue of whether the MHC genes are involved in the relative proportions of B-1a, B-1b and B-2 cells. Not o...

journal_title：Immunogenetics

authors： Pers JO,Jamin C,Lydyard PM,Charreire J,Youinou P

更新日期：2002-06-01 00:00:00

abstract：:The characterization of genes involved in the generation of the immune repertoire is an active area of research in lower vertebrate taxa. The recombination activating genes (RAG) have been shown to be essential for V (D) J recombination of T-cell antigen receptor (TCR) and immunoglobulin (Ig) genes, leading to the gen...

journal_title：Immunogenetics

authors： Hansen JD,Kaattari SL

更新日期：1995-01-01 00:00:00

abstract：:Human and mouse major histocompatibility complex class II beta chain alleles associated with predisposition to type I diabetes often encode a non-charged residue at position 57 rather than the negatively charged aspartate residue characteristic of non-susceptible haplotypes. The mechanism(s) whereby this polymorphism ...

journal_title：Immunogenetics

authors： Antoniou AN,Elliott J,Rosmarakis E,Dyson PJ

更新日期：1998-01-01 00:00:00

abstract：:MHC class II deficiency provokes a severe immunodeficiency characterized by a lack of antigen-specific immune response. In the absence of bone marrow transplantation (the only curative treatment), patients affected by this genetic recessive disease die in early childhood. However, others and we have recently described...

journal_title：Immunogenetics

authors： Prod'homme T,Dekel B,Barbieri G,Lisowska-Grospierre B,Katz R,Charron D,Alcaide-Loridan C,Pollack S

更新日期：2003-11-01 00:00:00

abstract：:The potential association between integration or deletion of mouse mammary tumor virus (MMTV) retroviral sequences and the appearance of non-H-2 histocompatibility (H) antigen mutations was investigated. Genomic blots from inbred strains carrying 22 loss, gain-loss, and gain mutations on the BALB/c and C57BL/6 backgro...

journal_title：Immunogenetics

authors： Colombo MP,Melvold RW,Wettstein PJ

更新日期：1987-01-01 00:00:00

abstract：:The immune capacity of young and adult axolotls (Ambystoma mexicanum) was evaluated by examining the combinatorial and junctional diversity of the VH chain. A large number of VDJ rearrangements isolated from 2.5-, 3.5-, 10-, and 24-month-old animals were sequenced. Six JH segments were identified with the canonical st...

journal_title：Immunogenetics

authors： Golub R,Fellah JS,Charlemagne J

更新日期：1997-01-01 00:00:00

abstract：:The major histocompatibility complex (MHC) class I-related molecule, MR1, presents vitamin B metabolites from bacteria and yeast to mucosal-associated invariant T (MAIT) cells. Despite the evolutionary conservation of MR1, we do not know whether different allele variants of MR1 exist within the nonhuman primate (NHP) ...

journal_title：Immunogenetics

authors： Ellis-Connell AL,Kannal NM,Balgeman AJ,O'Connor SL

更新日期：2019-02-01 00:00:00