Abstract:
:Human bladder carcinogenesis stands as a paradigm for research on the molecular genetic mechanisms of chemical carcinogenesis. The pathogenesis of bladder cancer is multistage with a typical onset later in life. Epidemiological studies associate occupational exposure to aromatic amines with increased bladder cancer risk. Biochemical studies show aromatic amine metabolism, covalent binding, and DNA adduct formation in human uroepithelial cells (HUC). Smoking increases bladder cancer risk. A possible link with certain strains of human papilloma virus (HPV) infection has recently been suggested. Molecular analyses of bladder cancers reveal multiple genetic alterations, including mutational activation of oncogenes and inactivation of suppressor genes. A working hypothesis proposes that bladder carcinogens cause mutations in cancer genes (oncogenes and suppressor genes) in HUC that, possibly together with HPV infection and viral DNA integration, lead to the development of bladder cancer. In this review, we describe how this model is currently being tested using a multistep HUC in vitro transformation system.
journal_name
Semin Cancer Bioljournal_title
Seminars in cancer biologyauthors
Reznikoff CA,Kao C,Messing EM,Newton M,Swaminathan Ssubject
Has Abstractpub_date
1993-06-01 00:00:00pages
143-52issue
3eissn
1044-579Xissn
1096-3650journal_volume
4pub_type
杂志文章,评审abstract::Clinical Oncologists have largely ignored the debate over genetic instability in human cancers. It is clear that genetic lesions themselves provide valuable information in the treatment of patients with cancer and those genetic lesions can be exploited successfully as therapeutic targets. Whether the mechanisms result...
journal_title:Seminars in cancer biology
pub_type: 杂志文章,评审
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abstract::Natural killer (NK) cells are important mediators of resistance against tumor growth and metastasis. NK cell reactivity is regulated by a balance of signals from activating and inhibitory receptors. While reactivity against tumor cells is beneficial, it is essential that NK cells do not attack normal tissue. The disti...
journal_title:Seminars in cancer biology
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journal_title:Seminars in cancer biology
pub_type: 杂志文章,评审
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journal_title:Seminars in cancer biology
pub_type: 杂志文章,评审
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journal_title:Seminars in cancer biology
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abstract::SINE-VNTR-Alus (SVA) are non-autonomous hominid specific retrotransposons that are associated with disease in humans. SVAs are evolutionarily young and presumably mobilized by the LINE-1 reverse transcriptase in trans. SVAs are currently active and may impact the host through a variety of mechanisms including insertio...
journal_title:Seminars in cancer biology
pub_type: 杂志文章,评审
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journal_title:Seminars in cancer biology
pub_type: 杂志文章,评审
doi:10.1016/j.semcancer.2013.09.001
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abstract::The yeast Saccharomyces provides a powerful system for investigating the biological effects of ionizing radiation, and studies have identified double-strand breaks in DNA as probably of critical importance in determining lethality. These breaks are normally repaired by a recombinational mechanism, but in the absence o...
journal_title:Seminars in cancer biology
pub_type: 杂志文章,评审
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abstract::Hepatocellular carcinoma (HCC) is among the most frequently occurring cancers and the leading causes of cancer mortality worldwide. Identification of the signaling pathways regulating liver carcinogenesis is critical in developing novel chemoprevention and targeted therapies. Mitogen-activated protein kinases (MAPKs),...
journal_title:Seminars in cancer biology
pub_type: 杂志文章,评审
doi:10.1016/j.semcancer.2010.10.011
更新日期:2011-02-01 00:00:00
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journal_title:Seminars in cancer biology
pub_type: 杂志文章,评审
doi:10.1016/j.semcancer.2019.09.001
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journal_title:Seminars in cancer biology
pub_type: 杂志文章,评审
doi:10.1016/s1044-579x(02)00103-7
更新日期:2003-02-01 00:00:00
abstract::The treatment of cancer with tumor vaccines has been a goal of physicians and scientists ever since effective immunization against infectious disease with vaccines was developed. In the past, major tumor antigens had not been molecularly characterized. Recent advances are, however, beginning to define potential molecu...
journal_title:Seminars in cancer biology
pub_type: 杂志文章,评审
doi:10.1016/1044-579x(95)90001-2
更新日期:1995-12-01 00:00:00
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journal_title:Seminars in cancer biology
pub_type: 杂志文章,评审
doi:10.1016/j.semcancer.2016.03.004
更新日期:2016-06-01 00:00:00
abstract::Clear cell renal cell carcinoma (ccRCC) is the most common type of kidney cancer, comprising approximately 75% of all kidney tumors. Recent the Cancer Genome Atlas (TCGA) and International Cancer Genome Consortium (ICGC) studies have significantly advanced the molecular characterization of RCC and facilitated the deve...
journal_title:Seminars in cancer biology
pub_type: 杂志文章,评审
doi:10.1016/j.semcancer.2018.06.004
更新日期:2019-04-01 00:00:00
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journal_title:Seminars in cancer biology
pub_type: 杂志文章,评审
doi:
更新日期:1990-02-01 00:00:00
abstract::The global burden of breast cancer (BC) is increasing significantly. This trend is caused by several factors such as late diagnosis, limited treatment options for certain BC subtypes, drug resistance which all lead to poor clinical outcomes. Recent research has reported the role of epigenetic alterations in the mechan...
journal_title:Seminars in cancer biology
pub_type: 杂志文章
doi:10.1016/j.semcancer.2020.08.009
更新日期:2020-08-25 00:00:00
abstract::Mucins are large molecular weight glycoproteins characterized by carbohydrate sugars attached via 'O-glycosidic' linkages to serine or threonine. Mucins are synthesized by a variety of epithelial tissues as membrane-bound or secreted proteins, encoded by several distinct mucin genes. Numerous alterations of mucin-asso...
journal_title:Seminars in cancer biology
pub_type: 杂志文章,评审
doi:
更新日期:1991-12-01 00:00:00
abstract::Tumor-stromal interactions induce expression of matrix metalloproteinases and serine proteases and, as shown recently, the cysteine protease cathepsin B. We speculate that such interactions upregulate the transcription factor Ets1, resulting in increased cathepsin B expression. This would be consistent with the observ...
journal_title:Seminars in cancer biology
pub_type: 杂志文章,评审
doi:10.1016/j.semcancer.2004.08.001
更新日期:2005-04-01 00:00:00
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journal_title:Seminars in cancer biology
pub_type: 杂志文章,评审
doi:10.1016/j.semcancer.2019.03.005
更新日期:2020-11-01 00:00:00
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journal_title:Seminars in cancer biology
pub_type: 杂志文章,评审
doi:10.1016/j.semcancer.2019.08.023
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journal_title:Seminars in cancer biology
pub_type: 杂志文章
doi:10.1016/j.semcancer.2020.12.006
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journal_title:Seminars in cancer biology
pub_type: 杂志文章,评审
doi:10.1016/j.semcancer.2007.12.001
更新日期:2008-06-01 00:00:00
abstract::Cancer cells show various types of mutations and aberrant expression in genes involved in DNA repair responses. These alterations induce genome instability and promote carcinogenesis steps and cancer progression processes. These defects in DNA repair have also been considered as suitable targets for cancer therapies. ...
journal_title:Seminars in cancer biology
pub_type: 杂志文章,评审
doi:10.1016/j.semcancer.2019.02.005
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abstract::Circular RNAs (circRNAs) are a class of single-stranded closed non-coding RNA molecules (ncRNAs), which are formed as a result of reverse splicing of mRNAs. Despite their relative abundance, an interest in understanding their regulatory importance is rather recent. High stability, abundance and evolutionary conservati...
journal_title:Seminars in cancer biology
pub_type: 杂志文章
doi:10.1016/j.semcancer.2020.12.026
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journal_title:Seminars in cancer biology
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doi:10.1016/j.semcancer.2019.05.003
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abstract::Overt neoplasia is often the result of a chronic disease process encompassing an extended segment of the lifespan of any species. A common pathway in the natural history of the disease is the appearance of focal proliferative lesions that are known to act as precursors for cancer development. It is becoming increasing...
journal_title:Seminars in cancer biology
pub_type: 杂志文章,评审
doi:10.1016/j.semcancer.2008.03.019
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abstract::Splenic marginal zone lymphoma is a rare mature B-cell malignancy involving the spleen, bone marrow and blood. Over the past years, the rapid expansion of sequencing technologies allowing the genome-wide assessment of genomic, epigenetic and transcriptional changes has revolutionized our understanding of the biologica...
journal_title:Seminars in cancer biology
pub_type: 杂志文章,评审
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abstract::Application of nanotechnologies to cancer therapy might increase solubility and/or bioavailability of bioactive compounds of natural or synthetic origin and offers other potential benefits in cancer therapy, including selective targeting. In the present review we aim to evaluate in vivo studies on the anticancer activ...
journal_title:Seminars in cancer biology
pub_type: 杂志文章,评审
doi:10.1016/j.semcancer.2019.08.029
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abstract::The anaphase promoting complex/ cyclosome (APC/C), is an evolutionarily conserved protein complex essential for cellular division due to its role in regulating the mitotic transition from metaphase to anaphase. In this review, we highlight recent work that has shed light on our understanding of the role of APC/C coact...
journal_title:Seminars in cancer biology
pub_type: 杂志文章,评审
doi:10.1016/j.semcancer.2020.03.001
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abstract::Malignant mesothelioma, a tumor of the pleura, pericardium, and peritoneum, is presently a worldwide problem. Current therapy is ineffective in slowing the course of the disease, and median survival from the time of diagnosis is rarely greater than 1 year. While the tumor was almost unknown prior to the second half of...
journal_title:Seminars in cancer biology
pub_type: 杂志文章,评审
doi:10.1006/scbi.2000.0347
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