Abstract:
:Dendritic cells (DC) are central to the initiation of immunity. To induce immune reactivity, DC are recruited at the site of antigen expression, uptake antigens and migrate to secondary lymphoid organs while receiving activation signals delivered by pathogens, dying cells, and/or T cells. Tumours can escape the immune system by interfering with the migration of DC or by not providing the necessary activation signals. Moreover, tumours promote the secretion of factors that inhibit DC differentiation and functions. We will review the current knowledge of the physiopathology of DC in cancer, which paves the way for novel strategies of therapeutic intervention.
journal_name
Semin Cancer Bioljournal_title
Seminars in cancer biologyauthors
Vicari AP,Caux C,Trinchieri Gdoi
10.1006/scbi.2001.0400keywords:
subject
Has Abstractpub_date
2002-02-01 00:00:00pages
33-42issue
1eissn
1044-579Xissn
1096-3650pii
S1044579X01904006journal_volume
12pub_type
杂志文章,评审abstract::More than 70% of gastrointestinal (GI) cancers are diagnosed with metastases, leading to poor prognosis. For some cancer patients with limited sites of metastatic tumors, the term oligometastatic disease (OMD) has been coined as opposed to systemic polymetastasis (PMD) disease. Stephan Paget first described an organ-s...
journal_title:Seminars in cancer biology
pub_type: 杂志文章,评审
doi:10.1016/j.semcancer.2019.08.026
更新日期:2020-02-01 00:00:00
abstract::The ubiquitin-proteasome system (UPS) plays a central role in the degradation of cellular proteins. Targeting protein degradation has been validated as an effective strategy for cancer therapy since 2003. Several components of the UPS have been validated as potential anticancer targets, including 20S proteasomes, 19S ...
journal_title:Seminars in cancer biology
pub_type: 杂志文章,评审
doi:10.1016/j.semcancer.2019.12.013
更新日期:2019-12-26 00:00:00
abstract::Small molecule inhibitors target specific metabolic pathways in tumor cells and are a promising class of drugs for the treatment of cancers. The best known example is the treatment of chronic myeloid leukemia (CML) with Gleevec. This is a small molecule inhibitor of the Bcr-Abl kinase which has been shown to drive the...
journal_title:Seminars in cancer biology
pub_type: 杂志文章,评审
doi:10.1016/j.semcancer.2005.07.002
更新日期:2005-12-01 00:00:00
abstract::The Signal Transducer and Activator of Transcription (STAT) family of proteins consists of transcription factors that play a complex and essential role in the regulation of physiologic cell processes, such as proliferation, differentiation, apoptosis and angiogenesis, and serves to organize the epigenetic landscape of...
journal_title:Seminars in cancer biology
pub_type: 杂志文章,评审
doi:10.1016/j.semcancer.2019.10.002
更新日期:2020-02-01 00:00:00
abstract::Cancer metastasis is the leading cause of mortality in patients with solid tumors. The majority of these deaths are associated with metastatic disease that occurs after a period of clinical remission, anywhere from months to decades following removal of the primary mass. This dormancy is prominent in cancers of the br...
journal_title:Seminars in cancer biology
pub_type: 杂志文章,评审
doi:10.1016/j.semcancer.2019.07.021
更新日期:2020-02-01 00:00:00
abstract::Gynaecological carcinosarcomas are the most lethal gynaecological malignancies that are often highly resistant to standard chemotherapy. They are composed of both carcinomatous and sarcomatous components and are associated with high rates of metastatic disease. Due to their rarity, molecular studies have been carried ...
journal_title:Seminars in cancer biology
pub_type: 杂志文章,评审
doi:10.1016/j.semcancer.2019.10.006
更新日期:2020-04-01 00:00:00
abstract::Despite continuous improvements in cancer management, locoregional recurrence or metastatic spread still occurs in a high proportion of patients after radiotherapy or combined treatments. One underlying reason might be a low efficacy of current treatments on eradication of cancer stem cells (CSCs). It has been recogni...
journal_title:Seminars in cancer biology
pub_type: 杂志文章,评审
doi:10.1016/j.semcancer.2010.02.003
更新日期:2010-04-01 00:00:00
abstract::Malignant cancer cells do not act as lone wolves to achieve metastasis, as they exist within a complex ecosystem consisting of an extracellular matrix scaffold populated by carcinoma-associated fibroblasts (CAFs), endothelial cells and immune cells. We recognize local (primary tumor) and distant ecosystems (metastasis...
journal_title:Seminars in cancer biology
pub_type: 杂志文章,评审
doi:10.1016/j.semcancer.2013.12.009
更新日期:2014-04-01 00:00:00
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journal_title:Seminars in cancer biology
pub_type: 杂志文章,评审
doi:10.1016/j.semcancer.2015.09.004
更新日期:2016-02-01 00:00:00
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journal_title:Seminars in cancer biology
pub_type: 杂志文章,评审
doi:10.1016/j.semcancer.2019.11.003
更新日期:2020-04-01 00:00:00
abstract::Understanding the molecular and genetic determinants of cancer will provide unique opportunities for developing rational and effective therapies. Malignant cells are frequently resistant to chemotherapy and radiation induced programmed cell death (apoptosis). This resistance can occur by mutations in the tumor suppres...
journal_title:Seminars in cancer biology
pub_type: 杂志文章,评审
doi:10.1016/s1044-579x(02)00134-7
更新日期:2003-04-01 00:00:00
abstract::The major cause of death from cancer is due to metastases that are resistant to conventional therapies. Several reasons account for the failure to treat metastases. First, neoplasms are biologically heterogeneous and contain subpopulations of cells with different angiogenic, invasive, and metastatic properties. Second...
journal_title:Seminars in cancer biology
pub_type: 杂志文章,评审
doi:10.1006/scbi.2001.0416
更新日期:2002-04-01 00:00:00
abstract::Human papillomavirus (HPV)-induced skin warts are classically benign lesions. However an association between specific HPV types and skin cancer becomes obvious in epidermodysplasia verruciformis (EV). The analysis of this disease suggests that lesions infected with HPV types 5 and 8 carry a high risk of developing squ...
journal_title:Seminars in cancer biology
pub_type: 杂志文章,评审
doi:
更新日期:1992-10-01 00:00:00
abstract::There is sufficient evidence to suggest that tumor growth elicits specific immune responses, including CD8(+) and CD4(+) T cell responses that may delay tumor growth and could potentially be harnessed to eradicate cancer. Nevertheless the frequent outcome of cancer is lethality associated with uncontrolled growth and ...
journal_title:Seminars in cancer biology
pub_type: 杂志文章,评审
doi:10.1016/j.semcancer.2005.11.006
更新日期:2006-04-01 00:00:00
abstract::Colorectal cancer (CRC) is one of the leading causes of cancer-related deaths worldwide. Similar to many other malignancies, CRC is a heterogeneous disease, making it a clinical challenge for optimization of treatment modalities in reducing the morbidity and mortality associated with this disease. A more precise under...
journal_title:Seminars in cancer biology
pub_type: 杂志文章,评审
doi:10.1016/j.semcancer.2018.05.002
更新日期:2019-04-01 00:00:00
abstract::Cancer-testis antigens (CTAs) are considered as unique and promising cancer biomarkers and targets for cancer therapy. CTAs are multifunctional protein group with specific expression patterns in normal embryonic and adult cells and various types of cancer cells. CTAs are involved in regulating of the basic cellular pr...
journal_title:Seminars in cancer biology
pub_type: 杂志文章,评审
doi:10.1016/j.semcancer.2018.08.006
更新日期:2018-12-01 00:00:00
abstract::The transgenic mouse has emerged as an important model system to assess the transforming potential of oncogenes in the mammary epithelium. Mammary gland-specific expression of oncogenes in transgenic mice has resulted in the induction of a variety of phenotypes ranging from benign epithelial hyperplasias to metastatic...
journal_title:Seminars in cancer biology
pub_type: 杂志文章,评审
doi:
更新日期:1994-02-01 00:00:00
abstract::Tumor cell invasion is now viewed as dysregulated physiologic invasion. Investigators have started to define the molecular events that are involved in this process. We find that there are many functional similarities with molecular events involved in physiologic process such as angiogenesis and wound healing. Matrix m...
journal_title:Seminars in cancer biology
pub_type: 杂志文章,评审
doi:10.1006/scbi.1996.0020
更新日期:1996-06-01 00:00:00
abstract::The discovery of microRNAs (miRNAs) is one of the major scientific breakthroughs in recent years and has revolutionized the way we look at gene regulation. Although we are still at a very early stage in understanding their impact on immunity, miRNAs are changing the way we think about the development of the immune sys...
journal_title:Seminars in cancer biology
pub_type: 杂志文章,评审
doi:10.1016/j.semcancer.2008.01.005
更新日期:2008-04-01 00:00:00
abstract::DNA copy number amplifications activate oncogenes and are found in the majority of advanced solid tumors. Cell-lineage specificity and oncogene affinity of DNA amplifications in cancer suggest that properties of precursor stem cells and selection pressure in the tissue micro-environment determine the genomic location ...
journal_title:Seminars in cancer biology
pub_type: 杂志文章,评审
doi:10.1016/j.semcancer.2006.10.005
更新日期:2007-02-01 00:00:00
abstract::Macroautophagy (herein autophagy) is an intracellular pathway in which cytoplasmic components are captured by double-membrane vesicles (autophagosomes) that eventually fuse with lysosomes to degrade the cargo. Basal levels of autophagy in all eukaryotic cells maintain cellular homeostasis and under conditions of stres...
journal_title:Seminars in cancer biology
pub_type: 杂志文章
doi:10.1016/j.semcancer.2020.02.015
更新日期:2020-11-01 00:00:00
abstract::While the centrality of aberrant cell proliferation in cancer was widely acknowledged long ago, it is only recently that the control of cell death has been recognized as an important target in carcinogenesis. Various lines of evidence now suggest that p53 is a positive regulator of cell death, and particularly of apop...
journal_title:Seminars in cancer biology
pub_type: 杂志文章,评审
doi:
更新日期:1994-06-01 00:00:00
abstract::Natural killer (NK) cells have important functions in the innate immunity to tumors. Recognition of tumor cells by NK cells is mediated by the interaction of activating and inhibitory NK cell receptors with ligands expressed on the tumor target. In addition, NK cell-target cell interactions require the engagement of a...
journal_title:Seminars in cancer biology
pub_type: 杂志文章,评审
doi:10.1016/j.semcancer.2006.07.002
更新日期:2006-10-01 00:00:00
abstract::The global burden of breast cancer (BC) is increasing significantly. This trend is caused by several factors such as late diagnosis, limited treatment options for certain BC subtypes, drug resistance which all lead to poor clinical outcomes. Recent research has reported the role of epigenetic alterations in the mechan...
journal_title:Seminars in cancer biology
pub_type: 杂志文章
doi:10.1016/j.semcancer.2020.08.009
更新日期:2020-08-25 00:00:00
abstract::Laminins are a growing family of alphabetagamma heterotrimeric proteins, commonly found in basement membranes (BMs). These large molecules promote cell adhesion and migration via integrins and other cell-surface receptors. Over 12 laminin isoforms are presently known. The various isoforms have a cell- and tissue-speci...
journal_title:Seminars in cancer biology
pub_type: 杂志文章,评审
doi:10.1016/S1044-579X(02)00023-8
更新日期:2002-06-01 00:00:00
abstract::Angiogenesis, the growth of blood capillaries, is regulated by soluble growth factors and insoluble extracellular matrix (ECM) molecules. Soluble angiogenic mitogens act over large distances to initiate capillary growth whereas changes in ECM govern whether individual cells will grow, differentiate, or involute in res...
journal_title:Seminars in cancer biology
pub_type: 杂志文章,评审
doi:
更新日期:1992-04-01 00:00:00
abstract::Neoplasms progress to cancer through a process of natural selection. The rate of evolution, and thus progression is determined by three parameters: mutation rate, population size of the evolving neoplastic cells, and intensity of selection or rate of clonal expansion. All three parameters are reviewed in the context o...
journal_title:Seminars in cancer biology
pub_type: 杂志文章,评审
doi:10.1016/j.semcancer.2005.06.004
更新日期:2005-12-01 00:00:00
abstract::T cells of the adaptive immune system monitor protein degradation products via their presentation on major histocompatibility complex (MHC) molecules to recognize infected cells. Both macroautophagy and endocytosis target intra- and extracellular constituents, respectively, for lysosomal degradation. This results in a...
journal_title:Seminars in cancer biology
pub_type: 杂志文章,评审
doi:10.1016/j.semcancer.2019.03.005
更新日期:2020-11-01 00:00:00
abstract::Viability is a fundamental determinant of all cellular functions, and regulation of cell viability is important in shaping tissue differentiation and organism development. The genes in the bcl-2 family can profoundly influence cell viability. In addition to bcl-2, cellular genes in this family include bcl-x, bax, mcl-...
journal_title:Seminars in cancer biology
pub_type: 杂志文章,评审
doi:10.1006/scbi.1995.0005
更新日期:1995-02-01 00:00:00
abstract::Metastasis is the main cause of cancer-related deaths. Disseminated tumor cells (DTCs), which seed metastasis, can remain undetected in a dormant state for decades after treatment of the primary tumor and their persistence is the main cause of late relapse and death in a substantial proportion of cancer patients. Unde...
journal_title:Seminars in cancer biology
pub_type: 杂志文章,评审
doi:10.1016/j.semcancer.2019.07.027
更新日期:2020-02-01 00:00:00