abstract：:High-throughput molecular profiling of tumors is a fundamental aspect of precision oncology, enabling the identification of genomic alterations that can be targeted therapeutically. In this context, a patient is matched to a specific drug or therapy based on the tumor's underlying genetic driver events rather than the...

journal_title：Seminars in cancer biology

authors： Jäger N

更新日期：2021-01-18 00:00:00

abstract：:Circular RNAs (circRNAs) are a class of single-stranded closed non-coding RNA molecules (ncRNAs), which are formed as a result of reverse splicing of mRNAs. Despite their relative abundance, an interest in understanding their regulatory importance is rather recent. High stability, abundance and evolutionary conservati...

journal_title：Seminars in cancer biology

authors： Beilerli A,Gareev I,Beylerli O,Yang G,Pavlov V,Aliev G,Ahmad A

更新日期：2021-01-09 00:00:00

abstract：:The understanding of the relationship between epigenetic alterations, their effects on gene expression and the knowledge that these epigenetic alterations are reversible, have opened up new therapeutic pathways for treating various diseases, including cancer. This has led the research for a better understanding of the...

journal_title：Seminars in cancer biology

authors： Ansari I,Chaturvedi A,Chitkara D,Singh S

更新日期：2021-01-06 00:00:00

abstract：:Epigenetic modifications are heritable yet reversible, essential for normal physiological functions and biological development. Aberrant epigenetic modifications, including DNA methylation, histone modification, and non-coding RNA (ncRNA)-mediated gene regulation play a crucial role in cancer progression. In cellular ...

journal_title：Seminars in cancer biology

authors： Mondal P,Natesh J,Penta D,Meeran SM

更新日期：2020-12-09 00:00:00

abstract：:Breast cancer (BC) cell de-sensitization to Tamoxifen (TAM) or other selective estrogen receptor (ER) modulators (SERM) is a complex process associated with BC heterogeneity and the transformation of ER signalling. The most influential resistance-related mechanisms include modifications in ER expression and gene regul...

journal_title：Seminars in cancer biology

authors： Sukocheva OA,Lukina E,Friedemann M,Menschikowski M,Hagelgans A,Aliev G

更新日期：2020-12-07 00:00:00

abstract：:The non-enzymatic glycosylation or non-enzymatic covalent modifications (NECMs) or glycation of cellular proteins result in the generation and accumulation of advanced glycation end products (AGEs) that are associated with the epigenetics of cancer. Epigenetic modifications are inheritable changes without alterations ...

journal_title：Seminars in cancer biology

authors： Rehman S,Aatif M,Rafi Z,Khan MY,Shahab U,Ahmad S,Farhan M

更新日期：2020-12-02 00:00:00

abstract：:The anaphase promoting complex/ cyclosome (APC/C), is an evolutionarily conserved protein complex essential for cellular division due to its role in regulating the mitotic transition from metaphase to anaphase. In this review, we highlight recent work that has shed light on our understanding of the role of APC/C coact...

journal_title：Seminars in cancer biology

authors： Schrock MS,Stromberg BR,Scarberry L,Summers MK

更新日期：2020-12-01 00:00:00

abstract：:Over the last decade, the development and progress of next-generation sequencers incorporated with classical biochemical analyses have drastically produced novel insights into transcription factors, including Sry-like high-mobility group box (SOX) factors. In addition to their primary functions in binding to and activ...

journal_title：Seminars in cancer biology

authors： Higashijima Y,Kanki Y

更新日期：2020-12-01 00:00:00

abstract：:Small cell lung cancer (SCLC) is a particular subtype of lung cancer with high mortality. Recent advances in understanding SCLC genomics and breakthroughs of immunotherapy have substantially expanded existing knowledge and treatment modalities. However, challenges associated with SCLC remain enigmatic and elusive. Mos...

journal_title：Seminars in cancer biology

authors： Khan P,Siddiqui JA,Maurya SK,Lakshmanan I,Jain M,Ganti AK,Salgia R,Batra SK,Nasser MW

更新日期：2020-11-18 00:00:00

abstract：:Macroautophagy (herein autophagy) is an intracellular pathway in which cytoplasmic components are captured by double-membrane vesicles (autophagosomes) that eventually fuse with lysosomes to degrade the cargo. Basal levels of autophagy in all eukaryotic cells maintain cellular homeostasis and under conditions of stres...

journal_title：Seminars in cancer biology

authors： Ammanathan V,Vats S,Abraham IM,Manjithaya R

更新日期：2020-11-01 00:00:00

abstract：:T cells of the adaptive immune system monitor protein degradation products via their presentation on major histocompatibility complex (MHC) molecules to recognize infected cells. Both macroautophagy and endocytosis target intra- and extracellular constituents, respectively, for lysosomal degradation. This results in a...

journal_title：Seminars in cancer biology

authors： Münz C

更新日期：2020-11-01 00:00:00

abstract：:In the setting of cancer pathology, molecular characterization of tumors providing diagnostic and predictive information is acquiring more and more relevance. Moreover, the advent of innovative technologies continuously improves the knowledge of the molecular landscape of tumors and strengthens the links between clini...

journal_title：Seminars in cancer biology

authors： Macerola E,Poma AM,Basolo F

更新日期：2020-10-19 00:00:00

abstract：:Breast cancer is the most common cancer in women worldwide. There have been many advancements in the treatment of breast cancer leading to an increased population of patients living with this disease. Accumulating evidence suggests that cancer diagnosis and aftermath experienced stress could not only affect the qualit...

journal_title：Seminars in cancer biology

authors： Andrijauskaite K,Wargovich MJ

更新日期：2020-09-03 00:00:00

abstract：:P-element-induced wimpy testis (PIWI) interacting RNAs (piRNAs) are a class of small regulatory RNAs mechanistically similar to but much less studied than microRNAs and small interfering RNAs. Today the best understood function of piRNAs is transposon control in animal germ cells, which has earned them the name 'guard...

journal_title：Seminars in cancer biology

authors： Lin Y,Zheng J,Lin D

更新日期：2020-09-01 00:00:00

abstract：:The global burden of breast cancer (BC) is increasing significantly. This trend is caused by several factors such as late diagnosis, limited treatment options for certain BC subtypes, drug resistance which all lead to poor clinical outcomes. Recent research has reported the role of epigenetic alterations in the mechan...

journal_title：Seminars in cancer biology

authors： Sher G,Salman NA,Khan AQ,Prabhu KS,Raza A,Kulinski M,Dermime S,Haris M,Junejo K,Uddin S

更新日期：2020-08-25 00:00:00

abstract：:Glioblastoma (GBM) is an aggressive and incurable brain tumor; its malignancy has been associated with the activity of tumor infiltrating myeloid cells. Myeloid cells play important roles in the tumor control by the immune response, but also in tumor progression. Indeed, GBM exploits multiple mechanisms to recruit and...

journal_title：Seminars in cancer biology

authors： Gabriely G,Quintana FJ

更新日期：2020-08-01 00:00:00

abstract：:Dysfunction of the TP53 (p53) gene occurs in most if not all human malignancies. Two principal mechanisms are responsible for this dysfunction; mutation and downregulation of wild-type p53 mediated by MDM2/MDM4. Because of its almost universal inactivation in malignancy, p53 is a highly attractive target for the devel...

journal_title：Seminars in cancer biology

authors： Duffy MJ,Synnott NC,O'Grady S,Crown J

更新日期：2020-07-31 00:00:00

abstract：:Data obtained from cutting-edge research have shown that deregulated epigenetic marks are critical hallmarks of cancer. Rapidly emerging scientific evidence has helped in developing a proper understanding of the mechanisms leading to control of cellular functions, from changes in chromatin accessibility, transcription...

journal_title：Seminars in cancer biology

authors： Farooqi AA,Fayyaz S,Poltronieri P,Calin G,Mallardo M

更新日期：2020-07-30 00:00:00

abstract：:Colorectal cancer is highly incident worldwide and presents a health burden with elevated mortality rate despite prevention, detection, and treatment, mainly due to metastatic liver disease. Histological growth patterns of colorectal cancer liver metastases have emerged as a reproducible prognostic factor, with biolog...

journal_title：Seminars in cancer biology

authors： Oliveira RC,Alexandrino H,Cipriano MA,Alves FC,Tralhão JG

更新日期：2020-07-14 00:00:00

abstract：:Human gut microbiota is a dynamic and variable system that can change over time and in response to different diets and treatments. There is currently no doubt that gut microbiota can provide interesting therapeutic opportunities, since it can metabolize biologically active molecules, drugs, and their precursors, and c...

journal_title：Seminars in cancer biology

authors： Wu WK,Ivanova EA,Orekhov AN

更新日期：2020-06-28 00:00:00

abstract：:A low vitamin D status is associated with an increased risk of various cancers, such as of colon, breast, prostate and hematological cells. The biologically most active vitamin D metabolite 1α,25-dihydroxyvitamin D3 (1,25(OH)2D3) is a high affinity ligand of the transcription factor vitamin D receptor (VDR). 1,25(OH)2...

journal_title：Seminars in cancer biology

authors： Carlberg C,Muñoz A

更新日期：2020-05-30 00:00:00

abstract：:Uveal melanoma (UM) is a type of intraocular tumor with a propensity to disseminate to the liver. Despite the identification of the early driver mutations during the development of the pathology, the process of UM metastasis is still not fully comprehended. A better understanding of the genetic, molecular, and environ...

journal_title：Seminars in cancer biology

authors： Bustamante P,Piquet L,Landreville S,Burnier JV

更新日期：2020-05-22 00:00:00

abstract：:The tumor microenvironment (TME) is a complex meshwork of extracellular matrix (ECM) macromolecules filled with a collection of cells including cancer-associated fibroblasts (CAFs), blood vessel associated smooth muscle cells, pericytes, endothelial cells, mesenchymal stem cells and a variety of immune cells. In tumor...

journal_title：Seminars in cancer biology

authors： Zeltz C,Primac I,Erusappan P,Alam J,Noel A,Gullberg D

更新日期：2020-05-01 00:00:00

abstract：:The need for more effective cancer therapies is omnipresent as the ever-complex, and highly adaptive, mechanisms of tumor biology allow this disease to elude even the most stringent treatment options. The expanding field of proteoglycan signaling is enticing as a reservoir of potential drug targets and prospects for n...

journal_title：Seminars in cancer biology

authors： Gubbiotti MA,Buraschi S,Kapoor A,Iozzo RV

更新日期：2020-05-01 00:00:00

abstract：:Over the past few decades, understanding how tumor cells evade the immune system and their communication with their tumor microenvironment, has been the subject of intense investigation, with the aim of developing new cancer immunotherapies. The current therapies against cancer such as monoclonal antibodies against ch...

journal_title：Seminars in cancer biology

authors： Espinoza-Sánchez NA,Götte M

更新日期：2020-05-01 00:00:00

abstract：:Managing cancer is now one of the biggest concerns of health organizations. Many strategies have been developed in drug discovery pipelines to help rectify this problem and two of the best ones are drug repurposing and computational methods. The combination of these approaches can have immense impact on the course of ...

journal_title：Seminars in cancer biology

authors： Sohraby F,Aryapour H

更新日期：2020-04-28 00:00:00

abstract：:Oral squamous cell carcinomas (OSCC) are a heterogeneous group of cancers arising from the mucosal lining of the oral cavity. A majority of these cancers are associated with lifestyle risk habits including smoking, excessive alcohol consumption and betel quid chewing. Cetuximab, targeting the epidermal growth factor r...

journal_title：Seminars in cancer biology

authors： Chai AWY,Lim KP,Cheong SC

更新日期：2020-04-01 00:00:00

abstract：:Sarcomas are a rare group of mesenchymal cancers comprising over 70 different histological subtypes. For the majority of these diseases, the molecular understanding of the basis of their initiation and progression remains unclear. As such, limited clinical progress in prognosis or therapeutic regimens have been made o...

journal_title：Seminars in cancer biology

authors： Burns J,Wilding CP,L Jones R,H Huang P

更新日期：2020-04-01 00:00:00

abstract：:Gynaecological carcinosarcomas are the most lethal gynaecological malignancies that are often highly resistant to standard chemotherapy. They are composed of both carcinomatous and sarcomatous components and are associated with high rates of metastatic disease. Due to their rarity, molecular studies have been carried ...

journal_title：Seminars in cancer biology

authors： Barker HE,Scott CL

更新日期：2020-04-01 00:00:00

abstract：:While current treatment regimens for acute leukemia can dramatically improve patient survival, there remains room for improvement. Due to its roles in cell differentiation, cell survival, and apoptotic signaling, modulation of the cyclic AMP (cAMP) pathway has provided a meaningful target in hematological malignancies...

journal_title：Seminars in cancer biology

authors： Perez DR,Sklar LA,Chigaev A,Matlawska-Wasowska K

更新日期：2020-02-07 00:00:00

abstract：:The escalating epidemic of overweight and obesity is currently recognized as one of the most significant health and economic concern worldwide. At the present time, over 1.9 billion adults and more than 600 million people can be, respectively, classified as overweight or obese, and numbers will continue to increase in...

journal_title：Seminars in cancer biology

authors： Barone I,Giordano C,Bonofiglio D,Andò S,Catalano S

更新日期：2020-02-01 00:00:00

abstract：:More than 70% of gastrointestinal (GI) cancers are diagnosed with metastases, leading to poor prognosis. For some cancer patients with limited sites of metastatic tumors, the term oligometastatic disease (OMD) has been coined as opposed to systemic polymetastasis (PMD) disease. Stephan Paget first described an organ-s...

journal_title：Seminars in cancer biology

authors： Zhao Y,Li J,Li D,Wang Z,Zhao J,Wu X,Sun Q,Lin PP,Plum P,Damanakis A,Gebauer F,Zhou M,Zhang Z,Schlösser H,Jauch KW,Nelson PJ,Bruns CJ

更新日期：2020-02-01 00:00:00

abstract：:Metastasis is the main cause of cancer-related deaths. Disseminated tumor cells (DTCs), which seed metastasis, can remain undetected in a dormant state for decades after treatment of the primary tumor and their persistence is the main cause of late relapse and death in a substantial proportion of cancer patients. Unde...

journal_title：Seminars in cancer biology

authors： Vera-Ramirez L

更新日期：2020-02-01 00:00:00

abstract：:The Signal Transducer and Activator of Transcription (STAT) family of proteins consists of transcription factors that play a complex and essential role in the regulation of physiologic cell processes, such as proliferation, differentiation, apoptosis and angiogenesis, and serves to organize the epigenetic landscape of...

journal_title：Seminars in cancer biology

authors： Verhoeven Y,Tilborghs S,Jacobs J,De Waele J,Quatannens D,Deben C,Prenen H,Pauwels P,Trinh XB,Wouters A,Smits ELJ,Lardon F,van Dam PA

更新日期：2020-02-01 00:00:00

abstract：:Cancer metastasis is the leading cause of mortality in patients with solid tumors. The majority of these deaths are associated with metastatic disease that occurs after a period of clinical remission, anywhere from months to decades following removal of the primary mass. This dormancy is prominent in cancers of the br...

journal_title：Seminars in cancer biology

authors： Ma B,Wells A,Clark AM

更新日期：2020-02-01 00:00:00

abstract：:Drug repurposing is a strategy that aims to develop novel cancer treatments through the reuse of existing medicines developed in other disease areas. Such a strategy includes the identification of candidate drugs, clinical development, drug licensing, reimbursement and clinical implementation. This review outlines a l...

journal_title：Seminars in cancer biology

authors： Pantziarka P,Verbaanderd C,Huys I,Bouche G,Meheus L

更新日期：2020-01-23 00:00:00

abstract：:Breast cancer is one of the most prevalent and reoccurring cancers and the second most common reason of death in women. Despite advancements in therapeutic strategies for breast cancer, early tumor recurrence and metastasis in patients indicate resistance to chemotherapeutic medicines, such as paclitaxel due to the ab...

journal_title：Seminars in cancer biology

authors： Ansari MA,Thiruvengadam M,Farooqui Z,Rajakumar G,Sajid Jamal QM,Alzohairy MA,Almatroudi A,Alomary MN,Chung IM,Al-Suhaimi EA

更新日期：2019-12-28 00:00:00

abstract：:The ubiquitin-proteasome system (UPS) plays a central role in the degradation of cellular proteins. Targeting protein degradation has been validated as an effective strategy for cancer therapy since 2003. Several components of the UPS have been validated as potential anticancer targets, including 20S proteasomes, 19S ...

journal_title：Seminars in cancer biology

authors： Yang H,Chen X,Li K,Cheaito H,Yang Q,Wu G,Liu J,Dou QP

更新日期：2019-12-26 00:00:00

abstract：:Amino-bisphosphonates (N-BPs) have been commercially available for over four decades and are used for the treatment of osteoporosis, Paget's disease, hypercalcemia of malignancy, and bone metastases derived from various cancer types. Zoledronate and alendronate, two of the most potent N-BPs, have demonstrated direct t...

journal_title：Seminars in cancer biology

authors： La-Beck NM,Liu X,Shmeeda H,Shudde C,Gabizon AA

更新日期：2019-12-23 00:00:00

abstract：:Drug repurposing for cancer therapy is currently a hot topic of research. Theoretically, in contrast to the known hurdles of developing new molecular entities, the approach of repurposing has several advantages. Mostly, it is said that it is faster, safer, easier, and cheaper. In the real world, however, there are onl...

journal_title：Seminars in cancer biology

authors： Gonzalez-Fierro A,Dueñas-González A

更新日期：2019-12-23 00:00:00