The retinoblastoma protein and its relatives.

abstract：:Patients with HIV infection are at increased risk of developing non-Hodgkin lymphoma and Hodgkin lymphoma. While the pathogenesis of these lymphomas is incompletely understood, evidence indicates that immune deregulation, genetic alterations and cytokine production play an important role in HIV lymphomagenesis. The ly...

journal_title：Seminars in cancer biology

authors： Pantanowitz L,Carbone A,Dolcetti R

更新日期：2015-10-01 00:00:00

abstract：:Diffuse large B cell lymphoma (DLBCL) is the most common form of B cell non-Hodgkin lymphoma worldwide and comprises a heterogeneous group of malignancies that originate from the malignant transformation of germinal center (GC) B cells. Over the past decade, significant improvement has been achieved in our understandi...

journal_title：Seminars in cancer biology

authors： Pasqualucci L,Zhang B

更新日期：2016-08-01 00:00:00

abstract：:We have found that not all Epstein-Barr viral (EBV) plasmids are duplicated each cell cycle. This inefficiency is intrinsic to EBV's mechanism of DNA synthesis in latently infected cells and necessarily leads to a loss of EBV plasmids from proliferating cells. If EBV provides its host cells advantages that allow those...

journal_title：Seminars in cancer biology

authors： Vereide D,Sugden B

更新日期：2009-12-01 00:00:00

abstract：:Cells adhere to one another and/or to matrices that surround them. Regulation of cell-cell (intercellular) and cell-matrix adhesion is tightly controlled in normal cells, however, defects in cell adhesion are common in the majority of human cancers. Multilateral communication among tumor cells with the extracellular m...

journal_title：Seminars in cancer biology

authors： Bourboulia D,Stetler-Stevenson WG

更新日期：2010-06-01 00:00:00

abstract：:Cancer metastasis is the leading cause of mortality in patients with solid tumors. The majority of these deaths are associated with metastatic disease that occurs after a period of clinical remission, anywhere from months to decades following removal of the primary mass. This dormancy is prominent in cancers of the br...

journal_title：Seminars in cancer biology

authors： Ma B,Wells A,Clark AM

更新日期：2020-02-01 00:00:00

abstract：:Dysfunction of the TP53 (p53) gene occurs in most if not all human malignancies. Two principal mechanisms are responsible for this dysfunction; mutation and downregulation of wild-type p53 mediated by MDM2/MDM4. Because of its almost universal inactivation in malignancy, p53 is a highly attractive target for the devel...

journal_title：Seminars in cancer biology

authors： Duffy MJ,Synnott NC,O'Grady S,Crown J

更新日期：2020-07-31 00:00:00

abstract：:The two major breast cancer susceptibility genes, BRCA1 and BRCA2, account for the majority of familial breast-ovarian cancer, but only a modest proportion of breast cancer families without ovarian or male breast cancer. Search for additional breast cancer genes with traditional linkage analysis has so far been unsucc...

journal_title：Seminars in cancer biology

authors： Borg A

更新日期：2001-10-01 00:00:00

abstract：:Close international collaboration between pediatric oncologists has led to marked improvements in the cure of patients, seen as a long-term overall survival rate of about 80%. Despite this progress, neuroblastoma remains a challenging disease for both clinicians and researchers. Major clinical problems include lack of...

journal_title：Seminars in cancer biology

authors： Øra I,Eggert A

更新日期：2011-10-01 00:00:00

abstract：:Intellectual property documents (patents and their published applications) are not only collections of legal exclusivity claims but also repositories of scientific and technical information, even though they are not peer reviewed. We have identified and analyzed international disclosures concerning drug repurposing fo...

journal_title：Seminars in cancer biology

authors： Mucke HAM

更新日期：2019-09-20 00:00:00

abstract：:Human papillomavirus (HPV)-induced skin warts are classically benign lesions. However an association between specific HPV types and skin cancer becomes obvious in epidermodysplasia verruciformis (EV). The analysis of this disease suggests that lesions infected with HPV types 5 and 8 carry a high risk of developing squ...

journal_title：Seminars in cancer biology

authors： Pfister H

更新日期：1992-10-01 00:00:00

abstract：:The role of F-box proteins in pancreatic tumorigenesis is emerging owing to their pivotal and indispensable roles in cell differentiation, cell cycle regulation and proliferation. In this review, we will focus on β-TrCP (β-transducin repeat-containing protein) and two other prototypical mammalian F-box proteins, Fbxw7...

journal_title：Seminars in cancer biology

authors： Wang H,Maitra A,Wang H

更新日期：2016-02-01 00:00:00

abstract：:Overt neoplasia is often the result of a chronic disease process encompassing an extended segment of the lifespan of any species. A common pathway in the natural history of the disease is the appearance of focal proliferative lesions that are known to act as precursors for cancer development. It is becoming increasing...

journal_title：Seminars in cancer biology

authors： Laconi E,Doratiotto S,Vineis P

更新日期：2008-10-01 00:00:00

abstract：:Cancer depends on cell death. It can emerge when cell death is deficient, and it could be treated through cancer-cell-specific induction of cell death. However, our understanding of cell death is still incomplete. While a few classical animal models have helped greatly in this respect, more may be learnt from non-clas...

journal_title：Seminars in cancer biology

authors： Golstein P

更新日期：2007-04-01 00:00:00

abstract：:The frequent loss of the INK4a/ARF locus, encoding for both p16(INK4a)and p19(ARF)in human melanoma, raises the question as to which INK4a/ARF gene product functions to suppress melanoma-genesis in vivo. Studies in the mouse have shown that activated RAS mutation can cooperate with INK4a(Delta 2/3)deficiency (null for...

journal_title：Seminars in cancer biology

authors： Yang FC,Merlino G,Chin L

更新日期：2001-06-01 00:00:00

abstract：:Nasopharyngeal carcinoma (NPC) is the human tumour showing the most consistent association with Epstein-Barr virus (EBV). The recent detection of EBV in in-situ NPC lesions has shed light on the sequence of events leading to the development of invasive NPC, and will be discussed in the context of what is known about E...

journal_title：Seminars in cancer biology

authors： Niedobitek G,Agathanggelou A,Nicholls JM

更新日期：1996-08-01 00:00:00

abstract：:Small cell lung cancer (SCLC) is a particular subtype of lung cancer with high mortality. Recent advances in understanding SCLC genomics and breakthroughs of immunotherapy have substantially expanded existing knowledge and treatment modalities. However, challenges associated with SCLC remain enigmatic and elusive. Mos...

journal_title：Seminars in cancer biology

authors： Khan P,Siddiqui JA,Maurya SK,Lakshmanan I,Jain M,Ganti AK,Salgia R,Batra SK,Nasser MW

更新日期：2020-11-18 00:00:00

abstract：:The HLA-G gene gives rise to six differently spliced mRNAs. The membrane bound HLA-G1 molecule containing all three extracellular domains presents peptides that follow motif requirements similar to those of classical HLA class I molecules. This isoform is also capable of inhibiting Natural Killer (NK) cells, but is on...

journal_title：Seminars in cancer biology

authors： Münz C,Nickolaus P,Lammert E,Pascolo S,Stevanović S,Rammensee HG

更新日期：1999-02-01 00:00:00

abstract：:In vitro transformation of replicating myogenic cells by a variety of oncogenes is always accompanied by inhibition of the transition to the terminally differentiated state. Three main levels of interference by oncogenes may ultimately prevent transcription of skeletal muscle-specific genes. First, the transcription o...

journal_title：Seminars in cancer biology

authors： Alemà S,Tatò F

更新日期：1994-04-01 00:00:00

abstract：:Extravasation has been described as a rate-limiting step in the process of hematogeneous metastasis formation. Thereby, transendothelial migration of tumor cells consists of a complex series of events involving multiple cell-cell and cell-matrix interactions. 3D-extravasation assays are valuable tools for the identifi...

journal_title：Seminars in cancer biology

authors： Brandt B,Heyder C,Gloria-Maercker E,Hatzmann W,Rötger A,Kemming D,Zänker KS,Entschladen F,Dittmar T

更新日期：2005-10-01 00:00:00

abstract：:As stated by Otto Warburg nearly a century ago, cancer is a metabolic disease, a fermentation caused by malfunctioning mitochondria, resulting in increased anabolism and decreased catabolism. Treatment should, therefore, aim at restoring the energy yield. To decrease anabolism, glucose uptake should be reduced (ketoge...

journal_title：Seminars in cancer biology

authors： Schwartz L,Seyfried T,Alfarouk KO,Da Veiga Moreira J,Fais S

更新日期：2017-04-01 00:00:00

abstract：:Over the last decade, the development and progress of next-generation sequencers incorporated with classical biochemical analyses have drastically produced novel insights into transcription factors, including Sry-like high-mobility group box (SOX) factors. In addition to their primary functions in binding to and activ...

journal_title：Seminars in cancer biology

authors： Higashijima Y,Kanki Y

更新日期：2020-12-01 00:00:00

abstract：:System approaches in biology have a long history. We focus here on the thinking of Paul A. Weiss and Ludwig von Bertalanffy, who contributed a great deal towards making the system concept operable in biology in the early 20th century. To them, considering whole living systems, which includes their organisation or orde...

journal_title：Seminars in cancer biology

authors： Drack M,Wolkenhauer O

更新日期：2011-06-01 00:00:00

abstract：:A low vitamin D status is associated with an increased risk of various cancers, such as of colon, breast, prostate and hematological cells. The biologically most active vitamin D metabolite 1α,25-dihydroxyvitamin D3 (1,25(OH)2D3) is a high affinity ligand of the transcription factor vitamin D receptor (VDR). 1,25(OH)2...

journal_title：Seminars in cancer biology

authors： Carlberg C,Muñoz A

更新日期：2020-05-30 00:00:00

abstract：:In this paper, we provide an overview of targeted anticancer therapies with small molecule kinase inhibitors. First, we discuss why a single constitutively active kinase emanating from a variety of aberrant genetic alterations is capable of transforming a normal cell, leading it to acquire the hallmarks of a cancer ce...

journal_title：Seminars in cancer biology

authors： Tsai CJ,Nussinov R

更新日期：2013-08-01 00:00:00

abstract：:In animal models complete and permanent eradication of tumors can be achieved by adoptive transfer of tumor specific T cells, combined with interleukin 2. The most active cells are CD8+ cytotoxic T lymphocytes (CTL), which recognize peptides of 8-10 amino acids in length, bound to the antigen presenting groove of MHC ...

journal_title：Seminars in cancer biology

authors： Melief CJ,Kast WM

更新日期：1991-10-01 00:00:00

abstract：:Distant metastasis is the major cause for therapeutic failures in clinical oncology. Active immunotherapy of patients with low tumor burden would not only contribute to further reduction of the remaining tumor burden to subclinical levels, but it would also establish a constant state of immunity, i.e. immunological me...

journal_title：Seminars in cancer biology

authors： Gilboa E,Lyerly HK,Vieweg J,Saito S

更新日期：1994-12-01 00:00:00

abstract：:Breast cancer is the most common female malignancy and a major cause of death in middle-aged women. A positive family history of breast cancer is one of the strongest risk factors for the disease. In addition, many afflicted breast cancer families are characterized by early onset and bilateral tumors, and also, in som...

journal_title：Seminars in cancer biology

authors： Arver B,Du Q,Chen J,Luo L,Lindblom A

更新日期：2000-08-01 00:00:00

abstract：:The understanding of the relationship between epigenetic alterations, their effects on gene expression and the knowledge that these epigenetic alterations are reversible, have opened up new therapeutic pathways for treating various diseases, including cancer. This has led the research for a better understanding of the...

journal_title：Seminars in cancer biology

authors： Ansari I,Chaturvedi A,Chitkara D,Singh S

更新日期：2021-01-06 00:00:00

abstract：:The Signal Transducer and Activator of Transcription (STAT) family of proteins consists of transcription factors that play a complex and essential role in the regulation of physiologic cell processes, such as proliferation, differentiation, apoptosis and angiogenesis, and serves to organize the epigenetic landscape of...

journal_title：Seminars in cancer biology

authors： Verhoeven Y,Tilborghs S,Jacobs J,De Waele J,Quatannens D,Deben C,Prenen H,Pauwels P,Trinh XB,Wouters A,Smits ELJ,Lardon F,van Dam PA

更新日期：2020-02-01 00:00:00

abstract：:Ubiquitination plays a key role in regulating the tumour suppressor p53. It targets p53 for degradation by the 26S proteasome. The ubiquitin pathway also regulates the activity and localisation of p53. Ubiquitination requires ubiquitin-activating and -conjugating enzymes and ubiquitin ligases. In addition, ubiquitinat...

journal_title：Seminars in cancer biology

authors： Allende-Vega N,Saville MK

更新日期：2010-02-01 00:00:00