Spatial genome organization in the formation of chromosomal translocations.

abstract：:Altering energy metabolism to meet the uncontrolled proliferation and metastasis has emerged as one of the most significant hallmarks in tumors. However, the detailed molecular mechanisms and regulatory actions underlying have not been fully elucidated. As a family of NAD+ dependent protein modifying enzymes, sirtuins...

journal_title：Seminars in cancer biology

authors： Zhu S,Dong Z,Ke X,Hou J,Zhao E,Zhang K,Wang F,Yang L,Xiang Z,Cui H

更新日期：2019-08-01 00:00:00

abstract：:Managing cancer is now one of the biggest concerns of health organizations. Many strategies have been developed in drug discovery pipelines to help rectify this problem and two of the best ones are drug repurposing and computational methods. The combination of these approaches can have immense impact on the course of ...

journal_title：Seminars in cancer biology

authors： Sohraby F,Aryapour H

更新日期：2020-04-28 00:00:00

abstract：:Breast cancer is the most common female malignancy and a major cause of death in middle-aged women. A positive family history of breast cancer is one of the strongest risk factors for the disease. In addition, many afflicted breast cancer families are characterized by early onset and bilateral tumors, and also, in som...

journal_title：Seminars in cancer biology

authors： Arver B,Du Q,Chen J,Luo L,Lindblom A

更新日期：2000-08-01 00:00:00

abstract：:Over the past few decades, understanding how tumor cells evade the immune system and their communication with their tumor microenvironment, has been the subject of intense investigation, with the aim of developing new cancer immunotherapies. The current therapies against cancer such as monoclonal antibodies against ch...

journal_title：Seminars in cancer biology

authors： Espinoza-Sánchez NA,Götte M

更新日期：2020-05-01 00:00:00

abstract：:Histamine is produced from histidine by histidine decarboxylase (HDC) in many cells including normal and malignant lymphocytes. We examined the expression of HDC and the effect of histamine receptor antagonists on the proliferation of a human T cell line, Jurkat and on antigen-driven proliferation of lymphocytes from ...

journal_title：Seminars in cancer biology

authors： Radvány Z,Darvas Z,Kerekes K,Prechl J,Szalai C,Pállinger E,Valéria L,Varga VL,Sandor M,Erdei A,Falus A

更新日期：2000-02-01 00:00:00

abstract：:Epigenetic modifications are heritable yet reversible, essential for normal physiological functions and biological development. Aberrant epigenetic modifications, including DNA methylation, histone modification, and non-coding RNA (ncRNA)-mediated gene regulation play a crucial role in cancer progression. In cellular ...

journal_title：Seminars in cancer biology

authors： Mondal P,Natesh J,Penta D,Meeran SM

更新日期：2020-12-09 00:00:00

abstract：:There is sufficient evidence to suggest that tumor growth elicits specific immune responses, including CD8(+) and CD4(+) T cell responses that may delay tumor growth and could potentially be harnessed to eradicate cancer. Nevertheless the frequent outcome of cancer is lethality associated with uncontrolled growth and ...

journal_title：Seminars in cancer biology

authors： Khazaie K,von Boehmer H

更新日期：2006-04-01 00:00:00

abstract：:The non-enzymatic glycosylation or non-enzymatic covalent modifications (NECMs) or glycation of cellular proteins result in the generation and accumulation of advanced glycation end products (AGEs) that are associated with the epigenetics of cancer. Epigenetic modifications are inheritable changes without alterations ...

journal_title：Seminars in cancer biology

authors： Rehman S,Aatif M,Rafi Z,Khan MY,Shahab U,Ahmad S,Farhan M

更新日期：2020-12-02 00:00:00

abstract：:Hepatocellular carcinoma (HCC) is the most common histological form of primary liver cancer; the tumor cells having retained features of hepatocytic differentiation. It is important to emphasize the heterogeneity of the histological background on which the tumor develops. Most HCCs complicate the evolution of an activ...

journal_title：Seminars in cancer biology

authors： Bréchot C,Gozuacik D,Murakami Y,Paterlini-Bréchot P

更新日期：2000-06-01 00:00:00

abstract：:Ubiquitination plays a key role in regulating the tumour suppressor p53. It targets p53 for degradation by the 26S proteasome. The ubiquitin pathway also regulates the activity and localisation of p53. Ubiquitination requires ubiquitin-activating and -conjugating enzymes and ubiquitin ligases. In addition, ubiquitinat...

journal_title：Seminars in cancer biology

authors： Allende-Vega N,Saville MK

更新日期：2010-02-01 00:00:00

abstract：:Nutrigenomics effects have an important role in the manipulation of dietary components for human benefit, particularly in cancer prevention or treatment. The impact of dietary components, including phytochemicals, is largely studied by nutrigenomics, looking at the gene expression and molecular mechanisms interacting ...

journal_title：Seminars in cancer biology

authors： Braicu C,Mehterov N,Vladimirov B,Sarafian V,Nabavi SM,Atanasov AG,Berindan-Neagoe I

更新日期：2017-10-01 00:00:00

abstract：:Neutrophils in the tumor host may promote tumor progression by enhancing angiogenesis, invasion and metastasis. Granulocytic myeloid-derived suppressor cells (MDSC) share many features with neutrophils. Classically, MDSC are viewed as and defined as immunosuppressive cells. In this article we summarize and critically ...

journal_title：Seminars in cancer biology

authors： Brandau S,Moses K,Lang S

更新日期：2013-06-01 00:00:00

abstract：:Bone marrow transplantation is currently used to treat a variety of life-threatening diseases. Its applications could be expanded if the risks of graft-versus-host disease (GVHD), a complex pathologic disease, could be reduced. Immunotoxins may provide a means to control drug refractory GVHD. This article will discuss...

journal_title：Seminars in cancer biology

authors： Vallera DA

更新日期：1996-04-01 00:00:00

abstract：:Hormone-related cancers may originate in utero. Accumulating evidence is given by animal studies, descriptive epidemiologic data and analytic etiologic studies. Indicators of high levels of endogenous pregnancy hormones, like high birth weight and jaundice in the offspring, are associated with increased risk for breas...

journal_title：Seminars in cancer biology

authors： Ekbom A

更新日期：1998-08-01 00:00:00

abstract：:The two major breast cancer susceptibility genes, BRCA1 and BRCA2, account for the majority of familial breast-ovarian cancer, but only a modest proportion of breast cancer families without ovarian or male breast cancer. Search for additional breast cancer genes with traditional linkage analysis has so far been unsucc...

journal_title：Seminars in cancer biology

authors： Borg A

更新日期：2001-10-01 00:00:00

abstract：:System approaches in biology have a long history. We focus here on the thinking of Paul A. Weiss and Ludwig von Bertalanffy, who contributed a great deal towards making the system concept operable in biology in the early 20th century. To them, considering whole living systems, which includes their organisation or orde...

journal_title：Seminars in cancer biology

authors： Drack M,Wolkenhauer O

更新日期：2011-06-01 00:00:00

abstract：:Inhibition of Ras signalling has been a goal almost since its central role in cell signalling and its deregulation in disease were discovered. Early attempts at inhibiting its post-translational modification using peptidomimetics were successful in cell culture but failed spectacularly in clinical trials, making indus...

journal_title：Seminars in cancer biology

authors： Mott HR,Owen D

更新日期：2019-02-01 00:00:00

abstract：:Cathepsin X is a cysteine carboxypeptidase, localized predominantly in immune cells, regulating their proliferation, maturation, migration and adhesion. It has recently been confirmed as a significant promoter of malignant progression. Its role in signal transduction was first implied through the interaction with inte...

journal_title：Seminars in cancer biology

authors： Kos J,Vižin T,Fonović UP,Pišlar A

更新日期：2015-04-01 00:00:00

abstract：:Dendritic cells (DC) are central to the initiation of immunity. To induce immune reactivity, DC are recruited at the site of antigen expression, uptake antigens and migrate to secondary lymphoid organs while receiving activation signals delivered by pathogens, dying cells, and/or T cells. Tumours can escape the immune...

journal_title：Seminars in cancer biology

authors： Vicari AP,Caux C,Trinchieri G

更新日期：2002-02-01 00:00:00

abstract：:Understanding the molecular and genetic determinants of cancer will provide unique opportunities for developing rational and effective therapies. Malignant cells are frequently resistant to chemotherapy and radiation induced programmed cell death (apoptosis). This resistance can occur by mutations in the tumor suppres...

journal_title：Seminars in cancer biology

authors： Lebedeva IV,Su ZZ,Sarkar D,Fisher PB

更新日期：2003-04-01 00:00:00

abstract：:Amongst the various types of cancer, breast cancer is a highly heterogeneous disease and known as the leading cause of death among women globally. The extensive interdisciplinary investigation in nanotechnology and cancer biomedical research has been evolved over the years for its effective treatment. However, the adv...

journal_title：Seminars in cancer biology

authors： Afzal M,Ameeduzzafar,Alharbi KS,Alruwaili NK,Al-Abassi FA,Al-Malki AAL,Kazmi I,Kumar V,Kamal MA,Nadeem MS,Aslam M,Anwar F

更新日期：2019-12-20 00:00:00

abstract：:Matrix metalloproteinases (MMPs) are members of zinc-dependent endopeptidases implicated in a variety of physiological and pathological processes. Over the decades, MMPs have been studied for their role in cancer progression, migration, and metastasis. As a result, accumulated evidence of MMPs incriminating role has m...

journal_title：Seminars in cancer biology

authors： Alaseem A,Alhazzani K,Dondapati P,Alobid S,Bishayee A,Rathinavelu A

更新日期：2019-06-01 00:00:00

abstract：:The frequent loss of the INK4a/ARF locus, encoding for both p16(INK4a)and p19(ARF)in human melanoma, raises the question as to which INK4a/ARF gene product functions to suppress melanoma-genesis in vivo. Studies in the mouse have shown that activated RAS mutation can cooperate with INK4a(Delta 2/3)deficiency (null for...

journal_title：Seminars in cancer biology

authors： Yang FC,Merlino G,Chin L

更新日期：2001-06-01 00:00:00

abstract：:Glioblastoma (GBM) is an aggressive and incurable brain tumor; its malignancy has been associated with the activity of tumor infiltrating myeloid cells. Myeloid cells play important roles in the tumor control by the immune response, but also in tumor progression. Indeed, GBM exploits multiple mechanisms to recruit and...

journal_title：Seminars in cancer biology

authors： Gabriely G,Quintana FJ

更新日期：2020-08-01 00:00:00

abstract：:Dietary flavonoids and other polyphenols show great potential as cancer chemopreventive agents in cell culture studies. This does not translate well into in vivo activity, because of extensive conjugative metabolism of these compounds in the intestine and liver. This paper presents a review of a flavonoid subclass in ...

journal_title：Seminars in cancer biology

authors： Walle T

更新日期：2007-10-01 00:00:00

abstract：:Oral squamous cell carcinomas (OSCC) are a heterogeneous group of cancers arising from the mucosal lining of the oral cavity. A majority of these cancers are associated with lifestyle risk habits including smoking, excessive alcohol consumption and betel quid chewing. Cetuximab, targeting the epidermal growth factor r...

journal_title：Seminars in cancer biology

authors： Chai AWY,Lim KP,Cheong SC

更新日期：2020-04-01 00:00:00

abstract：:Among unusual models to study cell death mechanisms, the protist Dictyostelium is remarkable because of its strategic phylogenetic position, with early emergence among eukaryotes and unicellular/multicellular transition, and its very favorable experimental and genetic flexibility. Dictyostelium shows developmental vac...

journal_title：Seminars in cancer biology

authors： Tresse E,Kosta A,Luciani MF,Golstein P

更新日期：2007-04-01 00:00:00

abstract：:Cancer cells are exposed to adverse conditions within the tumor microenvironment that challenge cells to adapt and survive. Several of these homeostatic perturbations insults alter the normal function of the endoplasmic reticulum (ER), resulting in the accumulation of misfolded proteins. ER stress triggers a conserved...

journal_title：Seminars in cancer biology

authors： González-Quiroz M,Urra H,Limia CM,Hetz C

更新日期：2018-06-01 00:00:00

abstract：:T cells of the adaptive immune system monitor protein degradation products via their presentation on major histocompatibility complex (MHC) molecules to recognize infected cells. Both macroautophagy and endocytosis target intra- and extracellular constituents, respectively, for lysosomal degradation. This results in a...

journal_title：Seminars in cancer biology

authors： Münz C

更新日期：2020-11-01 00:00:00

abstract：:Angiogenesis plays a pivotal role in cancer progression and is required for tissue invasion and metastasis. Starting with Folkman's initial observations in 1971, basic research continued to shed new molecular insight into this multifaceted process, leading to the development of several anti-angiogenic drugs. To date, ...

journal_title：Seminars in cancer biology

authors： Ricciuti B,Foglietta J,Bianconi V,Sahebkar A,Pirro M

更新日期：2019-06-01 00:00:00