Abstract:
:Extravasation has been described as a rate-limiting step in the process of hematogeneous metastasis formation. Thereby, transendothelial migration of tumor cells consists of a complex series of events involving multiple cell-cell and cell-matrix interactions. 3D-extravasation assays are valuable tools for the identification of genes, which are the key players at switchboards of the intracellular signaling pathways. In consequence, the combination of 3D-modeling and whole genome expression analysis lead to unravel molecular parameters which descripe distinct clinical phenotypes of cancer and therefore, work as prognosticators, predictors of therapy and new therapy targets.
journal_name
Semin Cancer Bioljournal_title
Seminars in cancer biologyauthors
Brandt B,Heyder C,Gloria-Maercker E,Hatzmann W,Rötger A,Kemming D,Zänker KS,Entschladen F,Dittmar Tdoi
10.1016/j.semcancer.2005.06.006keywords:
subject
Has Abstractpub_date
2005-10-01 00:00:00pages
387-95issue
5eissn
1044-579Xissn
1096-3650pii
S1044-579X(05)00039-8journal_volume
15pub_type
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journal_title:Seminars in cancer biology
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journal_title:Seminars in cancer biology
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journal_title:Seminars in cancer biology
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journal_title:Seminars in cancer biology
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journal_title:Seminars in cancer biology
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