Carbohydrate antigens on cancer-associated mucin-like molecules.

abstract：:Distant metastasis is the major cause for therapeutic failures in clinical oncology. Active immunotherapy of patients with low tumor burden would not only contribute to further reduction of the remaining tumor burden to subclinical levels, but it would also establish a constant state of immunity, i.e. immunological me...

journal_title：Seminars in cancer biology

authors： Gilboa E,Lyerly HK,Vieweg J,Saito S

更新日期：1994-12-01 00:00:00

abstract：:The escalating epidemic of overweight and obesity is currently recognized as one of the most significant health and economic concern worldwide. At the present time, over 1.9 billion adults and more than 600 million people can be, respectively, classified as overweight or obese, and numbers will continue to increase in...

journal_title：Seminars in cancer biology

authors： Barone I,Giordano C,Bonofiglio D,Andò S,Catalano S

更新日期：2020-02-01 00:00:00

abstract：:Although much of cancer research relies on Nowell's clonal evolution hypothesis as a conceptual framework, large gaps remain in understanding how tumors develop. The multistage skin cancer model in mice provides continuing insight on fundamental aspects of tumor evolution. In this model, mutation of the oncogene Hras ...

journal_title：Seminars in cancer biology

authors： Kemp CJ

更新日期：2005-12-01 00:00:00

abstract：:Splenic marginal zone lymphoma is a rare mature B-cell malignancy involving the spleen, bone marrow and blood. Over the past years, the rapid expansion of sequencing technologies allowing the genome-wide assessment of genomic, epigenetic and transcriptional changes has revolutionized our understanding of the biologica...

journal_title：Seminars in cancer biology

authors： Spina V,Rossi D

更新日期：2016-08-01 00:00:00

abstract：:Abnormally activated RAS proteins are the main oncogenic driver that governs the functioning of major signaling pathways involved in the initiation and development of human malignancies. Mutations in RAS genes and or its regulators, most frequent in human cancers, are the main force for incessant RAS activation and as...

journal_title：Seminars in cancer biology

authors： Khan AQ,Kuttikrishnan S,Siveen KS,Prabhu KS,Shanmugakonar M,Al-Naemi HA,Haris M,Dermime S,Uddin S

更新日期：2019-02-01 00:00:00

abstract：:Dendritic cells (DC) are central to the initiation of immunity. To induce immune reactivity, DC are recruited at the site of antigen expression, uptake antigens and migrate to secondary lymphoid organs while receiving activation signals delivered by pathogens, dying cells, and/or T cells. Tumours can escape the immune...

journal_title：Seminars in cancer biology

authors： Vicari AP,Caux C,Trinchieri G

更新日期：2002-02-01 00:00:00

abstract：:As stated by Otto Warburg nearly a century ago, cancer is a metabolic disease, a fermentation caused by malfunctioning mitochondria, resulting in increased anabolism and decreased catabolism. Treatment should, therefore, aim at restoring the energy yield. To decrease anabolism, glucose uptake should be reduced (ketoge...

journal_title：Seminars in cancer biology

authors： Schwartz L,Seyfried T,Alfarouk KO,Da Veiga Moreira J,Fais S

更新日期：2017-04-01 00:00:00

abstract：:Breast cancer is the most common cancer in women worldwide. There have been many advancements in the treatment of breast cancer leading to an increased population of patients living with this disease. Accumulating evidence suggests that cancer diagnosis and aftermath experienced stress could not only affect the qualit...

journal_title：Seminars in cancer biology

authors： Andrijauskaite K,Wargovich MJ

更新日期：2020-09-03 00:00:00

abstract：:The retinoblastoma tumor suppressor gene is inactivated in retinoblastomas and a variety of other tumor types. In addition, it is one of several cellular proteins targeted by the transforming proteins of the small DNA tumor viruses. At least two other cellular proteins that are targeted by the viral transforming prote...

journal_title：Seminars in cancer biology

authors： Whyte P

更新日期：1995-04-01 00:00:00

abstract：:Despite continuous improvements in cancer management, locoregional recurrence or metastatic spread still occurs in a high proportion of patients after radiotherapy or combined treatments. One underlying reason might be a low efficacy of current treatments on eradication of cancer stem cells (CSCs). It has been recogni...

journal_title：Seminars in cancer biology

authors： Koch U,Krause M,Baumann M

更新日期：2010-04-01 00:00:00

abstract：:Cells adhere to one another and/or to matrices that surround them. Regulation of cell-cell (intercellular) and cell-matrix adhesion is tightly controlled in normal cells, however, defects in cell adhesion are common in the majority of human cancers. Multilateral communication among tumor cells with the extracellular m...

journal_title：Seminars in cancer biology

authors： Bourboulia D,Stetler-Stevenson WG

更新日期：2010-06-01 00:00:00

abstract：:Breast cancer is one of the most prevalent and reoccurring cancers and the second most common reason of death in women. Despite advancements in therapeutic strategies for breast cancer, early tumor recurrence and metastasis in patients indicate resistance to chemotherapeutic medicines, such as paclitaxel due to the ab...

journal_title：Seminars in cancer biology

authors： Ansari MA,Thiruvengadam M,Farooqui Z,Rajakumar G,Sajid Jamal QM,Alzohairy MA,Almatroudi A,Alomary MN,Chung IM,Al-Suhaimi EA

更新日期：2019-12-28 00:00:00

abstract：:Nucleotide sequence analysis at five distinct loci across the 140, 000 bp genomes of more than 60 KSHV samples from KS and PEL tumors from North America, Africa, the Middle East, Asia and the Pacific revealed that they cluster into four major subtypes (A, B, C and D) that have close associations with the geographic an...

journal_title：Seminars in cancer biology

authors： Hayward GS

更新日期：1999-06-01 00:00:00

abstract：:Chromosomal translocations and genomic instability are universal hallmarks of tumor cells. While the molecular mechanisms leading to the formation of translocations are rapidly being elucidated, a cell biological understanding of how chromosomes undergo translocations in the context of the cell nucleus in vivo is larg...

journal_title：Seminars in cancer biology

authors： Meaburn KJ,Misteli T,Soutoglou E

更新日期：2007-02-01 00:00:00

abstract：:Natural killer (NK) cells are important mediators of resistance against tumor growth and metastasis. NK cell reactivity is regulated by a balance of signals from activating and inhibitory receptors. While reactivity against tumor cells is beneficial, it is essential that NK cells do not attack normal tissue. The disti...

journal_title：Seminars in cancer biology

authors： Johansson MH,Höglund P

更新日期：2006-10-01 00:00:00

abstract：:Notch signaling is mediated by cell-cell interactions and is critical for cell fate determination in many species. Recently, a family of mastermind-like (MAML) transcriptional co-activator genes was identified that encode proteins that cooperate with Notch and CSL to activate transcription. Here, we review our current...

journal_title：Seminars in cancer biology

authors： Wu L,Griffin JD

更新日期：2004-10-01 00:00:00

abstract：:Macroautophagy (herein autophagy) is an intracellular pathway in which cytoplasmic components are captured by double-membrane vesicles (autophagosomes) that eventually fuse with lysosomes to degrade the cargo. Basal levels of autophagy in all eukaryotic cells maintain cellular homeostasis and under conditions of stres...

journal_title：Seminars in cancer biology

authors： Ammanathan V,Vats S,Abraham IM,Manjithaya R

更新日期：2020-11-01 00:00:00

abstract：:Over the last decade, the development and progress of next-generation sequencers incorporated with classical biochemical analyses have drastically produced novel insights into transcription factors, including Sry-like high-mobility group box (SOX) factors. In addition to their primary functions in binding to and activ...

journal_title：Seminars in cancer biology

authors： Higashijima Y,Kanki Y

更新日期：2020-12-01 00:00:00

abstract：:Primary liver cancer is the second most common malignancy, and currently results in 360,000 incident cases, and 350,000 deaths a year in China. For the past four decades, three national surveys on cancer mortality during the periods of 1973-1975, 1990-1992, and 2004-2005 have made it possible to estimate China's past ...

journal_title：Seminars in cancer biology

authors： Chen JG,Zhang SW

更新日期：2011-02-01 00:00:00

abstract：:Among unusual models to study cell death mechanisms, the protist Dictyostelium is remarkable because of its strategic phylogenetic position, with early emergence among eukaryotes and unicellular/multicellular transition, and its very favorable experimental and genetic flexibility. Dictyostelium shows developmental vac...

journal_title：Seminars in cancer biology

authors： Tresse E,Kosta A,Luciani MF,Golstein P

更新日期：2007-04-01 00:00:00

abstract：:The role of F-box proteins in pancreatic tumorigenesis is emerging owing to their pivotal and indispensable roles in cell differentiation, cell cycle regulation and proliferation. In this review, we will focus on β-TrCP (β-transducin repeat-containing protein) and two other prototypical mammalian F-box proteins, Fbxw7...

journal_title：Seminars in cancer biology

authors： Wang H,Maitra A,Wang H

更新日期：2016-02-01 00:00:00

abstract：:System approaches in biology have a long history. We focus here on the thinking of Paul A. Weiss and Ludwig von Bertalanffy, who contributed a great deal towards making the system concept operable in biology in the early 20th century. To them, considering whole living systems, which includes their organisation or orde...

journal_title：Seminars in cancer biology

authors： Drack M,Wolkenhauer O

更新日期：2011-06-01 00:00:00

abstract：:The study of polyomavirus has benefited immensely from two scientific methodologies, cell culture and in vitro studies on one side and the use of transgenic mice as experimental models on the other. Both approaches allowed us to identify cellular products targeted by the viruses, the consequences of these interactions...

journal_title：Seminars in cancer biology

authors： Sáenz Robles MT,Pipas JM

更新日期：2009-08-01 00:00:00

abstract：:Extravasation has been described as a rate-limiting step in the process of hematogeneous metastasis formation. Thereby, transendothelial migration of tumor cells consists of a complex series of events involving multiple cell-cell and cell-matrix interactions. 3D-extravasation assays are valuable tools for the identifi...

journal_title：Seminars in cancer biology

authors： Brandt B,Heyder C,Gloria-Maercker E,Hatzmann W,Rötger A,Kemming D,Zänker KS,Entschladen F,Dittmar T

更新日期：2005-10-01 00:00:00

abstract：:Prostate specific antigen (PSA) is serine protease produced at high concentrations by normal and malignant prostatic epithelium. It is mainly secreted into seminal fluid, where it digests the gel forming after ejaculation. Only minor amounts of PSA leak out into circulation from the normal prostate, but the release of...

journal_title：Seminars in cancer biology

authors： Stenman UH,Leinonen J,Zhang WM,Finne P

更新日期：1999-04-01 00:00:00

abstract：:Hepatocellular carcinoma (HCC) is among the most frequently occurring cancers and the leading causes of cancer mortality worldwide. Identification of the signaling pathways regulating liver carcinogenesis is critical in developing novel chemoprevention and targeted therapies. Mitogen-activated protein kinases (MAPKs),...

journal_title：Seminars in cancer biology

authors： Min L,He B,Hui L

更新日期：2011-02-01 00:00:00

abstract：:Disseminated tumor cells are present in many patients at diagnosis. At a time when the disseminated disease becomes prominent, patients have already been treated with many cycles of therapy to which their metastases were also exposed. These metastases have genetically evolved from primary tumors. Furthermore, their in...

journal_title：Seminars in cancer biology

authors： Lehembre F,Regenass U

更新日期：2012-06-01 00:00:00

abstract：:Liver cancer is the fifth most common cancer and the third most common cause of cancer related death in the world. The recent development of new techniques for the investigations of global change in the gene expression, signaling pathways and wide genome binding has provided novel information for the mechanisms underl...

journal_title：Seminars in cancer biology

authors： Iakova P,Timchenko L,Timchenko NA

更新日期：2011-02-01 00:00:00

abstract：:Although chemokines and their receptors were initially identified as regulators of cell trafficking during inflammation and immune response, they have emerged as crucial players in all stages of tumor development, primary growth, migration, angiogenesis, and establishment as metastases in distant target organs. Neuroe...

journal_title：Seminars in cancer biology

authors： Gross N,Meier R

更新日期：2009-04-01 00:00:00

abstract：:Growing evidence indicates that antisense oligodeoxynucleotides can specifically inhibit gene expression thereby providing an essential tool for understanding gene function and the potential to affect abnormal cell proliferation. Because oncogene activation is intimately involved in tumour initiation and progression, ...

journal_title：Seminars in cancer biology

authors： Calabretta B,Skorski T,Zon G

更新日期：1992-12-01 00:00:00