Abstract:
:SINE-VNTR-Alus (SVA) are non-autonomous hominid specific retrotransposons that are associated with disease in humans. SVAs are evolutionarily young and presumably mobilized by the LINE-1 reverse transcriptase in trans. SVAs are currently active and may impact the host through a variety of mechanisms including insertional mutagenesis, exon shuffling, alternative splicing, and the generation of differentially methylated regions (DMR). Here we review SVA biology, including SVA insertions associated with known diseases. Further, we discuss a model describing the initial formation of SVA and the mechanisms by which SVA may impact the host.
journal_name
Semin Cancer Bioljournal_title
Seminars in cancer biologyauthors
Hancks DC,Kazazian HH Jrdoi
10.1016/j.semcancer.2010.04.001subject
Has Abstractpub_date
2010-08-01 00:00:00pages
234-45issue
4eissn
1044-579Xissn
1096-3650pii
S1044-579X(10)00022-2journal_volume
20pub_type
杂志文章,评审abstract::Tumor masses are deprived of oxygen and characterized by enhanced glucose uptake followed by glycolysis. Elevated glucose levels induce non-enzymatic glycosylation or glycation of proteins which leads to accumulation of advanced glycation end products (AGE). These AGE molecules bind to their respective receptors calle...
journal_title:Seminars in cancer biology
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journal_title:Seminars in cancer biology
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journal_title:Seminars in cancer biology
pub_type: 杂志文章,评审
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journal_title:Seminars in cancer biology
pub_type: 杂志文章,评审
doi:
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journal_title:Seminars in cancer biology
pub_type: 杂志文章,评审
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abstract::Distant metastasis is the major cause for therapeutic failures in clinical oncology. Active immunotherapy of patients with low tumor burden would not only contribute to further reduction of the remaining tumor burden to subclinical levels, but it would also establish a constant state of immunity, i.e. immunological me...
journal_title:Seminars in cancer biology
pub_type: 杂志文章,评审
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abstract::DNA damaging agents (ionizing radiation and chemotherapeutics) are considered as most effective in cancer treatment. However, there is a subpopulation of carcinoma cells within the tumour demonstrating resistance to DNA damaging treatment approaches. It is suggested that limited tumour response to this kind of therapy...
journal_title:Seminars in cancer biology
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journal_title:Seminars in cancer biology
pub_type: 杂志文章,评审
doi:
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journal_title:Seminars in cancer biology
pub_type: 杂志文章
doi:10.1016/j.semcancer.2020.08.009
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journal_title:Seminars in cancer biology
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journal_title:Seminars in cancer biology
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journal_title:Seminars in cancer biology
pub_type: 杂志文章,评审
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journal_title:Seminars in cancer biology
pub_type: 杂志文章,评审
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journal_title:Seminars in cancer biology
pub_type: 杂志文章,评审
doi:
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journal_title:Seminars in cancer biology
pub_type: 杂志文章,评审
doi:
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journal_title:Seminars in cancer biology
pub_type: 杂志文章,评审
doi:10.1016/j.semcancer.2006.10.008
更新日期:2007-02-01 00:00:00
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journal_title:Seminars in cancer biology
pub_type: 杂志文章,评审
doi:10.1016/j.semcancer.2003.10.001
更新日期:2004-06-01 00:00:00
abstract::The ubiquitin-proteasome system (UPS) plays a central role in the degradation of cellular proteins. Targeting protein degradation has been validated as an effective strategy for cancer therapy since 2003. Several components of the UPS have been validated as potential anticancer targets, including 20S proteasomes, 19S ...
journal_title:Seminars in cancer biology
pub_type: 杂志文章,评审
doi:10.1016/j.semcancer.2019.12.013
更新日期:2019-12-26 00:00:00
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journal_title:Seminars in cancer biology
pub_type: 杂志文章,评审
doi:10.1006/scbi.1998.0105
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journal_title:Seminars in cancer biology
pub_type: 杂志文章,评审
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journal_title:Seminars in cancer biology
pub_type: 杂志文章
doi:10.1016/j.semcancer.2020.12.006
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journal_title:Seminars in cancer biology
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journal_title:Seminars in cancer biology
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journal_title:Seminars in cancer biology
pub_type: 杂志文章,评审
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abstract::Mitochondria-shaping proteins control the dynamic equilibrium between fusion and fission of the mitochondrial network. Their balance is strictly required to regulate various processes, including the quality of mitochondria, cell metabolism, cell death, proliferation and cell migration. Alterations in these processes a...
journal_title:Seminars in cancer biology
pub_type: 杂志文章,评审
doi:10.1016/j.semcancer.2017.06.007
更新日期:2017-12-01 00:00:00
abstract::Hormone-related cancers may originate in utero. Accumulating evidence is given by animal studies, descriptive epidemiologic data and analytic etiologic studies. Indicators of high levels of endogenous pregnancy hormones, like high birth weight and jaundice in the offspring, are associated with increased risk for breas...
journal_title:Seminars in cancer biology
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abstract::The non-enzymatic glycosylation or non-enzymatic covalent modifications (NECMs) or glycation of cellular proteins result in the generation and accumulation of advanced glycation end products (AGEs) that are associated with the epigenetics of cancer. Epigenetic modifications are inheritable changes without alterations ...
journal_title:Seminars in cancer biology
pub_type: 杂志文章
doi:10.1016/j.semcancer.2020.11.019
更新日期:2020-12-02 00:00:00
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journal_title:Seminars in cancer biology
pub_type: 杂志文章,评审
doi:10.1016/j.semcancer.2014.07.002
更新日期:2015-04-01 00:00:00
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journal_title:Seminars in cancer biology
pub_type: 杂志文章,评审
doi:10.1016/j.semcancer.2013.02.007
更新日期:2013-06-01 00:00:00
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journal_title:Seminars in cancer biology
pub_type: 杂志文章,评审
doi:10.1016/j.semcancer.2019.09.011
更新日期:2020-04-01 00:00:00