Abstract:
:As genetically engineered mutant mice deficient in single genes are usually generated on a C57BL/6 background, to study mast cell trafficking in mutant mice, we initially investigated whether mast cells accumulated in bronchi in C57BL/6 mice challenged with OVA allergen acutely or chronically for 1 to 3 months. The total number of bronchial mast cells were quantitated using toluidine blue staining in airways of different sizes, i.e. , small (<90 microm), medium (90-155 microm), or large (>150 microm) airways. Non-OVA challenged and acute OVA challenged mice (C57BL/6 and BALB/c) had no detectable bronchial mast cells. Chronic OVA challenge in BALB/c mice for 1 or 3 months induced a significant increase in the number of bronchial mast cells in small-, medium-, and large-sized airways but minimal change in the number of bronchial mast cells in C57BL/6 mice. Both BALB/c and C57BL/6 mice developed significant lung eosinophilia following acute or chronic OVA challenge. Studies of IL-9-deficient mice on a BALB/c background demonstrated a significant increase in the number of bronchial mast cells in IL-9-deficient mice suggesting that IL-9 was not required for the bronchial accumulation of mast cells. Overall, these studies demonstrate that the chronic OVA challenge protocol we have utilized in BALB/c mice provides a model to study the mechanism of bronchial mast cell accumulation and that bronchial mast cell accumulation in chronic OVA challenged mice is independent of IL-9 in this model.
journal_name
Immunogeneticsjournal_title
Immunogeneticsauthors
Pae S,Cho JY,Dayan S,Miller M,Pemberton AD,Broide DHdoi
10.1007/s00251-010-0452-1subject
Has Abstractpub_date
2010-08-01 00:00:00pages
499-506issue
8eissn
0093-7711issn
1432-1211journal_volume
62pub_type
杂志文章相关文献
IMMUNOGENETICS文献大全abstract::Macaques are the most widely used experimental nonhuman primate (NHP) species. Rhesus (Macaca mulatta, Macmul), cynomolgus (Macaca fascicularis, Macfas), and pigtail (Macaca nemestrina, Macnem) macaques continue to be popular models for vaccine and infectious diseases research, especially HIV infection and AIDS, and f...
journal_title:Immunogenetics
pub_type: 杂志文章
doi:10.1007/s00251-014-0775-4
更新日期:2014-06-01 00:00:00
abstract::The recombination activating genes RAG-1 and RAG-2 are adjacent genes that act synergistically to activate variable-diversity-joining (V(D)J) recombination. Southern analysis of hybrid cell lines derived from patients with the Wilms tumor-aniridia-genitourinary defects-mental retardation (WAGR) syndrome and from mutag...
journal_title:Immunogenetics
pub_type: 杂志文章
doi:10.1007/BF00189518
更新日期:1992-01-01 00:00:00
abstract::The KIR gene cluster exhibits a high degree of polymorphism in terms of gene content as well as allelic polymorphism, and data suggest that it is evolving rapidly. The KIR3DL1 locus is one of the most polymorphic loci within this cluster and is unique in that it encodes an activating receptor KIR3DS1, as well as multi...
journal_title:Immunogenetics
pub_type: 杂志文章
doi:10.1007/s00251-007-0240-8
更新日期:2007-10-01 00:00:00
abstract::The rat major histocompatibility complex loci RT1-B and RT1-D are equivalent to the human leucocyte antigens HLA-DQ and HLA-DR respectively. Here we describe the complementary DNA (cDNA) sequence encoding the alpha and beta chains of both the RT1-B and RT1-D locus genes of the rat RT1u haplotype. We have found entire ...
journal_title:Immunogenetics
pub_type: 杂志文章
doi:10.1007/s00251-003-0584-7
更新日期:2003-08-01 00:00:00
abstract::Using cDNA hybridization selection techniques, we identified seven new genes in a 280 kilobase YAC covering the HLA-F locus. The new genes were mapped back to the YAC by a combination of optical restriction mapping and pulse field gel electrophoresis. Northern analysis of individual clones demonstrated the presence of...
journal_title:Immunogenetics
pub_type: 杂志文章
doi:10.1007/BF02660056
更新日期:1996-01-01 00:00:00
abstract::Natural killer (NK) cells express receptors for MHC class I that contain immunoreceptor tyrosine-based inhibitory motif (ITIM) sequences in their cytoplasmic domain. Whereas these receptors inhibit NK cell cytotoxicity, certain isoforms of these NK receptors (e.g., KIR2DS, CD94/NKG2C, and Ly49D) do not have ITIMs, but...
journal_title:Immunogenetics
pub_type: 杂志文章
doi:10.1007/s002510050642
更新日期:2000-05-01 00:00:00
abstract::Nova Scotia duck tolling retrievers are predisposed to a SLE-related disease complex including immune-mediated rheumatic disease (IMRD) and steroid-responsive meningitis-arteritis (SRMA). IMRD involves symptoms that resemble those seen in systemic autoimmune rheumatic diseases, such as systemic lupus erythematosus, SL...
journal_title:Immunogenetics
pub_type: 杂志文章
doi:10.1007/s00251-009-0387-6
更新日期:2009-08-01 00:00:00
abstract::We report the sequence of a cDNA encoding a rabbit immunoglobulin gamma heavy chain of d12 and e14 allotypes with high homology to partial cDNA sequences from rabbits of d11 and e15 allotypes. The encoded rabbit protein shows homologies with human (68-70%) and mouse (60-63%) gamma chains. The nucleotide sequence homol...
journal_title:Immunogenetics
pub_type: 杂志文章
doi:10.1007/BF00372471
更新日期:1983-01-01 00:00:00
abstract::TL antigens are class I glycoproteins which are expressed on thymocytes and which are coded by the Tla region of the major histocompatibility complex of the mouse. Biochemical analysis of TL molecules from different strains of mice revealed structural variation determined by the Tla region which is detectable by pepti...
journal_title:Immunogenetics
pub_type: 杂志文章
doi:10.1007/BF00373117
更新日期:1986-01-01 00:00:00
abstract::In a series of newly isolated AKR leukemias, some tumors expressed large amounts of both H-2K and H-2D molecules, while others had reduced levels of both antigens. The number of H-2 antigens expressed in steady state showed a consistent correlation with the rate of synthesis of the H-2 class I heavy chain and the beta...
journal_title:Immunogenetics
pub_type: 杂志文章
doi:10.1007/BF00418093
更新日期:1985-01-01 00:00:00
abstract::The effect of the H-2dm1 mutation on Qa-m2 expression was examined. The mutant strain B10.D2-H-2dm1 showed a fourfold increase in Qa-m2 expression when compared with the parental strain B10.D2. Qa-m2 molecules immunoprecipitated from B10.D2-H-2dm1, C57BL/10, and B10.D2 spleen cells were identical by two-dimensional (2...
journal_title:Immunogenetics
pub_type: 杂志文章
doi:10.1007/BF00345969
更新日期:1983-01-01 00:00:00
abstract::Mutation rates of H2 and non-H2 histocompatibility genes in the mouse are examined over a 25-year period. Detected by skin graft rejections, the mutations were screened in inbred and hybrid mice from a continuously maintained and monitored colony and from a regularly supplied set of mice provided from the National Can...
journal_title:Immunogenetics
pub_type: 杂志文章
doi:10.1007/s002510050325
更新日期:1997-01-01 00:00:00
abstract::To assess the role interleukins and mitogens play in regulating immunoglobulin (Ig) gene expression via the Ig enhancer and promoter, transgenic mice carrying two different Ig gene regulatory regions were generated. One, EmukCAT, contains the Ig heavy chain enhancer (Emu) and the kappa light chain promoter driving the...
journal_title:Immunogenetics
pub_type: 杂志文章
doi:10.1007/BF00216623
更新日期:1992-01-01 00:00:00
abstract::As the only native insular Newfoundland canid between the extinction of the wolf in the 1930s and the recent arrival of coyotes, the red fox (Vulpes vulpes deletrix Bangs 1898) poses interesting questions about genetic distinctiveness and the post-glacial colonization history of the island's depauperate mammalian faun...
journal_title:Immunogenetics
pub_type: 杂志文章
doi:10.1007/s00251-016-0907-0
更新日期:2016-05-01 00:00:00
abstract::Individual mice were tested for their proliferation T-cell response to H-Y- and H-3-incompatible stimulator cells in secondary mixed lymphocyte culture. Responders expressing the H-2b haplotype were restricted in their response to stimulators presenting H-Y and H-3 in the context of H-2b. Lymphocytes from individual B...
journal_title:Immunogenetics
pub_type: 杂志文章
doi:10.1007/BF00342193
更新日期:1981-01-01 00:00:00
abstract::We investigated the Nco I restriction fragment length polymorphism (RFLP) of the tumor necrosis factor beta (TNFB) gene in 173 patients with systemic lupus erythematosus (SLE), 192 unrelated healthy controls, and eleven panel families, all of German origin. The phenotype frequency of the TNFB*1 allele was significantl...
journal_title:Immunogenetics
pub_type: 杂志文章
doi:10.1007/BF00222469
更新日期:1993-01-01 00:00:00
abstract::Asthma is a chronic inflammatory disorder of the airways, and a number of genetic loci are associated with the disease. Candidate gene association studies have been regarded as effective tools to study complex traits. Knowledge of the sequence variation and structure of the candidate genes is required for association ...
journal_title:Immunogenetics
pub_type: 杂志文章
doi:10.1007/s00251-005-0024-y
更新日期:2005-10-01 00:00:00
abstract::Rh-related transcripts present in bone marrow samples from several species of nonhuman primates (chimpanzee, gorilla, gibbon, crab-eating macaque) have been amplified by RT-polymerase chain reaction using primers deduced from the sequence of human RH genes. Nucleotide sequence analysis of the nonhuman transcripts reve...
journal_title:Immunogenetics
pub_type: 杂志文章
doi:10.1007/BF00172151
更新日期:1995-01-01 00:00:00
abstract::The peptide repertoire presented on human leukocyte antigen (HLA) class I molecules is largely determined by the structure of the peptide binding groove. It is expected that the molecules having similar grooves (i.e., belonging to the same supertype) might present similar/overlapping peptides. However, the extent of p...
journal_title:Immunogenetics
pub_type: 杂志文章
doi:10.1007/s00251-011-0552-6
更新日期:2011-11-01 00:00:00
abstract::The size of B-cell subsets appears to be under genetic control, but the mechanism of this regulation is unknown. By analyzing five congenic strains of mice that differ only in their H2 haplotype, we addressed the issue of whether the MHC genes are involved in the relative proportions of B-1a, B-1b and B-2 cells. Not o...
journal_title:Immunogenetics
pub_type: 杂志文章
doi:10.1007/s00251-002-0457-5
更新日期:2002-06-01 00:00:00
abstract::The immune response to bovine insulin (BI) in the rat is controlled by the major histocompatibility complex (Mhc)-linked immune response gene (Ir-BI) and immune suppression gene (Is-BI). In the present study, we investigated the low responsiveness to BI in the WKAH rat (RT1k) and attempted to explore the functional li...
journal_title:Immunogenetics
pub_type: 杂志文章
doi:10.1007/BF00364426
更新日期:1988-01-01 00:00:00
abstract::IgM and IgD genes of the Japanese flounder were cloned and characterized from a genomic bacterial artificial chromosome (BAC) library. The micro gene contained four constant region exons (Cmi1-Cmi4), and two transmembrane exons (miTM1 and miTM2), which conforms to the organizational pattern of all other vertebrate mic...
journal_title:Immunogenetics
pub_type: 杂志文章
doi:10.1007/s00251-004-0689-7
更新日期:2004-07-01 00:00:00
abstract::Here we describe the Immunogenetic Management Software (IMS) system, a novel web-based application that permits multiplexed analysis of complex immunogenetic traits that are necessary for the accurate planning and execution of experiments involving large animal models, including nonhuman primates. IMS is capable of ho...
journal_title:Immunogenetics
pub_type: 杂志文章
doi:10.1007/s00251-011-0587-8
更新日期:2012-04-01 00:00:00
abstract::In mammals many natural killer (NK) cell receptors, encoded by the leukocyte receptor complex (LRC), regulate the cytotoxic activity of NK cells and provide protection against virus-infected and tumor cells. To investigate the origin of the Ig-like domains encoded by the LRC genes, a subset of C2-type Ig-like domain s...
journal_title:Immunogenetics
pub_type: 杂志文章
doi:10.1007/s00251-004-0764-0
更新日期:2005-04-01 00:00:00
abstract::Infection of humans and chimpanzees with Hepatitis C virus (HCV) results in either the resolution of the acute infection or its progression to a persistent infection associated with chronic liver disease. In cohorts of human patients, resolution of HCV infection has been associated with homozygosity for both C1(+)HLA-...
journal_title:Immunogenetics
pub_type: 杂志文章
doi:10.1007/s00251-015-0863-0
更新日期:2015-10-01 00:00:00
abstract::Immunofluorescent and immunoelectron-microscopic staining methods were utilized to investigate the localization of Ia antigens in murine keratinizing epithelia. Approximately 3-5% of epidermal cells were shown to be Ia positive. Only dendritic Langerhans cells in the interfollicular epidermis and outer root sheaths we...
journal_title:Immunogenetics
pub_type: 杂志文章
doi:10.1007/BF01844036
更新日期:1978-12-01 00:00:00
abstract::In this study we have sequenced peptides eluted from a truncated recombinant HLA-A*6602 molecule, and compared their features with data reported for peptides presented in the A*6601 molecule. A striking change in the amino-acid binding preferences was observed at peptide position P1, which interacts with pocket A of t...
journal_title:Immunogenetics
pub_type: 杂志文章
doi:10.1007/s00251-004-0677-y
更新日期:2004-05-01 00:00:00
abstract::Apoptosis has been suggested as a major mechanism for the CD4(+) T-lymphocyte depletion observed in patients infected with human immunodeficiency virus 1 (HIV-1). To evaluate the impact of genetic variations to apoptosis during progression of acquired immunodeficiency syndrome (AIDS), we have performed an extensive ge...
journal_title:Immunogenetics
pub_type: 杂志文章
doi:10.1007/s00251-004-0664-3
更新日期:2004-04-01 00:00:00
abstract::The killer cell immunoglobulin-like receptor (KIR) gene cluster exhibits extensive allelic and haplotypic diversity. Variation at the locus is associated with an increasing number of human diseases, reminiscent of the HLA loci. Characterization of diversity at the KIR locus has progressed over the past several years, ...
journal_title:Immunogenetics
pub_type: 杂志文章
doi:10.1007/s00251-008-0334-y
更新日期:2008-12-01 00:00:00
abstract::Major histocompatibility complex (MHC) molecules are only found in jawed vertebrates and not in more primitive species. MHC class II type structures likely represent the ancestral structure of MHC molecules. Efficient MHC class II transport to endosomal compartments depends on association with a specialized chaperone,...
journal_title:Immunogenetics
pub_type: 杂志文章,评审
doi:10.1007/s00251-018-1090-2
更新日期:2019-03-01 00:00:00