Abstract：
:The tumor microenvironment (TME) is a complex meshwork of extracellular matrix (ECM) macromolecules filled with a collection of cells including cancer-associated fibroblasts (CAFs), blood vessel associated smooth muscle cells, pericytes, endothelial cells, mesenchymal stem cells and a variety of immune cells. In tumors the homeostasis governing ECM synthesis and turnover is disturbed resulting in abnormal blood vessel formation and excessive fibrillar collagen accumulations of varying stiffness and organization. The disturbed ECM homeostasis opens up for new types of paracrine, cell-cell and cell-ECM interactions with large consequences for tumor growth, angiogenesis, metastasis, immune suppression and resistance to treatments. As a main producer of ECM and paracrine signals the CAF is a central cell type in these events. Whereas the paracrine signaling has been extensively studied in the context of tumor-stroma interactions, the nature of the numerous integrin-mediated cell-ECM interactions occurring in the TME remains understudied. In this review we will discuss and dissect the role of known and potential CAF interactions in the TME, during both tumorigenesis and chemoresistance-induced events, with a special focus on the "interaction landscape" in desmoplastic breast, lung and pancreatic cancers. As an example of the multifaceted mode of action of the stromal collagen receptor integrin α11β1, we will summarize our current understanding on the role of this CAF-expressed integrin in these three tumor types.
journal_name
Semin Cancer Bioljournal_title
Seminars in cancer biologyauthors
Zeltz C,Primac I,Erusappan P,Alam J,Noel A,Gullberg Ddoi
10.1016/j.semcancer.2019.08.004subject
Has Abstractpub_date
2020-05-01 00:00:00pages
166-181eissn
1044-579Xissn
1096-3650pii
S1044-579X(19)30038-0journal_volume
62pub_type
杂志文章,评审abstract：:The study of polyomavirus has benefited immensely from two scientific methodologies, cell culture and in vitro studies on one side and the use of transgenic mice as experimental models on the other. Both approaches allowed us to identify cellular products targeted by the viruses, the consequences of these interactions...
journal_title：Seminars in cancer biology
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abstract：:People are continuously exposed exogenously to varying amounts of chemicals that have been shown to have carcinogenic or mutagenic properties in experimental systems. Exposure can occur exogenously when these agents are present in food, air or water, and also endogenously when they are products of metabolism or pathop...
journal_title：Seminars in cancer biology
pub_type： 杂志文章,评审
doi：10.1016/j.semcancer.2004.06.010
更新日期：2004-12-01 00:00:00
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journal_title：Seminars in cancer biology
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journal_title：Seminars in cancer biology
pub_type： 杂志文章
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journal_title：Seminars in cancer biology
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journal_title：Seminars in cancer biology
pub_type： 杂志文章,评审
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pub_type： 杂志文章,评审
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journal_title：Seminars in cancer biology
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journal_title：Seminars in cancer biology
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journal_title：Seminars in cancer biology
pub_type： 杂志文章,评审
doi：
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journal_title：Seminars in cancer biology
pub_type： 杂志文章,评审
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更新日期：2008-10-01 00:00:00
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journal_title：Seminars in cancer biology
pub_type： 杂志文章,评审
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journal_title：Seminars in cancer biology
pub_type： 杂志文章,评审
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journal_title：Seminars in cancer biology
pub_type： 杂志文章,评审
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journal_title：Seminars in cancer biology
pub_type： 杂志文章,评审
doi：10.1016/j.semcancer.2019.05.003
更新日期：2020-05-01 00:00:00
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journal_title：Seminars in cancer biology
pub_type： 杂志文章,评审
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pub_type： 杂志文章,评审
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journal_title：Seminars in cancer biology
pub_type： 杂志文章,评审
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journal_title：Seminars in cancer biology
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journal_title：Seminars in cancer biology
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journal_title：Seminars in cancer biology
pub_type： 杂志文章,评审
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journal_title：Seminars in cancer biology
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journal_title：Seminars in cancer biology
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journal_title：Seminars in cancer biology
pub_type： 杂志文章,评审
doi：
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journal_title：Seminars in cancer biology
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journal_title：Seminars in cancer biology
pub_type： 杂志文章,评审
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journal_title：Seminars in cancer biology
pub_type： 杂志文章,评审
doi：
更新日期：1990-02-01 00:00:00
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journal_title：Seminars in cancer biology
pub_type： 杂志文章,评审
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更新日期：2014-10-01 00:00:00
abstract：:Hepatocellular carcinoma (HCC) is the most common histological form of primary liver cancer; the tumor cells having retained features of hepatocytic differentiation. It is important to emphasize the heterogeneity of the histological background on which the tumor develops. Most HCCs complicate the evolution of an activ...
journal_title：Seminars in cancer biology
pub_type： 杂志文章,评审
doi：10.1006/scbi.2000.0321
更新日期：2000-06-01 00:00:00
