The major histocompatibility complex of tassel-eared squirrels. I. Genetic diversity associated with Kaibab squirrels.

abstract：:Kinetics and family transmission of antigen-specific in vitro cell-mediated responses were investigated in 68, and serum-antibody responses to tetanus toxoid (TT) in 73 individuals from a total of 12 families. Proliferative responses to highly purified TT monomer were studied in 6- to 7-day lymphocyte cultures. The ef...

journal_title：Immunogenetics

authors： Ballet JJ,Rabian-Herzog C,Lathrop M,Bourge JF,Agrapart M,Drouet J,Lalouel JM,Dausset J

更新日期：1983-01-01 00:00:00

abstract：:Transcription of major histocompatibility complex class I genes is controlled by the class I regulatory complex in the 5' flanking region. To investigate the molecular basis of this region, we studied the polymorphism of the promoter of the HLA-B locus extending from the ATG transcription initiation signal to -284 bas...

journal_title：Immunogenetics

authors： Yao Z,Volgger A,Scholz S,Albert ED

更新日期：1995-01-01 00:00:00

abstract：:The single nucleotide polymorphism (SNP)-derived Epitope Prediction program (SNEP) is now available to the public. It predicts minor histocompatibility antigens (miHAgs), which are T-cell epitopes containing polymorphic spots, from proteins listed in the SWISS-PROT database. SNEP recognizes polymorphisms (termed VARIA...

journal_title：Immunogenetics

authors： Schuler MM,Dönnes P,Nastke MD,Kohlbacher O,Rammensee HG,Stevanovic S

更新日期：2005-12-01 00:00:00

abstract：:We report here the structure of cDNA clones encoding axolotl light chains of the lambda type. A single IGLC gene and eight different potential IGLV genes belonging to four different families were detected. The axolotl Cgamma domain has several residues or stretches of residues that are typically conserved in mammalian...

journal_title：Immunogenetics

authors： André S,Guillet F,Charlemagne J,Fellah JS

更新日期：2000-11-01 00:00:00

abstract：:The anti-HLA-DQ3 monoclonal antibodies (mAb) KS13, SO1, SO2, SO3, SO4, and SO5 recognize spatially close but distinct antigenic determinants, since they crossinhibit each other in their binding to HLA-DQ3 antigens, but do not share idiotopes recognized in their antigen combining site by syngeneic and anti-id antisera ...

journal_title：Immunogenetics

authors： Iwasaki Y,Takabatake H,Monestier M,Ferrone S

更新日期：1995-01-01 00:00:00

abstract：:Since the discovery of human leukocyte antigens (HLAs), the function of major histocompatibility complex (MHC) gene families in a wide range of diseases have been the subject of research for decades. In particular, the associations of autoimmune disorders to allelic variants and candidate genes encoding the MHC are we...

journal_title：Immunogenetics

authors： Al Naqbi H,Mawart A,Alshamsi J,Al Safar H,Tay GK

更新日期：2021-02-02 00:00:00

abstract：:The interleukin-1 gene family encodes a group of related proteins that exhibit a remarkable pleiotropy in the context of health and disease. The set of indispensable functions they control suggests that these genes should be found in all eukaryotic species. The ligands and receptors of this family have been primarily ...

journal_title：Immunogenetics

authors： Gibson MS,Kaiser P,Fife M

更新日期：2014-08-01 00:00:00

abstract：:A graft-vs-host reaction (GVHR) develops after major histocompatibility complex (MHC)-compatible bone marrow-transplantation. In the genetic combination studied, B10.D2 donor cells differed from those of (DBA/2 x B10.D2)F1 mice for multiple DBA/2 minor histocompatibility antigens (mHAg) and minor lymphocyte stimulatin...

journal_title：Immunogenetics

authors： Miconnet I,de la Selle V,Tucek C,Huchet R,Bonardelle D,Bruley-Rosset M

更新日期：1994-01-01 00:00:00

abstract：:Human cDNA probes for 21-hydroxylase (21-OH) and for complement component C4 are used on restriction digests of the members of several families with interesting supratypes. The presence of two Taq I fragments of 3.7 kb and 3.2 kb in size with a 21-OH probe is confirmed in most individuals who show no evidence of C4 de...

journal_title：Immunogenetics

authors： Garlepp MJ,Wilton AN,Dawkins RL,White PC

更新日期：1986-01-01 00:00:00

abstract：:The ability of local ultraviolet B (UVB) irradiation to impair the induction of dinitrofluorobenzene (DNFB)-specific contact hypersensitivity (CH) in mice has been shown to be genetically determined. We have explored the possibility that the mouse Tnfa and Lps loci are involved. We demonstrate that C3H/HeN (Lpsn) stra...

journal_title：Immunogenetics

authors： Yoshikawa T,Streilein JW

更新日期：1990-01-01 00:00:00

abstract：:The protein kinase, interferon-inducible double-stranded (ds)RNA-dependent activator (PRKRA) is a dsRNA-binding protein which activates a protein kinase participating in the antiviral activity of interferon. Our previous studies indicated that the nucleotide sequence encoding PRKRA, which appeared to be an intronless ...

journal_title：Immunogenetics

authors： Chida S,Hohjoh H,Hirai M,Tokunaga K

更新日期：2001-01-01 00:00:00

abstract：:We analyzed the genetic regulation of spontaneous autoimmune thyroiditis (SAT) by means of crosses between Obese strain (OS) chickens with the disease, and healthy inbred chicken of line CB. Mononuclear cell infiltration of the thyroid was used as a criterion for the disease. We confirmed the existence of one recessiv...

journal_title：Immunogenetics

authors： Vasícek D,Vasícková K,Kaiser P,Drozenová R,Cítek J,Hala K

更新日期：2001-12-01 00:00:00

abstract：:Zaïre ebolavirus (ZEBOV) infection rapidly outruns the host's immunity and leads to death within a week. Fatal cases have been associated with an aberrant innate, proinflammatory immune response followed by a suppressed adaptive response leading to the rapid depletion of peripheral NK cells and lymphocytes. A critical...

journal_title：Immunogenetics

authors： Wauquier N,Padilla C,Becquart P,Leroy E,Vieillard V

更新日期：2010-12-01 00:00:00

abstract：:Leukocyte immunoglobulin-like receptor (LILR)B3 and LILRA6 represent a pair of inhibitory/activating receptors with identical extracellular domains and unknown ligands. LILRB3 can mediate inhibitory signaling via immunoreceptor tyrosine-based inhibition motifs in its cytoplasmic tail whereas LILRA6 can signal through ...

journal_title：Immunogenetics

authors： Bashirova AA,Apps R,Vince N,Mochalova Y,Yu XG,Carrington M

更新日期：2014-01-01 00:00:00

abstract：:Human IgG receptors (FcgammaR) display considerable heterogeneity, and are crucial immune response modulating molecules. FcgammaRIIA, FcgammaRIIIA, and FcgammaRIIIB display functional biallelic polymorphisms. FcgammaR polymorphisms have been found associated with susceptibility to infectious and autoimmune diseases. L...

journal_title：Immunogenetics

authors： van der Pol WL,Jansen MD,Sluiter WJ,van de Sluis B,Leppers-van de Straat FG,Kobayashi T,Westendorp RG,Huizinga TW,van de Winkel JG

更新日期：2003-07-01 00:00:00

abstract：:A mouse monoclonal antibody, Mo. Ab. 108.45, detecting cell-surface determinants associated with the T-cell receptor for alloantigen was produced by immunizing mice with an alloreactive human T-cell clone and fusing the splenocytes with the NS1 plasmocytoma. This Mo. Ab. reacts with the immunizing T-cell clone but not...

journal_title：Immunogenetics

authors： Haars R,Rohowsky-Kochan C,Reed E,King DW,Suciu-Foca N

更新日期：1984-01-01 00:00:00

abstract：:The present experiments were performed to study whether the genes responsible for the expression of T-idiotypes and allotypes could be mapped in relation to immunoglobulin (Ig) heavy chain V- and C-genes. Use was made of our antiserum 5936, which detects idiotypes in B6 and anti-B10.BR sera and on Lyt-1+, 2.3-B6 anti-...

journal_title：Immunogenetics

authors： Suzan M,Valsted F,Boned A,Rubin B

更新日期：1982-01-01 00:00:00

abstract：:TAP1 and TAP2 are two major histocompatibility complex (MHC) genes, located between HLA-DP and -DQ, whose products form a transporter molecule involved in endogenous antigen processing. Polymorphic residues have been described in both genes and, in this study, we have identified another polymorphic site within the ade...

journal_title：Immunogenetics

authors： Powis SH,Tonks S,Mockridge I,Kelly AP,Bodmer JG,Trowsdale J

更新日期：1993-01-01 00:00:00

abstract：:The human Lutheran (Lu) blood group antigens are carried by two glycoproteins (gps) that belong to the immunoglobulin (Ig) superfamily. These gps represent adhesion molecules that function as the unique erythroid receptors for laminin. We report here the cloning and functional expression of the orthologous mouse Lu mR...

journal_title：Immunogenetics

authors： Rahuel C,Colin Y,Goossens D,Gane P,El Nemer W,Cartron JP,Le Van Kim C

更新日期：1999-12-01 00:00:00

abstract：:To search for host genes for resistance/susceptibility to cancer metastasis, mutation analysis was employed. Ten putative mutants of resistance to lymphoma EL4 and four putative mutants of resistance to sarcoma MCA/77-23 of C57BL/6J (B6) mice were produced. These mutants were designated S (for "survivor") mutants; the...

journal_title：Immunogenetics

authors： Egorov OS,Liu Y,Sargent EE,Drizlikh GI,Egorov IK

更新日期：1992-01-01 00:00:00

abstract：:Using mouse bone marrow-derived macrophages we determined the role of interferon (IFN)-gamma at the different steps in expression of the I-A alpha chain of MHC class II molecules, from transcription to the cell surface. Levels of transcription, RNA, and protein were low in cells not stimulated with IFN-gamma. Treatmen...

journal_title：Immunogenetics

authors： Cullell-Young M,Barrachina M,López-López C,Goñalons E,Lloberas J,Soler C,Celada A

更新日期：2001-03-01 00:00:00

abstract：:The N-terminal domain of the chemokine CCL5/regulated upon activation normal T cell expressed and secreted (RANTES) has been shown to be critical for its biological activity on leukocytes. Several N-terminus-modified CCL5/RANTES derivatives, such as N-Terminal truncated CCL5/RANTES, Met-RANTES, and amino-oxypentane (A...

journal_title：Immunogenetics

authors： Capoulade-Métay C,Ayouba A,Kfutwah A,Lole K,Pêtres S,Dudoit Y,Deterre P,Menu E,Barré-Sinoussi F,Debré P,Theodorou I

更新日期：2006-07-01 00:00:00

abstract：:In a series of newly isolated AKR leukemias, some tumors expressed large amounts of both H-2K and H-2D molecules, while others had reduced levels of both antigens. The number of H-2 antigens expressed in steady state showed a consistent correlation with the rate of synthesis of the H-2 class I heavy chain and the beta...

journal_title：Immunogenetics

authors： Schmidt W,Henseling U,Bevec D,Alonzo AD,Festenstein H

更新日期：1985-01-01 00:00:00

abstract：:Apoptosis has been suggested as a major mechanism for the CD4(+) T-lymphocyte depletion observed in patients infected with human immunodeficiency virus 1 (HIV-1). To evaluate the impact of genetic variations to apoptosis during progression of acquired immunodeficiency syndrome (AIDS), we have performed an extensive ge...

journal_title：Immunogenetics

authors： Vasilescu A,Heath SC,Diop G,Do H,Hirtzig T,Hendel H,Bertin-Maghit S,Rappaport J,Therwath A,Lathrop GM,Matsuda F,Zagury JF

更新日期：2004-04-01 00:00:00

abstract：:The polymorphic major histocompatibility complex (MHC) has gained a specific relevance in pathogen resistance and mate choice. Particularly the antigen-binding site (ABS), encoded by exon 2 of the DRB class II gene, exhibits numerous alleles and extensive sequence variations between alleles. A lack of MHC variability ...

journal_title：Immunogenetics

authors： Becker L,Nieberg C,Jahreis K,Peters E

更新日期：2009-04-01 00:00:00

abstract：:Many immunoglobulin variable region (IgV) genes are present in the vertebrate genome and provide a basis for antibody diversity. IgV genes have been classified into distinct families according to DNA sequence similarity. Comparisons of VH and VL genes from two mammalian species (mouse and human) have led to the conclu...

journal_title：Immunogenetics

authors： Andersson E,Matsunaga T

更新日期：1995-01-01 00:00:00

abstract：:Complement is one of primary defense mechanisms against intravascular microorganisms and could play a role in the immune response to malignancy and hence its clinical behavior. We evaluated if the sole coding polymorphism of C1qA associates with outcome in patients with breast carcinoma. Genotyping for C1qA[276A/G] wa...

journal_title：Immunogenetics

authors： Racila E,Racila DM,Ritchie JM,Taylor C,Dahle C,Weiner GJ

更新日期：2006-02-01 00:00:00

abstract：:The major histocompatibility complex (MHC) includes highly polymorphic gene families encoding proteins crucial to the vertebrate acquired immune system. Classical MHC class I (MHCI) genes code for molecules expressed on the surfaces of most nucleated cells and are associated with defense against intracellular pathogen...

journal_title：Immunogenetics

authors： Buehler DM,Verkuil YI,Tavares ES,Baker AJ

更新日期：2013-03-01 00:00:00

abstract：:The cluster of differentiation 4 (CD4) molecule functions as a co-receptor for MHC class II binding to TCR in T helper cells. A CD4 epitope deficiency was identified in the swine MeLiM (melanoblastoma-bearing Libechov minipig) strain, a model for spontaneous cutaneous melanoma development and regression. Extensive seq...

journal_title：Immunogenetics

authors： Blanc F,Créchet F,Bruneau N,Piton G,Leplat JJ,Andréoletti F,Egidy G,Vincent-Naulleau S,Bourneuf E

更新日期：2018-04-01 00:00:00

abstract：:The mechanisms underlying Ir gene control of CMI were addressed by examining the DTH and Tprlf responses specific for the synthetic polymers GT, GAT, and GA. We show that BALB/c mice (GAT/GA responders, GT nonresponders) primed with GT fail to develop DTH and Tprlf responses specific for GT, GAT, or GA. GAT immunizati...

journal_title：Immunogenetics

authors： Kennedy MK,Jenkins MK,Miller SD

更新日期：1986-01-01 00:00:00