Lyb-8.2: A new B cell antigen defined and characterized with a monoclonal antibody.

Abstract:

:A DBA/1 B10.D2-specific monoclonal antibody (CY34) is described which defines a new murine B lymphocyte differentiation antigen designated Lyb-8.2. The ontogeny, strain distribution, and cell-surface density of the antigen were studied by radioimmunoassay and by fluorescence-activated cell sorter (FACS) analysis. Lyb-8.2 appears to be expressed on pre-B cells and on all mature B lymphocytes. Lyb-8.2 molecules immunoprecipitated from surface labeled B10.D2 spleen cells migrated in polyacrylamide gels with an apparent mol. wt. of 95,000-105,000 daltons and were bound by lentil lectin. The expression of Lyb-8.2 is controlled by a locus on chromosome 7 that is closely linked to Gpi-1 and RP-2. Added Lyb-8.2-specific antibody did not measurably impair B lymphocyte function in several in vitro systems studied.

journal_name

Immunogenetics

journal_title

Immunogenetics

authors

Symington FW,Subbarao B,Mosier DE,Sprent J

doi

10.1007/BF00372098

subject

Has Abstract

pub_date

1982-01-01 00:00:00

pages

381-91

issue

5

eissn

0093-7711

issn

1432-1211

journal_volume

16

pub_type

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