Lyb-8.2: A new B cell antigen defined and characterized with a monoclonal antibody.

abstract：:The interleukin-1 gene family encodes a group of related proteins that exhibit a remarkable pleiotropy in the context of health and disease. The set of indispensable functions they control suggests that these genes should be found in all eukaryotic species. The ligands and receptors of this family have been primarily ...

journal_title：Immunogenetics

authors： Gibson MS,Kaiser P,Fife M

更新日期：2014-08-01 00:00:00

abstract：:Human leukocyte antigen (HLA)-E molecules are potent inhibitors of NK cell-mediated killing. Low in polymorphisms, two alleles are widely expressed among diverse populations: HLA-E*01:01 and HLA-E*01:03. Both alleles are distinguished by one SNP resulting in the substitution Arg107Gly. Both alleles present a limited s...

journal_title：Immunogenetics

authors： Celik AA,Kraemer T,Huyton T,Blasczyk R,Bade-Döding C

更新日期：2016-01-01 00:00:00

abstract：:The strains BALB/cHeA (BALB/c) and STS/A (STS) differ in production of IL-4 and IL-10, two Th2 cytokines, after stimulation of spleen cells with Concanavalin A, STS being a low and BALB/c a high producer. We analyzed the genetic basis of this strain difference using the recombinant congenic (RC) strains of the BALB/c-...

journal_title：Immunogenetics

authors： Kosarová M,Havelková H,Krulová M,Demant P,Lipoldová M

更新日期：1999-02-01 00:00:00

abstract：:As the only native insular Newfoundland canid between the extinction of the wolf in the 1930s and the recent arrival of coyotes, the red fox (Vulpes vulpes deletrix Bangs 1898) poses interesting questions about genetic distinctiveness and the post-glacial colonization history of the island's depauperate mammalian faun...

journal_title：Immunogenetics

authors： Marshall HD,Langille BL,Hann CA,Whitney HG

更新日期：2016-05-01 00:00:00

abstract：:The level of HLA-B27 transgene expression on the cell surface is dependent on the host H-2 haplotype. Mice homozygous for the H-2b, H-2f, H-2s, H-2p, H-2r, and H-2k haplotypes express B27 at high levels. An intermediate level of B27 expression is observed in H-2v mice whereas low levels of B27 are expressed in H-2q an...

journal_title：Immunogenetics

authors： Nickerson-Nutter CL,Hogen KL,David CS

更新日期：1992-01-01 00:00:00

abstract：:The genealogy of 14 H-2Kb mutations arising spontaneously in the C57BL/6Kh colony is presented together with data from skin-graft monitoring and husbandry procedures. Eight of the 14 mutations have phenotypic and structural similarities, but the pedigree analysis and evaluation of the histocompatibility genetics of th...

journal_title：Immunogenetics

authors： Melvold RW,Kohn HI,Dunn GR

更新日期：1982-01-01 00:00:00

abstract：:The presentation of identical peptides by different major histocompatibility complex class I (MHC-I) molecules, termed promiscuity, is a controversial feature of T cell-mediated immunity to pathogens. The astounding diversity of MHC-I molecules in human populations, presumably to enable binding of equally diverse pept...

journal_title：Immunogenetics

authors： Maness NJ,Walsh AD,Rudersdorf RA,Erickson PA,Piaskowski SM,Wilson NA,Watkins DI

更新日期：2011-09-01 00:00:00

abstract：:Human Ia(-like) specificities controlled by gene loci other than HLA-DR were searched for at the molecular level in cells of human B-cell-type cell lines which carry two established DR specificities. Chevalier cells of DRw3 and 7 and U698M cells of DRw2 and 4 were used. Their Ia molecules were partially purified, radi...

journal_title：Immunogenetics

authors： Tanigaki N,Tosi R,Pressman D,Ferrara GB

更新日期：1980-01-01 00:00:00

abstract：:Transcription of major histocompatibility complex class I genes is controlled by the class I regulatory complex in the 5' flanking region. To investigate the molecular basis of this region, we studied the polymorphism of the promoter of the HLA-B locus extending from the ATG transcription initiation signal to -284 bas...

journal_title：Immunogenetics

authors： Yao Z,Volgger A,Scholz S,Albert ED

更新日期：1995-01-01 00:00:00

abstract：:In a series of newly isolated AKR leukemias, some tumors expressed large amounts of both H-2K and H-2D molecules, while others had reduced levels of both antigens. The number of H-2 antigens expressed in steady state showed a consistent correlation with the rate of synthesis of the H-2 class I heavy chain and the beta...

journal_title：Immunogenetics

authors： Schmidt W,Henseling U,Bevec D,Alonzo AD,Festenstein H

更新日期：1985-01-01 00:00:00

abstract：:The H-2K glycoprotein from the MHC mutant bm10 was analyzed biochemically to determine where primary structural differences distinguished it from the parental standard molecule, Kb. Comparative peptide maps showed differences in two peptides known to be part of the parental CNBr fragment spanning amino acids 139 to 22...

journal_title：Immunogenetics

authors： Pease LR,Ewenstein BM,McGovern D,Melvold RW,Nisizawa T,Nathenson SG

更新日期：1983-01-01 00:00:00

abstract：:The mouse Fcgr1 gene encoding the high-affinity IgG receptor (FcgammaRI) exists as two known alleles, FcgammaRI-BALB and FcgammaRI-NOD, and these alleles exhibit functional differences. To determine whether other alleles exist in mouse strains, Fcgr1 coding regions from 35 strains of mice were sequenced and a further ...

journal_title：Immunogenetics

authors： Gavin AL,Leiter EH,Hogarth PM

更新日期：2000-03-01 00:00:00

abstract：:Mutants of the EB virus-transformed cell line T5-1 (HLA-A1, 2; B8, 27), bearing well-characterized alterations in HLA-A2 antigen expression and unable to bind the HLA-A2-specific monoclonal antibody BB7.2, have been tested for their susceptibility to EB virus-specific cytolysis using effector T-cell preparations funct...

journal_title：Immunogenetics

authors： Gaston JS,Wallace LE,Rickinson AB,Epstein MA,Pious D

更新日期：1984-01-01 00:00:00

abstract：:Described here is a new, more efficient method for defining major histocompatibility complex-Y (MHC-Y) genotypes in chickens. The MHC-Y region is genetically independent from the classical MHC (MHC-B) region. MHC-Y is highly polymorphic and potentially important in the genetics of disease resistance. MHC-Y haplotypes ...

journal_title：Immunogenetics

authors： Zhang J,Goto RM,Miller MM

更新日期：2020-07-01 00:00:00

abstract：:Two proteasome activators PA28alpha and beta, which have been implicated in antigen processing for loading class I MHC molecules, are synthesized in response to Ifn-gamma. The human genes encoding these activators (PSME1 and PSME2, respectively) were analyzed by sequencing. Each gene comprised 11 exons, consistent wit...

journal_title：Immunogenetics

authors： McCusker D,Wilson M,Trowsdale J

更新日期：1999-05-01 00:00:00

abstract：:Among the genes with the highest allelic polymorphism and sequence diversity are those encoding the classical class I and class II molecules of the major histocompatibility complex (MHC). Although many thousands of MHC sequences have been deposited in general sequence databases like GenBank, the availability of curate...

journal_title：Immunogenetics

authors： Afrache H,Tregaskes CA,Kaufman J

更新日期：2020-02-01 00:00:00

abstract：:Killer cell immunoglobulin-like receptors (KIRs) represent the most polymorphic genes responsible for natural killer cell function, while human leukocyte antigen (HLA) class I molecules define and restrict cytotoxic T lymphocyte responses. Specific KIR, HLA, or KIR-HLA combinations have been implicated in the outcome ...

journal_title：Immunogenetics

authors： Garrido-Rodríguez D,Ávila-Ríos S,García-Morales C,Valenzuela-Ponce H,Ormsby C,Reyes-Gopar H,Fernandez-Lopez JC,Reyes-Terán G

更新日期：2016-10-01 00:00:00

abstract：:Cichlid fishes of the East African Rift Valley lakes constitute an important model of adaptive radiation. Explosive speciation in the Great Lakes, in some cases as recently as 12 400 years ago, generated large species flocks that have been the focus of evolutionary studies for some time. The studies have, however, bee...

journal_title：Immunogenetics

authors： Sato A,Klein D,Sültmann H,Figueroa F,O'hUigin C,Klein J

更新日期：1997-01-01 00:00:00

abstract：:Mouse Ly6A and Ly6C cDNA probes were hybridized to total RNA of rat tissues and, as in mouse, the highest level of Ly6-related transcripts was detected in kidney. Therefore, Ly6-related cDNA clones were isolated from a commercial rat kidney cDNA library in lambda gt11. Four of these (RK3, RK6, RK10, and RK11) have bee...

journal_title：Immunogenetics

authors： Friedman S,Palfree RG,Sirlin S,Hämmerling U

更新日期：1990-01-01 00:00:00

abstract：:In three families with an apparent non-expressed factor B (BF) allele (BF*Q0), advanced methods of isoelectric focusing for the determination of BF F subtypes revealed different hypomorphic BF products (BF QL) with functional hemolytic activity expressed by the assumed BF*Q0 allele. A Taq I and a Msp I restriction fra...

journal_title：Immunogenetics

authors： Siemens I,Brenden M,Mauff G,Abbal M,Du Toit E,Bertrams J,Geserick G

更新日期：1992-01-01 00:00:00

abstract：:Human cDNA probes for 21-hydroxylase (21-OH) and for complement component C4 are used on restriction digests of the members of several families with interesting supratypes. The presence of two Taq I fragments of 3.7 kb and 3.2 kb in size with a 21-OH probe is confirmed in most individuals who show no evidence of C4 de...

journal_title：Immunogenetics

authors： Garlepp MJ,Wilton AN,Dawkins RL,White PC

更新日期：1986-01-01 00:00:00

abstract：:We describe a bioinformatic analysis of germline and rearranged immunoglobulin kappa chain (IGK) gene sequences, performed in order to assess the completeness and reliability of the reported IGK repertoire. In contrast to the reported heavy-chain gene repertoire, which includes many dubious sequences, only five IGK va...

journal_title：Immunogenetics

authors： Collins AM,Wang Y,Singh V,Yu P,Jackson KJ,Sewell WA

更新日期：2008-11-01 00:00:00

abstract：:The polymorphism of exon 2 of the DAB genes (major histocompatibility complex [MHC] class IIB) was investigated for the first time in the freshwater cyprinid fish species, Squalius cephalus, in the wide range of its distribution in Europe. We identified 111 different MHC class IIB variants in 15 chub populations distr...

journal_title：Immunogenetics

authors： Seifertová M,Simková A

更新日期：2011-03-01 00:00:00

abstract：:In the absence of suitable rodent animal models for Plasmodium falciparum malaria, the efficacy testing of asexual blood-stage vaccine candidates in Aotus nancymaae represents a tool to select between different formulations before conducting expensive human clinical trials. CpG oligonucleotides (ODN) specifically prom...

journal_title：Immunogenetics

authors： Spirig R,Peduzzi E,Patarroyo ME,Pluschke G,Daubenberger CA

更新日期：2005-05-01 00:00:00

abstract：:Using the fluorescence-activated cell sorter (FACS II), we have analyzed the expression of H-2K- and H-2D-gene products on the membrane of various cellular components of the murine immune system. Using this serological technique we show a basic difference between T and B lymphocytes. Whereas all cellular components an...

journal_title：Immunogenetics

authors： Tartakovsky B,De Baetselier P,Segal S

更新日期：1980-01-01 00:00:00

abstract：:The region inclusive of the thioester and the isotype-determining sites of the sheep C4 genes from a single animal was amplified by polymerase chain reaction (PCR). Two bands, at 880 base pairs (bp) and 1000 bp, were resolved by agarose gel electrophoresis. Four different clones were obtained for the 880 bp (type 1) p...

journal_title：Immunogenetics

authors： Ren XD,Dodds AW,Law SK

更新日期：1993-01-01 00:00:00

abstract：:We have performed an extensive analysis of Th1/Th2 cytokine receptors IL2Ralpha, IL4Ralpha, IL10Ralpha, and IFNgammaR1 gene polymorphisms to evaluate their impact on AIDS progression. The coding regions and promoters of these genes were sequenced in the genetics of resistance to immunodeficiency virus cohort, composed...

journal_title：Immunogenetics

authors： Do H,Vasilescu A,Diop G,Hirtzig T,Coulonges C,Labib T,Heath SC,Spadoni JL,Therwath A,Lathrop M,Matsuda F,Zagury JF

更新日期：2006-04-01 00:00:00

abstract：:Cosmid clones containing T-cell receptor Tcra V2 subfamily gene segments have been isolated from a BALB/c cosmid library and subjected to DNA sequence analysis. The V gene segments in the Tcra V2 subfamily differ from each other by 3%-7% at the nucleotide level and 5%-16% at the amino acid level. T-cell receptor Tcra ...

journal_title：Immunogenetics

authors： Wang K,Kuo CL,Cheng KC,Lee MK,Paeper B,Koop BF,Yoo TJ,Hood L

更新日期：1994-01-01 00:00:00

abstract：:Here we describe the Immunogenetic Management Software (IMS) system, a novel web-based application that permits multiplexed analysis of complex immunogenetic traits that are necessary for the accurate planning and execution of experiments involving large animal models, including nonhuman primates. IMS is capable of ho...

journal_title：Immunogenetics

authors： Johnson ZP,Eady RD,Ahmad SF,Agravat S,Morris T,Else J,Lank SM,Wiseman RW,O'Connor DH,Penedo MC,Larsen CP,Kean LS

更新日期：2012-04-01 00:00:00

abstract：:Immunoprecipitation of NP-40 lysates of 125I-labeled lymph-node cells with different anti-H-2 sera and with anti-Qa-2 serum has shown that the BALB/cByA strain (H-2d, Qa-2-negative) expresses, besides H-2Ld, another molecule that is not detectable in the BALB/c-H-2dm2 strain. Electrophoresis in SDS polyacrylamide gels...

journal_title：Immunogenetics

authors： Démant P,Roos MH

更新日期：1982-01-01 00:00:00