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Genetic control of streptococcus-induced hepatic granulomatous lesions in mice.

Abstract：

:Hepatic granulomatous lesions were induced in mice by a single intraperitoneal injection of 3 mg of disrupted Streptococcus pyogenes cell-wall material. Mice carrying the H-2b or H-2k haplotypes were highly susceptible to the induction and three weeks after the injection produced numerous granulomas. In contrast, mice of the H-2d haplotype were resistant and produced only a few hepatic granulomas. Resistance was inherited as a dominant trait and in the backcross generation segregated together with the H-2d phenotype. Testing of the H-2-recombinant mice indicated that the putative gene(s) determining resistance/susceptibility is located to the right of the S and to the left of the D region. This location corresponds to the recently described gene cluster consisting of tumor necrosis factor (TNF) and lymphotoxin genes and several BAT sequences. The known effect of TNF on granuloma formation in mice is consistent with a possible effect of TNF genes, and their variants, on S. pyogenes-inducibility of hepatic granulomas in mice.

journal_name

Immunogenetics

journal_title

Immunogenetics

authors

Chen CY,Cohen SA,Zaleski MB,Albini B

doi

10.1007/BF00209289

subject

Has Abstract

pub_date

1992-01-01 00:00:00

pages

28-32

issue

1

eissn

0093-7711

issn

1432-1211

journal_volume

36

pub_type

杂志文章

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