Microenvironment and HIV-related lymphomagenesis.

abstract：:Colorectal cancer (CRC) is one of the leading causes of cancer related-deaths. The risk of development of CRC is complex and multifactorial, and includes disruption of homeostasis of the intestinal epithelial layer mediated though dysregulations of tumor suppressing/promoting signaling pathways. Guanylate cyclase 2C (...

journal_title：Seminars in cancer biology

authors： Yarla NS,Gali H,Pathuri G,Smriti S,Farooqui M,Panneerselvam J,Kumar G,Madka V,Rao CV

更新日期：2019-06-01 00:00:00

abstract：:While current treatment regimens for acute leukemia can dramatically improve patient survival, there remains room for improvement. Due to its roles in cell differentiation, cell survival, and apoptotic signaling, modulation of the cyclic AMP (cAMP) pathway has provided a meaningful target in hematological malignancies...

journal_title：Seminars in cancer biology

authors： Perez DR,Sklar LA,Chigaev A,Matlawska-Wasowska K

更新日期：2020-02-07 00:00:00

abstract：:Malignant mesothelioma, a tumor of the pleura, pericardium, and peritoneum, is presently a worldwide problem. Current therapy is ineffective in slowing the course of the disease, and median survival from the time of diagnosis is rarely greater than 1 year. While the tumor was almost unknown prior to the second half of...

journal_title：Seminars in cancer biology

authors： Rizzo P,Bocchetta M,Powers A,Foddis R,Stekala E,Pass HI,Carbone M

更新日期：2001-02-01 00:00:00

abstract：:Neutrophils in the tumor host may promote tumor progression by enhancing angiogenesis, invasion and metastasis. Granulocytic myeloid-derived suppressor cells (MDSC) share many features with neutrophils. Classically, MDSC are viewed as and defined as immunosuppressive cells. In this article we summarize and critically ...

journal_title：Seminars in cancer biology

authors： Brandau S,Moses K,Lang S

更新日期：2013-06-01 00:00:00

abstract：:Rel/NF-kappa B is a ubiquitous transcription factor that consists of multiple polypeptide subunits, and is subject to complex regulatory mechanisms that involve protein-protein interactions, phosphorylation, ubiquitination, proteolytic degradation, and nucleocytoplasmic translocation. The sophisticated control of Rel/...

journal_title：Seminars in cancer biology

authors： Mosialos G

更新日期：1997-04-01 00:00:00

abstract：:Mitochondria-shaping proteins control the dynamic equilibrium between fusion and fission of the mitochondrial network. Their balance is strictly required to regulate various processes, including the quality of mitochondria, cell metabolism, cell death, proliferation and cell migration. Alterations in these processes a...

journal_title：Seminars in cancer biology

authors： Simula L,Nazio F,Campello S

更新日期：2017-12-01 00:00:00

abstract：:The study of polyomavirus has benefited immensely from two scientific methodologies, cell culture and in vitro studies on one side and the use of transgenic mice as experimental models on the other. Both approaches allowed us to identify cellular products targeted by the viruses, the consequences of these interactions...

journal_title：Seminars in cancer biology

authors： Sáenz Robles MT,Pipas JM

更新日期：2009-08-01 00:00:00

abstract：:Oral squamous cell carcinomas (OSCC) are a heterogeneous group of cancers arising from the mucosal lining of the oral cavity. A majority of these cancers are associated with lifestyle risk habits including smoking, excessive alcohol consumption and betel quid chewing. Cetuximab, targeting the epidermal growth factor r...

journal_title：Seminars in cancer biology

authors： Chai AWY,Lim KP,Cheong SC

更新日期：2020-04-01 00:00:00

abstract：:The retinoblastoma tumor suppressor gene is inactivated in retinoblastomas and a variety of other tumor types. In addition, it is one of several cellular proteins targeted by the transforming proteins of the small DNA tumor viruses. At least two other cellular proteins that are targeted by the viral transforming prote...

journal_title：Seminars in cancer biology

authors： Whyte P

更新日期：1995-04-01 00:00:00

abstract：:The major cause of death from cancer is due to metastases that are resistant to conventional therapies. Several reasons account for the failure to treat metastases. First, neoplasms are biologically heterogeneous and contain subpopulations of cells with different angiogenic, invasive, and metastatic properties. Second...

journal_title：Seminars in cancer biology

authors： Fidler IJ

更新日期：2002-04-01 00:00:00

abstract：:Epidemiological studies implicate steroid hormones as important factors in the development of neoplasia, and hormonal manipulation constitutes an important treatment arm in cancer therapy. Recent studies demonstrate a key role for nuclear receptor proteins in the expression of genes encoding the cytochrome P450 enzyme...

journal_title：Seminars in cancer biology

authors： Parker KL,Schimmer BP

更新日期：1994-10-01 00:00:00

abstract：:Recently, work on the mechanism of action of the von Hippel-Lindau tumour suppressor protein (pVHL) and studies on hypoxic gene regulation have converged, providing insights into both cellular oxygen sensing and cancer pathogenesis. pVHL is the recognition component of the E3-ubiquitin ligase complex involved in the d...

journal_title：Seminars in cancer biology

authors： Pugh CW,Ratcliffe PJ

更新日期：2003-02-01 00:00:00

abstract：:A low vitamin D status is associated with an increased risk of various cancers, such as of colon, breast, prostate and hematological cells. The biologically most active vitamin D metabolite 1α,25-dihydroxyvitamin D3 (1,25(OH)2D3) is a high affinity ligand of the transcription factor vitamin D receptor (VDR). 1,25(OH)2...

journal_title：Seminars in cancer biology

authors： Carlberg C,Muñoz A

更新日期：2020-05-30 00:00:00

abstract：:Nucleotide sequence analysis at five distinct loci across the 140, 000 bp genomes of more than 60 KSHV samples from KS and PEL tumors from North America, Africa, the Middle East, Asia and the Pacific revealed that they cluster into four major subtypes (A, B, C and D) that have close associations with the geographic an...

journal_title：Seminars in cancer biology

authors： Hayward GS

更新日期：1999-06-01 00:00:00

abstract：:Extravasation has been described as a rate-limiting step in the process of hematogeneous metastasis formation. Thereby, transendothelial migration of tumor cells consists of a complex series of events involving multiple cell-cell and cell-matrix interactions. 3D-extravasation assays are valuable tools for the identifi...

journal_title：Seminars in cancer biology

authors： Brandt B,Heyder C,Gloria-Maercker E,Hatzmann W,Rötger A,Kemming D,Zänker KS,Entschladen F,Dittmar T

更新日期：2005-10-01 00:00:00

abstract：:Primary liver cancer is the second most common malignancy, and currently results in 360,000 incident cases, and 350,000 deaths a year in China. For the past four decades, three national surveys on cancer mortality during the periods of 1973-1975, 1990-1992, and 2004-2005 have made it possible to estimate China's past ...

journal_title：Seminars in cancer biology

authors： Chen JG,Zhang SW

更新日期：2011-02-01 00:00:00

abstract：:Dysfunction of the TP53 (p53) gene occurs in most if not all human malignancies. Two principal mechanisms are responsible for this dysfunction; mutation and downregulation of wild-type p53 mediated by MDM2/MDM4. Because of its almost universal inactivation in malignancy, p53 is a highly attractive target for the devel...

journal_title：Seminars in cancer biology

authors： Duffy MJ,Synnott NC,O'Grady S,Crown J

更新日期：2020-07-31 00:00:00

abstract：:The cysteine proteinase cathepsin B has been implicated in the progression of tumors from a premalignant to a malignant state. Activity of cathepsin B has been shown to be elevated in parallel with malignancy or metastatic potential of human and rodent tumors. These increases in cathepsin B activity correspond in part...

journal_title：Seminars in cancer biology

authors： Sloane BF

更新日期：1990-04-01 00:00:00

abstract：:High-throughput molecular profiling of tumors is a fundamental aspect of precision oncology, enabling the identification of genomic alterations that can be targeted therapeutically. In this context, a patient is matched to a specific drug or therapy based on the tumor's underlying genetic driver events rather than the...

journal_title：Seminars in cancer biology

authors： Jäger N

更新日期：2021-01-18 00:00:00

abstract：:Circular RNAs (circRNAs) are a class of single-stranded closed non-coding RNA molecules (ncRNAs), which are formed as a result of reverse splicing of mRNAs. Despite their relative abundance, an interest in understanding their regulatory importance is rather recent. High stability, abundance and evolutionary conservati...

journal_title：Seminars in cancer biology

authors： Beilerli A,Gareev I,Beylerli O,Yang G,Pavlov V,Aliev G,Ahmad A

更新日期：2021-01-09 00:00:00

abstract：:Laminins are a growing family of alphabetagamma heterotrimeric proteins, commonly found in basement membranes (BMs). These large molecules promote cell adhesion and migration via integrins and other cell-surface receptors. Over 12 laminin isoforms are presently known. The various isoforms have a cell- and tissue-speci...

journal_title：Seminars in cancer biology

authors： Patarroyo M,Tryggvason K,Virtanen I

更新日期：2002-06-01 00:00:00

abstract：:Angiogenesis plays a pivotal role in cancer progression and is required for tissue invasion and metastasis. Starting with Folkman's initial observations in 1971, basic research continued to shed new molecular insight into this multifaceted process, leading to the development of several anti-angiogenic drugs. To date, ...

journal_title：Seminars in cancer biology

authors： Ricciuti B,Foglietta J,Bianconi V,Sahebkar A,Pirro M

更新日期：2019-06-01 00:00:00

abstract：:Cancer metastasis is the leading cause of mortality in patients with solid tumors. The majority of these deaths are associated with metastatic disease that occurs after a period of clinical remission, anywhere from months to decades following removal of the primary mass. This dormancy is prominent in cancers of the br...

journal_title：Seminars in cancer biology

authors： Ma B,Wells A,Clark AM

更新日期：2020-02-01 00:00:00

abstract：:Cancer cells show various types of mutations and aberrant expression in genes involved in DNA repair responses. These alterations induce genome instability and promote carcinogenesis steps and cancer progression processes. These defects in DNA repair have also been considered as suitable targets for cancer therapies. ...

journal_title：Seminars in cancer biology

authors： Motegi A,Masutani M,Yoshioka KI,Bessho T

更新日期：2019-10-01 00:00:00

abstract：:Tumor cell invasion is now viewed as dysregulated physiologic invasion. Investigators have started to define the molecular events that are involved in this process. We find that there are many functional similarities with molecular events involved in physiologic process such as angiogenesis and wound healing. Matrix m...

journal_title：Seminars in cancer biology

authors： Stetler-Stevenson WG,Hewitt R,Corcoran M

更新日期：1996-06-01 00:00:00

abstract：:Growing evidence indicates that antisense oligodeoxynucleotides can specifically inhibit gene expression thereby providing an essential tool for understanding gene function and the potential to affect abnormal cell proliferation. Because oncogene activation is intimately involved in tumour initiation and progression, ...

journal_title：Seminars in cancer biology

authors： Calabretta B,Skorski T,Zon G

更新日期：1992-12-01 00:00:00

abstract：:While the centrality of aberrant cell proliferation in cancer was widely acknowledged long ago, it is only recently that the control of cell death has been recognized as an important target in carcinogenesis. Various lines of evidence now suggest that p53 is a positive regulator of cell death, and particularly of apop...

journal_title：Seminars in cancer biology

authors： Oren M

更新日期：1994-06-01 00:00:00

abstract：:Although chemokines and their receptors were initially identified as regulators of cell trafficking during inflammation and immune response, they have emerged as crucial players in all stages of tumor development, primary growth, migration, angiogenesis, and establishment as metastases in distant target organs. Neuroe...

journal_title：Seminars in cancer biology

authors： Gross N,Meier R

更新日期：2009-04-01 00:00:00

abstract：:Mitochondria play fundamental roles in the regulation of life and death of eukaryotic cells. They mediate aerobic energy conversion through the oxidative phosphorylation (OXPHOS) system, and harbor and control the intrinsic pathway of apoptosis. As a descendant of a bacterial endosymbiont, mitochondria retain a vestig...

journal_title：Seminars in cancer biology

authors： Kim HJ,Maiti P,Barrientos A

更新日期：2017-12-01 00:00:00

abstract：:Ubiquitination plays a key role in regulating the tumour suppressor p53. It targets p53 for degradation by the 26S proteasome. The ubiquitin pathway also regulates the activity and localisation of p53. Ubiquitination requires ubiquitin-activating and -conjugating enzymes and ubiquitin ligases. In addition, ubiquitinat...

journal_title：Seminars in cancer biology

authors： Allende-Vega N,Saville MK

更新日期：2010-02-01 00:00:00