Targeting the ubiquitin-proteasome system to activate wild-type p53 for cancer therapy.

abstract：:Uveal melanoma (UM) is a type of intraocular tumor with a propensity to disseminate to the liver. Despite the identification of the early driver mutations during the development of the pathology, the process of UM metastasis is still not fully comprehended. A better understanding of the genetic, molecular, and environ...

journal_title：Seminars in cancer biology

authors： Bustamante P,Piquet L,Landreville S,Burnier JV

更新日期：2020-05-22 00:00:00

abstract：:The key molecule for normal B cells is the surface Ig (sIg) of the B-cell receptor, which influences cell behaviour, even after neoplastic transformation. During B-cell maturation, sIg accumulates somatic mutations in the Ig variable region (V) genes and tumours retain these patterns, thereby revealing the point of di...

journal_title：Seminars in cancer biology

authors： Packham G,Stevenson F

更新日期：2010-12-01 00:00:00

abstract：:Mitochondria are essential intracellular organelles that regulate energy metabolism, cell death, and signaling pathways that are important for cell proliferation and differentiation. Therefore, mitochondria are fundamentally implicated in cancer biology, including initiation, growth, metastasis, relapse, and acquired ...

journal_title：Seminars in cancer biology

authors： Kim HK,Noh YH,Nilius B,Ko KS,Rhee BD,Kim N,Han J

更新日期：2017-12-01 00:00:00

abstract：:Abnormally activated RAS proteins are the main oncogenic driver that governs the functioning of major signaling pathways involved in the initiation and development of human malignancies. Mutations in RAS genes and or its regulators, most frequent in human cancers, are the main force for incessant RAS activation and as...

journal_title：Seminars in cancer biology

authors： Khan AQ,Kuttikrishnan S,Siveen KS,Prabhu KS,Shanmugakonar M,Al-Naemi HA,Haris M,Dermime S,Uddin S

更新日期：2019-02-01 00:00:00

abstract：:As stated by Otto Warburg nearly a century ago, cancer is a metabolic disease, a fermentation caused by malfunctioning mitochondria, resulting in increased anabolism and decreased catabolism. Treatment should, therefore, aim at restoring the energy yield. To decrease anabolism, glucose uptake should be reduced (ketoge...

journal_title：Seminars in cancer biology

authors： Schwartz L,Seyfried T,Alfarouk KO,Da Veiga Moreira J,Fais S

更新日期：2017-04-01 00:00:00

abstract：:Small molecule inhibitors target specific metabolic pathways in tumor cells and are a promising class of drugs for the treatment of cancers. The best known example is the treatment of chronic myeloid leukemia (CML) with Gleevec. This is a small molecule inhibitor of the Bcr-Abl kinase which has been shown to drive the...

journal_title：Seminars in cancer biology

authors： Wodarz D,Komarova NL

更新日期：2005-12-01 00:00:00

abstract：:In vitro transformation of replicating myogenic cells by a variety of oncogenes is always accompanied by inhibition of the transition to the terminally differentiated state. Three main levels of interference by oncogenes may ultimately prevent transcription of skeletal muscle-specific genes. First, the transcription o...

journal_title：Seminars in cancer biology

authors： Alemà S,Tatò F

更新日期：1994-04-01 00:00:00

abstract：:A key regulator of cell morphology is the actin cytoskeleton and it has long been appreciated that the cytoskeleton is characteristically altered in cancer. Actin is organized into polymeric structures with distinct dynamics which in turn participate in a wide variety of cell processes including adhesion, migration, c...

journal_title：Seminars in cancer biology

authors： O'Neill GM,Stehn J,Gunning PW

更新日期：2008-02-01 00:00:00

abstract：:The understanding of the relationship between epigenetic alterations, their effects on gene expression and the knowledge that these epigenetic alterations are reversible, have opened up new therapeutic pathways for treating various diseases, including cancer. This has led the research for a better understanding of the...

journal_title：Seminars in cancer biology

authors： Ansari I,Chaturvedi A,Chitkara D,Singh S

更新日期：2021-01-06 00:00:00

abstract：:Cancer depends on cell death. It can emerge when cell death is deficient, and it could be treated through cancer-cell-specific induction of cell death. However, our understanding of cell death is still incomplete. While a few classical animal models have helped greatly in this respect, more may be learnt from non-clas...

journal_title：Seminars in cancer biology

authors： Golstein P

更新日期：2007-04-01 00:00:00

abstract：:Dysfunction of the TP53 (p53) gene occurs in most if not all human malignancies. Two principal mechanisms are responsible for this dysfunction; mutation and downregulation of wild-type p53 mediated by MDM2/MDM4. Because of its almost universal inactivation in malignancy, p53 is a highly attractive target for the devel...

journal_title：Seminars in cancer biology

authors： Duffy MJ,Synnott NC,O'Grady S,Crown J

更新日期：2020-07-31 00:00:00

abstract：:Macroautophagy (herein autophagy) is an intracellular pathway in which cytoplasmic components are captured by double-membrane vesicles (autophagosomes) that eventually fuse with lysosomes to degrade the cargo. Basal levels of autophagy in all eukaryotic cells maintain cellular homeostasis and under conditions of stres...

journal_title：Seminars in cancer biology

authors： Ammanathan V,Vats S,Abraham IM,Manjithaya R

更新日期：2020-11-01 00:00:00

abstract：:Sequencing of whole genomes has provided new perspectives into the blueprints of diverse organisms. Knowing the sequences, however, does not always tell us much about the function of the genes that regulate development and homeostasis. RNA interference (RNAi) is becoming the method of choice for gene function analysis...

journal_title：Seminars in cancer biology

authors： Kittler R,Buchholz F

更新日期：2003-08-01 00:00:00

abstract：:Hormone-related cancers may originate in utero. Accumulating evidence is given by animal studies, descriptive epidemiologic data and analytic etiologic studies. Indicators of high levels of endogenous pregnancy hormones, like high birth weight and jaundice in the offspring, are associated with increased risk for breas...

journal_title：Seminars in cancer biology

authors： Ekbom A

更新日期：1998-08-01 00:00:00

abstract：:Application of nanotechnologies to cancer therapy might increase solubility and/or bioavailability of bioactive compounds of natural or synthetic origin and offers other potential benefits in cancer therapy, including selective targeting. In the present review we aim to evaluate in vivo studies on the anticancer activ...

journal_title：Seminars in cancer biology

authors： Aiello P,Consalvi S,Poce G,Raguzzini A,Toti E,Palmery M,Biava M,Bernardi M,Kamal MA,Perry G,Peluso I

更新日期：2019-08-24 00:00:00

abstract：:Maintenance and accurate propagation of the genetic material are key features for physiological development and wellbeing. The replication licensing machinery is crucial for replication precision as it ensures that replication takes place once per cell cycle. Thus, the expression status of the components comprising th...

journal_title：Seminars in cancer biology

authors： Petrakis TG,Komseli ES,Papaioannou M,Vougas K,Polyzos A,Myrianthopoulos V,Mikros E,Trougakos IP,Thanos D,Branzei D,Townsend P,Gorgoulis VG

更新日期：2016-06-01 00:00:00

abstract：:The frequent loss of the INK4a/ARF locus, encoding for both p16(INK4a)and p19(ARF)in human melanoma, raises the question as to which INK4a/ARF gene product functions to suppress melanoma-genesis in vivo. Studies in the mouse have shown that activated RAS mutation can cooperate with INK4a(Delta 2/3)deficiency (null for...

journal_title：Seminars in cancer biology

authors： Yang FC,Merlino G,Chin L

更新日期：2001-06-01 00:00:00

abstract：:Clear cell renal cell carcinoma (ccRCC) is the most common type of kidney cancer, comprising approximately 75% of all kidney tumors. Recent the Cancer Genome Atlas (TCGA) and International Cancer Genome Consortium (ICGC) studies have significantly advanced the molecular characterization of RCC and facilitated the deve...

journal_title：Seminars in cancer biology

authors： Li QK,Pavlovich CP,Zhang H,Kinsinger CR,Chan DW

更新日期：2019-04-01 00:00:00

abstract：:Overt neoplasia is often the result of a chronic disease process encompassing an extended segment of the lifespan of any species. A common pathway in the natural history of the disease is the appearance of focal proliferative lesions that are known to act as precursors for cancer development. It is becoming increasing...

journal_title：Seminars in cancer biology

authors： Laconi E,Doratiotto S,Vineis P

更新日期：2008-10-01 00:00:00

abstract：:While tumours arise from acquired mutations in oncogenes or tumour-suppressor genes, it is clearly established that cancers are metabolic diseases characterized by metabolic alterations in tumour cells, and also non-tumour cells of the host organism resulting in tumour cachexia and patient weakness. In this review, we...

journal_title：Seminars in cancer biology

authors： Dumas JF,Brisson L,Chevalier S,Mahéo K,Fromont G,Moussata D,Besson P,Roger S

更新日期：2017-04-01 00:00:00

abstract：:Nutrigenomics effects have an important role in the manipulation of dietary components for human benefit, particularly in cancer prevention or treatment. The impact of dietary components, including phytochemicals, is largely studied by nutrigenomics, looking at the gene expression and molecular mechanisms interacting ...

journal_title：Seminars in cancer biology

authors： Braicu C,Mehterov N,Vladimirov B,Sarafian V,Nabavi SM,Atanasov AG,Berindan-Neagoe I

更新日期：2017-10-01 00:00:00

abstract：:While the centrality of aberrant cell proliferation in cancer was widely acknowledged long ago, it is only recently that the control of cell death has been recognized as an important target in carcinogenesis. Various lines of evidence now suggest that p53 is a positive regulator of cell death, and particularly of apop...

journal_title：Seminars in cancer biology

authors： Oren M

更新日期：1994-06-01 00:00:00

abstract：:Nasopharyngeal carcinoma (NPC) has a striking geographical and ethnical distribution. It occurs with high frequency in southern China and Southeast Asia. Family clustering was also observed in NPC and a typical family with 15 NPC cases was introduced in this paper. Epidemiological and genetic studies have been carried...

journal_title：Seminars in cancer biology

authors： Zeng YX,Jia WH

更新日期：2002-12-01 00:00:00

abstract：:Drug repurposing for cancer therapy is currently a hot topic of research. Theoretically, in contrast to the known hurdles of developing new molecular entities, the approach of repurposing has several advantages. Mostly, it is said that it is faster, safer, easier, and cheaper. In the real world, however, there are onl...

journal_title：Seminars in cancer biology

authors： Gonzalez-Fierro A,Dueñas-González A

更新日期：2019-12-23 00:00:00

abstract：:Viability is a fundamental determinant of all cellular functions, and regulation of cell viability is important in shaping tissue differentiation and organism development. The genes in the bcl-2 family can profoundly influence cell viability. In addition to bcl-2, cellular genes in this family include bcl-x, bax, mcl-...

journal_title：Seminars in cancer biology

authors： Craig RW

更新日期：1995-02-01 00:00:00

abstract：:Mucins are large molecular weight glycoproteins characterized by carbohydrate sugars attached via 'O-glycosidic' linkages to serine or threonine. Mucins are synthesized by a variety of epithelial tissues as membrane-bound or secreted proteins, encoded by several distinct mucin genes. Numerous alterations of mucin-asso...

journal_title：Seminars in cancer biology

authors： Ho SB,Kim YS

更新日期：1991-12-01 00:00:00

abstract：:Understanding the molecular and genetic determinants of cancer will provide unique opportunities for developing rational and effective therapies. Malignant cells are frequently resistant to chemotherapy and radiation induced programmed cell death (apoptosis). This resistance can occur by mutations in the tumor suppres...

journal_title：Seminars in cancer biology

authors： Lebedeva IV,Su ZZ,Sarkar D,Fisher PB

更新日期：2003-04-01 00:00:00

abstract：:Notch signaling is mediated by cell-cell interactions and is critical for cell fate determination in many species. Recently, a family of mastermind-like (MAML) transcriptional co-activator genes was identified that encode proteins that cooperate with Notch and CSL to activate transcription. Here, we review our current...

journal_title：Seminars in cancer biology

authors： Wu L,Griffin JD

更新日期：2004-10-01 00:00:00

abstract：:There is sufficient evidence to suggest that tumor growth elicits specific immune responses, including CD8(+) and CD4(+) T cell responses that may delay tumor growth and could potentially be harnessed to eradicate cancer. Nevertheless the frequent outcome of cancer is lethality associated with uncontrolled growth and ...

journal_title：Seminars in cancer biology

authors： Khazaie K,von Boehmer H

更新日期：2006-04-01 00:00:00

abstract：:The marginal level of clinical responses to the Chloroethylnitrosoureas (CENU, i.e. BCNU, CCNU, MeCCNU) suggests that there may exist an innate mechanism of resistance in tumors to these chemotherapeutic agents. A decade of research from many laboratories around the world has led to the identification of the mechanism...

journal_title：Seminars in cancer biology

authors： Erickson LC

更新日期：1991-08-01 00:00:00