Abstract:
:The polymorphic major histocompatibility complex (MHC) has gained a specific relevance in pathogen resistance and mate choice. Particularly the antigen-binding site (ABS), encoded by exon 2 of the DRB class II gene, exhibits numerous alleles and extensive sequence variations between alleles. A lack of MHC variability has attributed to instances such as bottleneck effects or relaxed selection pressure and has a certain impact on the long-term viability of the species concerned. As a result of seriously decreased population density during the last century, the current population of the endangered European mink (Mustela lutreola, L. 1761) has suffered from geographic isolation. In this study, we amplified a partial sequence of the MHC class II DRB exon 2 (229 bp), assessed the degree of genetic variation and compared the variability with those of other Mustelidae. As a result, nine alleles were detected in 20 investigated individuals, which differ from each other by four to 25 nucleotide substitutions (two to 11 amino acid substitutions). Whilst an equal ratio for synonymous and non-synonymous substitutions was found inside the ABS, synonymous substitutions were significantly higher than non-synonymous substitutions in the non-ABS region. Results might indicate that no positive selection exists within the ex situ population of M. lutreola, at least in the analysed fragment. In addition, phylogenetic analyses support the trans-species model of evolution.
journal_name
Immunogeneticsjournal_title
Immunogeneticsauthors
Becker L,Nieberg C,Jahreis K,Peters Edoi
10.1007/s00251-009-0362-2subject
Has Abstractpub_date
2009-04-01 00:00:00pages
281-8issue
4eissn
0093-7711issn
1432-1211journal_volume
61pub_type
杂志文章相关文献
IMMUNOGENETICS文献大全abstract::Macaques are the most widely used experimental nonhuman primate (NHP) species. Rhesus (Macaca mulatta, Macmul), cynomolgus (Macaca fascicularis, Macfas), and pigtail (Macaca nemestrina, Macnem) macaques continue to be popular models for vaccine and infectious diseases research, especially HIV infection and AIDS, and f...
journal_title:Immunogenetics
pub_type: 杂志文章
doi:10.1007/s00251-014-0775-4
更新日期:2014-06-01 00:00:00
abstract::The mouse Fcgr1 gene encoding the high-affinity IgG receptor (FcgammaRI) exists as two known alleles, FcgammaRI-BALB and FcgammaRI-NOD, and these alleles exhibit functional differences. To determine whether other alleles exist in mouse strains, Fcgr1 coding regions from 35 strains of mice were sequenced and a further ...
journal_title:Immunogenetics
pub_type: 杂志文章
doi:10.1007/s002510050033
更新日期:2000-03-01 00:00:00
abstract::Control of HIV-1 viremia and progression to AIDS has been associated with specific HLA genes. The tumor necrosis factor ( TNF) and the non-classical major histocompatibility (MHC) class I chain-related A ( MICA) genes are located in the genomic segment between the HLA class I and II genes and variants of both genes ha...
journal_title:Immunogenetics
pub_type: 杂志文章
doi:10.1007/s00251-003-0604-7
更新日期:2003-10-01 00:00:00
abstract::Chickens of the Iowa State S1 line have been selected for ability to regress Rous sarcoma virus-induced (RSV) tumors, humoral immune response to GAT (Ir-GAT), and erythrocyte antigen B. Sublines homozygous at the major histocompatibility complex (MHC), as well as F1 heterozygotes and F2 segregants, were tested for res...
journal_title:Immunogenetics
pub_type: 杂志文章
doi:10.1007/BF00404420
更新日期:1987-01-01 00:00:00
abstract::Genes of the major histocompatibility complex (MHC) have been characterized in all extant lineages of mammals. The tammar wallaby (Macropus eugenii) is well established as a model marsupial species; however, no classical MHC sequences have been described from this species. We have isolated two MHC class II beta-chain ...
journal_title:Immunogenetics
pub_type: 杂志文章
doi:10.1007/s00251-004-0644-7
更新日期:2004-02-01 00:00:00
abstract::The recent identification of a large and diverse family of leukocyte immune-type receptors (IpLITRs) in channel catfish (Ictalurus punctatus) indicates that immunoglobulin superfamily (IgSF) members related to both mammalian Fc receptors (FcRs) and leukocyte receptor complex (LRC)-encoded proteins exist in fish. In th...
journal_title:Immunogenetics
pub_type: 杂志文章
doi:10.1007/s00251-006-0169-3
更新日期:2007-01-01 00:00:00
abstract::Here we describe the Immunogenetic Management Software (IMS) system, a novel web-based application that permits multiplexed analysis of complex immunogenetic traits that are necessary for the accurate planning and execution of experiments involving large animal models, including nonhuman primates. IMS is capable of ho...
journal_title:Immunogenetics
pub_type: 杂志文章
doi:10.1007/s00251-011-0587-8
更新日期:2012-04-01 00:00:00
abstract::Rearrangements of the immunoglobulin heavy chain joining region (JH) genes occur in some T lymphocytes, probably because the mechanism for assembly of T-cell receptor encoded genes is very similar to that for immunoglobulins. Two such rearrangements described previously represented proper fusion of a DH and JH gene. W...
journal_title:Immunogenetics
pub_type: 杂志文章
doi:10.1007/BF00345502
更新日期:1988-01-01 00:00:00
abstract::Severe combined immune deficiency (scid) mice are assumed to have two types of abnormalities: one is high radiosensitivity and the other is abnormal recombination in immunoglobulin and T-cell receptor genes. The human chromosome 8 q1.1 region has an ability to complement the scid aberrations. Moreover, the localizatio...
journal_title:Immunogenetics
pub_type: 杂志文章
doi:10.1007/s002510050159
更新日期:1996-01-01 00:00:00
abstract::The human T-cell receptor gamma (TCRG) locus comprises 14 variable genes (TRGV), five joining segments (TRGJ), and two constant region genes (TRGC). The constant gamma 1 gene, TRGC1, consists of three exons, whereas the TRGC2 gene contains four or five exons due to the duplication or triplication of exon 2 and spans 9...
journal_title:Immunogenetics
pub_type: 杂志文章
doi:10.1007/BF00373641
更新日期:1989-01-01 00:00:00
abstract::The inbred strain STS/A exhibits a higher proliferative response in the mixed lymphocyte culture (MLC) to stimulator cells of all 11 tested inbred mouse strains with 10 different major histocompatibility complex (MHC) haplotypes, as well as to stimulation with IL-2 than does the strain BALB/cHeA. However, alloantigen-...
journal_title:Immunogenetics
pub_type: 杂志文章
doi:10.1007/BF02602654
更新日期:1996-01-01 00:00:00
abstract::The evolution of the mouse immunoglobulin heavy chain variable region (Igh-V) locus was investigated by the comprehensive analysis of variable region (Vh) gene family content and restriction fragment polymorphism in the genus Mus. The examination of natural Mus domesticus populations suggests an important role for rec...
journal_title:Immunogenetics
pub_type: 杂志文章
doi:10.1007/BF02425271
更新日期:1989-01-01 00:00:00
abstract::The H-2K glycoprotein from the MHC mutant bm10 was analyzed biochemically to determine where primary structural differences distinguished it from the parental standard molecule, Kb. Comparative peptide maps showed differences in two peptides known to be part of the parental CNBr fragment spanning amino acids 139 to 22...
journal_title:Immunogenetics
pub_type: 杂志文章
doi:10.1007/BF00364285
更新日期:1983-01-01 00:00:00
abstract::On a B10 (Lshs) genetic background the development of acquired T-cell-mediated immunity to Leishmania donovani infection in mice is under H-2-linked genetic control. Three phenotypic patterns of recovery were previously observed: "early cure" (H-2s, H-2r), "cure" (H-2b) and "noncure" (H-2d, H-2q, H-2f), with cure beha...
journal_title:Immunogenetics
pub_type: 杂志文章
doi:10.1007/BF00368537
更新日期:1983-01-01 00:00:00
abstract::TL antigens are class I glycoproteins which are expressed on thymocytes and which are coded by the Tla region of the major histocompatibility complex of the mouse. Biochemical analysis of TL molecules from different strains of mice revealed structural variation determined by the Tla region which is detectable by pepti...
journal_title:Immunogenetics
pub_type: 杂志文章
doi:10.1007/BF00373117
更新日期:1986-01-01 00:00:00
abstract::The immune response to bovine insulin (BI) in the rat is controlled by the major histocompatibility complex (Mhc)-linked immune response gene (Ir-BI) and immune suppression gene (Is-BI). In the present study, we investigated the low responsiveness to BI in the WKAH rat (RT1k) and attempted to explore the functional li...
journal_title:Immunogenetics
pub_type: 杂志文章
doi:10.1007/BF00364426
更新日期:1988-01-01 00:00:00
abstract::The level of HLA-B27 transgene expression on the cell surface is dependent on the host H-2 haplotype. Mice homozygous for the H-2b, H-2f, H-2s, H-2p, H-2r, and H-2k haplotypes express B27 at high levels. An intermediate level of B27 expression is observed in H-2v mice whereas low levels of B27 are expressed in H-2q an...
journal_title:Immunogenetics
pub_type: 杂志文章
doi:10.1007/BF00185114
更新日期:1992-01-01 00:00:00
abstract::Avian influenza is a serious threat to the poultry industry and, as the potential source of a human pandemic virus, to public health. Different Mx alleles have been reported to confer resistance or susceptibility to influenza virus replication, and so knowledge of their frequencies is important when considering the po...
journal_title:Immunogenetics
pub_type: 杂志文章
doi:10.1007/s00251-007-0235-5
更新日期:2007-08-01 00:00:00
abstract::Codon bias and base composition in major histocompatibility complex (MHC) sequences have been studied for both class I and II loci in Homo sapiens and Pan troglodytes. There is low to moderate codon bias for the MHC of humans and chimpanzees. In the class I loci, the same level of moderate codon bias is seen for HLA-B...
journal_title:Immunogenetics
pub_type: 杂志文章
doi:10.1007/s002510050493
更新日期:1999-04-01 00:00:00
abstract::Determining the genomic organization of the Ovis aries (Ovar) major histocompatibility complex class IIa region is essential for future functional studies related to antigen presentation. In this study, a bacterial artificial chromosome (BAC) library of genomic DNA from peripheral blood leukocytes (PBL) of a Rambouill...
journal_title:Immunogenetics
pub_type: 杂志文章
doi:10.1007/s00251-008-0275-5
更新日期:2008-04-01 00:00:00
abstract::Human and mouse major histocompatibility complex class II beta chain alleles associated with predisposition to type I diabetes often encode a non-charged residue at position 57 rather than the negatively charged aspartate residue characteristic of non-susceptible haplotypes. The mechanism(s) whereby this polymorphism ...
journal_title:Immunogenetics
pub_type: 杂志文章
doi:10.1007/s002510050351
更新日期:1998-01-01 00:00:00
abstract::Cattle in Africa are a genetically diverse population that has resulted from successive introduction of Asian Bos indicus and European B. taurus cattle. However, analysis of mitochondrial genetic diversity in African cattle identified three lineages, one associated with Asian B. indicus, one with European B. taurus, a...
journal_title:Immunogenetics
pub_type: 杂志文章
doi:10.1007/s002510000276
更新日期:2001-01-01 00:00:00
abstract::We report here the structure of cDNA clones encoding axolotl light chains of the lambda type. A single IGLC gene and eight different potential IGLV genes belonging to four different families were detected. The axolotl Cgamma domain has several residues or stretches of residues that are typically conserved in mammalian...
journal_title:Immunogenetics
pub_type: 杂志文章
doi:10.1007/s002510000264
更新日期:2000-11-01 00:00:00
abstract::Almost 10,000 single nucleotide polymorphisms (SNPs) had been identified in the RT1 complex, the major histocompatibility complex of the rat, but less than approximately 0.5% have been characterized. In the context of the incomplete characterization of most SNPs, simple sequence length polymorphism (SSLP) marker devel...
journal_title:Immunogenetics
pub_type: 杂志文章
doi:10.1007/s00251-008-0352-9
更新日期:2009-03-01 00:00:00
abstract::An H-2-restricted graft-versus-host reaction can be demonstrated when irradiated bone marrow-protected recipients receive injections of cells from radiation chimeras. The cells responsible are Thy-1-positive, thymus-dependent, radiation-sensitive and pass through a nylon wool column, i.e., they are T cells. Treatment ...
journal_title:Immunogenetics
pub_type: 杂志文章
doi:10.1007/BF00364767
更新日期:1984-01-01 00:00:00
abstract::Immunofluorescent and immunoelectron-microscopic staining methods were utilized to investigate the localization of Ia antigens in murine keratinizing epithelia. Approximately 3-5% of epidermal cells were shown to be Ia positive. Only dendritic Langerhans cells in the interfollicular epidermis and outer root sheaths we...
journal_title:Immunogenetics
pub_type: 杂志文章
doi:10.1007/BF01844036
更新日期:1978-12-01 00:00:00
abstract::With the use of monospecific rabbit anti-G protein and mouse monoclonal anti-H-2Kk, we have analyzed the spatial relationship of the serologically defined H-2Kk antigens and the major surface glycoprotein (G protein) of vesicular stomatitis virus (VSV) to those antigens recognized by B10.A (k, d) anti-VSV cytotoxic T ...
journal_title:Immunogenetics
pub_type: 杂志文章
doi:10.1007/BF01572582
更新日期:1980-01-01 00:00:00
abstract::An I-J-subregion controlled determinant is expressed on Ly-1 inducer and Ly-1,2 acceptor T cells in the feedback suppression circuit. Ly-1 T cells absorb the I-J antibody reactive with the Ly-1,2 acceptor T cell, suggesting that both inducer and acceptor T cells have the same I-J determinant. Since less than 10 percen...
journal_title:Immunogenetics
pub_type: 杂志文章
doi:10.1007/BF01567824
更新日期:1980-01-01 00:00:00
abstract::The common fruit fly Drosophila melanogaster is a powerful model for studying signaling pathway regulation. Conserved signaling pathways underlying physiological processes signify evolutionary relationship between organisms and the nature of the mechanisms they control. This study explores the cross-talk between the w...
journal_title:Immunogenetics
pub_type: 杂志文章
doi:10.1007/s00251-019-01119-8
更新日期:2019-07-01 00:00:00
abstract::Despite matching donors and recipients for the human leukocyte antigens (HLAs) expressed by the major histocompatibility genomic region of the short arm of chromosome 6, several recipients still develop acute graft-versus-host disease (aGVHD) after bone marrow transplantation (BMT). This is possibly due to non-HLA gen...
journal_title:Immunogenetics
pub_type: 杂志文章
doi:10.1007/s00251-006-0186-2
更新日期:2007-02-01 00:00:00