Cellular and viral ligands that interact with the EGF receptor.

abstract：:Inhibition of Ras signalling has been a goal almost since its central role in cell signalling and its deregulation in disease were discovered. Early attempts at inhibiting its post-translational modification using peptidomimetics were successful in cell culture but failed spectacularly in clinical trials, making indus...

journal_title：Seminars in cancer biology

authors： Mott HR,Owen D

更新日期：2019-02-01 00:00:00

abstract：:The anaphase promoting complex/ cyclosome (APC/C), is an evolutionarily conserved protein complex essential for cellular division due to its role in regulating the mitotic transition from metaphase to anaphase. In this review, we highlight recent work that has shed light on our understanding of the role of APC/C coact...

journal_title：Seminars in cancer biology

authors： Schrock MS,Stromberg BR,Scarberry L,Summers MK

更新日期：2020-12-01 00:00:00

abstract：:Distant metastasis is the major cause for therapeutic failures in clinical oncology. Active immunotherapy of patients with low tumor burden would not only contribute to further reduction of the remaining tumor burden to subclinical levels, but it would also establish a constant state of immunity, i.e. immunological me...

journal_title：Seminars in cancer biology

authors： Gilboa E,Lyerly HK,Vieweg J,Saito S

更新日期：1994-12-01 00:00:00

abstract：:Small cell lung cancer (SCLC) is a particular subtype of lung cancer with high mortality. Recent advances in understanding SCLC genomics and breakthroughs of immunotherapy have substantially expanded existing knowledge and treatment modalities. However, challenges associated with SCLC remain enigmatic and elusive. Mos...

journal_title：Seminars in cancer biology

authors： Khan P,Siddiqui JA,Maurya SK,Lakshmanan I,Jain M,Ganti AK,Salgia R,Batra SK,Nasser MW

更新日期：2020-11-18 00:00:00

abstract：:Colorectal cancer (CRC) is one of the leading causes of cancer related-deaths. The risk of development of CRC is complex and multifactorial, and includes disruption of homeostasis of the intestinal epithelial layer mediated though dysregulations of tumor suppressing/promoting signaling pathways. Guanylate cyclase 2C (...

journal_title：Seminars in cancer biology

authors： Yarla NS,Gali H,Pathuri G,Smriti S,Farooqui M,Panneerselvam J,Kumar G,Madka V,Rao CV

更新日期：2019-06-01 00:00:00

abstract：:Although much of cancer research relies on Nowell's clonal evolution hypothesis as a conceptual framework, large gaps remain in understanding how tumors develop. The multistage skin cancer model in mice provides continuing insight on fundamental aspects of tumor evolution. In this model, mutation of the oncogene Hras ...

journal_title：Seminars in cancer biology

authors： Kemp CJ

更新日期：2005-12-01 00:00:00

abstract：:The understanding of the relationship between epigenetic alterations, their effects on gene expression and the knowledge that these epigenetic alterations are reversible, have opened up new therapeutic pathways for treating various diseases, including cancer. This has led the research for a better understanding of the...

journal_title：Seminars in cancer biology

authors： Ansari I,Chaturvedi A,Chitkara D,Singh S

更新日期：2021-01-06 00:00:00

abstract：:Metastasis is the main cause of cancer-related deaths. Disseminated tumor cells (DTCs), which seed metastasis, can remain undetected in a dormant state for decades after treatment of the primary tumor and their persistence is the main cause of late relapse and death in a substantial proportion of cancer patients. Unde...

journal_title：Seminars in cancer biology

authors： Vera-Ramirez L

更新日期：2020-02-01 00:00:00

abstract：:Hormone-related cancers may originate in utero. Accumulating evidence is given by animal studies, descriptive epidemiologic data and analytic etiologic studies. Indicators of high levels of endogenous pregnancy hormones, like high birth weight and jaundice in the offspring, are associated with increased risk for breas...

journal_title：Seminars in cancer biology

authors： Ekbom A

更新日期：1998-08-01 00:00:00

abstract：:Human bladder carcinogenesis stands as a paradigm for research on the molecular genetic mechanisms of chemical carcinogenesis. The pathogenesis of bladder cancer is multistage with a typical onset later in life. Epidemiological studies associate occupational exposure to aromatic amines with increased bladder cancer ri...

journal_title：Seminars in cancer biology

authors： Reznikoff CA,Kao C,Messing EM,Newton M,Swaminathan S

更新日期：1993-06-01 00:00:00

abstract：:Cancer cells are exposed to adverse conditions within the tumor microenvironment that challenge cells to adapt and survive. Several of these homeostatic perturbations insults alter the normal function of the endoplasmic reticulum (ER), resulting in the accumulation of misfolded proteins. ER stress triggers a conserved...

journal_title：Seminars in cancer biology

authors： González-Quiroz M,Urra H,Limia CM,Hetz C

更新日期：2018-06-01 00:00:00

abstract：:We have found that not all Epstein-Barr viral (EBV) plasmids are duplicated each cell cycle. This inefficiency is intrinsic to EBV's mechanism of DNA synthesis in latently infected cells and necessarily leads to a loss of EBV plasmids from proliferating cells. If EBV provides its host cells advantages that allow those...

journal_title：Seminars in cancer biology

authors： Vereide D,Sugden B

更新日期：2009-12-01 00:00:00

abstract：:Understanding the molecular and genetic determinants of cancer will provide unique opportunities for developing rational and effective therapies. Malignant cells are frequently resistant to chemotherapy and radiation induced programmed cell death (apoptosis). This resistance can occur by mutations in the tumor suppres...

journal_title：Seminars in cancer biology

authors： Lebedeva IV,Su ZZ,Sarkar D,Fisher PB

更新日期：2003-04-01 00:00:00

abstract：:Gene vectors with an untargeted insertion profile have been explored in preclinical models and clinical trials for the transfer of potentially therapeutic genetic information into somatic cells that have a high replicative potential. The gene-modified cell population can be viewed as a genetic mosaic whose complexity ...

journal_title：Seminars in cancer biology

authors： Kustikova O,Brugman M,Baum C

更新日期：2010-08-01 00:00:00

abstract：:Natural killer (NK) cells are important mediators of resistance against tumor growth and metastasis. NK cell reactivity is regulated by a balance of signals from activating and inhibitory receptors. While reactivity against tumor cells is beneficial, it is essential that NK cells do not attack normal tissue. The disti...

journal_title：Seminars in cancer biology

authors： Johansson MH,Höglund P

更新日期：2006-10-01 00:00:00

abstract：:There is sufficient evidence to suggest that tumor growth elicits specific immune responses, including CD8(+) and CD4(+) T cell responses that may delay tumor growth and could potentially be harnessed to eradicate cancer. Nevertheless the frequent outcome of cancer is lethality associated with uncontrolled growth and ...

journal_title：Seminars in cancer biology

authors： Khazaie K,von Boehmer H

更新日期：2006-04-01 00:00:00

abstract：:The ubiquitin-proteasome system (UPS) plays a central role in the degradation of cellular proteins. Targeting protein degradation has been validated as an effective strategy for cancer therapy since 2003. Several components of the UPS have been validated as potential anticancer targets, including 20S proteasomes, 19S ...

journal_title：Seminars in cancer biology

authors： Yang H,Chen X,Li K,Cheaito H,Yang Q,Wu G,Liu J,Dou QP

更新日期：2019-12-26 00:00:00

abstract：:Nutrigenomics effects have an important role in the manipulation of dietary components for human benefit, particularly in cancer prevention or treatment. The impact of dietary components, including phytochemicals, is largely studied by nutrigenomics, looking at the gene expression and molecular mechanisms interacting ...

journal_title：Seminars in cancer biology

authors： Braicu C,Mehterov N,Vladimirov B,Sarafian V,Nabavi SM,Atanasov AG,Berindan-Neagoe I

更新日期：2017-10-01 00:00:00

abstract：:SINE-VNTR-Alus (SVA) are non-autonomous hominid specific retrotransposons that are associated with disease in humans. SVAs are evolutionarily young and presumably mobilized by the LINE-1 reverse transcriptase in trans. SVAs are currently active and may impact the host through a variety of mechanisms including insertio...

journal_title：Seminars in cancer biology

authors： Hancks DC,Kazazian HH Jr

更新日期：2010-08-01 00:00:00

abstract：:The major cause of death from cancer is due to metastases that are resistant to conventional therapies. Several reasons account for the failure to treat metastases. First, neoplasms are biologically heterogeneous and contain subpopulations of cells with different angiogenic, invasive, and metastatic properties. Second...

journal_title：Seminars in cancer biology

authors： Fidler IJ

更新日期：2002-04-01 00:00:00

abstract：:Investigations across a range of disciplines over the past decade have brought the study of cell motility and its role in invasion to an exciting threshold. The biophysical forces proximally involved in generating cell locomotion, as well as the underlying signaling and genomic regulatory processes, are gradually beco...

journal_title：Seminars in cancer biology

authors： Kassis J,Lauffenburger DA,Turner T,Wells A

更新日期：2001-04-01 00:00:00

abstract：:Application of nanotechnologies to cancer therapy might increase solubility and/or bioavailability of bioactive compounds of natural or synthetic origin and offers other potential benefits in cancer therapy, including selective targeting. In the present review we aim to evaluate in vivo studies on the anticancer activ...

journal_title：Seminars in cancer biology

authors： Aiello P,Consalvi S,Poce G,Raguzzini A,Toti E,Palmery M,Biava M,Bernardi M,Kamal MA,Perry G,Peluso I

更新日期：2019-08-24 00:00:00

abstract：:P-element-induced wimpy testis (PIWI) interacting RNAs (piRNAs) are a class of small regulatory RNAs mechanistically similar to but much less studied than microRNAs and small interfering RNAs. Today the best understood function of piRNAs is transposon control in animal germ cells, which has earned them the name 'guard...

journal_title：Seminars in cancer biology

authors： Lin Y,Zheng J,Lin D

更新日期：2020-09-01 00:00:00

abstract：:Circular RNAs (circRNAs) are a class of single-stranded closed non-coding RNA molecules (ncRNAs), which are formed as a result of reverse splicing of mRNAs. Despite their relative abundance, an interest in understanding their regulatory importance is rather recent. High stability, abundance and evolutionary conservati...

journal_title：Seminars in cancer biology

authors： Beilerli A,Gareev I,Beylerli O,Yang G,Pavlov V,Aliev G,Ahmad A

更新日期：2021-01-09 00:00:00

abstract：:Oral squamous cell carcinomas (OSCC) are a heterogeneous group of cancers arising from the mucosal lining of the oral cavity. A majority of these cancers are associated with lifestyle risk habits including smoking, excessive alcohol consumption and betel quid chewing. Cetuximab, targeting the epidermal growth factor r...

journal_title：Seminars in cancer biology

authors： Chai AWY,Lim KP,Cheong SC

更新日期：2020-04-01 00:00:00

abstract：:The ski oncogene is the transforming gene, v-ski, of the defective SKV avian carcinoma viruses. V-ski transformation causes increased proliferation of embryo fibroblasts and also induces a number of genes characteristic of the muscle lineage. In natural SKV isolates the 49 kDa v-ski polypeptide is expressed as a fusio...

journal_title：Seminars in cancer biology

authors： Colmenares C,Stavnezer E

更新日期：1990-12-01 00:00:00

abstract：:The marginal level of clinical responses to the Chloroethylnitrosoureas (CENU, i.e. BCNU, CCNU, MeCCNU) suggests that there may exist an innate mechanism of resistance in tumors to these chemotherapeutic agents. A decade of research from many laboratories around the world has led to the identification of the mechanism...

journal_title：Seminars in cancer biology

authors： Erickson LC

更新日期：1991-08-01 00:00:00

abstract：:Epstein-Barr virus (EBV)-encoded small RNA (EBER) is the most abundant EBV viral transcript and is used as a target molecule to detect EBV-infected cells in tissues by in situ hybridization. EBER is expected to form double-stranded RNA-like structures. The results of the present study show that EBER contributes to onc...

journal_title：Seminars in cancer biology

authors： Takada K

更新日期：2012-04-01 00:00:00

abstract：:Rel/NF-kappa B is a ubiquitous transcription factor that consists of multiple polypeptide subunits, and is subject to complex regulatory mechanisms that involve protein-protein interactions, phosphorylation, ubiquitination, proteolytic degradation, and nucleocytoplasmic translocation. The sophisticated control of Rel/...

journal_title：Seminars in cancer biology

authors： Mosialos G

更新日期：1997-04-01 00:00:00

abstract：:Utilization of thermal therapy (hyperthermia) is defined as the application of exogenous heat induction and represents a concept that is far from new as it goes back to ancient times when heat was used for treating various diseases, including malignancies. Such therapeutic strategy has gained even more popularity (ove...

journal_title：Seminars in cancer biology

authors： Mantso T,Goussetis G,Franco R,Botaitis S,Pappa A,Panayiotidis M

更新日期：2016-06-01 00:00:00